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Negatively correlated firing: the functional meaning of lateral inhibition within cortical columns

Simon Durrant, Jianfeng Feng
2006 Biological cybernetics  
In this paper, we outline a model of position tracking using cortical columns of integrate-and-fire neurons which respond optimally to a particular location, to show that negatively-correlated firing patterns  ...  However, these accounts fail to explain the functional role of inhibition in cortical columns, such as those in V1, where neurons have similar response properties.  ...  Lateral inhibition within columns means neurons with the same response properties inhibiting each other. What could be the functional role for this local inhibitory mechanism?  ... 
doi:10.1007/s00422-006-0096-2 pmid:16964512 fatcat:3hbyyk4auvaxld2cng2fkevk4m

Uncorrelated Neural Firing in Mouse Visual Cortex during Spontaneous Retinal Waves

Matthew T. Colonnese, Jing Shen, Yasunobu Murata
2017 Frontiers in Cellular Neuroscience  
However, whether the micro-patterning of activity within early bursts is unique to this early age and specifically tuned for early development is poorly understood, particularly within the column.  ...  These findings suggest that the bursts of spontaneous activity during early visual development do not drive hyper-synchronous activity within columns.  ...  spike correlations within a cortical column.  ... 
doi:10.3389/fncel.2017.00289 pmid:28979189 pmcid:PMC5611364 fatcat:shsrqprx45c6pp5wk2h2mthham

Sleep, synaptic homeostasis and neuronal firing rates

Chiara Cirelli
2017 Current Opinion in Neurobiology  
I will emphasize that central to SHY is the idea that what is being regulated across the sleep/wake cycle is synaptic strength, not firing rate, and firing rate taken in isolation is not necessarily an  ...  The synaptic homeostasis hypothesis (SHY) states that wake brings about a net overall increase in synaptic strength in many brain circuits that needs to be renormalized by sleep.  ...  Acknowledgments Supported by National Institute of Health grants 1R01MH099231 and 1P01NS083514. I thank Giulio Tononi for his comments.  ... 
doi:10.1016/j.conb.2017.03.016 pmid:28399462 pmcid:PMC5605801 fatcat:y7vxqqrygrfoza67ehx4lqcsdq

An integrate-and-fire spiking neural network model simulating artificially induced cortical plasticity [article]

Larry Shupe, Eberhard E. Fetz
2020 bioRxiv   pre-print
We describe an integrate-and-fire (IF) spiking neural network that incorporates spike-timing dependent plasticity (STDP) and simulates the experimental outcomes of four different conditioning protocols  ...  A fourth protocol involved open-loop delivery of pairs of stimuli at neighboring cortical sites.  ...  The ratio of the number of correlated to uncorrelated spikes each unit receives can be modified to control the degree of synchronization within a column.  ... 
doi:10.1101/2020.07.23.217265 fatcat:rkbxhicc4nhnbfewusgsqbs7bi

Modulation of Firing Rate by Background Synaptic Noise Statistics in Rat Visual Cortical Neurons

Michael P. Sceniak, Shasta L. Sabo
2010 Journal of Neurophysiology  
Here, the dependence of firing rate on the statistical properties of the excitatory to inhibitory balance (EI) in cortical pyramidal neurons was studied.  ...  Modulation of firing rate by background synaptic noise statistics in rat visual cortical neurons. .  ...  D I S C L O S U R E S No conflicts of interest, financial or otherwise, are declared by the authors.  ... 
doi:10.1152/jn.00023.2010 pmid:20739598 fatcat:kpleri325jcytkegtzq734hazi

An Integrate-and-Fire Spiking Neural Network Model Simulating Artificially Induced Cortical Plasticity

Larry Shupe, Eberhard Fetz
2021 eNeuro  
The model consists of integrate-and-fire (IF) spiking units and incorporates spike-timing-dependent plasticity (STDP).  ...  We describe an integrate-and-fire (IF) spiking neural network that incorporates spike-timing-dependent plasticity (STDP) and simulates the experimental outcomes of four different conditioning protocols  ...  The ratio of the number of correlated to uncorrelated spikes each unit receives can be modified to control the degree of synchronization within a column.  ... 
doi:10.1523/eneuro.0333-20.2021 pmid:33632810 pmcid:PMC7986529 fatcat:p462gtzymbe7toq2g6y26hxzpa

Correlation Between Uncoupled Conductance-Based Integrate-and-Fire Neurons Due to Common and Synchronous Presynaptic Firing

Sybert Stroeve, Stan Gielen
2001 Neural Computation  
., common input by neurons, which do not re in synchrony) cannot induce suf cient postsynaptic correlation, we conclude that lateral couplings are essential to establish clusters of synchronously ring  ...  We investigate the ring characteristics of conductance-based integrateand-re neurons and the correlation of ring for uncoupled pairs of neurons as a result of common input and synchronous ring of multiple  ...  We also acknowledge the useful comments of the reviewers, which led to an improvement of this article.  ... 
doi:10.1162/089976601750399281 pmid:11516355 fatcat:yzf4grf6wbayfjmt42fj4x2c4q

Feedback Enhances Feedforward Figure-Ground Segmentation by Changing Firing Mode

Hans Supèr, August Romeo, Olaf Sporns
2011 PLoS ONE  
In the visual cortex, feedback projections are conjectured to be crucial in figure-ground segregation. However, the precise function of feedback herein is unclear.  ...  We propose that feedback controlsfigure-ground segregation by influencing the neural firing patterns of feedforward projecting neurons.  ...  L Pérez for their helpful comments on earlier versions of the manuscript. Author Contributions Conceived and designed the experiments: HS. Performed the experiments: HS AR.  ... 
doi:10.1371/journal.pone.0021641 pmid:21738747 pmcid:PMC3125197 fatcat:krdd3wf4zvhmlixpianzkvfnpq

Firing-Rate Based Network Modeling of the dLGN Circuit: Effects of Cortical Feedback on Spatiotemporal Response Properties of Relay Cells [article]

Milad Hobbi Mobarhan, Geir Halnes, Pablo Martinez-Canada, Torkel Hafting, Marianne Fyhn, Gaute Einevoll
2018 bioRxiv   pre-print
Here we use a firing-rate model, the extended difference-of-gaussians (eDOG) model, to explore cortical feedback effects on visual responses of dLGN relay cells.  ...  Despite four decades of experimental and theoretical studies, the functional role of this feedback is still debated.  ...  Acknowledgments We wish to thank Svenn-Arne Dragly, Simen Tennøe, and Helene Midtfjord for their helpful inputs and discussions regarding the design of the pyLGN simulator.  ... 
doi:10.1101/246140 fatcat:24ak3fb52batves5x3qsdi5iie

Kindling Changes Burst Firing, Neural Synchrony and Tonotopic Organization of Cat Primary Auditory Cortex

P. A. Valentine
2004 Cerebral Cortex  
Spontaneous activity of single units in fully kindled animals showed a decrease in the mean firing rate compared to sham controls, and a reduction in the rate of burst firing as well as in the mean interspike  ...  A 40% enhancement of spontaneous neural synchrony, as measured by spike cross-correlation, was found.  ...  Notes This investigation was supported by grants from the Alberta Heritage Foundation for Medical Research, the Neuroscience Canada Foundation, the Natural Sciences and Engineering Research Council of  ... 
doi:10.1093/cercor/bhh041 pmid:15054056 fatcat:wxe636yjpvefvde6koigazwkku

Correlated Connectivity and the Distribution of Firing Rates in the Neocortex

A. A. Koulakov, T. Hromadka, A. M. Zador
2009 Journal of Neuroscience  
Second, the distribution of nonzero synaptic strengths between nearby cortical neurons can also be described by a lognormal distribution.  ...  Two recent experimental observations pose a challenge to many cortical models. First, the activity in the auditory cortex is sparse, and firing rates can be described by a lognormal distribution.  ...  Later, we will include inhibitory neurons by making some of the matrix elements negative.  ... 
doi:10.1523/jneurosci.4500-08.2009 pmid:19321765 pmcid:PMC2784918 fatcat:dknfuwa3xnglpiehpzsrak46xe

In vitro Cortical Network Firing is Homeostatically Regulated: A Model for Sleep Regulation

Sohrab Saberi-Moghadam, Alessandro Simi, Hesam Setareh, Cyril Mikhail, Mehdi Tafti
2018 Scientific Reports  
Specifically, the inter-burst intervals decreased, the burst duration increased, the network showed higher cross-correlation and strong phasic synchronized burst activity.  ...  Computer simulation suggested that a small number of clustered neurons could potently drive the behavior of the network both at baseline and during recovery.  ...  Acknowledgements The work was supported by the Swiss National Science Foundation (146615 to M.T.), the University of Lausanne, and the Novartis Foundation (to M.T.).  ... 
doi:10.1038/s41598-018-24339-6 pmid:29674729 pmcid:PMC5908861 fatcat:u33dxymt3fdhtbic4whzqawyg4

Correlated Firing Improves Stimulus Discrimination in a Retinal Model

Garrett T. Kenyon, James Theiler, John S. George, Bryan J. Travis, David W. Marshak
2004 Neural Computation  
Synchronous firing limits the amount of information that can be extracted by averaging the firing rates of similarly tuned neurons.  ...  Here, we show that the loss of rate-coded information between retinal ganglion cells due to synchronous oscillations can be overcome by exploiting the information encoded by the correlations themselves  ...  by cortical and sub-cortical neurons [Usrey, 2000 Alonso, 1996 .  ... 
doi:10.1162/0899766041941916 pmid:15476601 fatcat:eao6kj5k5nabjhbudlprsu7xc4

Burst Firing in Bee Gustatory Neurons Prevents Adaptation

Ashwin Miriyala, Sébastien Kessler, F. Claire Rind, Geraldine A. Wright
2018 Current Biology  
Bursts of spikes resulted when a sucrose-activated GRN was inhibited by another GRN at a frequency of ~22 Hz during the first 1 s of stimulation.  ...  Here, we show the first evidence that concentrated sugar evokes a temporally-structured, burst pattern of spiking involving two GRNs within the gustatory sensilla of bumblebees.  ...  GRN 1 fired near the peak of the oscillatory component with a mean phase of 17±72° (mean ± SD), and GRN 2 spikes were positioned on the negative slope with a mean phase of 83 ± 36° (Figure 1 G) .  ... 
doi:10.1016/j.cub.2018.03.070 pmid:29754900 fatcat:2asne523nrfkxpnk6aus3nggsm

Dynamics of neuronal firing correlation: modulation of "effective connectivity"

A. M. Aertsen, G. L. Gerstein, M. K. Habib, G. Palm
1989 Journal of Neurophysiology  
These allow separation of the "raw" correlation into components caused by direct stimulus modulations of the single-neuron firing rates and those caused by various types of interaction between the two  ...  Appropriate control calculations are made to allow the separation of direct stimulus effects from other contributions to the "raw" correlation.  ...  A possible source for such correlations would be the neuron's refractory mechanism: the firing in one bin would be negatively correlated with the firing in adjacent bins (especially because WC assume our  ... 
doi:10.1152/jn.1989.61.5.900 pmid:2723733 fatcat:dvusgbkpvvdajj764q4d43y7ci
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