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Here, we propose an online computational framework, termed Mutalisk, which correlates somatic mutations with various genomic, transcriptional and epigenomic features in order to understand mutational processes ... As a result, the regional somatic mutation rate is dependent on the local DNA sequence, the DNA replication/RNA transcription dynamics and epigenomic chromatin organization landscape in the genome. ... While mutational signature decomposition has been developed in various software packages (18, 19) and as a web-based analysis tool (20) , user-friendly toolkit that associates somatic mutations with ...doi:10.1093/nar/gky406 pmid:29790943 pmcid:PMC6030918 fatcat:3qfd4klsbzhlrosqzswqrioiyu