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Detection of Multiple Polycyclic Aromatic Hydrocarbon-DNA Adducts by a High-Performance Liquid Chromatography- 32 P-Postlabeling Method

Nancy J. Gorelick, Nancy L. Reeder
1993 Environmental Health Perspectives  
FIGURE 5 . 5 Effect of the amount of [3H]benzo[a]pyrene (BaP)/DNA on i'tm' 1.1 j> = recovery of 32P-labeled BaP-diol epoxide (BPDE) adducts.  ...  Modified from Gorelick and Wogan (1). FIGURE 2 .FIGURE 3 . 23 Structures of the polycyclic aromatic hydrocarbon diol epoxide metabolites reacted with DNA.  ... 
doi:10.2307/3431483 pmid:8319625 pmcid:PMC1567073 fatcat:b6tlinkkmzgchapt7mcjkfebc4

Femtomole SHAPE Reveals Regulatory Structures in the Authentic XMRV RNA Genome

Jacob K. Grohman, Sumith Kottegoda, Robert J. Gorelick, Nancy L. Allbritton, Kevin M. Weeks
2011 Journal of the American Chemical Society  
Regions with the largest changes in SHAPE reactivity for the RNA analyzed inside virions, relative to the ex virio RNA, are identified (a-d, bottom panel) with the same labels used in J Am Chem Soc  ... 
doi:10.1021/ja2070945 pmid:22126209 pmcid:PMC3241870 fatcat:he6ywxpd5vdmfgu6olvff2h2nm

Evaluation of Survival, Recurrence Patterns and Adjuvant Therapy in Surgically Staged High-Grade Endometrial Cancer with Retroperitoneal Metastases

Jennifer McEachron, Lila Marshall, Nancy Zhou, Van Tran, Margaux J Kanis, Constantine Gorelick, Yi-Chun Lee
2021 Cancers  
We seek to evaluate the difference in recurrence patterns and survival among stage IIIC high-grade endometrial cancer treated with surgery followed by adjuvant chemotherapy alone, radiation therapy alone, or both (chemoradiation). A multicenter retrospective analysis of surgically staged IIIC HGEC receiving adjuvant therapy was conducted. HGEC was defined as grade 3 endometrioid adenocarcinoma, serous, clear cell and carcinosarcoma. Differences in the frequency of recurrence sites and treatment
more » ... delays were identified using Pearson's χ2 test. Progression-free survival (PFS) and overall survival (OS) were calculated using Kaplan-Meier estimates. A total of 155 patients were evaluable: 41.9% carcinosarcoma, 36.8% serous, 17.4% grade 3 and 3.9% clear cell. Of these, 67.1% received chemoradiation, 25.8% received chemotherapy and 7.1% received radiation therapy. There was no difference in the frequency of treatment delays between regimens (p = 0.571). There was a trend towards greater retroperitoneal recurrence with chemotherapy (25.9%) versus chemoradiation (8.4%) and radiation therapy (7.7%) (p = 0.252). Grade 3 tumors had improved progression-free and overall survival (26 and 42 months, respectively) versus serous (17 and 30 months, respectively), carcinosarcoma (14 and 24 months, respectively) and clear cell (24 and 30 months respectively) (p = 0.002, p < 0.001). Overall, chemoradiation was superior to chemotherapy and radiation therapy in PFS (p < 0.001) and OS (p < 0.001). Upon multivariate analysis, only histology and receipt of chemoradiation were independent predictors of survival. The majority of stage IIIC high-grade endometrial carcinomas recurred. Chemoradiation was associated with improved survival and less retroperitoneal recurrence. Grade 3 tumors demonstrated improved survival versus other histologies regardless of adjuvant treatment modality.
doi:10.3390/cancers13092052 pmid:33922792 fatcat:d3n6h5mj5vet3pdhxnw233jf54

Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection

Cynthia L. Gay, Joann D. Kuruc, Shane D. Falcinelli, Joanna A. Warren, Sarah A. Reifeis, Jennifer L. Kirchherr, Katherine S. James, Morgan G. Dewey, Alyson Helms, Brigitte Allard, Erin Stuelke, Alicia Gamble (+11 others)
2020 Scientific Reports  
Approaches to deplete persistent HIV infection are needed. We investigated the combined impact of the latency reversing agent vorinostat (VOR) and AGS-004, an autologous dendritic cell immunotherapeutic, on the HIV reservoir. HIV+, stably treated participants in whom resting CD4+ T cell-associated HIV RNA (rca-RNA) increased after VOR exposure ex vivo and in vivo received 4 doses of AGS-004 every 3 weeks, followed by VOR every 72 hours for 30 days, and then the cycle repeated. Change in
more » ... onsive host gene expression, HIV-specific T cell responses, low-level HIV viremia, rca-RNA, and the frequency of resting CD4+ T-cell infection (RCI) was measured at baseline and after each cycle. No serious treatment-related adverse events were observed among five participants. As predicted, VOR-responsive host genes responded uniformly to VOR dosing. Following cycles of AGS-004 and VOR, rca-RNA decreased significantly in only two participants, with a significant decrease in SCA observed in one of these participants. However, unlike other cohorts dosed with AGS-004, no uniform increase in HIV-specific immune responses following vaccination was observed. Finally, no reproducible decline of RCI, defined as a decrease of >50%, was observed. AGS-004 and VOR were safe and well-tolerated, but no substantial impact on RCI was measured. In contrast to previous clinical data, AGS-004 did not induce HIV-specific immune responses greater than those measured at baseline. More efficacious antiviral immune interventions, perhaps paired with more effective latency reversal, must be developed to clear persistent HIV infection.
doi:10.1038/s41598-020-61878-3 pmid:32198428 fatcat:2j5mhylv5bht7cw5y4xzilmhvm

Prediction of Survival by [18F]Fluorodeoxyglucose Positron Emission Tomography in Patients With Locally Advanced Non–Small-Cell Lung Cancer Undergoing Definitive Chemoradiation Therapy: Results of the ACRIN 6668/RTOG 0235 Trial

Mitchell Machtay, Fenghai Duan, Barry A. Siegel, Bradley S. Snyder, Jeremy J. Gorelick, Janet S. Reddin, Reginald Munden, Douglas W. Johnson, Larry H. Wilf, Albert DeNittis, Nancy Sherwin, Kwan Ho Cho (+7 others)
2013 Journal of Clinical Oncology  
J Clin Oncol, doi:10.1200/jco.2012.47.4189 (2013).  ...  J ClinOncol, doi:10.1200Oncol, doi:10. / jco.2012Oncol, doi:10. .47.3983 (2013.  ... 
doi:10.1200/jco.2012.47.5947 pmid:24043740 pmcid:PMC3795891 fatcat:gtpnykm2jjehfgmvlffdspdtwq

Page 204 of Journal of Poetry Therapy Vol. 1-5, Issue CUMULATIVE CONTENTS [page]

1987 Journal of Poetry Therapy  
White Consultation Corner Kenneth Gorelick  ...  204 List of Contents Brief Report Poems on AIDS Express a Patchwork of Emotions Nancy Pate Columns Poetry Therapy Corner Arthur Lerner Book Review Charles Rossiter Journal File Barbara W.  ... 

Page 2262 of Genetics Vol. 174, Issue 4 [page]

2006 Genetics  
9962 Gorelick, Root Goto, Hiroki Gottesman, Susan Gottschling, Daniel E. Goudet, Jerome Gould, Fred Goulian, Mark Greenman, Chris Greenspan, Ralph J. Greenstein, David I. Gresham, David J.  ...  Hollingsworth, Nancy M. Holm, Magnus Holmes, Edward C. Holmes, Scott G. Holmgren, Robert Holsinger, Kent Hooper, Joan E. Hooykaas, Paul Horvat, Simon Hospital, Frederic Hout, Fabian J. Hou, Steven X.  ... 

Page 1603 of Genetics Vol. 183, Issue 8 [page]

2009 Genetics  
Hollingsworth, Nancy M. Holt, lan J. Jannink, Jean-Luc 1603 Honigberg, Saul Hoskins, Roger A.  ...  Goodnight, Charles J. Gordenin, Dmitry A. Gorelick, Root Gorjanc, Gregor Gottesman, Susan Goudet, Jerome Govind, Shubha Goyal, Sidhartha Grant, David M. Graze, Rita M.  ... 

Page 97 of Rehabilitation Literature Vol. 23, Issue 3 [page]

1962 Rehabilitation Literature  
., 218 Arieff, Alex J., 215 Ashcroft, Samuel C., 174 Bamping, Frank, 170 Barron, J.  ...  M., 235 Los Angeles State Coll. of Applied Arts and Sciences, 189 Mabel, Sanford, 209 McHugh, Nancy, 190 McKenzie. D.  ... 

Page 97 of Rehabilitation Literature Vol. 23, Issue 3 [page]

1962 Rehabilitation Literature  
., 218 Arieff, Alex J., 215 Ashcroft, Samuel C., 174 Bamping, Frank, 170 Barron, J.  ...  M., 235 Los Angeles State Coll. of Applied Arts and Sciences, 189 Mabel, Sanford, 209 McHugh, Nancy, 190 McKenzie. D.  ... 

Page 1567 of EMBO (European Molecular Biology Organization) Journal Vol. 17, Issue 6 [page]

1998 EMBO (European Molecular Biology Organization) Journal  
EMBO J., 16, 4531-4539. Fu,W., Gorelick,R.J. and Rein,A. (1994) Characterization of human immunodeficiency virus type | dimeric RNA from wild-type and protease-defective virions. J.  ...  Acknowledgements We thank Chris Hill, Theresa Gamble and Sanghee Yoo for helpful discussions on the structural basis for capsid assembly; Maureen McMurray, Hui Wang and Nancy Chandler for technical assistance  ... 

Page 33 of Rehabilitation Literature Vol. 31, Issue 1 [page]

1970 Rehabilitation Literature  
., 2 Golden, Nancy E., 19 Goldin, George J., 28 Gordon, H., 26 Gore, George V., III, 16 Gorelick, Molly C., 43 Green, Albert, p. 10 Greenwood, James, Jr., 31 Gruber, Joseph J., 52 Hartig, Charles H., 25  ...  W., 41 Rieman, Dwight W., 7 Robb, J.  ... 

Page 353 of Rehabilitation Literature Vol. 35, Issue 11 [page]

1974 Rehabilitation Literature  
J., 601 Gorelick, Molly C., 650 Gray, Jennifer, 607 Green, Alan J., 655 Green, Michael F., 601 Griffin, Kathleen M., 627 Grinspoon, Lester, 608 Hagen, John W., 620 Hall, Michael, 601 Hammer, Edwin K.,  ...  ., 601 Andrews, Gavin, 654 Asher, Nancy Weinberg, 638 Assn. for Children with Learning Disabili- ties, 619 Baldwin, Victor L., 603 Beathard, Gerald A., 645 Bechtol, Charles O., 636 Beck, Rochelle, 608  ... 

Page 2477 of Psychological Abstracts Vol. 82, Issue 5 [page]

1995 Psychological Abstracts  
M., 18196 Gersten, Russell M., 19363 Golden, Larry, 19408 Gray, Jeffrey A., 17953 Guerra, Nancy G., 15923, 17766, Getty, David J bs 19594 Golding, Jacqueline M., 17844 Gray, Mi 18705 19683 Getty, Thomas  ...  ., 16385, 16412 Gremillion, Helen, 18033 Haapalinna, Antti, 16748 Gillstrom, Asa, 19251 Gonzalez-Mariscal, Gabriela, 16645 Haas, Nancy S., 19369 Gilmore, David J., 16139 Gonzalez-Mora, Jose Luis, 16383  ... 

Page 256 of Rehabilitation Literature Vol. 37, Issue 8 [page]

1976 Rehabilitation Literature  
Tobias, Jack, and Gorelick, Jack. Work Characteristics of Retarded Adults at Trainable Levels. Mental Retarda- tion. Dec., 1963. 1:6:338-344. 16. Wehman, Paul H.  ...  Five stages of adjustment to disability are outlined by Nancy Cohen. These are: shock and denial, expectancy of recovery, mourning, healthy and neurotic defenses (2 substages), and adjustment.  ... 
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