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Mutalisk: a web-based somatic MUTation AnaLyIS toolKit for genomic, transcriptional and epigenomic signatures

Jongkeun Lee, Andy Jinseok Lee, June-Koo Lee, Jongkeun Park, Youngoh Kwon, Seongyeol Park, Hyonho Chun, Young Seok Ju, Dongwan Hong
2018 Nucleic Acids Research  
Here, we propose an online computational framework, termed Mutalisk, which correlates somatic mutations with various genomic, transcriptional and epigenomic features in order to understand mutational processes  ...  As a result, the regional somatic mutation rate is dependent on the local DNA sequence, the DNA replication/RNA transcription dynamics and epigenomic chromatin organization landscape in the genome.  ...  While mutational signature decomposition has been developed in various software packages (18, 19) and as a web-based analysis tool (20) , user-friendly toolkit that associates somatic mutations with  ... 
doi:10.1093/nar/gky406 pmid:29790943 pmcid:PMC6030918 fatcat:3qfd4klsbzhlrosqzswqrioiyu