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Neural correlates of high and craving during cocaine self-administration using BOLD fMRI

Robert C. Risinger, Betty Jo Salmeron, Thomas J. Ross, Shelley L. Amen, Michael Sanfilipo, Raymond G. Hoffmann, Alan S. Bloom, Hugh Garavan, Elliot A. Stein
2005 NeuroImage  
In this study, a more naturalistic model of cocaine self-administration (SA) was employed in order to identify those sites associated with druginduced high and craving as measures of reward and motivation  ...  This study provides the first evidence in humans that changes in subjective state surrounding cocaine self-administration reflect neural activity of the endogenous reward system. D  ...  Acknowledgments This research was supported in part by NIDA grants DA09465 (RCR), K23 DA00486 (RCR), RO1 DA 11326 (ASB) and NCRR GCRC grant 5M01RR00058. The assistance of Mrs.  ... 
doi:10.1016/j.neuroimage.2005.03.030 pmid:15886020 fatcat:dgjldipk3bcanoagltnhmzewsq

The use of brain imaging to elucidate neural circuit changes in cocaine addiction

Colleen Hanlon, Canterberry
2012 Substance Abuse and Rehabilitation  
contribute to the stages of initial craving, dependence, abstinence, and relapse.  ...  The application of functional imaging methods to cocaine dependent patients and individuals in treatment programs, has revealed that the effects of cocaine are not limited to dopamine-rich subcortical  ...  self-reported craving, and has been negatively correlated with reports of feeling high after administration. 29, 44 The OFC is active in response to both implicit and explicit cocaine cues. 42, 44  ... 
doi:10.2147/sar.s35153 pmid:23162375 pmcid:PMC3499034 fatcat:unc6gafh6fcunbnqoqzh7llwka

Functional neural changes following behavioral therapies and disulfiram for cocaine dependence

Elise E. DeVito, Guangheng Dong, Hedy Kober, Jiansong Xu, Kathleen M. Carroll, Marc N. Potenza
2017 Psychology of Addictive Behaviors  
A growing literature exists on neural correlates of treatment outcome. However, different types-or components of-treatment have distinct theorized mechanisms of action.  ...  Participants with cocaine use disorders in a randomized clinical trial received cognitive-behavioral therapy (CBT) plus, in a 2 ϫ 2 design, contingency management (CM) or no CM, and disulfiram or placebo  ...  of self-reported days of cocaine abstinence during treatment.  ... 
doi:10.1037/adb0000298 pmid:28714728 pmcid:PMC5548432 fatcat:cbdzlzq4svgpjlzxsccqibfkzi

Biomarkers for Success [chapter]

C.A. Hanlon, L.T. Dowdle, J.L. Jones
2016 International review of neurobiology  
Cocaine dependence is one of the most difficult substance use disorders to treat.  ...  While the powerful effects of chronic cocaine use on behavior were documented in the 19 th century, it was not until the late 20 th century that we realized chronic cocaine use was affecting brain tissue  ...  Functional neuroimaging has shown that the OFC is active during self-reported craving, and has been negatively correlated with reports of feeling high after administration.  ... 
doi:10.1016/bs.irn.2016.06.006 pmid:27503451 pmcid:PMC5492974 fatcat:mutztf7iq5h3fpefqvxvefuzpe

Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients

C.-s. R. Li, P. T. Morgan, D. Matuskey, O. Abdelghany, X. Luo, J. L. K. Chang, B. J. Rounsaville, Y.-s. Ding, R. T. Malison
2010 Proceedings of the National Academy of Sciences of the United States of America  
S1 shows the rating of euphoria, anxiety, and craving, as well as heart rate and systolic and diastolic pressure, before and after i.v. administration of saline (placebo or P session) or methylphenidate  ...  Prior research points to the importance of psychostimulants in improving self-control. However, the neural substrates underlying such improvement remain unclear.  ...  We thank Andreas Rodrigues and Nikkia  ... 
doi:10.1073/pnas.1002467107 pmid:20660731 pmcid:PMC2922598 fatcat:2czvxjshwvbjzinvw5a7woxgt4

Neural correlates of adherence to extended-release naltrexone pharmacotherapy in heroin dependence

A-L Wang, I Elman, S B Lowen, S J Blady, K G Lynch, J M Hyatt, C P O'Brien, D D Langleben
2015 Translational Psychiatry  
examine neural correlates of XRNTX adherence.  ...  During the treatment, cigarette smoking behaviors followed patterns of opioid use, while cocaine consumption was increased with reductions in opioid use.  ...  Illness Research, Education and Clinical Center (MIRECC) and the Center for Magnetic Resonance and Spectroscopy of the University of Pennsylvania.  ... 
doi:10.1038/tp.2015.20 pmid:25781230 pmcid:PMC4354350 fatcat:cvcqt2awqrabjbozprzunpoplu

Self-regulation of the dopaminergic reward circuit in cocaine users with mental imagery and neurofeedback

Matthias Kirschner, Ronald Sladky, Amelie Haugg, Philipp Stämpfli, Elisabeth Jehli, Martina Hodel, Etna Engeli, Sarah Hösli, Markus R. Baumgartner, James Sulzer, Quentin J.M. Huys, Erich Seifritz (+3 others)
2018 EBioMedicine  
Here, we examined whether cocaine users (CU) can use mental imagery of non-drug rewards to self-regulate the ventral tegmental area and substantia nigra (VTA/SN).  ...  We expected that obsessive and compulsive thoughts about cocaine consumption would hamper the ability to self-regulate the VTA/SN activity and tested if real-time fMRI (rtfMRI) neurofeedback (NFB) can  ...  FS was supported by the Swiss National Science Foundation (BSSG10_155915, 100014_178841, 32003B_166566), the Foundation for Research in Science and the Humanities at the University of Zurich (STWF-17-012  ... 
doi:10.1016/j.ebiom.2018.10.052 pmid:30377073 pmcid:PMC6286189 fatcat:cqfzhgsy7bd77cvxqa7hlib4o4

Neural Correlates of Drug-Biased Choice in Currently Using and Abstinent Individuals With Cocaine Use Disorder

Scott J. Moeller, Anna Zilverstand, Anna B. Konova, Prantik Kundu, Muhammad A. Parvaz, Rebecca Preston-Campbell, Keren Bachi, Nelly Alia-Klein, Rita Z. Goldstein
2018 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging  
Actively-using (N=18) and abstaining (N=19) individuals with a history of cocaine use disorder (CUD: dependence or abuse), and matched healthy controls (N=26), participated.  ...  Future studies can validate these behavioral and neural abnormalities as markers of drug-seeking and relapse in treatment contexts.  ...  of Preventive Medicine and Social Work Services to KB).  ... 
doi:10.1016/j.bpsc.2017.11.001 pmid:29735157 pmcid:PMC5944613 fatcat:ii6ps2yyefhz7leavri2felpzy

Marijuana craving in the brain

F. M. Filbey, J. P. Schacht, U. S. Myers, R. S. Chavez, K. E. Hutchison
2009 Proceedings of the National Academy of Sciences of the United States of America  
Activation of the orbitofrontal cortex and nucleus accumbens was also positively correlated with problems related to marijuana use, such that greater BOLD activation was associated with greater number  ...  This study used functional magnetic resonance imaging (fMRI) to examine cue-elicited craving for marijuana.  ...  During the second session, participants completed a battery of neuropsychological tests and self-report measures of mood and craving. Participants were then placed in the fMRI scanner.  ... 
doi:10.1073/pnas.0903863106 pmid:19651613 pmcid:PMC2716383 fatcat:2mc6jrvmzbd6lnkgwfh7poxcee

Robust Changes in Reward Circuitry During Reward Loss in Current and Former Cocaine Users During Performance of a Monetary Incentive Delay Task

Krishna T. Patel, Michael C. Stevens, Shashwath A. Meda, Christine Muska, Andre D. Thomas, Marc N. Potenza, Godfrey D. Pearlson
2013 Biological Psychiatry  
In addition, impulsivity-related factors correlated positively with BOLD activation in amygdala and negatively with anterior cingulate activation during loss anticipation.  ...  Methods-We used a functional MRI Monetary Incentive Delay Task (MIDT) to investigate reward-loss neural response differences among current cocaine users (N=42), former cocaine users (N=35) and healthy  ...  Daniel Hommer for help and encouragement in designing the MID task.  ... 
doi:10.1016/j.biopsych.2013.04.029 pmid:23778289 pmcid:PMC3775945 fatcat:bqandjachjbcncdvfwi5kmiwsa

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

Rita Z. Goldstein, Nora D. Volkow
2011 Nature Reviews Neuroscience  
executive function (for example, self-control, salience attribution and awareness).  ...  However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic reward regions and its involvement in higher-order  ...  Acknowledgements This study was supported by grants from the US National Institute on Drug Abuse (R01DA023579 to R.Z.G.), the Intramural NIAAA program and the Department of Energy, Office of Biological  ... 
doi:10.1038/nrn3119 pmid:22011681 pmcid:PMC3462342 fatcat:vrfpkzqyuvc3tdwno5ahxgqqiu

Functional imaging of craving

D W Hommer
1999 Alcohol Research and Health  
A study using SPECT technology in alcoholics, however, found altered brain activity in only some of those regions during craving.  ...  Studies using these three approaches have been reviewed in order to evaluate the validity of a proposed model of the brain regions involved in alcoholism and the craving for alcohol.  ...  Another fMRI study of cocaine craving used cocaine administration to induce both euphoria and craving in 10 nontreatment-seeking cocaine abusers (Breiter et al. 1997) .  ... 
pmid:10890814 fatcat:oyfz2i55ezau3di5euedsp3bva

Pharmacological Applications of fMRI [chapter]

Betty Jo Salmeron, Elliot A. Stein
2006 Functional MRI  
For example, Breiter and colleagues 36 collected self-ratings of high, rush, craving, and low once per minute before and after intravenous cocaine administration, and subsequently used these ratings as  ...  Interpretation of such results becomes quite problematic. Figure 17.4. Correlations of self-reported rush and craving with BOLD data after cocaine injection.  ...  Acknowledgment The authors gratefully acknowledge the contributions of Dr. Thomas Ross to discussions related to data analysis methods.  ... 
doi:10.1007/0-387-34665-1_17 fatcat:lclvwa3aj5dhdhwo4ff67pdjw4

Applications of fMRI to Psychiatry [chapter]

Deborah A. Yurgelun-Todd, Perry F. Renshaw, Lisa A. Femia
2006 Functional MRI  
Correlation between self-reported levels of craving and activation found.  ...  Functional MRI BOLD imaging also has been used to investigate the neural circuits affect by the use of cocaine.  ... 
doi:10.1007/0-387-34665-1_8 fatcat:zhuhsj63lngf7mb5kbtxfa7oaq

Self-regulation of the Dopaminergic Reward Circuit in Cocaine Users with Mental Imagery and Neurofeedback [article]

Matthias Kirschner, Ronald Sladky, Amelie Haugg, Philipp Staempfli, Elisabeth Jehli, Martina Hodel, Etna Engeli, Sarah Hoesli, Markus R. Baumgartner, James Sulzer, Quentin J.M. Huys, Erich Seifritz (+3 others)
2018 bioRxiv   pre-print
Here we examine whether cocaine users (CU) can use mental imagery of non-drug rewards to self-regulate the ventral tegmental area and substantia nigra (VTA/SN).  ...  Finally, we tested if self-regulation of the VTA/SN can be improved with real-time fMRI (rtfMRI) neurofeedback (NFB).  ...  Furthermore, we would like to thank all participants for their time and interest in our study. All rights reserved. No reuse allowed without permission.  ... 
doi:10.1101/321166 fatcat:kkwbj62ezjd3jnxerazfcp5ao4
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