A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
Filters
Integrated polymer micro-ring resonators for optical sensing applications
2015
Journal of Applied Physics
Preserved Fulltext
Micro-resonators (MR) have become a key element for integrated optical sensors due to their integration capability and their easy fabrication with low cost polymer materials. Nowadays, there is a growing need on MRs as highly sensitive and selective functions especially in the areas of food and health. The context of this work is to implement and study integrated micro-ring resonators devoted to sensing applications. They are fabricated by processing SU8 polymer as core layer and PMATRIFE
doi:10.1063/1.4914308
fatcat:crzl4dshkze33nezmylfyqolxe
more »
... r as lower cladding layer. The refractive index of the polymers and of the waveguide structure as a function of the wavelength are presented. Using these results, a theoretical study of the coupling between ring and straight waveguides has been undertaken in order to define the MR design. Sub-micronic gaps of 0.5 µm to 1 µm between the ring and the straight waveguides have been successfully achieved with UV (i-lines) photolithography. Different superstrates such as air, water and aqueous solutions with glucose at different concentrations have been studied. First results show a good normalized transmission contrast of 0.98, a resonator quality factor around 1.5x10 4 corresponding to a coupling ratio of 14.7 % and ring propagation losses around 5 dB/cm. Preliminary sensing experiments have been performed for different concentrations of glucose; a sensitivity of 115 ± 8 nm/RIU at 1550 nm has been obtained with this couple of polymers.
The Mouse (Mus musculus) T Cell Receptor Beta Variable (TRBV), Diversity (TRBD) and Joining (TRBJ) Genes
2000
Experimental and Clinical Immunogenetics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2013; you can also visit the original URL.
The file type is application/pdf.
Exp Clin Immunogenet 2000;17:216-228
Exp Clin Immunogenet 2000;17:216-228 Bosc/Lefranc ...
doi:10.1159/000019141
pmid:11096260
fatcat:2s6sa5e7xrgkdgtbljpkmvs45e
The Mouse (Mus musculus) T Cell Receptor Delta Variable (TRDV), Diversity (TRDD) and Joining (TRDJ) Genes
2001
Experimental and Clinical Immunogenetics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2013; you can also visit the original URL.
The file type is application/pdf.
/Contet/Lefranc
Exp Clin Immunogenet 2001;18:51-58 Bosc/Contet/Lefranc ...
available at the IMGT Marie-Paule page from IMGT, the international ImMuno-GeneTics database (http://imgt.cines.fr:8104) created by Marie-Paule Lefranc, Université Exp Clin Immunogenet 2001;18:51-58 Bosc ...
doi:10.1159/000049087
pmid:11150853
fatcat:ltcpekwp6ncx7cdz6vpue2z4z4
Micro-resonators based on integrated polymer technology for optical sensing
2014
Optical Sensing and Detection III
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2014; you can also visit the original URL.
The file type is application/pdf.
Research on sensors has experienced a noticeable development over the last decades especially in label free optical biosensors. However, compact sensors without markers for rapid, reliable and inexpensive detection of various substances induces a significant research of new technological solutions. The context of this work is the development of a sensor based on easily integrated and inexpensive micro-resonator (MR) component in integrated optics, highly sensitive and selective mainly in the
doi:10.1117/12.2052622
fatcat:4wxyci6rsraifayvjxvjtbersq
more »
... as of health and food. In this work, we take advantage of our previous studies on filters based on micro-resonators (MR) to experiment a new couple of polymers in the objective to use MR as a sensing function. MRs have been fabricated by processing SU8 polymer as core and PMATRIFE polymer as cladding layer of the waveguide. The refractive index contrast reaches 0.16 @ 1550 nm. Sub-micronic ring waveguides gaps from 0.5 to 1 µm have been successfully achieved with UV (i-line) photolithography. This work confirms our forecasts, published earlier, about the resolution that can be achieved. First results show a good extinction coefficient of ~17 dB, a quality factor around 10 4 and a finesse of 12. These results are in concordance with the theoretical study and they allow us to validate our technology with this couple of polymers. Work is going on with others lower cladding materials that will be used to further increase refractive index contrast for sensing applications.
The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma
2018
OncoTarget
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Gemcitabine is a standard treatment for pancreatic adenocarcinoma. Many mechanisms are involved in gemcitabine resistance, such as reduced expression of the human equilibrative nucleoside transporter 1 (hENT1) membrane transporter, deoxycytidine kinase deficiency, and changes in the signal transmission of mitogenactivity protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) pathways. Aim: To evaluate the anti-tumor efficiency of blocking signaling pathways using combined action of
doi:10.18632/oncotarget.25560
pmid:29963262
pmcid:PMC6021353
fatcat:bhsflgvurjbqrk2xylf7nix33u
more »
... tabine, everolimus and zoledronic acid versus gemcitabine alone in a mouse subcutaneous xenograft. Methods: Implantations of two human pancreatic adenocarcinoma cells lines (PANC1, K-ras mutated and gemcitabine-resistant; and BxPc3, wild-type K-ras and gemcitabine-sensitive) were performed on male athymic nude mice. The mice received different treatments: gemcitabine, gemcitabine plus everolimus, everolimus, gemcitabine plus zoledronic acid, everolimus plus zoledronic acid, or gemcitabine plus everolimus and zoledronic acid, for 28 days. We measured the tumor volume and researched the expression of the biomarkers involved in the signaling pathways or in gemcitabine resistance. Results: In wild-type K-ras tumors, the combinations of gemcitabine plus everolimus; zoledronic acid plus everolimus; and gemcitabine plus zoledronic acid and everolimus slowed tumor growth, probably due to caspase-3 overexpression and reduced Annexin II expression. In mutated K-ras tumors, gemcitabine plus everolimus and zoledronic acid, and the combination of zoledronic acid and everolimus, decreased tumor volume as compared to gemcitabine alone, inhibiting the ERK feedback loop induced by everolimus. Conclusion: The combination of zoledronic acid and everolimus has an antitumor effect and could increase gemcitabine efficacy.
IMGT-ONTOLOGY for immunogenetics and immunoinformatics
2003
In Silico Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
., 2001; Bosc and Lefranc, 2003 ]. ...
pmid:15089751
fatcat:7dswqqx3vvhtjmd4fbhyh4lfg4
Metastatic hepatocellular carcinoma: When surgery and successive palliative treatments lead to remission
2014
Clinics And Research in Hepatology and Gastroenterology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Type de
publication
Article de revue
Auteur
Brochard, Charlène [1], Hamy, Antoine [2], Michalak, Sophie [3], Aubé, Christophe
[4], Picquet, Jean [5], Nebout, Nathalie [6], Caroli-Bosc, François-Xavier ...
doi:10.1016/j.clinre.2013.02.006
pmid:23608740
fatcat:uwg47w4htfhmjnw2lfbhgmrlsm
IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains
2005
Developmental and Comparative Immunology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf.
IMGT, the international ImMunoGeneTics information system w (http://imgt.cines.fr) provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs.
doi:10.1016/j.dci.2004.07.003
pmid:15572068
fatcat:yjiotyragzhx5kvr3eip3ntgay
more »
... n this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species. q
Analysis of blood parameters and molecular endometrial markers during early reperfusion in two ovine models of uterus transplantation
2021
PLoS ONE
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Data curation: Marie Carbonnel, Nathalie Cornet. Formal analysis: Marie Carbonnel, Nathalie Cornet.
PLOS ONE ...
doi:10.1371/journal.pone.0251474
pmid:34003831
fatcat:ztz5h4g2pzb4vawc2vrvjfcur4
Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
2015
Nature Communications
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia
2021
Journal of Experimental Medicine
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, PDXs, and patients with acute myeloid leukemia (AML) harboring an IDH mutation displayed an enhanced mitochondrial oxidative metabolism. Along with an increase in TCA cycle intermediates, this AML-specific metabolic behavior mechanistically occurred through the increase in electron transport chain complex
doi:10.1084/jem.20200924
pmid:33760042
pmcid:PMC7995203
fatcat:apdtontvurbonjv6irxpijhlca
more »
... I activity, mitochondrial respiration, and methylation-driven CEBPα-induced fatty acid β-oxidation of IDH1 mutant cells. While IDH1 mutant inhibitor reduced 2-HG oncometabolite and CEBPα methylation, it failed to reverse FAO and OxPHOS. These mitochondrial activities were maintained through the inhibition of Akt and enhanced activation of peroxisome proliferator-activated receptor-γ coactivator-1 PGC1α upon IDH1 mutant inhibitor. Accordingly, OxPHOS inhibitors improved anti-AML efficacy of IDH mutant inhibitors in vivo. This work provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH mutant AML patients, especially those unresponsive to or relapsing from IDH mutant inhibitors.
Page 633 of National Union Catalog Vol. 39, Issue
[page]
1958
National Union Catalog
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
Lyon, Bosc, 1958. 55 p. illus. (Faculté de médecine et de pharmacie de Lyon. ...
NNC
Sarraute, Nathalie. Martereau; roman. Witsch (1959) 1
Koln, Kiepenheuer &
Sarraute, Nathalie.
a novel. Translated by Maria Jolas. New
York, G. ...
Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibraltar (Antiquité – Moyen Âge). I. Représentations, perceptions, imaginaires
2020
Atlante
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibral... ...
Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibral... ...
doi:10.4000/atlante.644
fatcat:7wf7ybcbaraz3gnzzcuozzk2oe
Page 543 of Applied Mechanics Reviews Vol. 10, Issue 11
[page]
1957
Applied Mechanics Reviews
Preserved Fulltext
The Internet Archive has digitized a microfilm copy of this work. It may be possible to borrow a copy for reading.
Bosc ocwe en a Seer Collomosse, H. ........3731 Cen. B Bikciscssscvaeee eS Se eee Corces: Gs. Mn os <scsncoeee Copem, B Giissccsccesceee Coulter” M.. ...
Huntington, R.
coe eee ee ee se et WUIIO EAWASHAT, 2. cee eee eee we ot
ececeoeo cece ee eo tHSU 8 JAURCE, 2Be ceo ereeeeeees el
dee ee ee ee eee at
Gamberoni, Nathalie .
ee. ae a Gosser, Bi. ...
ENTOMOLOGICAL NOTES
1884
Canadian Entomologist
Preserved Fulltext
The Internet Archive has a preservation copy of this work in our general collections.
A ferv such I here indicate ;-Nathalis iole Bd. Not abundant. Jnnonia Iavinia Cran. Common. Argus labrusca f{ub. Occasionally. Dilophonota ello Linn. Not common. 'Ihysania zenobia Cram. ...
On Anas bosc/tas. Occurs in Europe on many species of ducks. Europe.
TRINOTON.
PEDICUI-ID10.
Pediculus capitis and aestirnenti and. p/zthirius inguinalis'aturalry
present no variations. ...
doi:10.4039/ent16199-10
fatcat:vjmlscx4hzfvphriplmlzpvcki
« Previous
Showing results 1 — 15 out of 135 results