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Neocortical reorganization in spina bifida

Jenifer Juranek, Jack M. Fletcher, Khader M. Hasan, Joshua I. Breier, Paul T. Cirino, Paula Pazo-Alvarez, Javier D. Diaz, Linda Ewing-Cobbs, Maureen Dennis, Andrew C. Papanicolaou
2008 NeuroImage  
We investigated total cerebral volumes, neocortical surface area, and neocortical thickness in 16 children with a neural tube defect, spina bifida myelomeningocele (SB), and 16 age-matched typically developing  ...  Group comparisons of neocortical surface area assessments were significantly smaller in the occipital regions for SB, with no significant group differences in the frontal regions.  ...  We wish to thank Vipul Kumar Patel for assistance with MRI data acquisition and Amy Walker Hampson for recruitment of spina bifida participants.  ... 
doi:10.1016/j.neuroimage.2008.01.043 pmid:18337124 pmcid:PMC2410089 fatcat:kcsr57jhqvbezk66cqchymakaq

Spina bifida

Andrew J. Copp, N. Scott Adzick, Lyn S. Chitty, Jack M. Fletcher, Grayson N. Holmbeck, Gary M. Shaw
2015 Nature Reviews Disease Primers  
Spina bifida is a birth defect in which the vertebral column is open (bifid), often with spinal cord involvement.  ...  Clinically most significant is myelomeningocele (MMC; open spina bifida) in which the spinal neural tube fails to close during embryonic development.  ...  Neocortical reorganization in spina bifida. Neuroimage. 2008; 40:1516-1522. [PubMed: 18337124] 54. Del Bigio MR. Neuropathology and structural changes in hydrocephalus.  ... 
doi:10.1038/nrdp.2015.7 pmid:27189655 pmcid:PMC4898641 fatcat:yr3y52r3wvhchnenf7mzpos2gu

Etiology and Pathophysiology of the Spina Bifida [chapter]

René Opšenák, Romana Richterová, Branislav Kolarovszki
2021 Spina Bifida and Craniosynostosis - New Perspectives and Clinical Applications [Working Title]  
The spina bifida is a congenital anomaly that results in an abnormal formation of the spine and the spinal cord.  ...  Genetic, nutritional and environmental factors play a role in the etiology and pathogenesis of the spina bifida.  ...  Overall reduction in white matter and increased neocortical thickness in the frontal lobes suggest that the spina bifida reflects a long-term disruption of brain development that extends far beyond the  ... 
doi:10.5772/intechopen.97467 fatcat:yqvr5uazo5corl5gtjzvde4xxi

Partial agenesis of the corpus callosum in spina bifida meningomyelocele and potential compensatory mechanisms

H. Julia Hannay, Maureen Dennis, Larry Kramer, Susan Blaser, Jack M. Fletcher
2009 Journal of Clinical and Experimental Neuropsychology  
CC agenesis, and the results of an examination of magnetic resonance imaging (MRI) data of the CC in 193 children with spina bifida meningomyelocele (SBM).  ...  The hippocampal commissure, enlarged in 13%, may be a more promising candidate. Overall, however, the functionality of anomalous fiber tracts and commissures in SBM is yet to be determined.  ...  Acknowledgments This research was funded by National Institutes of Child Health and Human Development Grant PO1 HD35946, "Spina Bifida: Cognitive and Neurobehavioral Variability."  ... 
doi:10.1080/13803390802209954 pmid:19052950 pmcid:PMC2692259 fatcat:e32j3n5epjf6ze2pakuuhgbqka

Age, plasticity, and homeostasis in childhood brain disorders

Maureen Dennis, Brenda J. Spiegler, Jenifer J. Juranek, Erin D. Bigler, O. Carter Snead, Jack M. Fletcher
2013 Neuroscience and Biobehavioral Reviews  
Cerebellar resculpting in spina bifida meningomyelocele, on the other hand, may promote increased functionality of eye movements.  ...  Hyperdevelopment of the midsagittal vermis in spina bifida meningomyelocele is associated with sparing of ocular motor function (Salman, Dennis, & Sharpe, 2009 ).  ... 
doi:10.1016/j.neubiorev.2013.09.010 pmid:24096190 pmcid:PMC3859812 fatcat:gp2x5shfh5fz5bses55org7kpq

Brain mechanisms for reading and language processing in spina bifida meningomyelocele: A combined magnetic source- and structural magnetic resonance imaging study

Panagiotis G. Simos, Andrew C. Papanicolaou, Eduardo Martinez Castillo, Jenifer Juranek, Paul T. Cirino, Roozbeh Rezaie, Jack M. Fletcher
2011 Neuropsychology  
The present study explored features of brain organization in children with spina bifida meningomyelocele (SBM) and shunted hydrocephalus, who commonly present with precocious development of word reading  ...  Conclusions: A complex pattern of changes in cortical morphology and activation may serve as evidence for structural and functional brain reorganization ensuring preservation of language and decoding abilities  ...  Spina bifida was verified by medical review of pathology and neurosurgical operative reports.  ... 
doi:10.1037/a0023694 pmid:21574714 pmcid:PMC3175695 fatcat:sesbb4u5jrcxlc3ptzcue63uoa

Wnt signaling in development and disease

Jennifer L. Freese, Darya Pino, Samuel J. Pleasure
2010 Neurobiology of Disease  
Dvl2 null mutants have thoracic spina bifida and Dvl1/2 double mutants produce even more severe NTD (Hamblet et al., 2002) .  ...  LRP6 mutant mice exhibit neocortical defects that are consistent with an essential role for canonical Wnt signaling in the neocortical VZ (Zhou et al., 2004b) .  ... 
doi:10.1016/j.nbd.2009.09.003 pmid:19765659 pmcid:PMC2854277 fatcat:wy5yinijs5by7k7czdh2pjefgq

Zagreb research collection of human brains for developmental neurobiologists and clinical neuroscientists

I Kostovic, M Judas, L Kostovic-Knezevic, G Simic, I Delalle, D Chudy, B Sajin, Z Petanjek
1991 International Journal of Developmental Biology  
We concluded that structural remodeling and reorganization of the brain, from the transient patterns of the fetal organization through the postnatal phase of transient overproduction of circuitry elements  ...  evidence concerning the timing and pattern of development of afferent fiber systems in the human cortex.  ...  bifida), brains of fetuses and infants with trisomy syndromes (Down's syndrome, Syndroma Patau and Syndroma Edwards).  ... 
pmid:1687658 fatcat:2bcjtwwrajcdjnhnaszz5potsu

Page 269 of Psychological Abstracts Vol. 87, Issue Subject Index [page]

Psychological Abstracts  
Volume 87 SUBJECT INDEX development & organization of corpus callosum & cogni- tive functioning, children with early hydrocephalus re- sulting in spina bifida or aqueductal stenosis or prematurity-intraventricular  ...  memory for normal vs distorted pictures, 19-30 yr olds, 7037 motor control reorganization in abductor pollicis brevis & abductor digiti minimi muscles, motor cortical EPs, 40 yr old male with mirror movements  ... 

MJMS at the Dawn of Its Electronic Era

Wan Ilma Dewiputri, Irfan Mohamad
2011 Malaysian Journal of Medical Sciences  
In addition, we also discussed the future directions of MJMS.  ...  This special editorial assessed the recent developments in Malaysian Journal of Medical Sciences (MJMS) and examined the characteristics of the submission, peer review, and publication processes for MJMS  ...  Malaysia (IIUM), for their continuous effort and assistance in the care and treatment of the patients.  ... 
pmid:22135566 pmcid:PMC3216199 fatcat:t7qjful37nftdl7q3itniobxwi

Applying evolutionary genetics to developmental toxicology and risk assessment

Maxwell C.K. Leung, Andrew C. Procter, Jared V. Goldstone, Jonathan Foox, Robert DeSalle, Carolyn J. Mattingly, Mark E. Siddall, Alicia R. Timme-Laragy
2017 Reproductive Toxicology  
in vitro and whole-organism models.  ...  Yet, there is a communication gap between evolutionary biologists and toxicologists in recognizing the connections among developmental pathways, high-throughput screening, and birth defects in humans.  ...  bifida), and so forth (Thorogood 1997; Epstein 2008) .  ... 
doi:10.1016/j.reprotox.2017.03.003 pmid:28267574 pmcid:PMC5829367 fatcat:3syrlt3m4bc3xn2b5dg73aojhu

Neuroimaging of typical and atypical development: A perspective from multiple levels of analysis

MARK H. JOHNSON, HANIFE HALIT, SARAH J. GRICE, ANNETTE KARMILOFF–SMITH
2002 Development and Psychopathology  
in interregional interactions rather than searching for localized, discrete lesions; examine the temporal dynamics of neural processing; and move away from deficits to image tasks in which atypical participants  ...  This alternative view, based on an "interactive specialization" approach to postnatal brain development, indicates that there is a need to: obtain data from early in development; focus more on differences  ...  How-terations in brain development are spina bifida and anencephaly, in which the gross mor-ever, with a few exceptions, these large-scale regions generally do not map onto the detailed phology of the  ... 
doi:10.1017/s0954579402003073 fatcat:q6ae44f7nvfnbjgmgocbajddei

Mena and Vasodilator-Stimulated Phosphoprotein Are Required for Multiple Actin-Dependent Processes That Shape the Vertebrate Nervous System

A. S. Menzies
2004 Journal of Neuroscience  
Mice deficient in either Mena or VASP exhibit subtle defects in forebrain commissure formation and platelet aggregation, respectively.  ...  In this study, we investigated the consequence of deleting both Mena and VASP.  ...  Neurulation defects in M Ϫ/Ϫ V Ϫ/Ϫ mice are restricted to the cephalic neural tube, resulting in exencephaly but not spina bifida.  ... 
doi:10.1523/jneurosci.1057-04.2004 pmid:15371503 fatcat:w64p4picwvgdhck5uccgajy2qq

World Journal of Pharmacy and Biotechnology A Review on Epilepsy

Journal Home, B Kumar, G Divya, M Gobinath
2015 WJPBT   unpublished
The brain is involved in nearly every bodily function, including the higher cortical functions.  ...  If the affected cortical network is in the visual cortex, the clinical manifestations are visual phenomena.  ...  Patients on valproate or carbamazepine need careful screening to detect spina bifida.  ... 
fatcat:yvx3cmxdxnevpj65eyxcen3vri

Final Program, Thirty-Eighth Annual Meeting International Neuropsychological Society

2010 Journal of the International Neuropsychological Society  
Although left distraction increased leftward errors in both groups, "where" distraction bias was more leftward in controls, and in pAD subjects, left distraction was associated with decreased rightward  ...  Conclusions: We found "where" left-sided distraction in controls was not observed in pAD, rather left-sided distraction potentially influenced "aiming" bias.  ...  Executive Functions and Self-Care Initiation in Adolescents and Young Adults With Spina Bifida. Objective: Executive functioning deficits have been well-documented in youth with Spina Bifida (SB).  ... 
doi:10.1017/s1355617710000226 fatcat:cvsuvca32nhnbf3f66rmxq7eiq
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