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Neural pathways of embarrassment and their modulation by social anxiety

L. Müller-Pinzler, V. Gazzola, C. Keysers, J. Sommer, A. Jansen, S. Frässle, W. Einhäuser, F.M. Paulus, S. Krach
2015 NeuroImage  
Targeting these neural markers of embarrassment in the (para-)limbic system provides new perspectives for developing treatment strategies for social anxiety disorders.  ...  The converging integration of information from mentalizing areas and arousal processing systems within the ventral anterior insula and amygdala forms the neural pathways of embarrassment.  ...  (PhD scholarship for SF and grant), the von Behring-Röntgen-Stiftung (KR 60-0023), and by The Netherlands Organization for Scientific Research (NWO; VENI Grant 451-09-006 to VG).  ... 
doi:10.1016/j.neuroimage.2015.06.036 pmid:26093329 pmcid:PMC5008438 fatcat:q2rxrzuvire3vg523omurlthtq

Oxytocin Facilitates Empathic- and Self-embarrassment Ratings by Attenuating Amygdala and Anterior Insula Responses

YaYuan Geng, Weihua Zhao, Feng Zhou, Xiaole Ma, Shuxia Yao, Benjamin Becker, Keith M. Kendrick
2018 Frontiers in Endocrinology  
and neural responses to embarrassment experienced by others or by self.  ...  The neural effects of oxytocin were more pronounced stronger in individuals with high trait anxiety suggesting that it may particularly reduce their anxiety in embarrassing situations.  ...  ACKNOWLEDGMENTS This study was supported by the National Natural Science Foundation of China (NSFC) grant 563 (grants 31530032; 91632117), the Fundamental Research Funds for the Central Universities of  ... 
doi:10.3389/fendo.2018.00572 fatcat:bhof6mjtgvftpf6sep6zo7fcbu

Oxytocin facilitates empathic- and self-embarrassment ratings by attenuating amygdala and anterior insula responses [article]

Yayuan Geng, Weihua Zhao, Feng Zhou, Xiaole Ma, Shuxia Yao, Benjamin Becker, Keith Kendrick
2018 bioRxiv   pre-print
and neural responses to embarrassment experienced by others or by self.  ...  The neural effects of oxytocin are also stronger in individuals with high trait anxiety suggesting that it may particularly reduce their anxiety in embarrassing situations.  ...  The neural effects of embarrassment are also modulated by anxiety (Mueller-Prinzler et al., 2015) and autism (Krach et al., 2016) .  ... 
doi:10.1101/343616 fatcat:loefnywekjbw7ly66qtkawbjbq

Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience

Justin D. Caouette, Amanda E. Guyer
2014 Developmental Cognitive Neuroscience  
Yet some degree of social anxiety can be normative and non-impairing.  ...  One fruitful approach taken to understand the mechanisms of social anxiety has been to use neuroimaging to link affect and cognition with neural networks implicated in the neurodevelopmental social reorientation  ...  Acknowledgements This work was supported by National Institute of Health grants to A.E.G. (R00-MH080076) and to J.D.C. (T32-MH020006).The authors wish to thank Dr. Daniel S. Pine and Dr.  ... 
doi:10.1016/j.dcn.2013.10.003 pmid:24239049 pmcid:PMC3960349 fatcat:n6wa2xjvmnfhdhu4aap7ormggm

Social Circuits: Peptidergic Regulation of Mammalian Social Behavior

Elaine E. Storm, Laurence H. Tecott
2005 Neuron  
Neural pathways the neurobiology of social behavior in diverse mammaemploying the nonapeptides vasopressin and oxytolian species is experimentally tractable and relevant to cin play a particularly prominent  ...  over the last decade, indicating that sights into their neural substrates.  ...  to wonder whether the neural pathways and cance, so can species differences in the action of these neuropeptides.  ... 
doi:10.1016/j.neuron.2005.08.004 pmid:16102531 fatcat:zwcpego6tfgwrmfni4va4uyfka

Editorial: Neuroendocrine Research in Health and Disease

Yu-Feng Wang, Xuequn Chen, Lei Sha, Keith M. Kendrick, Leo T. O. Lee, Christopher H. K. Cheng
2020 Frontiers in Neuroscience  
Eiden, and James A. Carr for participation in the editorial process and Dr. Benjamin C. Nephew and the many other reviewers for their valuable contributions to the quality of our accepted papers.  ...  Interestingly, the neural effects of OT are stronger in individuals with high trait anxiety, suggesting that they may particularly reduce their anxiety in embarrassing situations.  ...  A paper by Cheng et al. demonstrated that androgens and androgenic signaling are involved in the occurrence of depression and anxiety.  ... 
doi:10.3389/fnins.2020.00176 pmid:32265620 pmcid:PMC7105775 fatcat:airetbnzojb37kep3mxbv5z25i

Shame in Parkinson'S Disease: A Review

Julio Angulo, Vanessa Fleury, Julie Anne Péron, Louise Penzenstadler, Daniele Zullino, Paul Krack
2019 Journal of Parkinson's Disease  
Shame is a self-conscious emotion marked by an intensely negative self-evaluation. It is exhibited by an individual upon realizing that she/he has violated an important (usually social) norm.  ...  Shame can be a source of emotional distress leading to social withdrawal and depression, with a significant negative impact on quality of life. In Parkinson's disease (PD), shame is rarely addressed.  ...  This mode of defense is a known pathway to severe depression and suicide, the most common risk factors for suicidal ideation being hopelessness, depression and social isolation [75] .  ... 
doi:10.3233/jpd-181462 pmid:31081792 pmcid:PMC6700625 fatcat:nm5yy5r2abhxfpfjgie2spf3my

Toward an integrative understanding of social phobia

D Li, P Chokka, P Tibbo
2001 Journal of Psychiatry & Neuroscience  
The biologic distinctiveness of social phobia from anxiety disorders and physiological validation of differences between generalized and discrete social phobia subtypes have been implicated in genetic,  ...  understanding of social phobia in the framework of a hypothetical neural circuit.  ...  Introduction Social phobia (SP), also termed social anxiety disorder, is a disorder characterized by extreme anxiety in social and performance situations.  ... 
pmid:11394189 pmcid:PMC1408296 fatcat:364v3dqcinb6dijpxhj6xnzvqm

Social Impairments in Mental Disorders: Recent Developments in Studying the Mechanisms of Interactive Behavior

Konrad Lehmann, Lara Maliske, Anne Böckler, Philipp Kanske
2019 Clinical Psychology in Europe  
in Autism Spectrum Disorder (ASD), Personality Disorder, Social Anxiety Disorder (SAD), and Schizophrenia.  ...  In individuals with ASD, these methods revealed reduced sensitivity to the presence of a real interaction partner as well as diminished behavioral and neural synchronicity with interaction partners.  ...  Author Contributions: The first and second author contributed equally to this work.  ... 
doi:10.32872/cpe.v1i2.33143 fatcat:zxnibbidkvc5hgg6bmnyebjum4

Molecular and neurocircuitry mechanisms of social avoidance

Anne-Kathrin Gellner, Jella Voelter, Ulrike Schmidt, Eva Carolina Beins, Valentin Stein, Alexandra Philipsen, René Hurlemann
2020 Cellular and Molecular Life Sciences (CMLS)  
Humans and animals live in social relationships shaped by actions of approach and avoidance. Both are crucial for normal physical and mental development, survival, and well-being.  ...  Active withdrawal from social interaction is often induced by the perception of threat or unpleasant social experience and relies on adaptive mechanisms within neuronal networks associated with social  ...  Within this framework, avoidant responses are modulated by subjects' level of anxiety and by previous episodes of social stress.  ... 
doi:10.1007/s00018-020-03649-x pmid:32997200 fatcat:thtvj6yei5cr3ein6g3lzkobte

OFC and its connectivity with amygdala as predictors for future social anxiety in adolescents

Yu Mao, Xinian Zuo, Cody Ding, Jiang Qiu
2020 Developmental Cognitive Neuroscience  
Mediation analysis revealed that the relationship between social anxiety and attention avoidance is partly mediated by the FC of OFC-amygdala.  ...  The present study investigated the neural basis of social anxiety using voxel-based morphometry (VBM) and functional connectivity analysis.  ...  However, little is known about the neural and cognitive basis of social anxiety in adolescents.  ... 
doi:10.1016/j.dcn.2020.100804 pmid:32716853 pmcid:PMC7301179 fatcat:npmt5p5eardrjjgsujky5sm3ye

Treatment Options for Fear of Blushing

Peter D. Drummond, Graeme B. Shapiro, Milica Nikolić, Susan M. Bögels
2020 Current Psychiatry Reports  
Psychological risk factors for fear of blushing include social anxiety, coupled with heightened self-focused attention and inflated beliefs about the likelihood and social costs of blushing.  ...  However, selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors are effective treatments for social anxiety disorder and may thus help some patients manage their fear  ...  Such people assess their social performance by relying on these biased appraisals; thus, negative perceptual bias is thought to be important for maintaining social anxiety and fear of blushing.  ... 
doi:10.1007/s11920-020-01152-5 pmid:32377882 fatcat:a65ciozoorfqfbm2gwv3ca6smu


Ashwani Arya, Gulshan Sindhwani
2016 Asian Journal of Pharmaceutical and Clinical Research  
,poor coping skills, palpitation, sweating, agoraphobia, and social withdrawal.  ...  Anxiety disorders are characterized by alterationsin a diverse range of neurochemical systems, suggesting ample novel targets for drug therapies.  ...  NEURAL CIRCUITS INVOLVED IN ANXIETY The neurobiology of anxiety disorders is not fully understood, but several different biologic abnormalities have been implicated in their etiology [44] .  ... 
doi:10.22159/ajpcr.2016.v9s3.11820 fatcat:s5xgsd5manhihe2e3uwigmi4se

Watch and Learn: Vicarious Threat Learning across Human Development

Yael Skversky-Blocq, Jan Haaker, Tomer Shechner
2021 Brain Sciences  
Next, we focus on the social factors influencing vicarious threat learning; this is followed by a review of vicarious threat learning among children and adolescents.  ...  To conclude, we encourage future research directions that will help elucidate how vicarious threat learning emerges and how it relates to the development of normative fear and pathological anxiety.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/brainsci11101345 pmid:34679409 fatcat:bb7j7ur6pfhmpgw6czdlkaaqbi

"Update to Pseudobulbar affect (suddenly emotions of crying/laughing without control)"

Jorge Garza Ulloa
2021 American Journal of Biomedical Science & Research  
Low levels of "serotonin" in the brain may cause depression, anxiety, and sleep trouble. And many other neurotransmitters types are used in the synapses in the neural pathways.  ...  circuits known as: "neural pathways".  ... 
doi:10.34297/ajbsr.2021.13.001837 fatcat:4tpw75zdfvaunoukyn4cf3q7nu
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