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Rodents have developed a great capacity to for finding and storing seeds, and the ability of each species to find seeds in sufficient numbers could determine rodent abundance. To investigate this ability, we compared the differential ability of four murid rodents (Akodon molinae, Graomys griseoflavus, Calomys musculinus and Eligmodontia typus) to detect buried seeds. We also measured the variables (seed type, number of seeds in caches, soil depth and soil moisture) that would be affecting suchdoi:10.1111/j.1439-0310.2008.01605.x fatcat:t6wyloemqze5dheh4i7pk4yqwi
more »... bility. Results showed a differential ability to find seeds among rodents, E. typus was the most successful species, and C. musculinus and G. griseoflavus were the least successful. Conditions of wet sand and grouped seeds were the most favourable for murids to find higher number of seeds. These rodents showed preference for the sunflower seed, which is large, with good hygroscopic capacity and high in lipids, whereas millet is the opposite. The use of food storage strategies would give murid species a differential adaptive advantage, providing them with a greater ability to locate and exploit food sources more efficiently in periods of lower food abundance and after rainfall events.
Practical recommendations Magda Campins 1 , Yolima Cossio 1 , Xavier Martínez 1 and Natalia Borruel 2 regulated cytokines; similar anti-inflammatory treatments are used for their control, including corticoids ...doi:10.4321/s1130-01082013000200006 pmid:23659508 fatcat:ghl7y53d5fcmhlkbx4yr52nyme
To cite: Pascal V, Pozuelo M, Borruel N, et al. Gut 2017;66:813-822. ► Additional material is published online only. To view please visit the journal online (http://dx. ...doi:10.1136/gutjnl-2016-313235 pmid:28179361 pmcid:PMC5531220 fatcat:mmpbxeomunebpiqlp4zm5bj3dq
Patient preferences with respect to available therapies must be taken into account if the quality of care of patients with Crohn´s disease is to be improved. The objective was to develop the IMPLICA preferences questionnaire for Crohn´s disease patients treated with biological therapies. As per standard methodology, the questionnaire was developed in Spanish language, in five stages: 1. Literature review to identify attributes related to biological therapies in Crohn´s disease; 2. Expertpmid:25361447 fatcat:zvzpihdnprazxjkaek3rmjpiuu
more »... to identify attributes most relevant for patients; 3. Scoring of the most relevant attributes and generation of scenarios; 4. Patient comprehension test for selection and validation of scenarios; and 5. Final list of scenarios and qualitative evaluation of those most accepted by patients. Three attributes related to various characteristics of biological treatments were selected: route of administration, place/duration of administration and person administering the treatment; a combination of them produced seven possible scenarios. The comprehension test gave rise to significant modifications in the instructions, text of the scenarios and response categories. IMPLICA is the first questionnaire to evaluate treatment preferences of Crohn´s disease patients receiving biological therapies. This questionnaire facilitates patient´s selection of the most appropriate real world treatment option and, therefore, it can be considered a useful tool when deciding the most appropriate and feasible treatment in normal clinical practice.
Urol. 2014; 67 (2): 206-209 Natalia Miranda-Utrera, Manuel Pamplona Casamayor, Susana Borruel Nacenta, R. Villar Esnal, y Rafael Díaz González. Servicio de Urología. ... Borruel Nacenta, et al. ...pmid:24691045 fatcat:vkuif6dwvfakzk5njy4lejelni
The importance of tuco-tucos (Ctenomys eremophilus) and cavies (Microcavia australis) as herbivores in the Monte Desert was assessed on a creosotebush community dominated by Larrea cuneifolia. Herbivory by tuco-tucos or cavies affected 35% of the total plants. The most highly damaged plant species was Atriplex lampa, followed by Larrea cuneifolia and Lycium sp. The level of damage caused by Ctenomys was higher than that produced by cavies.doi:10.1006/jare.1997.0378 fatcat:vqhnrq4pvnau7kdnvp7iv3gz7y
Borruel, Antonio Torrejón, Ester Navarro, Andrés Peláez and Francesc Casellas Fatigue Impact Scale (DFIS), Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS), and to determine which ... three questionnaires for measuring fatigue: Daily Questionnaires for measuring fatigue and its impact on health perception in inflammatory bowel disease María Dolores Castillo-Cejas, Virginia Robles, Natalia ...doi:10.4321/s1130-01082013000300005 pmid:23735021 fatcat:2izmxsqc3bh4xpjnoq242agssm
In recent years anti-TNF therapy has been associated with leishmaniasis in immunocompromised patients from endemic areas. Nevertheless, data on asymptomatic Leishmania infection in such patients is scarce. The aim of this study was to determine the prevalence of asymptomatic infection in inflammatory bowel disease (IBD) patients treated with TNF inhibitors living in an endemic area (Catalonia) and to follow up them to study how the infection evolved. 192 IBD patients (143 Crohn's disease; 49doi:10.1016/j.heliyon.2020.e03940 pmid:32420499 pmcid:PMC7218013 fatcat:6ps34zbbrvfthfte7skuiyjab4
more »... erative colitis) from Catalonia (Spain), an area endemic for L. infantum, were recruited. Peripheral blood samples were collected and tested for anti-Leishmania antibodies by Western blotting (WB). Leishmania kinetoplast DNA was detected in peripheral blood mononuclear cells (PBMC) by a quantitative PCR. Serology was positive in 3.1% and Leishmania DNA was found in 8.8%, with a low parasitic load and humoral response. The prevalence was 10.9%, patients being considered infected if they tested positive by at least one of the techniques. Eight out of the 21 patients with asymptomatic leishmaniasis were monitored for 3-8 months after the first test. None of them showed an increased parasitemia or humoral response, or developed leishmaniasis during the follow-up period. The prevalence of Leishmania asymptomatic infection detected in our IBD cohort is similar to that found in healthy population in close endemic areas. Due to the short monitoring period, it is not possible to reach a conclusion about the risk of Leishmania reactivation from this study.
Inflammatory bowel disease impairs patients' health related quality of life (HRQOL). AntiTNFα agents control disease activity effectively. An ambitious goal of treatment is to achieve the normalization of health. This can be assessed by using a cut-off scoring threshold of the IBDQ-36 questionnaire. It has not been established if antiTNFα treatment is able to restore to normal patients' HRQOL. Aims: To determine whether patients with Crohn's disease (CD) and ulcerative colitis (UC) in clinicaldoi:10.1016/j.crohns.2012.01.019 pmid:22398074 fatcat:357fpz6je5akdjvuhgi64udj6e
more »... emission after one year treatment with antiTNFα agents achieve normalization of their HRQOL. Methods: Observational and cross-sectional study in patients treated with antiTNFα for one year and in sustained clinical remission. Patients completed the specific questionnaire IBDQ-36. Complete restoration of health was considered achieved when global score of IBDQ-36 was higher than 209 points. Results: 54 patients (43 with CD and 11 with UC) were included. Thirty patients received adalimumab and 24 infliximab. Median global score of the IBDQ-36 was 231, without differences between CD and UC (228 vs 235 respectively, p = ns). Normalization of HRQOL was achieved in all 11 UC patients and in 29 out of 43 CD patients (67%). In our sample population, restoration of health was significantly more frequent in UC than in CD (p b 0.05). Conclusions: One-year clinical remission induced by antiTNFα treatment restores perception of health to normal in most patients with IBD.
Borruel-Sainz, Antonio Torrejón-Herrera and Isabel Castells Unitat d'Atenció Crohn-Colitis (UACC). ... more markedly than the number of hospital admissions due to IBD (squares on broken line).ON PATIENTS WITH INFLAMMATORY BOWEL DISEASE REV ESP ENFERM DIG 2012; 104 (1): 16-20 Francesc Casellas-Jordá, Natalia ...doi:10.4321/s1130-01082012000100004 fatcat:tbysdx6a4vfwtn7l3qhyy72yni
Anemia is a common complication of inflammatory bowel disease (IBD) and contributes to the deterioration of health-related quality of life (HRQOL). Iron deficiency (ID) is a prevalent underlying factor, present in up to 90% of patients. In the absence of anemia, it is unclear as to what extent ID can affect HRQOL in patients with IBD. Our aim was to determine whether ID without anemia negatively affects normal perception of HRQOL in patients with IBD in remission. Methods: We conducted adoi:10.1097/mib.0000000000000768 pmid:27057682 fatcat:drqphyikufdzvernq5jxjlmznm
more »... tive, cross-sectional study in patients with IBD in remission without anemia. Blood samples were obtained to determine iron status, and patients completed the Inflammatory Bowel Disease Questionnaire-36. ID was defined on serum ferritin ,30 ng/mL and transferrin saturation ,16%. Restoration of HRQOL was defined as $209 on the Inflammatory Bowel Disease Questionnaire-36. Results: One hundred-four patients with IBD in clinical remission were included; 45 patients were iron deficient and 59 had normal iron status. All patients were in clinical remission, with a median Harvey-Bradshaw Index #0 and Simple Clinical Colitis Activity Index #0. Median hemoglobin was 12.8 g/dL in the ID group and 13.9 g/dL in the normal iron status group (P , 0.05). Prevalence of female patients was higher in the ID group (odds ratio, 4.45; 95% CI, 1.7-11.7; P , 0.01). The median global value of Inflammatory Bowel Disease Questionnaire-36 was not different between the groups (219 in the ID group versus 230 in the normal iron status group, P ¼ not significant), but restoration of health was significantly less frequent in patients with ID (odds ratio, 2.83; 95% CI, 1.22-6.6; P , 0.05). Conclusions: ID in absence of anemia negatively impacts normal perception of HRQOL in patients with IBD in remission. Correction of ID may be a new target in the treatment of these patients.
Although human papillomavirus (HPV) routine vaccination programmes have been implemented around the world and recommendations have been expanded to include other high-risk individuals, current recommendations often differ between countries in Europe, as well as worldwide. To find and summarise the best available evidence of HPV vaccination in high-risk patients aiding clinicians and public health workers in the day-to-day vaccine decisions relating to HPV in Spain. We conducted a systematicdoi:10.2807/1560-7917.es.2019.24.7.1700857 pmid:30782268 pmcid:PMC6381660 fatcat:ihebjb62xnaifhrspg2chnhkbi
more »... ew of the immunogenicity, safety and efficacy/effectiveness of HPV vaccination in high-risk populations between January 2006 and June 2016. HPV vaccination recommendations were established with levels of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. A strong recommendation about HPV vaccination was made in the following groups: HIV infected patients aged 9-26 years; men who have sex with men aged 9-26 years; women with precancerous cervical lesions; patients with congenital bone marrow failure syndrome; women who have received a solid organ transplant or hematopoietic stem cell transplantation aged 9-26 years; and patients diagnosed with recurrent respiratory papillomatosis. Data concerning non-routine HPV vaccination in populations with a high risk of HPV infection and associated lesions were scarce. We have developed a document to evaluate and establish evidence-based guidelines on HPV vaccination in high-risk populations in Spain, based on best available scientific evidence.
Stem Cell Reports
Crohn's disease (CD) is characterized by the expansion of mesenteric fat, also known as "creeping fat." We explored the plasticity and immune properties of adipose-derived stem cells (ASCs) in the context of CD as potential key players in the development of creeping fat. Mesenteric CD-derived ASCs presented a more proliferative, inflammatory, invasive, and phagocytic phenotype than equivalent cells from healthy donors, irrespective of the clinical stage. Remarkably, ASCs from the subcutaneousdoi:10.1016/j.stemcr.2017.07.014 pmid:28966116 pmcid:PMC5639166 fatcat:x6m6whbqk5fwnlo2n3qiydden4
more »... pot of patients with CD also showed an activated immune response that was associated with a reduction in their immunosuppressive properties. The invasive phenotype of mesenteric CD ASCs was governed by an inflammasome-mediated inflammatory state since blocking inflammasome signaling, mainly the secretion of interleukin-1b, reversed this characteristic. Thus, CD alters the biological functions of ASCs as adipocyte precursors, but also their immune properties. Selection of ASCs with the best immunomodulatory properties is advocated for the success of cell-based therapies.
Interleukin 17 (IL-17) is a proinflammatory cytokine that has been the focus of intensive research because of its crucial role in the pathogenesis of different diseases across many medical specialties. In this context, the present review in which a panel of 13 experts in immunology, dermatology, rheumatology, neurology, hematology, infectious diseases, hepatology, cardiology, ophthalmology and oncology have been involved, puts in common the mechanisms through which IL-17 is considered adoi:10.1016/j.autrev.2019.102429 pmid:31734402 fatcat:m3p2lbgzuvfu5n3mi753fpl7iu
more »... r target for the development of novel biological therapies in these different fields. A comprehensive review of the literature and analysis of the most outstanding evidence have provided the basis for discussing the most relevant data related to IL-17A blocking agents for the treatment of different disorders, such as psoriasis, psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, cardiovascular disorders, non alcoholic fatty liver disease, multiple sclerosis, inflammatory bowel disease, uveitis, hematological and solid cancer. Current controversies are presented giving an opening line for future research.
Author contributions Cristina Solé, Susie Guilly, Kevin Da Silva, Marta Llopis, Natalia Borruel, Magali Berland, Francesc Casellas, and Elsa Solà contributed to the conception and design of the study, ...doi:10.1053/j.gastro.2020.08.054 pmid:32941879 fatcat:qhcfotfzrbhivhfrevgxhbgybq
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