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NEZHA: Efficient Domain-Independent Differential Testing

Theofilos Petsios, Adrian Tang, Salvatore Stolfo, Angelos D. Keromytis, Suman Jana
2017 2017 IEEE Symposium on Security and Privacy (SP)  
Based on δ-diversity, we design two efficient domain-independent input generation mechanisms for differential testing, one gray-box and one blackbox.  ...  In this paper, we address these issues by designing and implementing NEZHA, an efficient input-formatagnostic differential testing framework.  ...  One may argue that being domain-independent, NEZHA may not be as efficient as successful domain-specific frameworks.  ... 
doi:10.1109/sp.2017.27 dblp:conf/sp/PetsiosTSKJ17 fatcat:j3poc4sdnbftne7svn4pl2clhq

Coverage-guided differential testing of TLS implementations based on syntax mutation

Yan Pan, Wei Lin, Yubo He, Yuefei Zhu, Licheng Wang
2022 PLoS ONE  
Researchers are attempting to find the differences in protocol implementations based on differential testing, which is conducive to discovering the vulnerabilities.  ...  The proposed method is developed based on open-source tools, i.e., NEZHA and TLS-diff.  ...  For the TLS handshake process, the mutation efficiency is reduced due to the independence of the domain of NEZHA and the strong structure of the data packet.  ... 
doi:10.1371/journal.pone.0262176 pmid:35073360 pmcid:PMC8786154 fatcat:2ol6csi32ndqhns4tuenihbuba

CLASP2 interacts with p120-catenin and governs microtubule dynamics at adherens junctions

Marta N. Shahbazi, Diego Megias, Carolina Epifano, Anna Akhmanova, Gregg G. Gundersen, Elaine Fuchs, Mirna Perez-Moreno
2013 Journal of Cell Biology  
Interestingly, both CLASP2 and Nezha interact with p120 through the N-terminal domain, but we found Nezha localized in the suprabasal differentiated layers of the epidermis, in which MTs are substantially  ...  Nezha localizes in the suprabasal differentiated layers of the epidermis, probably interacting with p120. DP, desmoplakin. (n = 16 cells, 5 profiles per cell, 3 independent experiments).  ... 
doi:10.1083/jcb.201306019 pmid:24368809 pmcid:PMC3871427 fatcat:4slh65j66ndhtbq5dxsgzgxqmq

Microtubule Minus-End-Targeting Proteins

Anna Akhmanova, Casper C. Hoogenraad
2015 Current Biology  
The recent characterization of the CAMSAP/Patronin/Nezha family members as specific 'minus-end-targeting proteins' ('-TIPs') has provided important new insights into the mechanisms governing minus-end  ...  current state of knowledge on how microtubule minus ends are controlled and how minus-end regulators contribute to non-centrosomal microtubule organization and function during cell division, migration and differentiation  ...  CAMSAP/Patronin/Nezha Family Proteins are Specific Microtubule Minus-end Regulators The CAMSAP/Patronin/Nezha family is characterized by the presence of the signature domain CKK (which stands for C-terminal  ... 
doi:10.1016/j.cub.2014.12.027 pmid:25689915 fatcat:lcx747fkurfcffkmyw2u5xvccm

Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin

M. C. Hendershott, R. D. Vale
2014 Proceedings of the National Academy of Sciences of the United States of America  
However, we find that, in both cases, a highly conserved C-terminal domain and a more variable central domain cooperate to suppress minus-end dynamics in vitro and that both regions are required to stabilize  ...  By using truncation analysis, we find that somewhat different minimal domains of CAMSAP and Patronin are involved in minus-end localization.  ...  Results compiled from two independent experiments (>100 MTs scored per assay). Fig. 2 .Fig. 3 . 23 CAMSAPs differentially affect tubulin subunit addition at MT minusends.  ... 
doi:10.1073/pnas.1404133111 pmid:24706919 pmcid:PMC4000804 fatcat:zcydwd5zpzez7i3larws3yziii

SAM 2020 Conference Program

2020 2020 IEEE 11th Sensor Array and Multichannel Signal Processing Workshop (SAM)  
Researcher, USA) MIMO Radar Waveform Joint Optimization Design in Time and Frequency Domain Chu Chun-hua (Institute of Information and Navigation, Air Force Enginnering University, China); Yijun Chen  ...  II, Italy); Luca Venturino (Universita' degli Studi di Cassino e del Lazio Merdionale & Consorzio Nazionale Interuniversitario per le Telecomunicazioni (CNIT), Italy)Persymmetric Subspace Rao and Wald Tests  ... 
doi:10.1109/sam48682.2020.9104325 fatcat:axqtfgjaunaw7dix4b2fzqvkh4

SAM 2020 Author Index

2020 2020 IEEE 11th Sensor Array and Multichannel Signal Processing Workshop (SAM)  
Differential Microphone Arrays Comon, Pierre SS12.3 On the convergence of Jacobi-type algorithms for Independent Component Analysis Cong, Jingyu SS01.5 Feasible Spare Spectrum Fitting for DOA  ...  , Yanan SS11.3 Enhanced DOA Estimation for MIMO radar in the Case of Limited Snapshots Ma, Yirong R06.4 Hyperspectral Image Clustering based on Variational Expectation Maximization Mamouni, Nezha  ... 
doi:10.1109/sam48682.2020.9104397 fatcat:cfp5gsikrzabhhcnkalahjkxze

PLEKHA7 Recruits PDZD11 to Adherens Junctions to Stabilize Nectins

Diego Guerrera, Jimit Shah, Ekaterina Vasileva, Sophie Sluysmans, Isabelle Méan, Lionel Jond, Ina Poser, Matthias Mann, Anthony A. Hyman, Sandra Citi
2016 Journal of Biological Chemistry  
PDZD11 is required for the efficient assembly of apical junctions of epithelial cells at early time points in the calcium-switch model.  ...  PDZD11 forms a complex with nectin-1 and nectin-3, and its PDZ domain interacts directly with the PDZ-binding motif of nectin-1.  ...  Afadin/␣-catenin and nezha provide the linkage of the complexes to actin filaments and microtubules, respectively.  ... 
doi:10.1074/jbc.m115.712935 pmid:27044745 pmcid:PMC4900252 fatcat:bb3mqc7p4zeojhwvyjf4ds4ma4

Microtubule Minus-End Stabilization by Polymerization-Driven CAMSAP Deposition

Kai Jiang, Shasha Hua, Renu Mohan, Ilya Grigoriev, Kah Wai Yau, Qingyang Liu, Eugene A. Katrukha, A.F. Maarten Altelaar, Albert J.R. Heck, Casper C. Hoogenraad, Anna Akhmanova
2014 Developmental Cell  
Here, we focus on the mechanisms underlying the regulation of microtubule minus-ends by the CAMSAP/Nezha/Patronin protein family.  ...  The plot is based on three independent experiments. Error bars represent SD. **p < 0.01, t test.  ...  t test.  ... 
doi:10.1016/j.devcel.2014.01.001 pmid:24486153 fatcat:qq2wsexcezardc4zi4rrv34efe

Role of the microtubule-targeting drug vinflunine on cell-cell adhesions in bladder epithelial tumour cells

Luis A Aparicio, Raquel Castosa, Mar Haz-Conde, Marta Rodríguez, Moisés Blanco, Manuel Valladares, Angélica Figueroa
2014 BMC Cancer  
Results: We show that VFL induces cell death in bladder cancer cells and activates epithelial differentiation of the remaining living cells, leading to an increase of E-cadherin-dependent cell-cell adhesion  ...  It contains an extracellular domain that forms homophilic interactions in a calcium-dependent manner and is responsible for cell-to-cell adhesions, and a cytoplasmic domain linked to the actin cytoskeleton  ...  In cultured mammalian epithelial cells, depletion of either Nezha or PLEKHA7, which is responsible for recruiting Nezha to p120-ctn, disrupted the ability of cells to concentrate E-cadherin to the apical  ... 
doi:10.1186/1471-2407-14-507 pmid:25012153 pmcid:PMC4107965 fatcat:zwwlwqzkejaghpqilbcrscxtzu

Developmental Trajectories of Associative Memory from Childhood to Adulthood: A Behavioral and Neuroimaging Study

Bérengère Guillery-Girard, Sylvie Martins, Sebastien Deshayes, Lucie Hertz-Pannier, Catherine Chiron, Isabelle Jambaqué, Brigitte Landeau, Patrice Clochon, Gaël Chételat, Francis Eustache
2013 Frontiers in Behavioral Neuroscience  
Behavioral data outlined differential developmental trajectories according to the type of association, with a continuous increase of factual associative memory efficiency until 10 years, a linear increase  ...  We conducted a behavioral study aimed at testing the effects of age in a large sample of 160 children, adolescents, and young adults (6-23 years old).  ...  ACKNOWLEDGMENTS We would like to thank Valerie Gyselinck and Maud Markus for their contribution to the WHAT-WHERE-WHEN paradigm development, and Nezha Bissara, and Lionel Allirol for their assistance with  ... 
doi:10.3389/fnbeh.2013.00126 pmid:24098276 pmcid:PMC3784827 fatcat:d63dtjpfsjacbp4ptabd5d4bra

Microtubule Minus-End Binding Protein CAMSAP2 Controls Axon Specification and Dendrite Development

Kah Wai Yau, Sam F.B. van Beuningen, Inês Cunha-Ferreira, Bas M.C. Cloin, Eljo Y. van Battum, Lena Will, Philipp Schätzle, Roderick P. Tas, Jaap van Krugten, Eugene A. Katrukha, Kai Jiang, Phebe S. Wulf (+6 others)
2014 Neuron  
Using live-cell imaging, high-resolution microscopy, and laser-based microsurgery techniques, we show that the CAMSAP/Nezha/Patronin family protein CAMSAP2 specifically localizes to noncentrosomal microtubule  ...  The efficiency of CAMSAP2 protein depletion was tested by introducing two independent CAMSAP2 shRNAs into neuronal cultures by lentiviral transduction.  ...  These findings show that the minimal CAMSAP2 minus-end binding domain is not sufficient to restore dendrite morphology, suggesting that additional domains of CAMSAP2 are critical for CAMSAP2 function.  ... 
doi:10.1016/j.neuron.2014.04.019 pmid:24908486 fatcat:sgwzpfsufrb37gnvff7nqkdwde

Functions of p120ctn in development and disease

Tim Pieters
2012 Frontiers in Bioscience  
Differential regulation of RhoGTPases by p120ctn in cancer 9.4. p120ctn isoforms: effects on proliferation and tumor growth 9.5. p120ctn isoforms: effects on motility and invasion 9.6. p120ctn and anchorage-independent  ...  p120ctn and anchorage-independent growth Anchorage-independent growth (AIG) is a hallmark of tumor formation and is dependent on endogenous p120ctn.  ...  The p120ctn-depleted cells have been employed for testing the potential of different p120ctn isoforms to induce invasion.  ... 
doi:10.2741/3956 pmid:22201773 fatcat:3w6olwcdu5dpfeec44hmzrpjli

Control of apico–basal epithelial polarity by the microtubule minus-end-binding protein CAMSAP3 and spectraplakin ACF7

Ivar Noordstra, Qingyang Liu, Wilco Nijenhuis, Shasha Hua, Kai Jiang, Matthijs Baars, Sanne Remmelzwaal, Maud Martin, Lukas C. Kapitein, Anna Akhmanova
2016 Journal of Cell Science  
For knockdown efficiency tests, fluorescence intensity was measured per cell and corrected for the cell surface area using ImageJ 1.50b.  ...  ., 2007) and by proteins that bind to microtubule minus ends independently of γ-tubulin.  ... 
doi:10.1242/jcs.194878 pmid:27802168 fatcat:ezpo73jadfeitdqm7mrclykqxm

Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling

Tim Pieters
2012 Frontiers in Bioscience  
When TLR4 binds LPS, it activates the MyD88-dependent and MyD88-independent pathways.  ...  These p120ctn-depleted cell lines are also suitable for testing the effect of various p120ctn isoforms on RhoA activity.  ... 
doi:10.2741/4012 pmid:22201829 fatcat:2v7ayvaawveu5mrrrmq24rtxue
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