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Kondo Effect in High-TcCuprates

Naoto Nagaosa, Patrick A. Lee
1997 Physical Review Letters  
We study the Kondo effect due to the nonmagnetic impurity, e.g., Zn, in high-T_c cuprates based on the spin-change separated state.  ...  In the optimal or overdoped case with the Kondo screening, the residual resistivity is dominated by the spinons while the T-dependent part determined by the holons.  ...  Kondo effect is a phenomenon shown by a magnetic impurity put into a nonmagnetic metal [1] .  ... 
doi:10.1103/physrevlett.79.3755 fatcat:k2gged2lcfgnrkrqitnpphaxvq

Enhanced Spin Hall Effect by Resonant Skew Scattering in the Orbital-Dependent Kondo Effect

Guang-Yu Guo, Sadamichi Maekawa, Naoto Nagaosa
2009 Physical Review Letters  
Kondo limit.  ...  ., Nature Materials 7, 125 (2008)) is attributed to the orbital-dependent Kondo effect of Fe in the Au host metal, where the t_2g-orbitals are in the mixed-valence region while e_g-orbitals are in the  ...  This is reasonable since the Fe in Au is known as a Kondo impurity but the Kondo temperature is as low as 0.4 K.  ... 
doi:10.1103/physrevlett.102.036401 pmid:19257372 fatcat:ytzxngpqt5hmtbbn2nbswtloqm

Resection of lung metastasis from gallbladder carcinoma: immunohistochemistry of RCAS1 and CD8+T cells in primary and metastatic tumors

Taro Oshikiri, Takayuki Morita, Miyoshi Fujita, Yuji Miyasaka, Naoto Senmaru, Hidehisa Yamada, Naoto Kaji, Satoshi Kondo
2006 Cancer Letters  
This research demonstrated that the mAb 22-1-1 recognizes Kondo S, Katoh H, Clinical significance of immune cell infiltration within gallbladder cancer, Br J Cancer 89 (2003) 1736-1742.  ... 
doi:10.1016/j.canlet.2005.05.050 pmid:16039043 fatcat:fzql5tbvmrg3dmt37g2bxo2d7m

New Predictor for Intraaneurysmal Embolization Using Guglielmi Detachable Coils

Yasushi MATSUMOTO, Masayuki EZURA, Ryushi KONDO, Naoto KIMURA, Akira TAKAHASHI
2009 Neurologia medico-chirurgica  
Aneurysm volume/virtual column volume (AV/CV) ratio, calculated from measurements derived from reconstructed images based on rotational three-dimensional digital subtraction angiography (3D-DSA), was investigated as a predictor of the success of intraaneurysmal embolization in 20 unruptured widenecked internal carotid artery aneurysms treated by Guglielmi detachable coils. AV and neck area were automatically calculated with a workstation. CV was defined as the product of height and neck area of
more » ... the aneurysm. The percentage of aneurysm occlusion at the end of the procedure was evaluated by volume embolization ratio (VER). Successful intraaneurysmal embolization (VER AE20%) was achieved in 10 of 11 aneurysms with AV/CV ratios of more than 1.0, whereas failed embolization (VER = 0%) was observed in 3 of 4 aneurysms with AV/CV ratios of less than 0.8. The AV/CV ratio is a possible predictor of embolization success, which can be easily calculated using 3D-DSA.
doi:10.2176/nmc.49.100 pmid:19318733 fatcat:hcbtgv5hgbg25he6ovnboxnaxe

Orbital-dependent Kondo effect for Fe in Au : Combined approach of density functional theory and quantum Monte Carlo method

Bo Gu, Jing-Yu Gan, Nejat Bulut, Guang-Yu Guo, Naoto Nagaosa, Sadamichi Maekawa
2010 Journal of Physics, Conference Series  
We have studied the orbital-dependent Kondo effect for an Fe impurity in Au host by a combined approach of density functional theory and quantum Monte Carlo method.  ...  In addition, it is found that the difference of impurity-host hybridization is more important than the difference of impurity energy levels to induce the orbital-dependent Kondo effect.  ...  While, different opinion on the nature of Kondo effect for Fe in Au is also proposed [6] : They suggest an effective spin-3/2 3-channel Kondo model, involving local and band electrons of t 2g symmetry  ... 
doi:10.1088/1742-6596/200/6/062007 fatcat:7l7qscpzifbctg7lupwc5uj22e

Frequency of and Predictive Factors for Vascular Invasion after Radiofrequency Ablation for Hepatocellular Carcinoma

Yoshinari Asaoka, Ryosuke Tateishi, Ryo Nakagomi, Mayuko Kondo, Naoto Fujiwara, Tatsuya Minami, Masaya Sato, Koji Uchino, Kenichiro Enooku, Hayato Nakagawa, Yuji Kondo, Shuichiro Shiina (+3 others)
2014 PLoS ONE  
Vascular invasion in patients with hepatocellular carcinoma (HCC) is representative of advanced disease with an extremely poor prognosis. The detailed course of its development has not been fully elucidated. Methods: We enrolled 1057 consecutive patients with HCC who had been treated with curative intent by radiofrequency ablation (RFA) as an initial therapy from 1999 to 2008 at our department. We analyzed the incidence rate of and predictive factors for vascular invasion. The survival rate
more » ... r detection of vascular invasion was also analyzed. Results: During a mean follow-up period of 4.5 years, 6075 nodules including primary and recurrent lesions were treated by RFA. Vascular invasion was observed in 97 patients. The rate of vascular invasion associated with site of original RFA procedure was 0.66% on a nodule basis. The incidence rates of vascular invasion on a patient basis at 1, 3, and 5 years were 1.1%, 5.9%, and 10.4%, respectively. Univariate analysis revealed that tumor size, tumor number, alpha-fetoprotein (AFP), des-gamma-carboxy prothrombin (DCP), and Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein were significant risk predictors of vascular invasion. In multivariate analysis, DCP was the most significant predictor for vascular invasion (compared with a DCP of #100 mAu/mL, the hazard ratio was 1.95 when DCP was 101-200 mAu/mL and 3.22 when DCP was .200 mAu/mL). The median survival time after development of vascular invasion was only 6 months. Conclusion: Vascular invasion occurs during the clinical course of patients initially treated with curative intent. High-risk patients may be identified using tumor markers.
doi:10.1371/journal.pone.0111662 pmid:25397677 pmcid:PMC4232383 fatcat:pxzjbjxvwjbwraviepz5t3ubcm

A Low Picomole Fluorometric Detection System for Amino Acid Analysis

Naoto Kondo, Kunio Imai, Minoru Isobe, Goto Toshio
1984 Agricultural and Biological Chemistry  
An amino acid detection system was developed for low picomole analysis of amino acids including proline, based on OPA-post-labeling with a non-switching NaCIO flow system. A computer-controlled HPLCequipped with a three-solvent gradient mixer was assembled with the detection system to analyze 17 kinds of amino acids in 85 min with a stable base line. The optimum conditions of the NaCIOand OPAsolutions were determined as 0.002%-0.22ml/min and 0.16%-0.26ml/min, respectively. The use of
more » ... only approximately 30% decrease in fluorescence response of the usual amino acids, except for Pro and Cys, the latter even being enhanced by about 10 times. The detection limit for Pro and Gys was 500 and 1000 fmol, respectively, and that of the usual amino acids was 100 fmol. The calibration curves of all amino acids showed good linearity in a range between 5 and 500 pmol. This system was used as a detector for enantiomeric analysis of glutamic acid and cysteic acid with a reversed phase HPLC during stereochemical studies on the natural peptide derivative, oxycadystin.
doi:10.1080/00021369.1984.10866331 fatcat:ajzwp7sebjgatoyatrpz4axblm

A low picomole fluorometric detection system for amino acid analysis

Naoto Kondo, Kunio Imai, Minoru Isobe, Toshio Goto
1984 Agricultural and Biological Chemistry  
An amino acid detection system was developed for low picomole analysis of amino acids including proline, based on OPA-post-labeling with a non-switching NaCIO flow system. A computer-controlled HPLCequipped with a three-solvent gradient mixer was assembled with the detection system to analyze 17 kinds of amino acids in 85 min with a stable base line. The optimum conditions of the NaCIOand OPAsolutions were determined as 0.002%-0.22ml/min and 0.16%-0.26ml/min, respectively. The use of
more » ... only approximately 30% decrease in fluorescence response of the usual amino acids, except for Pro and Cys, the latter even being enhanced by about 10 times. The detection limit for Pro and Gys was 500 and 1000 fmol, respectively, and that of the usual amino acids was 100 fmol. The calibration curves of all amino acids showed good linearity in a range between 5 and 500 pmol. This system was used as a detector for enantiomeric analysis of glutamic acid and cysteic acid with a reversed phase HPLC during stereochemical studies on the natural peptide derivative, oxycadystin.
doi:10.1271/bbb1961.48.1595 fatcat:m3cxvs5ndbfzjkww5tbhjroeaa

SAPHO syndrome in which certolizumab pegol was effective: A case report

Naoki Kondo, Osamu Tanifuji, Tomoharu Mochizuki, Yosuke Sudo, Naoto Endo
2017 Trends in Immunotherapy  
A 45-year-old male suffered from persistent swelling and redness with pain in his left lower leg and ankle. Pathological findings isolated from the ankle joint by arthroscopic synovectomy showed mild synovitis. Initially, this case was diagnosed as chronic mild arthritis and later treated as phlegmon because of persistent redness and swelling inflammatory findings in his left lower leg. A systemic survey was performed. Based on findings, such as chronic ankle arthritis with ipsilateral plantar
more » ... ustulosis, chronic recurrent multifocal osteomyelitis in left distal tibia with MRI, calcaneal osteitis with computed tomography, and pathological findings that neither malignant tumor nor infection was detected, this case reached the definitive diagnosis of SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome. Hot spots detected in the bilateral sternoclavicular and costosternal joints with bone scintigraphy and their arthritic change detected by computed tomography also supported the diagnosis of SAPHO syndrome. This case was refractory to NSAIDS; therefore, the TNF inhibitor, certolizumab pegol was tried. This agent rapidly improved not only the chief complaints, but also objective symptoms and laboratory findings at most 6 weeks after its administration.
doi:10.24294/ti.v1.i2.51 fatcat:c5kjb73mfbgldhpsx7xrbnlrsi

Grip force control during object manipulation in cervical myelopathy

Naoto Noguchi, Bumsuk Lee, Shoya Kamiya, Ken Kondo, Ryoto Teshima, Masatake Ino, Koji Tanaka, Tsuneo Yamazaki
2020 Spinal Cord  
Cross-sectional research. To objectively evaluate grip force (GF) control while holding a freely movable object in individuals with cervical myelopathy (CM). Harunaso Hospital, Takasaki, Japan. We studied 52 hands from 26 individuals with CM. Participants performed a grip-and-lift task by pulp pinch using the thumb and index finger before surgery. We monitored individual finger GF (N) during the first 3 s while lifting and holding an object. Correlations between the GF and other clinical tests
more » ... ere evaluated. A multiple stepwise regression analysis was used to examine the contribution of the GF to the severity of clinical symptoms. Thumb GF was negatively correlated with the 10-s test (rs = -0.32), and index finger GF was positively correlated with its cutaneous pressure threshold (rs = 0.34). Multiple regression for the severity of upper extremity symptoms revealed that the model including the GF had a larger adjusted R2 and a lower AIC value than that of conventionally used clinical tests. These results suggested that the assessment of individual finger GF control could provide an indicator of the clinical severity of upper extremity in individuals with CM.
doi:10.1038/s41393-020-0414-x pmid:31942043 fatcat:6museuiaandgjbu4wbdqtgssq4

Polycation liposome-mediated gene transfer in vivo

Mitsuo Matsuura, Yukako Yamazaki, Mayu Sugiyama, Masami Kondo, Hidetsugu Ori, Mamoru Nango, Naoto Oku
2003 Biochimica et Biophysica Acta - Biomembranes  
The polycation liposome (PCL), a recently developed gene transfer system, is simply prepared by a modification of liposomes with cetylated polyethylenimine (PEI), and shows remarkable transgene efficiency with low cytotoxicity. In the present study, we investigated the applicability of PCLs for in vivo gene transfer, since the PCL-mediated transgene efficiency was found to be maintained in the presence of serum. PCLs composed of dioleoylphosphatidylethanolamine (DOPE) with 5 mol% cetyl PEI (PEI
more » ... average mr. wt. 1800), were superior for transfection to those of dipalmitoylphosphatidylcholine (DPPC) and cholesterol (2:1 as molar ratio) with 5 mol% cetyl PEI in vitro, although the latter PCLs were more efficient for gene transfer in vivo. PCL -DNA complexes were injected into mice via a tail or the portal vein, with the DNA being a plasmid encoding green fluorescent protein (GFP) or luciferase; and the expression was monitored qualitatively or quantitatively, respectively. Tail vein injection resulted in high expression of both GFP and luciferase genes in lung, and portal vein injection resulted in high expression of both genes in the liver. Concerning the gene delivery efficiency, the PCL was found to be superior to PEI or cetyl PEI alone. The optimal conditions for in vivo transfection with PCLs were also examined. D
doi:10.1016/s0005-2736(03)00109-3 pmid:12787931 fatcat:l3vmop4x2jgxznqnjygr56qp6u

Glucosyltyrosine in silkworm haemolymph as a transient metabolite of insects

Minoru ISOBE, Naoto KONDO, Kunio IMAI, Okitsugu YAMASHITA, Toshio GOTO
1981 Agricultural and Biological Chemistry  
Trehalose, the major haemolymphsugar in the silkworm, is partly regulated in concentration by diapause hormone. During the course of our re-investigation on the developmental changes of sugars in polyvoltine silkworm pupae, a new sugar (Sugar-A) was found out at the late stage of pupal-adult development. The amount of Sugar-A was five times as muchas that of trehalose at its maximum,but it disappeared almost completely with emergence. The structure of Sugar-A was determined as
more » ... osine by 270 MHzPMR, FDMS and chemical methods. The physiological function of glucosyltyrosine is also discussed. Important phenomenain insects are under the control of the several organic compounds, as the hormones such as ecdysone, juvenile hormone, brain hormone, diapause hormone, etc. We have long been involved in the chemical studies on the diapause hormone (DH),â nd have also become interested in the dynamic or transient metabolites concerning the diapause. DHin the silkworm is secreted from the suboesophageal ganglion and induces the embryonic (ogg) diapause.2) DH also regulates the various metabolisms in developing ovaries for the preparation of their eggs to diapause. For instance, Yamashita (one of the authors) and Hasegawa3) disclosed that the ovary glycogen in the female silkworm was synthesized at the oocytes from glucose which derived from the blood (haemolymph) trehalose digested by the action of ovary trehalase. Enhanced activity of the trehalase by DHresulted in a rapid diminution of the blood trehalose. The trehalose content was determined in enzymatic method by a combination of trehalase and glucoseoxydase, which was a highly specific method. We herein describe our reinvestigated results about these carbohydrates and others in the haemolymph by a relatively nonspecific method, thus by means with HPLC and colorimetric or refractive-index detection. A new sugar (Sugar-A) was found in the silk-wormhaemolymphas the major sugar component at a certain pupal stage, and the structure of Sugar-A was elucidated. Wewill also discuss the possible physiological function of this metabolite in the silkworm. METHODS AND RESULTS Materials. Haemolymph was collected from the pupae of the polyvoltine race of the silkworm (N4) by cutting their final segments. The liquid was frozen rapidly to -78°C and then kept at -20°C until use. For the analyses on the developmental changes, four of the pupae were sacrificed every day throughout their pupal-adult development. Each aliquot of the haemolymph (0.1 ml out of the stored ca. 0.5 ml) was voltexed with ethanol (0.4ml) and centrifuged. The supernatant (0.4 ml) was transferred into a vial, evaporated to dryness and then dissolved in 50 /u\ of distilled water. HPLCanalyses. Each sample prepared above was analyzed by HPLC under the following condition:
doi:10.1271/bbb1961.45.687 fatcat:6mqkk524gbhlvenrgybmkscit4

Subcutaneous Tocilizumab Is Effective for Treatment of Elderly-Onset Rheumatoid Arthritis

Naoki Kondo, Junichi Fujisawa, Naoto Endo
2020 Tohoku journal of experimental medicine  
Rheumatoid arthritis (RA) is an autoimmune disease characterized by systemic articular and bone manifestations and its pathogenesis is driven by a complex network of proinflammatory cytokines, including tumor necrosis factor and interleukin (IL)-6. Treatment of rheumatoid arthritis (RA) has been standardized by the introduction of a treat-to-target approach. Subcutaneous tocilizumab (TCZ-SC) is a humanized anti-IL-6 receptor monoclonal antibody, and is widely used for refractory RA patients in
more » ... he clinical settings. However, it remains unknown whether TCZ-SC shows effectiveness for elderly onset RA. The study was aimed to assess the effectiveness and safety of TCZ-SC in elderly-onset rheumatoid arthritis (EORA) patients in daily practice. Fifty-five RA patients were divided into two age groups upon TCZ-SC administration: young (Y) group (< 65 years old, n = 30) and elderly-onset (EO) group (> 65 years old, n = 25). Disease activity score-28 (DAS28) upon TCZ-SC administration (4.84 in EO group vs. 4.41 in Y group) was significantly decreased to 1.94 vs. 1.93 at 3 months and 1.61 vs. 1.75 at 12 months after administration. The clinical remission (DAS28 < 2.6) rate was 75% in EO group vs. 83% in Y group at 3 months and 90% vs. 85% at 12 months. The retention rate at 12 months was 88% in EO group and 92% in Y group without significant difference. The cessation cases of adverse events were two in each group. In conclusion, TCZ-SC showed good clinical effectiveness and safety in EORA patients. TCZ-SC is a useful agent for patients with EORA.
doi:10.1620/tjem.251.9 pmid:32404541 fatcat:l4b7trskdjfo5e6ptxps7f5ohe

Bone Histomorphometric Findings in Ankylosing Spondylitis: A Case Report

Naoki Kondo, Noriaki Yamamoto, Kei Watanabe, Naoto Endo
2018 Journal of Bone Biology and Osteoporosis  
There is minimal information on bone Histomorphometric characteristics in ankylosing spondylitis. We here report a case of a 36-year-old Japanese male that suffered from lumbago and could not gaze in the forward direction. Ultimately, a diagnosis of ankylosing spondylitis was made, and vertebroplasty was performed to correct the third lumbar spine. Histomorphometry of the iliac bone showed reduced bone volume parameters (bone volume, and trabecular thickness and width) than reference values. In
more » ... addition, bone formation parameters (osteoid thickness and osteoblast surface per bone surface) and bone resorption parameters (eroded surface per bone surface and osteoclast number per bone surface) were also lower than reference values, indicating low bone turnover. By contrast, there was not a clear trend in bone resorption markers: bone- pecific alkaline phosphatase (17 U/l) was normal, TRACP-5b (136 mU/dl) was slightly lower, urinary N-terminal telopeptide (45.3 nmol BCE/mmol Cr) was normal, and deoxypyridinoline (9.1 nM/mM Cre) was higher than reference values. However, there was deficiency in 25-hydroxy vitamin D (25-OH-D; 14.4 ng/ml). This case highlights the rare possibility of performing bone histomorphometry, and indicates that a low bone volume and low bone turnover (in both bone formation and resorption) are characteristics of ankylosing spondylitis, although bone formation markers (bone-specific alkaline phosphatase) and bone mineral density are within the normal range. The possibility of a serum 25-OH-D deficient status in ankylosing spondylitis should be further considered.
doi:10.18314/jbo.v4i1.1511 fatcat:mozz3rz2zndsbcrihdjr7us52a

Comprehensive miRNA expression analysis for histological subtypes of soft tissue sarcoma

Ryuto Tsuchiya, Yuki Yoshimatsu, Naoto Tsuchiya, Seiji Ohtori, Akira Kawai, Tadashi Kondo
2021 Journal of Electrophoresis  
Sarcoma is a rare mesenchymal malignancy that comprises more than 50 histological subtypes. Because of the rarity and diversity of sarcomas, their differential diagnosis is difficult, and there is still a need for biomarkers to support pathological diagnoses. Micro RNAs (miRNAs) are small noncoding RNAs that regulate the behavior of tumors, such as invasion and metastasis. The expression patterns of miRNAs reflect the origin of malignancy and are considered to be candidate biomarkers. To
more » ... and the molecular background of those histological subtypes, we investigated the miRNA expression in 89 tumor tissues of eight subtypes. The correlation coefficients between each sarcoma subtype on the basis of miRNA expression values were mostly higher than 0.7, reflecting the common mesenchymal origin. By contrast, hierarchical clustering and principal component analysis showed that three types of sarcoma with chromosomal translocation (i.e., dermatofibrosarcoma protuberans, myxoid liposarcoma, and synovial sarcoma) were grouped according to their histological subtypes, whereas five types with complex karyotypes (i.e., myxofibrosarcoma, malignant peripheral nerve sheath tumor, undifferentiated pleomorphic sarcoma, dedifferentiated liposarcoma, and pleomorphic liposarcoma) were not. Notably, the number of miRNAs whose expression pattern was unique to histological subtypes with statistical significance was higher in sarcomas with chromosome translocation than in those with complex karyotypes. Hence, it can be concluded that the miRNAs unique to histological subtypes are candidate biomarkers for the differential diagnosis of sarcomas, particularly in those with chromosomal translocation.
doi:10.2198/jelectroph.65.13 fatcat:loj4f6qwkja5vpzqv5ckt2tirq
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