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Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines
2021
International Journal of Molecular Sciences
Preserved Fulltext
The modification of natural phytochemicals with evidenced anti-tumor activity, including Bet, is one of the methods of receiving new compounds for potential implementation in oncological treatment. ...
Neuroblastoma (NB) and rhabdomyosarcoma (RMS), the most common pediatric extracranial solid tumors, still represent an important clinical challenge since no effective treatment is available for metastatic ...
The prediction of potential target proteins and target pathways for Bet and ASBDs was computed with The Balanced Substructure-Drug-Target Network-Based Inference (bSDTNBI) method using NetInfer web server ...
doi:10.3390/ijms222212299
pmid:34830180
pmcid:PMC8624615
fatcat:fqhvsivhcffcvlo3nr5jjm6hwa