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Multisite reliability of MR-based functional connectivity

Stephanie Noble, Dustin Scheinost, Emily S. Finn, Xilin Shen, Xenophon Papademetris, Sarah C. McEwen, Carrie E. Bearden, Jean Addington, Bradley Goodyear, Kristin S. Cadenhead, Heline Mirzakhanian, Barbara A. Cornblatt (+14 others)
2017 NeuroImage  
A B S T R A C T Recent years have witnessed an increasing number of multisite MRI functional connectivity (fcMRI) studies.  ...  Reliability was investigated in three types of connectivity analyses: (1) seed-based connectivity with posterior cingulate cortex (PCC), right motor cortex (RMC), and left thalamus (LT) as seeds; (2) the  ...  The results presented here suggest ways to maximize the reliability of multisite functional connectivity studies.  ... 
doi:10.1016/j.neuroimage.2016.10.020 pmid:27746386 pmcid:PMC5322153 fatcat:35uf4ybpgfarpj7bkdgvdohwwe

Toward Leveraging Human Connectomic Data in Large Consortia: Generalizability of fMRI-Based Brain Graphs Across Sites, Sessions, and Paradigms

Hengyi Cao, Sarah C McEwen, Jennifer K Forsyth, Dylan G Gee, Carrie E Bearden, Jean Addington, Bradley Goodyear, Kristin S Cadenhead, Heline Mirzakhanian, Barbara A Cornblatt, Ricardo E Carrión, Daniel H Mathalon (+12 others)
2018 Cerebral Cortex  
In addition, based on our present sample and after accounting for observed reliability, satisfactory statistical power can be achieved in multisite research with sample size of approximately 250 when the  ...  Our findings provide empirical evidence for the generalizability of brain functional graphs in large consortia, and encourage the aggregation of connectomic measures using multisite and multisession data  ...  The other authors report no conflicts of interest.  ... 
doi:10.1093/cercor/bhy032 pmid:29522112 fatcat:vcfk7xb7qzarvnnodvj7r63t4i

Statistical power and prediction accuracy in multisite resting-state fMRI connectivity

Christian Dansereau, Yassine Benhajali, Celine Risterucci, Emilio Merlo Pich, Pierre Orban, Douglas Arnold, Pierre Bellec
2017 NeuroImage  
We then implemented a series of Monte-Carlo simulations, based on real data, to evaluate the impact of the multisite effects on detection power in statistical tests comparing two groups (with and without  ...  We first empirically show that typical functional networks were reliably found at the group level in all sites, and that the amplitude of the inter-site effects was small to moderate, with a Cohen's effect  ...  We focus our analysis on connections showing a fair-to-good test-retest reliability based on a previous study reporting 11 connections likely impacted by Alzheimer's disease, see Orban et al. (2015)  ... 
doi:10.1016/j.neuroimage.2017.01.072 pmid:28161310 fatcat:jqmi7jhnbzggfg4b2ug3a4o7se

A deep learning-based multisite neuroimage harmonization framework established with traveling-subject dataset [article]

Dezheng Tian, Zilong Zeng, Xiaoyi Sun, Qiqi Tong, Huanjie Li, Hongjian He, Jiahong Gao, Yong He, Mingrui Xia
2021 bioRxiv   pre-print
Together, the proposed method offers a powerful and interpretable deep learning-based harmonization framework for multisite neuroimaging data that could enhance reliability and reproducibility in multisite  ...  Here, we proposed a deep learning-based framework to harmonize imaging data from pairs of sites, in which site factors and brain features can be disentangled and encoded.  ...  Acknowledgements This work was supported by National Natural Science Foundation of China (Nos. 82071998, 82021004, 81671767, and 81620108016)  ... 
doi:10.1101/2021.12.05.471192 fatcat:vr266imcwbgnplub6utv3f74yq

European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Emrah Düzel, Julio Acosta-Cabronero, David Berron, Geert Jan Biessels, Isabella Björkman-Burtscher, Michel Bottlaender, Richard Bowtell, Mark v Buchem, Arturo Cardenas-Blanco, Fawzi Boumezbeur, Dennis Chan, Stuart Clare (+19 others)
2019 Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring  
EUFIND combined consensus workshops and data sharing for multisite analysis, focusing on 7 core topics: clinical applications/clinical research, highest resolution anatomy, functional imaging, vascular  ...  The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in neurodegeneration  ...  We assessed whether PRC functional connectivity with the entorhinal cortex, hippocampal subfields, and cortical regions could be reliably delineated in multisite resting-state data and could be distinguished  ... 
doi:10.1016/j.dadm.2019.04.010 pmid:31388558 pmcid:PMC6675944 fatcat:d2stwb6otnekvfs5t6becyaxhm

Deep Learning-Based Segmentation to Establish East Asian Normative Volumes Using Multisite Structural MRI

Regina E. Y. Kim, Minho Lee, Dong Woo Kang, Sheng-Min Wang, Nak-Young Kim, Min Kyoung Lee, Hyun Kook Lim, Donghyeon Kim
2020 Diagnostics  
Eight sub-regional volumes were extracted in the left and right hemispheres using an in-house deep learning-based tool.  ...  Our results showed highly consistent outcomes with high reliability across sites.  ...  Postprocessing To increase the validity of the structures, we further applied connected-component labeling [14] .  ... 
doi:10.3390/diagnostics11010013 pmid:33374745 fatcat:aeolylmwjffcnia5a3pv5tc6ci

Editorial: Biomarkers to Enable Therapeutics Development in Neurodevelopmental Disorders

Mustafa Sahin, John A. Sweeney, Stephanie R. Jones
2020 Frontiers in Integrative Neuroscience  
Replicability of these EEG based biomarkers across such studies indicate that they could be scalable for use in multisite clinical trials.  ...  Aside from MRI and EEG, there are several other modalities that can utilized to investigate brain connectivity and function. These include transcranial magnetic stimulation (TMS) and eye tracking.  ... 
doi:10.3389/fnint.2020.616641 pmid:33262695 pmcid:PMC7686575 fatcat:vnv3j5v5kbeh5m5v5q6dnt6gxu

Multivariate consistency of resting-state fMRI connectivity maps acquired on a single individual over 2.5 years, 13 sites and 3 vendors [article]

AmanPreet Badhwar, Yannik Collin-Verreault, Pierre Orban, Sebastian Urchs, Isabelle Chouinard, Jacob Vogel, Olivier Potvin, Simon Duchesne, Pierre Bellec
2018 bioRxiv   pre-print
The main objective of this study was to assess the long-term consistency of rsfMRI connectivity maps derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol (CDIP,  ...  The consistency (spatial Pearson correlation) of rsfMRI connectivity maps for seven canonical networks ranged from about 0.4-0.8 (intra-site) to 0.3-0.8 (inter-vendor), with a negligible effect of time  ...  The impact of multisite acquisition on rsfMRI connectivity has recently gained attention in a series of studies.  ... 
doi:10.1101/497743 fatcat:dknejcdggvhubh6yb4x2pc6574

Multisite Autism Spectrum Disorder Classification Using Convolutional Neural Network Classifier and Individual Morphological Brain Networks

Jingjing Gao, Mingren Chen, Yuanyuan Li, Yachun Gao, Yanling Li, Shimin Cai, Jiaojian Wang
2021 Frontiers in Neuroscience  
of these features between regions.  ...  However, almost all the current existing classification methods for ASD based on structural MRI (sMRI) mainly utilize the independent local morphological features and do not consider the covariance patterns  ...  the reliability of our study.  ... 
doi:10.3389/fnins.2020.629630 pmid:33584183 pmcid:PMC7877487 fatcat:ftojrp5q6ve4llbwcfr72fz52a

Multisite Image Data Collection and Management Using the RSNA Image Sharing Network

Bradley J. Erickson, Patricio Fajnwaks, Steve G. Langer, John Perry
2014 Translational Oncology  
The execution of a multisite trial frequently includes image collection. The Clinical Trials Processor (CTP) makes removal of protected health information highly reliable.  ...  It also provides reliable transfer of images to a central review site.  ...  Another solution is to use an Internet-based intermediary.  ... 
doi:10.1593/tlo.13799 pmid:24772205 pmcid:PMC3998697 fatcat:32bfmw2p4vgcpkdwxeqqtqt6ni

New Multisite Cascading Calibration Approach for Hydrological Models: Case Study in the Red River Basin Using the VIC Model

Xianwu Xue, Ke Zhang, Yang Hong, Jonathan J. Gourley, Wayne Kellogg, Renee A. McPherson, Zhanming Wan, Barney N. Austin
2016 Journal of hydrologic engineering  
A novel multisite cascading calibration (MSCC) approach using the shuffled complex evolution-University of Arizona (SCE-UA) optimization method, developed at the University of Arizona, was employed to  ...  Results indicate that MSCC largely improves model performance by decreasing the number of stations with negative Nash-Sutcliffe coefficient of efficiency (NSCE) values from 69% (66%) for a priori parameters  ...  Cody Hudson of INTERA for sharing the script to download the USGS observed streamflow data and Mr. Manabendra Saharia and Mr. Humberto Vergara for peak flow qualification of USGS streamflow stations.  ... 
doi:10.1061/(asce)he.1943-5584.0001282 fatcat:f47pimtixzdvbmdgde6ycudgju

Compensatory Hyperconnectivity in Developing Brains of Young Children With Type 1 Diabetes

Manish Saggar, Eva Tsalikian, Nelly Mauras, Paul Mazaika, Neil H. White, Stuart Weinzimer, Bruce Buckingham, Tamara Hershey, Allan L. Reiss
2016 Diabetes  
The observed positive association of connectivity with cognitive functioning in T1D, without overall group differences in cognitive function, suggests a putative compensatory role of hyperintrinsic connectivity  ...  exercise patterns, and inability to reliably communicate signs or symptoms of hypoglycemia.  ...  The authors also thank their external collaborators for the use of their imaging facilities, including the University of California at San Francisco (San Francisco, CA), El Camino Hospital (Mountain View  ... 
doi:10.2337/db16-0414 pmid:27702833 pmcid:PMC5319714 fatcat:trdjxvkqijhxzfodvoygcuw244

Simultaneous PET/MRI: The future gold standard for characterizing motor neuron disease—A clinico-radiological and neuroscientific perspective

Freimut D. Juengling, Frank Wuest, Sanjay Kalra, Federica Agosta, Ralf Schirrmacher, Alexander Thiel, Wolfgang Thaiss, Hans-Peter Müller, Jan Kassubek
2022 Frontiers in Neurology  
Integration of multimodal data into a model of a continuing cascade of functional loss also calls for the best attempt to correlate the different molecular imaging measurements as performed at the shortest  ...  Neuroimaging assessment of motor neuron disease has turned into a cornerstone of its clinical workup.  ...  in MRI-based functional measures.  ... 
doi:10.3389/fneur.2022.890425 pmid:36061999 pmcid:PMC9428135 fatcat:heu5oaxwg5fl5glxvdkvqdvhm4

Gateway cloning vectors for the LexA-based binary expression system in Drosophila

Soeren Diegelmann, Michael Bate, Matthais Landgraf
2008 Fly  
Studies on the formation of connections in the developing nervous system are greatly aided by methods that permit the differential visualization and manipulation of pre-and postsynaptic partner neurons  ...  This has been facilitated by the advent of the LexA-based, GAL4/UASindependent, binary expression system.  ...  Lee for the generous gift of the original LexA-vectors, P. Salvaterra for the 7.4 Cha DNA, B. Ye and T. Lee for fly stocks and A. North for helpful comments.  ... 
doi:10.4161/fly.6817 pmid:18776741 pmcid:PMC2913122 fatcat:cls27c5wz5eznlmtc7n4ffp3ey

Influence of multisite calibration on streamflow estimation based on the hydrological model with CMADS inputs

Yongyu Song, Jing Zhang, Yuequn Lai
2021 Journal of Water and Climate Change  
To more accurately simulate the historical streamflow process within the Qujiang River Basin, we set up three calibration strategies (single-site, S1; multisite simultaneous, S2; and multisite sequential  ...  , S3) for four hydrological stations based on the SWAT (Soil and Water Assessment Tool) model driven by CMADS (China Meteorological Assimilation Driving Datasets for the SWAT model).  ...  Owing to the multisite simultaneous calibration strategy will take the average NSE of the four stations as the objective function and increase the weight of the internal sub-basin, the result of the LDX  ... 
doi:10.2166/wcc.2021.115 fatcat:55tona4ywzc2vpku4xwkq5kiwm
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