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Nanopublications for exposing experimental data in the life-sciences: a Huntington's Disease case study

Eleni Mina, Mark Thompson, Rajaram Kaliyaperumal, Jun Zhao, Eelke van der Horst, Zuotian Tatum, Kristina M Hettne, Erik A Schultes, Barend Mons, Marco Roos
2015 Journal of Biomedical Semantics  
Here, we use the nanopublication model to make scientific assertions that were concluded from a workflow analysis of Huntington's Disease data machine-readable, interoperable, and citable.  ...  These results indicate that nanopublications can provide an incentive for researchers to expose data that is interoperable and machine-readable for future use and preservation for which they can get credits  ...  Acknowledgements The work presented in this paper is supported by grants received from the Netherlands Bioinformatics Centre (  ... 
doi:10.1186/2041-1480-6-5 pmid:26464783 pmcid:PMC4603842 fatcat:ness72giubdffb4tmaw2cx65qa

D6.2: Final Report on the creation of a Comunity of Users in Genomics

Kristina Hettne, Marco Roos
2013 Zenodo  
We include a measure of the impact of Wf4Ever in the genomics target community, according to the indicators defined in WP8 (D8.2)  ...  We report the strategy that we followed in order to ensure the uptake of Wf4Ever technologies and tools, e.g. the target stakeholders and community leaders, our message, specific activities, how the scientific  ...  and Huntington's disease (HD) and develop workflows for these (see deliverable D6.3v3).  ... 
doi:10.5281/zenodo.6759939 fatcat:6tmx4nlt5barvltdxkvcegybv4

Structuring research methods and data with the research object model: genomics workflows as a case study

Kristina M Hettne, Harish Dharuri, Jun Zhao, Katherine Wolstencroft, Khalid Belhajjame, Stian Soiland-Reyes, Eleni Mina, Mark Thompson, Don Cruickshank, Lourdes Verdes-Montenegro, Julian Garrido, David de Roure (+7 others)
2014 Journal of Biomedical Semantics  
One of the main challenges for biomedical research lies in the computer-assisted integrative study of large and increasingly complex combinations of data in order to understand molecular mechanisms.  ...  We applied this model to a case study where we analysed human metabolite variation by workflows.  ...  Acknowledgements The research reported in this paper is supported by the EU Wf4Ever STREP project (270129) funded under EU FP7 (ICT-2009.4.1), the EP/G026238/1 EPSRC project myGrid: A Platform for e-Biology  ... 
doi:10.1186/2041-1480-5-41 pmid:25276335 pmcid:PMC4177597 fatcat:ejlb76ytordqvh57q4ho6xtev4

Improved Knowledge Acquisition and Creation of Structured Knowledge for Systems Toxicology

Sam Ansari, Justyna Szostak, Marja Talikka, Julia Hoeng, Juliane Fluck
2016 International Journal on Advances in Life Sciences   unpublished
In order to utilize this information in the growing field of systems toxicology, the published data must be transformed into a structured format suitable for knowledge modelling, reasoning, and ultimately  ...  The resulting BEL triples are then assembled to biological network models that represent specific biological processes for a given context, e.g., organism, tissue type, disease state.  ...  ACKNOWLEDGMENT We acknowledge Stephanie Boué for the creation of various graphics used in the figures.  ...