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Comparison of multi echo T2 relaxation and steady state approaches for myelin imaging in the central nervous system

Adam V. Dvorak, Emil Ljungberg, Irene M. Vavasour, Lisa Eunyoung Lee, Shawna Abel, David K. B. Li, Anthony Traboulsee, Alex L. MacKay, Shannon H. Kolind
2021 Scientific Reports  
AbstractThe traditional approach for measuring myelin-associated water with quantitative magnetic resonance imaging (MRI) uses multi-echo T2 relaxation data to calculate the myelin water fraction (MWF)  ...  We produced and compared multivariate atlases of MWF and fM in healthy human brain and cervical spinal cord (available online) and compared their ability to detect multiple sclerosis pathology.  ...  Acknowledgements We thank the volunteers for their time, and the UBC MRI Research Centre and its MRI technologists for supporting this study, as well as Dr. Sean Deoni  ... 
doi:10.1038/s41598-020-80585-7 pmid:33446710 fatcat:bbjdu5kefbcf5olobxdtf5ak3a

Neuroimaging in Multiple Sclerosis [chapter]

Elisabeth Andreadou
2012 Neuroimaging - Clinical Applications  
Between 50% and 90% of MS patients show hyperintense T2 lesions in the spinal cord, more frequently located in the cervical and the thoracic area (Lycklama et al., 2003; .  ...  Moreover, incidental spinal cord hyperintense foci do not occur with ageing (Lycklama et al., 2003) .  ...  knowledge in the fields of clinical and cognitive neuroscience.  ... 
doi:10.5772/24069 fatcat:dk3zwfkz6jhctdrgmrhj2hwhaq

ACTRIMS-ECTRIMS MSBoston 2014: Poster Sessions 2

2014 Multiple Sclerosis  
P492 Corpus callosal myelin water fraction and transcallosal inhibition in multiple sclerosis IM Background: Magnetic resonance imaging (MRI) techniques assessing T 2 relaxation can measure myelin water  ...  females) and 25 healthy controls (age: 35.1±2.2 years; 14 females) on a 3.0T scanner.  ...  We observed axonal loss of at least 49% throughout the spinal cord, however only at the cervical level was with loss -moderately -associated with demyelination.  ... 
doi:10.1177/1352458514547846 pmid:25205049 pmcid:PMC4244175 fatcat:gj757y4jlvejpnrfw22guoit7m

Myelin water imaging : development at 3.0T, application to the study of multiple sclerosis, and comparison to diffusion tensor imaging

Shannon Heather Kolind
T2 relaxation imaging can be used to measure signal from water trapped between myelin bilayers; the ratio of myelin water signal to total water is termed the myelin water fraction (MWF).  ...  Next, the single-slice T2 relaxation measurement was implemented, refined, and validated at 3.0 T.  ...  Myelin water fraction in human cervical spinal cord in vivo. J Comput Assist Tomogr. 30, 304-6. Xue R., van Zijl P.C.M., Crain B.J., Solaiyappan M., Mori S., 1999.  ... 
doi:10.14288/1.0066854 fatcat:xfej5arrkbbztbmiul6xwrype4


2006 Neuroradiology  
PURPOSE Medical complications after SAH include fever, anemia requiring transfusion, hyperglycemia, electrolyte abnormalities, pneumonia, hypertension, and neurogenic stunned myocardium and pulmonary  ...  Patient's gender or age was not correlated to the size of the cervical spinal cord in our study.  ...  CONCLUSION Cervical spinal cord dimensions measured by post-myelogram CT scan demonstrated that spinal cord is significantly smaller than previously considered.  ... 
doi:10.1007/s00234-006-0139-3 fatcat:hv57hmgk6jchtk65tdirm35j4y

Scientific poster session

2008 Neuroradiology  
DISCUSSION The differences in relaxation times and MT estimates between WM and GM might primarily be attributed to the differences in the microstructure like fiber density, amount of myelin water and composition  ...  To find the most suitable coil and the best slice directions for spinal cord DTI. To find unfit subjects for cervical spinal cord DTI and to discuss the clinical applications and usefulness.  ...  A MRI scan at age 55 of the lumbar spine revealed a normal alignment of the vertebral bodies and normal epidural scar formation after disc surgery.  ... 
doi:10.1007/s00234-008-0439-x fatcat:mjmp3aeejvadldcf6iuzjk77we

Myelin water measurement by magnetic resonance imaging in the healthy human spinal cord : reproducibility and changes with age

Erin Leigh MacMillan
Multi-echo T2 relaxation measurements of the human spinal cord (SC) reveal a short T2 pool of water believed to arise from water trapped between myelin bilayers, where the proportion of this water to the  ...  This study paves the way for the use of 3D myelin water imaging in the cervical spine at 3.0T for the assessment of SC WM pathology.  ...  Myelin water measurement in the healthy human spinal cord: Reproducibility and changes with age. Magn Reson Med.  ... 
doi:10.14288/1.0066616 fatcat:c4txlynstzhpfiyr3cu66yg624

Assessing structure and function of myelin in cervical spondylotic myelopathy: Evidence of demyelination

Hanwen Liu, Erin L MacMillian, Catherine R Jutzeler, Emil Ljungberg, Alex L MacKay, Shannon H Kolind, Burkhard Mädler, David K B Li, Marcel F Dvorak, Armin Curt, Cornelia Laule, John L K Kramer
Conclusion: Our findings provide evidence of decreased myelin content in the spinal cord associated with impaired spinal cord conduction in patients with CSM.  ...  Methods: Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole body magnetic resonance scanner.  ...  Dvorak: study concept and design, critical revision of manuscript for intellectual content. Armin ACKNOWLEDGMENT The authors thank the study participants and MRI technologists at their center.  ... 
doi:10.5167/uzh-139577 fatcat:gxtlym4n3ncflcfzvnzryx6j4q

ESNR 2016

2016 Neuroradiology  
and 30 healthy controls on a 1.5T scanner.  ...  We used analysis of variance to assess differences in SRT among groups and analysis of covariance (ANCOVA) including variables associated with cognitive scores (p<0.01) to analyze relations between DTI-metrics  ...  matter (WM) and gray matter (GM) of the cervical spinal cord of healthy subjects by integration with a high contrast GM/WM sequence (PSIR).  ... 
doi:10.1007/s00234-016-1734-6 pmid:27578442 fatcat:ia2lasp4prfqxf7u2sh7hsyvem

Scientific paper sessions

2008 Neuroradiology  
T2 imaging is important to determine edematous changes beyond the edges of the resection, specially for low grade tumors.  ...  RESULTS MRI is performed within 3 days after surgery in order to properly differentiate tumoral residue from post-operative changes specially for high grade neoplasms where contrast enhancement is the  ...  We measured T2 relaxation times in the infarct core to quantify the correlation between time from symptom onset and change in T2 values.  ... 
doi:10.1007/s00234-008-0440-4 fatcat:gtydgtcuzjcu5csnxlmcjep35a

Exploring myelin water imaging : from application to atlases to algorithms

Hanwen Liu
Myelin water imaging (MWI) is a quantitative magnetic resonance (MR) method that specifically measures the myelin content in the central nervous system.  ...  Secondly, the MWI atlases, which represent the MWI normative references of the normal myelin distribution in the brain and spinal cord, were created by coregistering and averaging the MWI images acquired  ...  Specifically, Chapter 2 illustrates the correlation of the deficits in function and the damages in myelin, which is measured by applying MWI in the cervical spinal cords from both healthy and pathological  ... 
doi:10.14288/1.0395104 fatcat:cqxaneiw5zaklfv4vlc7bylb44

Sympathetic neural control of integrated cardiovascular function: Insights from measurement of human sympathetic nerve activity

B. Gunnar Wallin, Nisha Charkoudian
2007 Muscle and Nerve  
, exercise, and mental stress in populations ranging from healthy controls to patients with hypertension and heart failure.  ...  Measurements of sympathetic nerve activity to skeletal muscle have provided extensive information regarding reflex control of blood pressure and blood flow in conditions ranging from rest to postural changes  ...  We thank the Mary Lou Fulton Endowment for their generous funding of this research project, Mitch Radigan for help with data collection, and Dr.  ... 
doi:10.1002/mus.20831 pmid:17623856 fatcat:ehjpmh4ztvbjfglbal2eo5qiua

Diffusion Tensor Imaging (DTI) of the Pediatric Spinal Cord [article]

(:Unkn) Unknown, University, My, Feroze B. Mohamed
The purpose of this study is to (a) evaluate the accuracy of cervical spinal cord DTI in children using a newly developed inner-Field-of-View (iFoV) sequence with spatially selective 2D RF excitations,  ...  While studies on diffusion imaging of the spinal cord in adults, as well as in animal models have been reported, a comprehensive study of the pediatric spinal cord examining the accuracy and reproducibility  ...  The differences in DTI values between control subjects, patients with complete SCI and those with incomplete SCI, along with the predictive accuracy of DTI for sacral sparing endpoints, motor level of  ... 
doi:10.34944/dspace/721 fatcat:ixs5sdsqdndoxaynuxwos7bkya


(:Unkn) Unknown, University, My, Nancy Pleshko, Feroze B. Mohamed
Data for both healthy subjects and subjects with spinal cord injury is collected and significant correlations are shown between DTI and cord morphology metrics.  ...  Diffusion tensor imaging (DTI) gives a non-invasive quantification of water diffusion in the spinal cord and can provide insight into white matter integrity, while high resolution volumetric imaging can  ...  10 pediatric subjects (age range 13.2 years) with chronic cervical spinal cord injury (at minimum 6 months post injury).  ... 
doi:10.34944/dspace/3262 fatcat:xfwxifcxhrf3nfsbyxvsfxya34

Multi Spectral Data Analysis for Diagnostic Enhancement of Pediatric Spinal Cord Injury [article]

(:Unkn) Unknown, University, My, Nancy Pleshko, Feroze B. Mohamed
MRI data from total of 43 subjects that includes 23 healthy TD subjects with the age range of 6-16 (11.94±3.26 (mean ±standard deviation)) who had no evidence of SCI or pathology and 20 SCI subjects with  ...  Initially, 168 quantitative measures of multi-spectral images (functional and structural) were calculated by using regions of interest (ROIs) manually drawn on the whole cord along the entire spinal cord  ...  subjects with the age range of 6-17 (11.94±3.26 (mean ±standard deviation)) with no evidence of spinal cord injury or pathology and 20 subjects with SCI (10 subjects with cervical, 8 subjects with thoracic  ... 
doi:10.34944/dspace/647 fatcat:75jqilhcbbcvhl6pqloxwwb6ou
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