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Vaginal Atresia with Transverse Septum in a Cat

Koichi NOMURA, Tetuyo KOREEDA, Mutsumi KAWATA, Yoshiko SHIRAISHI
1997 Journal of Veterinary Medical Science  
A six and half-year-old nulliparous mixed breed cat which had the complaints of vomiting, abdominal distention and depression was presented to the Veterinary Teaching Hospital of Osaka Prefecture University. She was suspected of pyometra by clinical signs and tests. By laparotomy, it was clarified that both uterine horns and vagina showed distension by the accumulation of secretions, and the vagina ended blindly leaving a tough connective tissue at the border between cranial and caudal part of
more » ... he vagina. Postoperative contrastradiograph of the remaining vagina proved it had no persistence of the hymen. From these findings, the condition was diagnosed as a feline atresia vaginalis with the transverse vaginal septum which is caused by the embryonic failure of canalization of the paramesonephric duct between the end of the Müllerian duct and the urogenital sinus. -KEY WORDS: feline, transverse vaginal septum, vaginal atresia.
doi:10.1292/jvms.59.1045 pmid:9409523 fatcat:c2pgpw7cvnahbpuydox75nitaa

Human Trial of Liposomal Lactoferrin Supplementation for Periodontal Disease

Atsushi Ishikado, Syoko Uesaki, Hirohisa Suido, Yoshio Nomura, Kazuhide Sumikawa, Mariko Maeda, Mutsumi Miyauchi, Takashi Takata, Taketoshi Makino
2010 Biological and Pharmaceutical Bulletin  
doi:10.1248/bpb.33.1758 pmid:20930389 fatcat:uiak33vf2zgbna27pqirh7ev6i

EVALUATION OF THORACOPLASTY CONCOMITANT WITH RESECTION FOR PULMONARY TUBERCULOSIS
切除同時成形の価値評価について

Osamu MIYASHITA, Takashi OKAMOTO, Masao MORIMOTO, Makoto OHASHI, Kiyoko OGATA, Yukio KURU, Mutsumi MURAMATSU, Michiko SHIMIZU, Hajime HOSOYA, Michio NOMURA
1967 Kekkaku (Tuberculosis)  
Thoracoplasty concomitant with resection' was conducted for the first time by Graham in 1933 on a case of lung cancer, and thereafter reports were presented by Iverson, Conklin, BjOrk, and in Japan by Miyasaka in 1959. In our sanatorium, thoracoplasty is conducted generally at one stage, and patients have come to dislike any additional operation. In the meantime, there is certain difficulty in getting adequate blood for transfusion at the time of
doi:10.11400/kekkaku1923.42.12_495 fatcat:hxmqxybg2jfvnomksgh53qtly4

Comparison of Stream Temperatures during Stormflow from Snowmelt and Rainfall and Hydrograph Separation

Daiji KOBAYASHI, Yoshiyuki ISHII, Mutsumi NOMURA
1994 JOURNAL OF JAPAN SOCIETY OF HYDROLOGY AND WATER RESOURCES  
The temperatures of streams under thick snow cover in the volcanic basin of Neogene period in northern Hokkaido Island,
doi:10.3178/jjshwr.7.6_512 fatcat:4lwiiuyssvemtg3qqa6eodxhse

Comparison of growth characteristics and tolerance to serpentine soil of three ectomycorrhizal spruce seedlings in northern Japan

Masazumi Kayama, Dongsu Choi, Hiroyuki Tobita, Hajime Utsugi, Mitsutoshi Kitao, Yutaka Maruyama, Mutsumi Nomura, Takayoshi Koike
2006 Trees  
Trans Fac 11 Hort Chiba Univ 6:1-105 (in Japanese and English summary) 12 Takagi K, Sasa K, Satoh F, Nomura M, Komiya K, Takahashi H, Hohjo H, Kaneko K, 13 Ichikawa K, Nakajima J, Ashiya D, Ishida N, Okuda  ... 
doi:10.1007/s00468-006-0057-3 fatcat:4wedgwsyi5dbdbkenyoang6nqy

A tandem reaction of organozinc reagent prepared from palladium-catalyzed umpolung method: diastereoselective formation of cyclohexene derivatives bearing three adjacent stereocenters

Mutsumi Sada, Kenichi Nomura, Seijiro Matsubara
2011 Organic and biomolecular chemistry  
doi:10.1039/c0ob00806k pmid:21206955 fatcat:7llnzzxvlfe2pmx4tuyjioivs4

Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status:In silicoand Biological Evaluations

Shingo Dan, Mutsumi Okamura, Mariko Seki, Kanami Yamazaki, Hironobu Sugita, Michiyo Okui, Yumiko Mukai, Hiroyuki Nishimura, Reimi Asaka, Kimie Nomura, Yuichi Ishikawa, Takao Yamori
2010 Cancer Research  
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers, and several agents targeting this pathway including PI3K/Akt/mammalian target of rapamycin inhibitors have recently entered clinical trials. One question is whether the efficacy of a PI3K pathway inhibitor can be predicted based on the activation status of pathway members. In this study, we examined the mutation, expression, and phosphorylation status of PI3K and Ras pathway members in a panel of 39
more » ... cologically well-characterized human cancer cell lines (JFCR39). Additionally, we evaluated the in vitro efficacy of 25 PI3K pathway inhibitors in addition to conventional anticancer drugs, combining these data to construct an integrated database of pathway activation status and drug efficacies (JFCR39-DB). In silico analysis of JFCR39-DB enabled us to evaluate correlations between the status of pathway members and the efficacy of PI3K inhibitors. For example, phospho-Akt and KRAS/BRAF mutations prominently correlated with the efficacy and the inefficacy of PI3K inhibitors, respectively, whereas PIK3CA mutation and PTEN loss did not. These correlations were confirmed in human tumor xenografts in vivo, consistent with their ability to serve as predictive biomarkers. Our findings show that JFCR39-DB is a useful tool to identify predictive biomarkers and to study the molecular pharmacology of the PI3K pathway in cancer. Cancer Res; 70(12); 4982-94.
doi:10.1158/0008-5472.can-09-4172 pmid:20530683 fatcat:wbssnamqq5hhhnz5hvymmk2w5m

Bluff Body (Fundamental Problem & Vehicle)

Takashi NOMURA, Yoji SUZUKI, Mutsumi UEMURA, Nobuyuki KOBAYASHI, Li Mingshui, Wang Weihua, Ni Zhangsong, Chen Xin, H. Kawai, K. Fujinami, Hiroaki NISHIMURA, Yoshihito TANIIKE (+8 others)
2001 Wind Engineers JAWE  
doi:10.5359/jawe.2001.89_481 fatcat:gctuuyd335bnjlmnqrgx3ywxuu

Efficacy of Tensed and Straight Free Jejunum Transfer for the Reduction of Postoperative Dysphagia

Satsuki Tachibana, Shimpei Miyamoto, Takahiro Goto, Katsuhiro Ishida, Takuya Iida, Mutsumi Okazaki, Sei Yoshida, Shogo Nomura, Ryuichi Hayashi, Minoru Sakuraba
2017 Plastic and Reconstructive Surgery, Global Open  
BACKGROUND Free jejunal transfer (FJT) is the favored method of reconstruction after total pharyngo-laryngo-cervical esophagectomy (TPLE) 1-3 because of its rich vascularization, self-lubricating character. Although Yu et al. 4 reported the superiority of the anterolateral thigh flap compared with the jejunal flap, we still believe that FJT is safer than classical skin flap roll reconstruction. 5 However, FJT after TPLE Background: Free jejunal transfer (FJT) is a standard method of
more » ... on after total pharyngo-laryngo-cervical esophagectomy (TPLE) in patients with advanced head and neck cancer. However, it is related to various degrees of postoperative swallowing dysfunction. This study aimed to assess whether the tensed and straight FJT method results in a reduced rate of postoperative dysphagia compared with historical controls. Methods: Patients who were undergoing FJT after TPLE for squamous cell carcinoma of the hypopharynx or cervical esophagus were enrolled. The primary endpoint was the rate of not developing dysphagia within 6 months of the surgery, and we compared this value with that obtained from historical data of patients who underwent FJT. The secondary endpoint was the rate of developing surgical complications. Results: Although 128 patients were registered between August 2012 and July 2015, 7 were excluded based on the exclusion criteria. Of the remaining 121 patients, FJT with the craniocaudally tensed and straight method was performed in all patients. The rate of not developing dysphagia and its 95% confidence interval (CI) were 66.1% and 57.0-74.5%, respectively. The lower limit of the CI was higher than the prespecified threshold value of 50.0%. The rate of developing complications of total necrosis of the jejunum was 3.3%, cervical infection was 9.9%, and major anastomotic leakage was 4.1%. Conclusions: Our findings revealed that the proportion of postoperative dysphagia decreased in patients who underwent tensed and straight FJT. This method may become the standard surgical method in reconstruction of defects after TPLE.
doi:10.1097/gox.0000000000001599 pmid:29632778 pmcid:PMC5889443 fatcat:5t6kt4qwyraclkynsajdib6ana

Comparison of the relationships of alcoholic and nonalcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia

Nobuyuki Toshikuni, Atsushi Fukumura, Nobuhiko Hayashi, Tomoe Nomura, Mutsumi Tsuchishima, Tomiyasu Arisawa, Mikihiro Tsutsumi
2013 Journal of clinical biochemistry and nutrition  
We compared the relationships of alcoholic fatty liver and non alcoholic fatty liver with hypertension, diabetes mellitus, and dyslipidemia. Using a nationwide Japanese survey, we collected data on subjects with biopsy proven alcoholic fatty liver or nonalcoholic fatty liver. Multiple logistic regression analysis was performed to determine whether alcoholic fatty liver and non alcoholic fatty liver are associated factors for these diseases. Data on 191 subjects (65, alcoholic fatty liver; 126,
more » ... onalcoholic fatty liver) were analyzed. Alcoholic fatty liver (odds ratio, 2.54; 95% confidence interval, 1.06-6.32; p = 0.040), age ≥55 years, and body mass index ≥25 kg/m 2 were correlated with hypertension, whereas nonalcoholic fatty liver (odds ratio, 2.32; 95% confidence interval, 1.08-5.20; p = 0.035) and serum γ glutamyl transpeptidase levels ≥75 IU/l were correlated with dyslipidemia. Furthermore, we found that there were biological interactions between alcoholic fatty liver and body mass index ≥25 kg/m 2 in ≥55 year old subjects (attributable proportion due to interaction, 0.68; 95% confidence interval, 0.19-1.17), as well as between alcoholic fatty liver and age ≥55 years in subjects with body mass index ≥25 kg/m 2 (attribut able proportion due to interaction, 0.71; 95% confidence interval, 0.24-1.18). Alcoholic fatty liver was more strongly associated with hypertension than nonalcoholic fatty liver and nonalcoholic fatty liver was more strongly associated with dyslipidemia than alcoholic fatty liver. Moreover, alcoholic fatty liver, obesity, and older age may interact to influence hypertension status.
doi:10.3164/jcbn.12-55 pmid:23341703 pmcid:PMC3541424 fatcat:lqk67itjafcb3lusmgfqg7ks6m

NFKB1 polymorphism is associated with age-related gene methylation in Helicobacter pylori-infected subjects

TOMIYASU ARISAWA, TOMOMITSU TAHARA, HISAKAZU SHIROEDA, HIDETO YAMADA, TOMOE NOMURA, RANJI HAYASHI, TAKASHI SAITO, TOMOKI FUKUYAMA, TOSHIMI OTSUKA, MASAKATSU NAKAMURA, NOBUYUKI TOSHIKUNI, MUTSUMI TSUCHISHIMA (+1 others)
2012 International Journal of Molecular Medicine  
CpG island aberrant methylation is shown to be an important mechanism in gene silencing. The important role of NF-κB in the inflammatory response to H. pylori colonization has been indicated. We investigated the influence of NFKB1 polymorphisms, -94 ins/del (rs28362491) and -449 C>G (rs72696119), on the aberrant gene methylation under H. pylori infection. Gastric mucosal samples were obtained from subsubjects without malignancies. Methylation status of genes (p14 ARF , p16 INK4a , DAPK and
more » ... was determined by methylation-specific PCR (MSP). The genotyping of NFKB1 was performed by PCR-SSCP. There was a strong allelic association between rs28362491 and rs72696119, and all H. pylori-infected -94 del/del homozygotes had a -449 GG genotype. The -94 del/ del homozygosity was significantly associated with risk for development of CpG island high methylation (CIHM) (two or more gene methylations), especially DAPK and CDH1 methylations, and the number of methylated genes was significantly higher in -94 del/del homozygotes than in ins/del and ins/ins (ins carrier) H. pylori-infected elder subjects. In addition, this methylated gene number was significantly increased with age in H. pylori-infected del/del homozygotes, but not in infected ins carriers. Furthermore, the inflammation score was significantly higher in H. pylori-infected del/del homozygotes compared to ins carriers. NFKB1 -94 ins/del ATTG polymorphism (rs28362491) was significantly associated with the increased risk for the development of age-related gene methylation in non-cancerous gastric mucosa under H. pylori-induced inflammation.
doi:10.3892/ijmm.2012.1004 pmid:22614238 fatcat:cy5vemiblvbolpc7olu2tlkkay

Effects of clear-cutting on nitrogen leaching and fine root dynamics in a cool-temperate forested watershed in northern Japan

Karibu Fukuzawa, Hideaki Shibata, Kentaro Takagi, Mutsumi Nomura, Noriko Kurima, Tatsuya Fukazawa, Fuyuki Satoh, Kaichiro Sasa
2006 Forest Ecology and Management  
Stream and soil solution chemistry, fine root biomass and soil nitrogen processing before and after clear-cutting of trees and subsequent strip-cutting of understory vegetation, dwarf bamboo (Sasa senanensis), were investigated to understand the effect of these disturbances on biogeochemical processes on forested watershed in northern Japan. Tree-cutting did not cause a significant increase of nitrate (NO 3 -) concentration in stream water during the growing season after the cutting. Subsequent
more » ... Sasa-cutting caused significant increase of stream NO 3 concentration to ca. 15μmol L -1 . There was no significant change of stream pH following both cuttings. NO 3 concentration in soil solution increased after both cutting, but the change of concentration was higher (>100μmol L -1 ) after the Sasa-cutting than after the tree-cutting. In a riparian conserved area, on the other hand, NO 3 in soil solution remained low after tree-cutting, suggesting the riparian area acted as a NO 3 sink after the tree-cutting. There was no significant change in total biomass of fine roots after the tree-cutting because of an increase in Sasa root biomass despite a decrease in tree roots. The subsequent Sasa-cutting caused a 50 % decrease of fine root biomass compared to that in the un-cut Sasa site. These results suggested that nitrogen uptake by Sasa was very important in preventing nitrogen leaching after tree-cutting, and decline of this nitrogen uptake after Sasa-cutting lead to marked NO 3 leaching to the stream.
doi:10.1016/j.foreco.2006.01.001 fatcat:pjk6xmuvhfgc5lfxuli3w6xc5a

A case of peripheral osteoma at the inferior border of the mandible
下顎下縁部にみられた周辺性骨腫の1例

Masaaki WATANABE, Ken-ichi NOTANI, Mutsumi KAJI, Katsuhiro NOMURA, Hiroshi FUKUDA
1999 Japanese Journal of Oral & Maxillofacial Surgery  
doi:10.5794/jjoms.45.199 fatcat:cfd7ko33djgn7arhkha3pzmism

The effects of synbiotics therapy on a patient with hepatic portal venous gas : A case report
シンバイオティクスが保存的治療に有用であったと考えられる門脈ガス血症

Hajime Nomura, Mutsumi Nakamura
2019 Online Journal of JSPEN  
doi:10.11244/ejspen.1.3_194 fatcat:y5pk7frvfvcohij3edjfmfitbe

Pneumonia Caused by Mycobacterium conspicuum, a Slow-Growing Nontuberculous Mycobacterium
発育の遅い非結核性抗酸菌Mycobacterium conspicuumによる感染を認めた1症例

Mieko AOYAMA, Akihiro NOMURA, Mutsumi OKANO, Kazuyo SATO, Takuaki TOYAMA
2015 JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE  
NTM Mycobacterium tuberuclosis Mycobacterium avium intrcellulare complex MAC Mycobacterium kansasii NTM MAC M. kansasii PCR DNA-DNA hybridization DDH X φ cm CRP Mycobacterium conspicuum NTM X φ cm PCR MTB MAC DDH Hsp RpoB Mycobacterium conspicuum NTM X CT NTM NTM Mycobacterium conspicuum β-D Ziehl-Neelsen PCR M. avium M. intracellulare DDH NTM CRP X B. Spinger M. conspicuum EB RFP SM PZA J. van Ingen INH RFP AMK RFP µg /ml SM µg/ml INH µg/ml KM µg/ml M. conspicuum M. conspicuum PCR DDH RpoB hsp NTM PCR DDH NTM HIV PCR DDH NTM
doi:10.2185/jjrm.64.50 fatcat:5pxsn5tqfjellmoanjquxafpoe
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