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Acetylenic Synthetic Betulin Derivatives Inhibit Akt and Erk Kinases Activity, Trigger Apoptosis and Suppress Proliferation of Neuroblastoma and Rhabdomyosarcoma Cell Lines

Sylwia K. Król, Ewa Bębenek, Magdalena Dmoszyńska-Graniczka, Adrianna Sławińska-Brych, Stanisław Boryczka, Andrzej Stepulak
2021 International Journal of Molecular Sciences  
The modification of natural phytochemicals with evidenced anti-tumor activity, including Bet, is one of the methods of receiving new compounds for potential implementation in oncological treatment.  ...  Neuroblastoma (NB) and rhabdomyosarcoma (RMS), the most common pediatric extracranial solid tumors, still represent an important clinical challenge since no effective treatment is available for metastatic  ...  The prediction of potential target proteins and target pathways for Bet and ASBDs was computed with The Balanced Substructure-Drug-Target Network-Based Inference (bSDTNBI) method using NetInfer web server  ... 
doi:10.3390/ijms222212299 pmid:34830180 pmcid:PMC8624615 fatcat:fqhvsivhcffcvlo3nr5jjm6hwa