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Multiscale modeling in the clinic: diseases of the brain and nervous system

William W. Lytton, Jeff Arle, Georgiy Bobashev, Songbai Ji, Tara L. Klassen, Vasilis Z. Marmarelis, James Schwaber, Mohamed A. Sherif, Terence D. Sanger
<span title="2017-05-09">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mkrnpcnuxraprbvqo4hu6naxfy" style="color: black;">Brain Informatics</a> </i> &nbsp;
Multiscale modeling will also help to extend the usefulness of animal models of human diseases in neuroscience, where the disconnects between clinical and animal phenomenology are particularly pronounced  ...  Computational neuroscience is a field that traces its origins to the efforts of Hodgkin and Huxley, who pioneered quantitative analysis of electrical activity in the nervous system.  ...  Acknowledgements The authors would like to thank Grace Peng, NIBIB and the Interagency Modeling and Analysis Group for providing opportunities they have provided to develop the ideas presented in this  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s40708-017-0067-5">doi:10.1007/s40708-017-0067-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28488252">pmid:28488252</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5709279/">pmcid:PMC5709279</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3ekhbqgpd5cbxpydkpgi33z3fi">fatcat:3ekhbqgpd5cbxpydkpgi33z3fi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729085156/https://link.springer.com/content/pdf/10.1007%2Fs40708-017-0067-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/54/d0/54d0e89e52ba9fb63e25b1c8f118aae710666496.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s40708-017-0067-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5709279" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Integrating Optimized Multiscale Entropy Model with Machine Learning for the Localization of Epileptogenic Hemisphere in Temporal Lobe Epilepsy Using Resting-State fMRI

Xiaoxuan Fu, Youhua Wang, Abdelkader Nasreddine Belkacem, Qirui Zhang, Chong Xie, Yingxin Cao, Hao Cheng, Shenghua Chen, Xiaoxia Yin
<span title="2021-10-27">2021</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/cswd2rqrire6lgrsm56kv4adue" style="color: black;">Journal of Healthcare Engineering</a> </i> &nbsp;
In this study, an optimization algorithm that could choose the parameters of the multiscale entropy (MSE) model was developed, while the optimized effectiveness for localizing the epileptogenic hemisphere  ...  The rfMRI data of 20 mesial temporal lobe epilepsy patients with positive indicators (the indicators of epileptogenic hemisphere in clinic) in the hippocampal formation on either left or right hemisphere  ...  Introduction Epilepsy is a chronic disease caused by abnormal neural discharges that could result in abnormal functions in the central nervous system. is disease could adversely impact the patient's quality  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/1834123">doi:10.1155/2021/1834123</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34745491">pmid:34745491</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8566056/">pmcid:PMC8566056</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xkk7slcjyjgovlcsw6fvxtjlda">fatcat:xkk7slcjyjgovlcsw6fvxtjlda</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220204195221/https://downloads.hindawi.com/journals/jhe/2021/1834123.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/01/9a/019ad569f0002eaa2ad7ef997d83d57b4fb8664b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1155/2021/1834123"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> hindawi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8566056" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Measuring entropy in functional neuroscience: pathophysiological and clinical applications

Chaur-Jong Hu, Chen-Chih Chung, Jiunn-Horng Kang
<span title="">2016</span> <i title="Dove Medical Press Ltd."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/uaweku3o4zdifizqltbfrhztga" style="color: black;">Neuroscience and Neuroeconomics</a> </i> &nbsp;
In this article, we aim to review the available evidence related to the pathophysiological nature of complexity and the clinical applications of entropy-derived measures in varied neurological disorders  ...  Aging or diseased status usually shows reduced entropy values and loss of complexity within the dynamics of physiological output.  ...  Disclosure The authors report no conflicts of interest in this work.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/nan.s73471">doi:10.2147/nan.s73471</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gcfts3zq55dxfpa7k33a2l77ua">fatcat:gcfts3zq55dxfpa7k33a2l77ua</a> </span>
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Multiscale Analysis of Intensive Longitudinal Biomedical Signals and Its Clinical Applications

Toru Nakamura, Ken Kiyono, Herwig Wendt, Patrice Abry, Yoshiharu Yamamoto
<span title="">2016</span> <i title="Institute of Electrical and Electronics Engineers (IEEE)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yfvtieuumfamvmjlc255uckdlm" style="color: black;">Proceedings of the IEEE</a> </i> &nbsp;
To link ILD to clinical applications, such as personalized healthcare and disease  ...  Recent advances in wearable and/or biomedical sensing technologies have made it possible to record continuous biomedical signals over long periods of time.  ...  of associations of SPA with brain structures or functions in the motor control systems [129] - [132] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/jproc.2015.2491979">doi:10.1109/jproc.2015.2491979</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/263pxiq6tjdb7hrkicocrly7qq">fatcat:263pxiq6tjdb7hrkicocrly7qq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180726030155/https://hal.archives-ouvertes.fr/hal-01518074/file/nakamura_17027.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f7/11/f711affc10324d167d72e8c99b83d4703c99e0b5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1109/jproc.2015.2491979"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> ieee.com </button> </a>

Credibility, Replicability, and Reproducibility in Simulation for Biomedicine and Clinical Applications in Neuroscience

Lealem Mulugeta, Andrew Drach, Ahmet Erdemir, C. A. Hunt, Marc Horner, Joy P. Ku, Jerry G. Myers Jr., Rajanikanth Vadigepalli, William W. Lytton
<span title="2018-04-16">2018</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/w7oms7cvvjfs7ht4yodsyhuzku" style="color: black;">Frontiers in Neuroinformatics</a> </i> &nbsp;
It is not yet directly applicable to the problems of patients with brain disease.  ...  In this manuscript, we introduce some basic concepts that will be important in the development of credible clinical neuroscience models: reproducibility and replicability; verification and validation;  ...  USE OF MODELING IN CLINICAL DOMAINS OF BRAIN DISEASE Simulations in the clinical neuroscience domain have largely focused on accounting for the neural activity patterns underlying brain disease.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fninf.2018.00018">doi:10.3389/fninf.2018.00018</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29713272">pmid:29713272</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5911506/">pmcid:PMC5911506</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qf2rkvtyc5gthd4awaoezvwxg4">fatcat:qf2rkvtyc5gthd4awaoezvwxg4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190308164238/http://pdfs.semanticscholar.org/eb72/c12be7097367ecb7dc79cdef4544d615fff3.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/eb/72/eb72c12be7097367ecb7dc79cdef4544d615fff3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fninf.2018.00018"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> frontiersin.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5911506" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Rich-club neurocircuitry: function, evolution, and vulnerability

Alessandra Griffa, Martijn P Van den Heuvel
<span title="">2018</span> <i title="Servier International"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/emz24fzomfafzkl3c6pvmsxmra" style="color: black;">Dialogues in Clinical Neuroscience</a> </i> &nbsp;
Brains, and more generally nervous systems, can be modeled as sets of elements (neurons, assemblies, or cortical chunks) that dynamically interact through a highly structured and adaptive neurocircuitry  ...  This review surveys recent neuroimaging, computational, and cross-species comparative literature to offer an insight into the function and origin of rich-club architecture in nervous systems, discussing  ...  Third, network generative and developmental models enable uncovering the roots and the evolutionary aspects of nervous systems' organization.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30250389">pmid:30250389</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6136122/">pmcid:PMC6136122</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mvlpxiyhsjgd5a7p6xz6kyg6fa">fatcat:mvlpxiyhsjgd5a7p6xz6kyg6fa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191202210947/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6136122&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6136122" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Radiomics in Glioblastoma: Current Status and Challenges Facing Clinical Implementation

Ahmad Chaddad, Michael Jonathan Kucharczyk, Paul Daniel, Siham Sabri, Bertrand J. Jean-Claude, Tamim Niazi, Bassam Abdulkarim
<span title="2019-05-21">2019</span> <i title="Frontiers Media SA"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/mefn5t5kjndavkrqau5bzfpaoe" style="color: black;">Frontiers in Oncology</a> </i> &nbsp;
, and robust statistical modeling validated in the prospective setting.  ...  Radiomics analysis has had remarkable progress along with advances in medical imaging, most notability in central nervous system malignancies.  ...  CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2011-2015. Neuro Oncol. (2018) 20:iv1-86. doi: 10.1093/neuonc/noy131 3.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3389/fonc.2019.00374">doi:10.3389/fonc.2019.00374</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31165039">pmid:31165039</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6536622/">pmcid:PMC6536622</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hdwtwfw6qja7zattkgblorbeku">fatcat:hdwtwfw6qja7zattkgblorbeku</a> </span>
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4581 Autonomic Dysfunction as a Marker of Depression and Coronary Artery Disease

Anish Sanjay Shah
<span title="">2020</span> <i title="Cambridge University Press (CUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5gomeaab35hcdke2rc6byidqeu" style="color: black;">Journal of Clinical and Translational Science</a> </i> &nbsp;
OBJECTIVES/GOALS: Dysfunction of the autonomic nervous system (ANS) may be important in both depression and coronary artery disease (CAD).  ...  Autonomic ECG markers may play an important role in assessing brain-heart pathology, and may be useful to study the interaction between depression and CAD.  ...  Autonomic Dysfunction as a Marker of Depression and Coronary Artery Disease Anish Sanjay Shah 1 1 Emory University OBJECTIVES/GOALS: Dysfunction of the autonomic nervous system (ANS) may be important in  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1017/cts.2020.291">doi:10.1017/cts.2020.291</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4wgrixvuofhghnovo2b2f6e7ba">fatcat:4wgrixvuofhghnovo2b2f6e7ba</a> </span>
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Modeling of Disease: Molecular Level, Overview [chapter]

William W. Lytton
<span title="">2013</span> <i title="Springer New York"> Encyclopedia of Computational Neuroscience </i> &nbsp;
Though molecular and cellular level modeling is the first step in the long of for clinical ladder multiscale modeling translational application, it may be regarded as the critical scale: "Where the rubber  ...  In the realm of translation, this point comes when we translate results to the clinical basic research setting.  ...  In particular, the (ENS) and are prone to disorders and will be important enteric nervous system autonomic nervous system (ANS) areas for modeling in the future.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-1-4614-7320-6_770-1">doi:10.1007/978-1-4614-7320-6_770-1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/vfate5ddijdjxewoktdwxavghm">fatcat:vfate5ddijdjxewoktdwxavghm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170811030609/http://it.neurosim.downstate.edu/pdfs/ecn_mod_350395.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7a/4f/7a4f3584c837c6dce78bb6c47d4a94655d3a1fc8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/978-1-4614-7320-6_770-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Computational Approaches for Translational Clinical Research in Disease Progression

Mary F. McGuire, Madurai Sriram Iyengar, David W. Mercer
<span title="2011-08-01">2011</span> <i title="BMJ"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xwb6ks7gznawzcx6edh5he5htm" style="color: black;">Journal of Investigative Medicine</a> </i> &nbsp;
Today, there is an ever-increasing amount of biological and clinical data available that could be used to enhance a systems-based understanding of disease progression through innovative computational analysis  ...  and therapy in disease progression.  ...  Moore 114 used equation based models to study the effects of primary blasts on the central nervous system, and found that blast waves directly propagate into the brain and that stresses develop in central  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2310/jim.0b013e318224d8cc">doi:10.2310/jim.0b013e318224d8cc</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21712727">pmid:21712727</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3196807/">pmcid:PMC3196807</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bxnxrhooefb4lgdpf6n6ezpppi">fatcat:bxnxrhooefb4lgdpf6n6ezpppi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206100449/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3196807&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dc/a9/dca9394355cc57ccb4907691dcb178c0087f1616.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2310/jim.0b013e318224d8cc"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196807" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Clinical Neurophysiological and Automated EEG-Based Diagnosis of the Alzheimer's Disease

Shreya Bhat, U. Rajendra Acharya, Nahid Dadmehr, Hojjat Adeli
<span title="">2015</span> <i title="S. Karger AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/waqch6lx5raqbkrcmbicg62sdi" style="color: black;">European Neurology</a> </i> &nbsp;
Other potential causes of dementia are head injury, brain tumor, stroke, cerebral nervous system infection, vitamin deficiency, alcohol, exposure to heavy metals, and so on.  ...  The clinical features of AD are summarized in table 1 . Abstract Alzheimer's disease (AD) is a progressive disorder affecting intellectual, behavioral and functional abilities.  ...  As such, early diagnosis is the key in the treatment of the disease.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000441447">doi:10.1159/000441447</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26588015">pmid:26588015</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jf6mvjtrerfjdkn6pqagsfqgde">fatcat:jf6mvjtrerfjdkn6pqagsfqgde</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190308011111/http://pdfs.semanticscholar.org/dfdc/4918fee3530873447581c98a4682ad2450e7.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/df/dc/dfdc4918fee3530873447581c98a4682ad2450e7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1159/000441447"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Cellular biomechanics of central nervous system injury [chapter]

David F. Meaney, Douglas H. Smith
<span title="">2015</span> <i title="Elsevier"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s6xp7m7pzngrhmimdoib7djyuq" style="color: black;">Handbook of Clinical Neurology</a> </i> &nbsp;
The nature and underlying conceptual framework for traumatic loading in the nervous system is reviewed in detail in other portions of this textbook.  ...  Not surprisingly, biomechanics is one of the core sciences used to understand how dynamic loading in the central nervous system (CNS) causes injury.  ...  Author Manuscript MEANEY and SMITH Page 16 Three phases of network changes that can affect the information flow in brain circuitry after traumatic brain injury.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/b978-0-444-52892-6.00007-6">doi:10.1016/b978-0-444-52892-6.00007-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25702212">pmid:25702212</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4946950/">pmcid:PMC4946950</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/qwirgem2v5e4lgejou47iva3gm">fatcat:qwirgem2v5e4lgejou47iva3gm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200504123631/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4946950&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/0d/45/0d45333f1edfe750458e96a4b8ddb3209fa37c58.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/b978-0-444-52892-6.00007-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4946950" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Systemic neurotransmitter responses to clinically approved and experimental neuropsychiatric drugs

Hamid R Noori, Lewis H Mervin, Vahid Bokharaie, Özlem Durmus, Lisamon Egenrieder, Stefan Fritze, Britta Gruhlke, Giulia Reinhardt, Hans-Hendrik Schabel, Sabine Staudenmaier, Nikos K Logothetis, Andreas Bender (+1 others)
<span title="2018-11-08">2018</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a4wan6l5o5dfzn767kyz7jqevi" style="color: black;">Nature Communications</a> </i> &nbsp;
Neuropsychiatric disorders are the third leading cause of global disease burden.  ...  Chemoinformatics analyses of the neurotransmitter responses suggest a mismatch between the current classification of neuropsychiatric drugs and spatiotemporal neurostransmitter response patterns at the  ...  Diego Sanchez for developing the MySQL database, inserting the data and IT administration.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-018-07239-1">doi:10.1038/s41467-018-07239-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/30410047">pmid:30410047</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6224407/">pmcid:PMC6224407</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iuqgb62sxnhxzhcv4a5zp5lwfe">fatcat:iuqgb62sxnhxzhcv4a5zp5lwfe</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190501032410/https://www.repository.cam.ac.uk/bitstream/handle/1810/288974/Systemic%20neurotransmitter%20responses%20to%20clinically%20approved%20and%20experimental%20neuropsychiatric%20drugs.pdf;jsessionid=31EC6A502AA800D5419C212263CAD31A?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ba/b5/bab54482eafa0774a6550ecd6b8fbafd25d472f5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41467-018-07239-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> nature.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224407" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

An examination of four models predicting fatigue in multiple sclerosis

L STROBER, P ARNETT
<span title="">2005</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/msxjglwgqbedhj4vank6tuu3cu" style="color: black;">Archives of Clinical Neuropsychology</a> </i> &nbsp;
The purpose of the present investigation was to examine the relationships among disease severity, depression, and sleep disturbance in MS, and their possible role in predicting fatigue.  ...  The best fitting model showed that all three were significant independent contributors to fatigue in MS, accounting for 43% of the variance, with sleep disturbance reigning as the largest contributor.  ...  Introduction Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with a varying course and uncertain prognosis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.acn.2005.04.002">doi:10.1016/j.acn.2005.04.002</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15894455">pmid:15894455</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xxabgqs57bg3xjjiri4oufagbi">fatcat:xxabgqs57bg3xjjiri4oufagbi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20110331235007/http://psych.la.psu.edu/research/facultyPapers/Strober%20&amp;%20Arnett.2005.reprint.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/01/1e/011e34c809a3d9256aed3f50309b078903e6df78.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.acn.2005.04.002"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Review and classification of variability analysis techniques with clinical applications

Andrea Bravi, André Longtin, Andrew JE Seely
<span title="">2011</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u2ij72rn4fgcljv3o6um2aiwge" style="color: black;">BioMedical Engineering OnLine</a> </i> &nbsp;
In medicine and in particular critical care, efforts have focussed on evaluating the clinical utility of variability.  ...  We review more than 70 variability techniques, providing for each technique a brief description of the underlying theory and assumptions, together with a summary of clinical applications.  ...  of delivering variability-directed clinical decision support to improve quality and efficiency of care.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-925x-10-90">doi:10.1186/1475-925x-10-90</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21985357">pmid:21985357</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3224455/">pmcid:PMC3224455</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/f3xofnuiubgedlcqefalfsj5c4">fatcat:f3xofnuiubgedlcqefalfsj5c4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20130523024404/http://www.biomedical-engineering-online.com/content/pdf/1475-925X-10-90.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/44/12/441226845704977edb7abf96d796c282be31fc13.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1475-925x-10-90"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3224455" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>
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