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Unsupervised Image Denoising with Frequency Domain Knowledge [article]

Nahyun Kim, Donggon Jang, Sunhyeok Lee, Bomi Kim, Dae-Shik Kim
2021 arXiv   pre-print
arXiv:2111.14362v1 fatcat:aoq7lx3uhrgpnkuu5okpdr7jei

3D4ALL: Toward an Inclusive Pipeline to Classify 3D Contents [article]

Nahyun Kwon, Chen Liang, Jeeeun Kim
2021 arXiv   pre-print
Algorithmic content moderation manages an explosive number of user-created content shared online everyday. Despite a massive number of 3D designs that are free to be downloaded, shared, and 3D printed by the users, detecting sensitivity with transparency and fairness has been controversial. Although sensitive 3D content might have a greater impact than other media due to its possible reproducibility and replicability without restriction, prevailed unawareness resulted in proliferation of
more » ... ve 3D models online and a lack of discussion on transparent and fair 3D content moderation. As the 3D content exists as a document on the web mainly consisting of text and images, we first study the existing algorithmic efforts based on text and images and the prior endeavors to encompass transparency and fairness in moderation, which can also be useful in a 3D printing domain. At the same time, we identify 3D specific features that should be addressed to advance a 3D specialized algorithmic moderation. As a potential solution, we suggest a human-in-the-loop pipeline using augmented learning, powered by various stakeholders with different backgrounds and perspectives in understanding the content. Our pipeline aims to minimize personal biases by enabling diverse stakeholders to be vocal in reflecting various factors to interpret the content. We add our initial proposal for redesigning metadata of open 3D repositories, to invoke users' responsible actions of being granted consent from the subject upon sharing contents for free in the public spaces.
arXiv:2102.12606v1 fatcat:e2qr2sa7xng2besaz4ignewgl4

Industrial–educational collaboration case study for fur design education

Nahyun Lee, Nayun Kim, Gahyun Kim, Jisoo Ha
2017 Fashion and Textiles  
Fig. 6 ' 6 Future Fur' fashion show II, photographed by Kim (2015) Fig. 7 Introduction and sharing of design development and working process at KiCK, photographed by the author except for 3rd picture in  ... 
doi:10.1186/s40691-017-0096-y fatcat:znzdgtydojfrbjuchypfumpwny

Hair growth promotion by necrostatin-1s

Mei Zheng, Nahyun Choi, YaeJi Jang, Da Eun Kwak, YoungSoo Kim, Won-Serk Kim, Sang Ho Oh, Jong-Hyuk Sung
2020 Scientific Reports  
Mice were maintained and anesthetized according to a protocol approved by the Kim et al. 13 . Pharmacopoeia and the Institutional Animal Care and Use Committee of Yonsei University (IACUC120002).  ... 
doi:10.1038/s41598-020-74796-1 pmid:33077863 fatcat:6trbk33t3je47bszk7xuopa5wq

Modeling Non-Alcoholic Fatty Liver Disease (NAFLD) Using "Good-Fit" Genome-Editing Tools

Uijin Kim, Nahyun Kim, Ha Youn Shin
2020 Cells  
Non-alcoholic fatty liver disease (NAFLD), which affects both adults and children, is the most common liver disorder worldwide. NAFLD is characterized by excess fat accumulation in the liver in the absence of significant alcohol use. NAFLD is strongly associated with obesity, insulin resistance, metabolic syndrome, as well as specific genetic polymorphisms. Severe NAFLD cases can further progress to cirrhosis, hepatocellular carcinoma (HCC), or cardiovascular complications. Here, we describe
more » ... pathophysiological features and critical genetic variants associated with NAFLD. Recent advances in genome-engineering technology have provided a new opportunity to generate in vitro and in vivo models that reflect the genetic abnormalities of NAFLD. We review the currently developed NAFLD models generated using clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) genome editing. We further discuss unique features of CRISPR/Cas9 and Cas9 variants, including base editors and prime editor, that are useful for replicating genetic features specific to NAFLD. We also compare advantages and limitations of currently available methods for delivering genome-editing tools necessary for optimal genome editing. This review should provide helpful guidance for selecting "good fit" genome-editing tools and appropriate gene-delivery methods for the successful development of NAFLD models and clinical therapeutics.
doi:10.3390/cells9122572 pmid:33271878 pmcid:PMC7760008 fatcat:kqcrj7tpjbg5bpjwxxf6uwiqne

Unraveling the Genome-Wide Impact of Recombinant Baculovirus Infection in Mammalian Cells for Gene Delivery

Ha Youn Shin, Hanul Choi, Nahyun Kim, Nayoung Park, Heesun Kim, Jaebum Kim, Young Bong Kim
2020 Genes  
We thank Uijin Kim for technical assistance with confocal microscopy and image analysis. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/genes11111306 pmid:33158084 fatcat:omnf455fg5cblcm5uzbmzisdxy

Establishment and characterization of 18 human colorectal cancer cell lines

Soon-Chan Kim, Hyun-Soo Kim, Jae Hyeon Kim, Nahyun Jeong, Young-Kyoung Shin, Min Jung Kim, Ji Won Park, Seung-Yong Jeong, Ja-Lok Ku
2020 Scientific Reports  
Acknowledgements This research was supported by the Korean Cell Line Research Foundation and Soon-Chan, Kim received a scholarship from the BK21-plus education program provided by the NRF.  ... 
doi:10.1038/s41598-020-63812-z pmid:32321971 fatcat:zivfdybiybhz3gsnqxamzbbvky

Creative Compensation (CC): Future of Jobs with Creative Works in 3D Printing [article]

Chen Liang, Nahyun Kwon, Jeeeun Kim
2021 arXiv   pre-print
With the continuous growth of online 3D printing community and the democratization of 3D printers, growing number of users start sharing their own 3D designs on open platforms, enabling a wide audience to search, download, and 3D print models for free. Although sharing is mostly for altruistic reasons at first, open platforms had also created potential job opportunities to compensate creative labors. This paper analyzes new job opportunities emerged in online 3D printing social platforms and
more » ... terns of seeking compensations, and reveals various motivations for posting creative content online. We find that offering exclusive membership through subscriptions, selling final products or printing services through web stores, and using affiliate links are primary means of earning profits, while there exist gaps between creators' expectations and realities. We show that various socio-economic promises emerged, leading to a win-win situation for both creators to gain extra income and audiences to have access to more quality content. We also discuss future challenges that need to be addressed, such as ethical use of opensource content.
arXiv:2111.04830v1 fatcat:et2gkj5xmbfjfkdhcanvozlzbm

Factors Influencing Rehabilitation among Cancer Survivors

Jooyeon Park, Nahyun Kim
2017 Korean Journal of Adult Nursing  
Purpose: The objective of the study was to identify impact of depression, fatigue, family support, and resilience on rehabilitation among cancer survivors. Methods: One hundred and twenty-four participants who visited an out-patient department were recruited from a university hospital in Korea. An inclusion criterion was no reported relapse following the primary cancer treatment. Data were collected from July 1st to August 31st, 2014. Data analysis included an independent t-test, ANOVA, Pearson
more » ... correlation coefficients and multiple regression using the SPSS 19.0 program. Results: Rehabilitation of those with colon and breast cancer was significantly correlated with depression, fatigue, family support and resilience. In a regression analysis, cancer rehabilitation accounted for 79.2% of the variance of depression, fatigue, monthly household income and resilience. The most significant factor affecting the success of rehabilitation was depression (β=-0.39, p<.001). Conclusion: The results of the study indicate the importance of managing depression for the successful rehabilitation of cancer survivors. Nurses should prioritize the development and implementation of effective interventions for the improvement of rehabilitation among cancer survivors.
doi:10.7475/kjan.2017.29.5.463 fatcat:xa6ji7jhindpncrqmufndu7nr4

Development of S-Methylmethionine Sulfonium Derivatives and Their Skin-Protective Effect against Ultraviolet Exposure

Won-Serk Kim, Wang-Kyun Kim, Nahyun Choi, Wonhee Suh, Jinu Lee, Dae-Duk Kim, Ikyon Kim, Jong-Hyuk Sung
2018 Biomolecules & Therapeutics  
et al., 2015 (Kim et al., , 2016 .  ...  Previously, we have demonstrated that SMMS confers wound-healing and photoprotective effects on skin and can thus be used as a cosmetic raw material (Kim et al., 2010 (Kim et al., , 2015 .  ... 
doi:10.4062/biomolther.2017.109 pmid:29129045 pmcid:PMC5933898 fatcat:fwo6xkfrkfctbcqbweue7gh24m

Deficiency of Capicua disrupts bile acid homeostasis

Eunjeong Kim, Sungjun Park, Nahyun Choi, Jieon Lee, Jeehyun Yoe, Soeun Kim, Hoe-Yune Jung, Kyong-Tai Kim, Hyojin Kang, John D. Fryer, Huda Y. Zoghbi, Daehee Hwang (+1 others)
2015 Scientific Reports  
Capicua (CIC) has been implicated in pathogenesis of spinocerebellar ataxia type 1 and cancer in mammals; however, the in vivo physiological functions of CIC remain largely unknown. Here we show that Cic hypomorphic (Cic-L -/-) mice have impaired bile acid (BA) homeostasis associated with induction of proinflammatory cytokines. We discovered that several drug metabolism and BA transporter genes were down-regulated in Cic-L -/liver, and that BA was increased in the liver and serum whereas bile
more » ... s decreased within the gallbladder of Cic-L -/mice. We also found that levels of proinflammatory cytokine genes were up-regulated in Cic-L -/liver. Consistent with this finding, levels of hepatic transcriptional regulators, such as hepatic nuclear factor 1 alpha (HNF1a), CCAAT/enhancer-binding protein beta (C/EBPb), forkhead box protein A2 (FOXA2), and retinoid X receptor alpha (RXRa), were markedly decreased in Cic-L -/mice. Moreover, induction of tumor necrosis factor alpha (Tnfa) expression and decrease in the levels of FOXA2, C/EBPb, and RXRa were found in Cic-L -/liver before BA was accumulated, suggesting that inflammation might be the cause for the cholestasis in Cic-L -/mice. Our findings indicate that CIC is a critical regulator of BA homeostasis, and that its dysfunction might be associated with chronic liver disease and metabolic disorders.
doi:10.1038/srep08272 pmid:25653040 pmcid:PMC4317698 fatcat:q6nm3b4jfffpnawwanzikx23bi

Cytotoxic 6-Alkylsalicylic Acids from the Endophytic Streptomyces laceyi

Nahyun Kim, Jin Chul Shin, Woncheol Kim, Bang Yeon Hwang, Beom Seok Kim, Young-Soo Hong, Dongho Lee
2006 Journal of antibiotics (Tokyo. 1968)  
Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC 50 values of 3.0 and 5.5 m g/ml, respectively. Fig. 1 Structures of salaceyins A (1) and B (2).
doi:10.1038/ja.2006.105 pmid:17323647 fatcat:ep4yliit7fbuhaxye6dxq2px6m

The Safe Baculovirus-Based PrM/E DNA Vaccine Protected Fetuses Against Zika Virus in A129 Mice

Hanul Choi, Jungmin Chun, Mina Park, Suyeon Kim, Nahyun Kim, Hee-Jung Lee, Minjee Kim, Ha Youn Shin, Yu-Kyoung Oh, Young Bong Kim
2021 Vaccines  
The Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family of enveloped RNA viruses. The correlation between viral infection and fetal microcephaly was revealed in 2015, yet we still lack a vaccine against ZIKV. Here, we present a genetic vaccine that delivers the premembrane (prM) and envelope (E) genes of ZIKV using a recombinant baculovirus vector that expresses a human endogenous retrovirus (HERV) envelope on its surface to enhance gene delivery. We observed that
more » ... es with HERV envelopes (AcHERV) exhibited specifically higher gene transfer efficiency in human cells compared to the wild-type baculovirus vector. Using the AcHERV baculovirus vector, we constructed a recombinant baculovirus vaccine encoding ZIKV prM/E genes (AcHERV-ZIKV), which are major targets of neutralizing antibodies. Mice immunized twice with AcHERV-ZIKV exhibited high levels of IgG, neutralizing antibodies, and IFN-γ. In challenge tests in IFN knock-out mice (A129), AcHERV-ZIKV showed complete protection in both challenge and pregnancy tests. These results suggest that AcHERV-ZIKV could be a potential vaccine candidate for human application.
doi:10.3390/vaccines9050438 pmid:33946611 fatcat:2cszmdvtdncjdb75q7woahfsby

Supramolecular agents for combination of photodynamic therapy and other treatments

Nahyun Kwon, Heejeong Kim, Xingshu Li, Juyoung Yoon
2021 Chemical Science  
Kim contributed to the editing of gures and manuscripts. J. Yoon and X. Li conceived and designed this review. All authors have read and approved the nal manuscript.  ... 
doi:10.1039/d1sc01125a pmid:34163818 pmcid:PMC8171357 fatcat:mzgounj5ejf5bn2jrycpaijkki

The Lived Experience of Anger in Elderly Women with Aggressive Tendency

Jung Hwa Han, Eun Ja Kim, Jin Sook Hyun, Nahyun Kim
2016 Journal of Korean Gerontological Nursing  
Purpose: The purpose of this study was to describe the essential structure of the lived experience of aggressive elderly women's anger. Methods: Seven elderly women with aggressive tendency were interviewed. Colaizzi analysis of phenomenological research was applied. Results: The meaning of experiences were identified as four categories from eight theme clusters and fourteen themes. The four categories were 'Lamenting over life that has been disrespected', 'Uncontrollable and deep resentment',
more » ... Rationalization for anger', 'Embers of the fire that have never been extinguished'. Conclusion: The findings of this study reveal a close similarity between the anger of older women and the anger of different age groups. However, this study is significant because the data came from an in-depth examination of aggressive older women's anger vented in the Korean social-cultural context, offering ample understanding of this anger. The results of this study can be used to develop diverse physical, psychological and social programs to help older women control and relieve their anger and have a healthier lifestyle. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. 서 론 1. 연구의 필요성 최근 평균 수명의 연장으로 65세 이상 노인이 전체 인구의 13.1%에 육박하고 있으며[1], 이중 여성노인이 58.2%를 차지 하고 있어, 여성노인의 건강문제에 대한 이슈가 점차 큰 비중 을 차지하고 있다. 특히, 우리나라 여성노인은 남성노인에 비 해 경제적 빈곤과 정서적 소외를 더 많이 겪고 있는 것으로 나 타나[2], 여성노인의 건강은 신체적 측면뿐만 아니라 정서적, 심리적 및 사회적 측면까지 고려한 포괄적 접근이 요구되고 있는 실정이다. 여성은 폐경기를 전후로 급격한 호르몬 변화를 경험하면서 다양한 심리적 격변기를 경험하게 된다. 이러한 심리적 특성 의 변화는 중년기에 나타나 노인기로 이어지는데, 특히 과거 유교적 가치관이 지배적인 사회를 살아온 우리나라 여성노인 ⓒ 2016 Korean Gerontological Nursing Society
doi:10.17079/jkgn.2016.18.2.95 fatcat:llcnymtyubab3hissjcmaxgnty
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