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Integrated polymer micro-ring resonators for optical sensing applications

Pauline Girault, Nathalie Lorrain, Luiz Poffo, Mohammed Guendouz, Jonathan Lemaitre, Christiane Carré, Michel Gadonna, Dominique Bosc, Guillaume Vignaud
2015 Journal of Applied Physics  
Micro-resonators (MR) have become a key element for integrated optical sensors due to their integration capability and their easy fabrication with low cost polymer materials. Nowadays, there is a growing need on MRs as highly sensitive and selective functions especially in the areas of food and health. The context of this work is to implement and study integrated micro-ring resonators devoted to sensing applications. They are fabricated by processing SU8 polymer as core layer and PMATRIFE
more » ... r as lower cladding layer. The refractive index of the polymers and of the waveguide structure as a function of the wavelength are presented. Using these results, a theoretical study of the coupling between ring and straight waveguides has been undertaken in order to define the MR design. Sub-micronic gaps of 0.5 µm to 1 µm between the ring and the straight waveguides have been successfully achieved with UV (i-lines) photolithography. Different superstrates such as air, water and aqueous solutions with glucose at different concentrations have been studied. First results show a good normalized transmission contrast of 0.98, a resonator quality factor around 1.5x10 4 corresponding to a coupling ratio of 14.7 % and ring propagation losses around 5 dB/cm. Preliminary sensing experiments have been performed for different concentrations of glucose; a sensitivity of 115 ± 8 nm/RIU at 1550 nm has been obtained with this couple of polymers.
doi:10.1063/1.4914308 fatcat:crzl4dshkze33nezmylfyqolxe

The Mouse (Mus musculus) T Cell Receptor Beta Variable (TRBV), Diversity (TRBD) and Joining (TRBJ) Genes

Nathalie Bosc, Marie-Paule Lefranc
2000 Experimental and Clinical Immunogenetics  
Exp Clin Immunogenet 2000;17:216-228 Exp Clin Immunogenet 2000;17:216-228 Bosc/Lefranc  ... 
doi:10.1159/000019141 pmid:11096260 fatcat:2s6sa5e7xrgkdgtbljpkmvs45e

The Mouse (Mus musculus) T Cell Receptor Delta Variable (TRDV), Diversity (TRDD) and Joining (TRDJ) Genes

Nathalie Bosc, Valérie Contet, Marie-Paule Lefranc
2001 Experimental and Clinical Immunogenetics  
/Contet/Lefranc Exp Clin Immunogenet 2001;18:51-58 Bosc/Contet/Lefranc  ...  available at the IMGT Marie-Paule page from IMGT, the international ImMuno-GeneTics database ( created by Marie-Paule Lefranc, Université Exp Clin Immunogenet 2001;18:51-58 Bosc  ... 
doi:10.1159/000049087 pmid:11150853 fatcat:ltcpekwp6ncx7cdz6vpue2z4z4

Micro-resonators based on integrated polymer technology for optical sensing

Pauline Girault, Jonathan Lemaitre, Mohammed Guendouz, Nathalie Lorrain, Luiz Poffo, Michel Gadonna, Dominique Bosc, Francis Berghmans, Anna G. Mignani, Piet De Moor
2014 Optical Sensing and Detection III  
Research on sensors has experienced a noticeable development over the last decades especially in label free optical biosensors. However, compact sensors without markers for rapid, reliable and inexpensive detection of various substances induces a significant research of new technological solutions. The context of this work is the development of a sensor based on easily integrated and inexpensive micro-resonator (MR) component in integrated optics, highly sensitive and selective mainly in the
more » ... as of health and food. In this work, we take advantage of our previous studies on filters based on micro-resonators (MR) to experiment a new couple of polymers in the objective to use MR as a sensing function. MRs have been fabricated by processing SU8 polymer as core and PMATRIFE polymer as cladding layer of the waveguide. The refractive index contrast reaches 0.16 @ 1550 nm. Sub-micronic ring waveguides gaps from 0.5 to 1 µm have been successfully achieved with UV (i-line) photolithography. This work confirms our forecasts, published earlier, about the resolution that can be achieved. First results show a good extinction coefficient of ~17 dB, a quality factor around 10 4 and a finesse of 12. These results are in concordance with the theoretical study and they allow us to validate our technology with this couple of polymers. Work is going on with others lower cladding materials that will be used to further increase refractive index contrast for sensing applications.
doi:10.1117/12.2052622 fatcat:4wxyci6rsraifayvjxvjtbersq

The combination of everolimus and zoledronic acid increase the efficacy of gemcitabine in a mouse model of pancreatic adenocarcinoma

Carole Vitellius, Lionel Fizanne, Elodie Menager-Tabourel, Joelle Nader, Nathalie Baize, Margot Laly, Emilie Lermite, Sandrine Bertrais, FX Caroli-Bosc
2018 OncoTarget  
Gemcitabine is a standard treatment for pancreatic adenocarcinoma. Many mechanisms are involved in gemcitabine resistance, such as reduced expression of the human equilibrative nucleoside transporter 1 (hENT1) membrane transporter, deoxycytidine kinase deficiency, and changes in the signal transmission of mitogenactivity protein kinase (MAPK) and the phosphoinositide 3-kinase (PI3K) pathways. Aim: To evaluate the anti-tumor efficiency of blocking signaling pathways using combined action of
more » ... tabine, everolimus and zoledronic acid versus gemcitabine alone in a mouse subcutaneous xenograft. Methods: Implantations of two human pancreatic adenocarcinoma cells lines (PANC1, K-ras mutated and gemcitabine-resistant; and BxPc3, wild-type K-ras and gemcitabine-sensitive) were performed on male athymic nude mice. The mice received different treatments: gemcitabine, gemcitabine plus everolimus, everolimus, gemcitabine plus zoledronic acid, everolimus plus zoledronic acid, or gemcitabine plus everolimus and zoledronic acid, for 28 days. We measured the tumor volume and researched the expression of the biomarkers involved in the signaling pathways or in gemcitabine resistance. Results: In wild-type K-ras tumors, the combinations of gemcitabine plus everolimus; zoledronic acid plus everolimus; and gemcitabine plus zoledronic acid and everolimus slowed tumor growth, probably due to caspase-3 overexpression and reduced Annexin II expression. In mutated K-ras tumors, gemcitabine plus everolimus and zoledronic acid, and the combination of zoledronic acid and everolimus, decreased tumor volume as compared to gemcitabine alone, inhibiting the ERK feedback loop induced by everolimus. Conclusion: The combination of zoledronic acid and everolimus has an antitumor effect and could increase gemcitabine efficacy.
doi:10.18632/oncotarget.25560 pmid:29963262 pmcid:PMC6021353 fatcat:bhsflgvurjbqrk2xylf7nix33u

IMGT-ONTOLOGY for immunogenetics and immunoinformatics

Marie-Paule Lefranc, Véronique Giudicelli, Chantal Ginestoux, Nathalie Bosc, Géraldine Folch, Delphine Guiraudou, Joumana Jabado-Michaloud, Séverine Magris, Dominique Scaviner, Valérie Thouvenin, Kora Combres, David Girod (+8 others)
2003 In Silico Biology  
., 2001; Bosc and Lefranc, 2003 ].  ... 
pmid:15089751 fatcat:7dswqqx3vvhtjmd4fbhyh4lfg4

Metastatic hepatocellular carcinoma: When surgery and successive palliative treatments lead to remission

Charlène Brochard, Antoine Hamy, Sophie Michalak, Christophe Aubé, Jean Picquet, Nathalie Nebout, François-Xavier Caroli-Bosc, Frédéric Oberti, Paul Calès, Jérôme Boursier
2014 Clinics And Research in Hepatology and Gastroenterology  
Type de publication Article de revue Auteur Brochard, Charlène [1], Hamy, Antoine [2], Michalak, Sophie [3], Aubé, Christophe [4], Picquet, Jean [5], Nebout, Nathalie [6], Caroli-Bosc, François-Xavier  ... 
doi:10.1016/j.clinre.2013.02.006 pmid:23608740 fatcat:uwg47w4htfhmjnw2lfbhgmrlsm

IMGT unique numbering for immunoglobulin and T cell receptor constant domains and Ig superfamily C-like domains

Marie-Paule Lefranc, Christelle Pommié, Quentin Kaas, Elodie Duprat, Nathalie Bosc, Delphine Guiraudou, Christelle Jean, Manuel Ruiz, Isabelle Da Piédade, Mathieu Rouard, Elodie Foulquier, Valérie Thouvenin (+1 others)
2005 Developmental and Comparative Immunology  
IMGT, the international ImMunoGeneTics information system w ( provides a common access to expertly annotated data on the genome, proteome, genetics and structure of immunoglobulins (IG), T cell receptors (TR), major histocompatibility complex (MHC), and related proteins of the immune system (RPI) of human and other vertebrates. The NUMEROTATION concept of IMGT-ONTOLOGY has allowed to define a unique numbering for the variable domains (V-DOMAINs) and for the V-LIKE-DOMAINs.
more » ... n this paper, this standardized characterization is extended to the constant domains (C-DOMAINs), and to the C-LIKE-DOMAINs, leading, for the first time, to their standardized description of mutations, allelic polymorphisms, two-dimensional (2D) representations and tridimensional (3D) structures. The IMGT unique numbering is, therefore, highly valuable for the comparative, structural or evolutionary studies of the immunoglobulin superfamily (IgSF) domains, V-DOMAINs and C-DOMAINs of IG and TR in vertebrates, and V-LIKE-DOMAINs and C-LIKE-DOMAINs of proteins other than IG and TR, in any species. q
doi:10.1016/j.dci.2004.07.003 pmid:15572068 fatcat:yjiotyragzhx5kvr3eip3ntgay

Analysis of blood parameters and molecular endometrial markers during early reperfusion in two ovine models of uterus transplantation

Marie Carbonnel, Nathalie Cornet, Aurélie Revaux, Angéline Favre-Inhofer, Laurent Galio, Mariam Raliou, Anne Couturier-Tarrade, Corinne Giraud-Delville, Gilles Charpigny, Valérie Gelin, Olivier Dubois, Barbara Hersant (+8 others)
2021 PLoS ONE  
Data curation: Marie Carbonnel, Nathalie Cornet. Formal analysis: Marie Carbonnel, Nathalie Cornet. PLOS ONE  ... 
doi:10.1371/journal.pone.0251474 pmid:34003831 fatcat:ztz5h4g2pzb4vawc2vrvjfcur4

Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Rebecca Deprez-Poulain, Nathalie Hennuyer, Damien Bosc, Wenguang G. Liang, Emmanuelle Enée, Xavier Marechal, Julie Charton, Jane Totobenazara, Gonzague Berte, Jouda Jahklal, Tristan Verdelet, Julie Dumont (+18 others)
2015 Nature Communications  
doi:10.1038/ncomms9250 pmid:26394692 pmcid:PMC4580987 fatcat:pzndo4gudnfa3ixiuis5rdc2oa

Mitochondrial metabolism supports resistance to IDH mutant inhibitors in acute myeloid leukemia

Lucille Stuani, Marie Sabatier, Estelle Saland, Guillaume Cognet, Nathalie Poupin, Claudie Bosc, Florence A Castelli, Lara Gales, Evgenia Turtoi, Camille Montersino, Thomas Farge, Emeline Boet (+41 others)
2021 Journal of Experimental Medicine  
Mutations in IDH induce epigenetic and transcriptional reprogramming, differentiation bias, and susceptibility to mitochondrial inhibitors in cancer cells. Here, we first show that cell lines, PDXs, and patients with acute myeloid leukemia (AML) harboring an IDH mutation displayed an enhanced mitochondrial oxidative metabolism. Along with an increase in TCA cycle intermediates, this AML-specific metabolic behavior mechanistically occurred through the increase in electron transport chain complex
more » ... I activity, mitochondrial respiration, and methylation-driven CEBPα-induced fatty acid β-oxidation of IDH1 mutant cells. While IDH1 mutant inhibitor reduced 2-HG oncometabolite and CEBPα methylation, it failed to reverse FAO and OxPHOS. These mitochondrial activities were maintained through the inhibition of Akt and enhanced activation of peroxisome proliferator-activated receptor-γ coactivator-1 PGC1α upon IDH1 mutant inhibitor. Accordingly, OxPHOS inhibitors improved anti-AML efficacy of IDH mutant inhibitors in vivo. This work provides a scientific rationale for combinatory mitochondrial-targeted therapies to treat IDH mutant AML patients, especially those unresponsive to or relapsing from IDH mutant inhibitors.
doi:10.1084/jem.20200924 pmid:33760042 pmcid:PMC7995203 fatcat:apdtontvurbonjv6irxpijhlca

Page 633 of National Union Catalog Vol. 39, Issue [page]

1958 National Union Catalog  
Lyon, Bosc, 1958. 55 p. illus. (Faculté de médecine et de pharmacie de Lyon.  ...  NNC Sarraute, Nathalie. Martereau; roman. Witsch (1959) 1 Koln, Kiepenheuer & Sarraute, Nathalie. a novel. Translated by Maria Jolas. New York, G.  ... 

Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibraltar (Antiquité – Moyen Âge). I. Représentations, perceptions, imaginaires

Sophie Hirel
2020 Atlante  
Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibral...  ...  Françoise Des Boscs, Yann Dejugnat et Arthur Haushalter, Le Détroit de Gibral...  ... 
doi:10.4000/atlante.644 fatcat:7wf7ybcbaraz3gnzzcuozzk2oe

Page 543 of Applied Mechanics Reviews Vol. 10, Issue 11 [page]

1957 Applied Mechanics Reviews  
Bosc ocwe en a Seer Collomosse, H. ........3731 Cen. B Bikciscssscvaeee eS Se eee Corces: Gs. Mn os <scsncoeee Copem, B Giissccsccesceee Coulter” M..  ...  Huntington, R. coe eee ee ee se et WUIIO EAWASHAT, 2. cee eee eee we ot ececeoeo cece ee eo tHSU 8 JAURCE, 2Be ceo ereeeeeees el dee ee ee ee eee at Gamberoni, Nathalie . ee. ae a Gosser, Bi.  ... 


P. R. Hoy
1884 Canadian Entomologist  
A ferv such I here indicate ;-Nathalis iole Bd. Not abundant. Jnnonia Iavinia Cran. Common. Argus labrusca f{ub. Occasionally. Dilophonota ello Linn. Not common. 'Ihysania zenobia Cram.  ...  On Anas bosc/tas. Occurs in Europe on many species of ducks. Europe. TRINOTON. PEDICUI-ID10. Pediculus capitis and aestirnenti and. p/zthirius inguinalis'aturalry present no variations.  ... 
doi:10.4039/ent16199-10 fatcat:vjmlscx4hzfvphriplmlzpvcki
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