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Bridging Scales in Alzheimer's Disease: Biological Framework for Brain Simulation With The Virtual Brain

Leon Stefanovski, Jil Mona Meier, Roopa Kalsank Pai, Paul Triebkorn, Tristram Lett, Leon Martin, Konstantin Bülau, Martin Hofmann-Apitius, Ana Solodkin, Anthony Randal McIntosh, Petra Ritter
2021 Frontiers in Neuroinformatics  
Next, we outline the potential to link molecular aspects of neurodegeneration in AD with large-scale brain network modeling using The Virtual Brain (www.thevirtualbrain.org), an open-source, multiscale  ...  Alzheimer's Disease (AD) is the most common cause of dementia and represents the most prevalent neurodegenerative disease.  ...  This lower efficiency is demonstrated in the example network by the shortest path length between the blue nodes D and E before and after the deletion of the red links (before: 4 links, after: 6 links).  ... 
doi:10.3389/fninf.2021.630172 pmid:33867964 pmcid:PMC8047422 fatcat:khujbqtyxfhwvk66l4azu7hg54

Cortical Network Topology in Prodromal and Mild Dementia Due to Alzheimer's Disease: Graph Theory Applied to Resting State EEG

Raffaella Franciotti, Nicola Walter Falasca, Dario Arnaldi, Francesco Famà, Claudio Babiloni, Marco Onofrj, Flavio Mariano Nobili, Laura Bonanni
2018 Brain Topography  
Graph theory analysis on resting state electroencephalographic rhythms disclosed topological properties of cerebral network. In Alzheimer's disease (AD) patients, this approach showed mixed results.  ...  Our results show that the topology of the network is altered in AD patients also in its prodromal stage, begins with the reduction of the number of edges and the loss of the local and global efficiency  ...  Flavio Mariano Nobili and Laura Bonanni equally contributed to the present work.  ... 
doi:10.1007/s10548-018-0674-3 pmid:30145728 fatcat:t2qnu4ru4vf4fgkcn7g6p5pdvi

Protofibrils of Amyloid-β are Important Targets of a Disease-Modifying Approach for Alzheimer's Disease

Kenjiro Ono, Mayumi Tsuji
2020 International Journal of Molecular Sciences  
Worldwide, Alzheimer's disease (AD) is the most common age-related neurodegenerative disease and is characterized by unique pathological hallmarks in the brain, including plaques composed of amyloid β-protein  ...  However, while these Aβ species form amyloid plaques of the type implicated in AD neurodegeneration, recent clinical trials designed to reduce the production of Aβ and/or the plaque burden have not demonstrated  ...  Introduction Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease, and spinocerebellar ataxia, have characteristic abnormal protein aggregates in the brain.  ... 
doi:10.3390/ijms21030952 pmid:32023927 pmcid:PMC7037706 fatcat:n3wn73ooizcyjpyohdzvh3kphy

Impaired Efficiency and Resilience of Structural Network in Spinocerebellar Ataxia Type 3

Yu-Te Wu, Shang-Ran Huang, Chi-Wen Jao, Bing-Wen Soong, Jiing-Feng Lirng, Hsiu-Mei Wu, Po-Shan Wang
2018 Frontiers in Neuroscience  
Random and targeted attacks were applied to measure the network resilience of normal and SCA3 groups.  ...  Recent studies have shown that the patients with spinocerebellar ataxia type 3 (SCA3) may not only have disease involvement in the cerebellum and brainstem but also in the cerebral regions.  ...  ACKNOWLEDGMENTS This study was supported by grants from the Ministry of Science and Technology, Taiwan (MOST 103-2221-E-010-003-MY3, MOST-106-2221-E-010-010-MY2) and Taiwan National Health Research Institutes  ... 
doi:10.3389/fnins.2018.00935 pmid:30618564 pmcid:PMC6304428 fatcat:zpyxvw42eveudaexvruoscumoy

ALZHEIMER'S DISEASE: FACTS AND FINDINGS

Neena Mishra, Prajna Mandal, Sukanya Das.
2017 International Journal of Advanced Research  
missing link between hypercholesterolemia and AD.  ...  other networks.  ... 
doi:10.21474/ijar01/4684 fatcat:be3qypyprzcwznpczsnxveqzei

A Comprehensive Review of Autophagy and Its Various Roles in Infectious, Non-Infectious, and Lifestyle Diseases: Current Knowledge and Prospects for Disease Prevention, Novel Drug Design, and Therapy

Rekha Khandia, Maryam Dadar, Ashok Munjal, Kuldeep Dhama, Kumaragurubaran Karthik, Ruchi Tiwari, Mohd. Iqbal Yatoo, Hafiz M.N. Iqbal, Karam Pal Singh, Sunil K. Joshi, Wanpen Chaicumpa
2019 Cells  
Genetic defects in autophagy can have pathological consequences, such as static childhood encephalopathy with neurodegeneration in adulthood, Crohn's disease, hereditary spastic paraparesis, Danon disease  ...  , X-linked myopathy with excessive autophagy, and sporadic inclusion body myositis.  ...  Acknowledgments: All the authors acknowledge and thank their respective Institutes and Universities.  ... 
doi:10.3390/cells8070674 pmid:31277291 pmcid:PMC6678135 fatcat:vvry4ey24rcjjjumigy267ct4e

SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases

Ramu Manjula, Kumari Anuja, Francisco J. Alcain
2021 Frontiers in Pharmacology  
There is compelling evidence to support the fact that SIRT1 and SIRT2 are shuttled between the nucleus and cytoplasm and perform context-dependent functions in neurodegenerative diseases including Alzheimer's  ...  In this review, we highlight the regulation of SIRT1 and SIRT2 in various neurological diseases.  ...  SIRT1 AND SIRT2 IN ALZHEIMER'S DISEASE About 1% of Alzheimer's disease (AD) cases have a familial component, whereas 99% are sporadic and have a late-onset.  ... 
doi:10.3389/fphar.2020.585821 pmid:33597872 pmcid:PMC7883599 fatcat:s7453ruwwvfbjmsmijvzgw4dwa

Literature-related discovery: common factors for Parkinson's Disease and Crohn's Disease

Ronald N. Kostoff
2014 Scientometrics  
Most of the downloaded records had Abstracts. For both the Title and Abstract phrases, about ten percent were shared between the two databases.  ...  ABSTRACT Literature-related discovery (LRD) is the linking of two or more literature concepts that have heretofore not been linked (i.e., disjoint), in order to produce novel, interesting, and intelligible  ...  Association between SORL1 and Alzheimer's disease in a genome-wide study. Genome-wide association studies for common diseases and complex traits. Gene-environment interactions in human diseases.  ... 
doi:10.1007/s11192-014-1298-3 fatcat:jpfukiwcb5ggfexqsv2dfpvvqa

Exploring the "Multiple-Hit Hypothesis" of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Kristin L. Patrick, Samantha L. Bell, Chi G. Weindel, Robert O. Watson
2019 Frontiers in Cellular and Infection Microbiology  
Chronic diseases like Alzheimer's, Parkinson's, and Multiple sclerosis are speculated to result from a combination of genetic and environmental factors, a concept commonly referred to as the "multiple  ...  This review will broadly explore the connections between bacterial infection, immune dysregulation, and CNS disorders.  ...  Nonetheless, additional animal and in vitro studies have provided support for a link between Borrelia and AD.  ... 
doi:10.3389/fcimb.2019.00138 pmid:31192157 pmcid:PMC6546885 fatcat:pzyavbobx5hvrablkyxhivwqce

Targeting Impaired Antimicrobial Immunity in the Brain for the Treatment of Alzheimer's Disease

Tamas Fulop, Shreyansh Tripathi, Serafim Rodrigues, Mathieu Desroches, Ton Bunt, Arnold Eiser, Francois Bernier, Pascale B Beauregard, Annelise E Barron, Abdelouahed Khalil, Adam Plotka, Katsuiku Hirokawa (+5 others)
2021 Neuropsychiatric Disease and Treatment  
Alzheimer's disease (AD) is the most common form of dementia and aging is the most common risk factor for developing the disease.  ...  A chronic inflammatory state is induced that results in neurodegeneration. Interventions that appear to prevent, retard or mitigate the development of AD also appear to modify the disease.  ...  [81] [82] [83] [84] [85] [86] [87] [88] [89] Because of the abovementioned relationships, inflammaging is one of the most important links between aging and the age-related neurodegenerative diseases  ... 
doi:10.2147/ndt.s264910 pmid:33976546 pmcid:PMC8106529 fatcat:w7z5xkidjraudaodgcywm7ibfy

Engineering enhanced protein disaggregases for neurodegenerative disease

Meredith E Jackrel, James Shorter
2015 Prion  
Nevertheless, the misfolding and toxicity of EWSR1, an RNA-binding protein with a prion-like domain linked to ALS and FTD, could not be buffered by potentiated Hsp104 variants, indicating that further  ...  Protein misfolding and aggregation underpin several fatal neurodegenerative diseases, including Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD).  ...  ACKNOWLEDGMENTS We thank Korrie Mack and Mariana Torrente for feedback on the manuscript.  ... 
doi:10.1080/19336896.2015.1020277 pmid:25738979 pmcid:PMC4601286 fatcat:met6j5fvqbe3nonf7x4ur5kfom

Investigating Pathogenetic Mechanisms of Alzheimer's Disease by Systems Biology Approaches for Drug Discovery

Shan-Ju Yeh, Ming-Hsun Chung, Bor-Sen Chen
2021 International Journal of Molecular Sciences  
Alzheimer's disease (AD) is the most common cause of dementia, characterized by progressive cognitive decline and neurodegenerative disorder.  ...  However, in spite of large-scale clinical studies and computational simulations, the molecular mechanisms of AD development and progression are still unclear.  ...  Introduction Alzheimer's disease (AD) is a brain disorder of neurodegeneration. The symptoms of AD are characterized into three main groups.  ... 
doi:10.3390/ijms222011280 pmid:34681938 pmcid:PMC8540696 fatcat:3wjiy6pynrgc7ofemnq3xuoxte

Electrical Stimulation of Cranial Nerves in Cognition and Disease

Devin Adair, Dennis Truong, Zeinab Esmaeilpour, Nigel Gebodh, Helen Borges, Libby Ho, J. Douglas Bremner, Bashar W. Badran, Vitaly Napadow, Vincent P. Clark, Marom Bikson
2020 Brain Stimulation  
Much prior cranial nerve stimulation work was conceptually limited to the production of sensory perception, with individual titration of intensity based on the level of perception and tolerability.  ...  We propose an intervention design framework based on driving cranial nerve pathways in targeted brain circuits, which are in turn linked to specific higher cognitive processes.  ...  and memory function in patients with Alzheimer's Disease  ... 
doi:10.1016/j.brs.2020.02.019 pmid:32289703 pmcid:PMC7196013 fatcat:fcec2w46njgbvktujshfs2rhra

Prions: Protein Aggregation and Infectious Diseases

Adriano Aguzzi, Anna Maria Calella
2009 Physiological Reviews  
ACKNOWLEDGMENTS This article honors the present and past members of the  ...  Typical examples are AA amyloidosis and Alzheimer's disease (AD).  ...  These traits were again found to be indistinguishable between BSE and human vCJD prions (118, 219) . A third line of evidence linking BSE to human vCJD comes from the epidemiology of the disease.  ... 
doi:10.1152/physrev.00006.2009 pmid:19789378 fatcat:ktvicfmvjnae7ounjzsq66qfo4

Abstracts from the 1st International Conference on Alzheimer's disease and Related Neurodegenerative Disorders Wuhan, China

2002 Journal of Alzheimer's Disease  
The data show a direct linkage between tau overexpression and APP trafficking which may be of significance in the pathogenesis of Alzheimer's disease.  ...  Supported by Deutsche Forschungsgemeinschaft. 7 Tau protein and Alzheimer's disease: phosphorylation and role in intracellular traffic One of the hallmarks of Alzheimer's disease is the aggregation and  ...  Laboratory for Alzheimer's disease, Brain Science Institute, RIKEN Dysfunction and filament formation of microtubule-binding protein tau are key markers of neurodegeneration, including Alzheimer's disease  ... 
doi:10.3233/jad-2002-4108 fatcat:2b56ux4aqnepdpeblenrxtllxy
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