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Multimodal surface-based morphometry reveals diffuse cortical atrophy in traumatic brain injury

And U Turken, Timothy J Herron, Xiaojian Kang, Larry E O'Connor, Donna J Sorenson, Juliana V Baldo, David L Woods
2009 BMC Medical Imaging  
Methods: Cortical abnormalities were quantified using multimodal surfaced-based morphometry (MSBM) that statistically combined information from high-resolution structural MRI and diffusion tensor imaging  ...  Patients with traumatic brain injury (TBI) often present with significant cognitive deficits without corresponding evidence of cortical damage on neuroradiological examinations.  ...  CONCLUSIONS The present findings highlight the potential of multimodal surface-based morphometry (MSBM) for detecting and characterizing TBI-related diffuse cortical pathology.  ... 
doi:10.1186/1471-2342-9-20 pmid:20043859 pmcid:PMC2811103 fatcat:dogyureekbgmtkbixzysdafhnq

The Shrinking Brain: Cerebral Atrophy Following Traumatic Brain Injury

Taylor C. Harris, Rijk de Rooij, Ellen Kuhl
2018 Annals of Biomedical Engineering  
Our review reveals that observations for mild traumatic brain injury remain inconclusive, whereas observations for moderate-to-severe traumatic brain injury converge towards robust patterns: brain tissue  ...  Cerebral atrophy in response to traumatic brain injury is a well-documented phenomenon in both primary investigations and review articles.  ...  Long-term declarative memory deficits in diffuse TBI: surface-based morphometry reveals diffuse cortical atrophy correlations with cortical thickness, white matter integrity in traumatic  ... 
doi:10.1007/s10439-018-02148-2 pmid:30341741 pmcid:PMC6757025 fatcat:56vgrfaen5fmndsn62yncqoqw4

Long-term structural changes after mTBI and their relation to post-concussion symptoms

Philip J. A. Dean, Joao Ricardo Sato, Gilson Vieira, Adam McNamara, Annette Sterr
2015 Brain Injury  
Primary Objective: To investigate sustained structural changes in the long-term (>1 year) after mild traumatic brain injury (mTBI), and their relationship to ongoing post-concussion syndrome (PCS).  ...  Conclusions: There is evidence for both white and grey matter damage in participants with mTBI over a year after injury.  ...  Introduction The majority (70-90%) of traumatic brain injury (TBI) hospital admissions are classified as mild traumatic brain injury (mTBI) [1, 2] .  ... 
doi:10.3109/02699052.2015.1035334 pmid:26067623 fatcat:knoixkhpabgujffkinbfojsmza

Neuroimaging of structural pathology and connectomics in traumatic brain injury: Toward personalized outcome prediction

Andrei Irimia, Bo Wang, Stephen R. Aylward, Marcel W. Prastawa, Danielle F. Pace, Guido Gerig, David A. Hovda, Ron Kikinis, Paul M. Vespa, John D. Van Horn
2012 NeuroImage: Clinical  
Recent contributions to the body of knowledge on traumatic brain injury (TBI) favor the view that multimodal neuroimaging using structural and functional magnetic resonance imaging (MRI and fMRI, respectively  ...  This is particularly the case when such methods are appropriately combined with volumetric/morphometric analysis of brain structures and with the exploration of TBI-related changes in brain network properties  ...  Introduction There are approximately 1.5 million new cases of non-fatal traumatic brain injury (TBI) in the US every year.  ... 
doi:10.1016/j.nicl.2012.08.002 pmid:24179732 pmcid:PMC3757727 fatcat:2yxon4yu6rfrlfpton5qc4k5si

Connectomic and Surface-Based Morphometric Correlates of Acute Mild Traumatic Brain Injury

Patrizia Dall'Acqua, Sönke Johannes, Ladislav Mica, Hans-Peter Simmen, Richard Glaab, Javier Fandino, Markus Schwendinger, Christoph Meier, Erika J. Ulbrich, Andreas Müller, Lutz Jäncke, Jürgen Hänggi
2016 Frontiers in Human Neuroscience  
Whole-brain connectivity based on diffusion tensor imaging was subjected to network-based statistics, whereas cortical surface area, thickness, and volume based on T1-weighted MRI scans were investigated  ...  Reduced integrity of white matter (WM) pathways and subtle anomalies in gray matter (GM) morphology have been hypothesized as mechanisms in mild traumatic brain injury (mTBI).  ...  Surface-Based Morphometry The surface-based morphometry analyses revealed that severity of complaints was inversely correlated with cortical surface area in mTBI patients.  ... 
doi:10.3389/fnhum.2016.00127 pmid:27065831 pmcid:PMC4809899 fatcat:cgqvwktqhnex5owbdy73mhn644

Tracking Changes following Spinal Cord Injury

Patrick Freund, Armin Curt, Karl Friston, Alan Thompson
2012 The Neuroscientist  
Traumatic spinal cord injury is often disabling and recovery of function is limited. As a consequence of damage, both spinal cord and brain undergo anatomical and functional changes.  ...  This review describes recent findings from multimodal imaging studies of remote anatomical changes (i.e., beyond the lesion site), cortical reorganization, and their relationship to clinical disability  ...  cortical gray and white matter volume using voxel-based morphometry (Freund and others 2010b) (A).  ... 
doi:10.1177/1073858412449192 pmid:22730072 pmcid:PMC4107798 fatcat:urruxy2r75fh7mjbelb6yktlte

Topographical Heterogeneity of Alzheimer's Disease Based on MR Imaging, Tau PET, and Amyloid PET

Seun Jeon, Jae Myeong Kang, Seongho Seo, Hye Jin Jeong, Thomas Funck, Sang-Yoon Lee, Kee Hyung Park, Yeong-Bae Lee, Byeong Kil Yeon, Tatsuo Ido, Nobuyuki Okamura, Alan C. Evans (+2 others)
2019 Frontiers in Aging Neuroscience  
Our surface-based multimodal framework has revealed three distinct subtypes among AD patients: medial temporal-dominant subtype (MT, n = 44), parietal-dominant subtype (P, n = 19), and diffuse atrophy  ...  The topography of cortical atrophy and THK5351 retention differentiates between the three subtypes.  ...  CONCLUSION Our surface-based multimodal imaging cluster analysis framework has revealed three distinct subtypes among AD patients in terms of the distribution of cortical atrophy, THK5351 retention, and  ... 
doi:10.3389/fnagi.2019.00211 pmid:31481888 pmcid:PMC6710378 fatcat:krl7h3hg4bfjlje7dsmdbwtt64

Multimodal neuroimaging computing: the workflows, methods, and platforms

Sidong Liu, Weidong Cai, Siqi Liu, Fan Zhang, Michael Fulham, Dagan Feng, Sonia Pujol, Ron Kikinis
2015 Brain Informatics  
The last two decades have witnessed the explosive growth in the development and use of noninvasive neuroimaging technologies that advance the research on human brain under normal and pathological conditions  ...  Multimodal neuroimaging computing is very challenging, and requires sophisticated computing to address the variations in spatiotemporal resolution and merge the biophysical/biochemical information.  ...  distributed under the terms of the Creative Commons Attribution 4.0 International License (http://crea, which permits unrestricted use, distribution, and reproduction in  ... 
doi:10.1007/s40708-015-0020-4 pmid:27747508 pmcid:PMC4737665 fatcat:hr5otfj36ngm7pyvbmvzwlyv4q

Imaging of intractable paediatric epilepsy

Sanjay Prabhu, Nasreen Mahomed
2015 South African Journal of Radiology  
these patients; and to highlight the value of multimodality and interdisciplinary approaches to the management of this group of children.  ...  In this subgroup of patients, neuroimaging plays an important role in identifying an epileptogenic focus.  ...  Post-traumatic epilepsy Seizures and epilepsy are relatively common in children with post-traumatic brain injury (TBI) and portend worse functional outcome. 23 The exact pathogenesis of posttraumatic  ... 
doi:10.4102/sajr.v19i2.936 fatcat:frlpfrxegzdllcvbes7q3ezcui

Neuroanatomical correlates of cognitive functioning in prodromal Huntington disease

Deborah L. Harrington, Dawei Liu, Megan M. Smith, James A. Mills, Jeffrey D. Long, Elizabeth H. Aylward, Jane S. Paulsen
2013 Brain and Behavior  
Although striatal atrophy correlates with some cognitive abilities, few studies of prHD have investigated whether cortical gray matter morphometry correlates in a regionally specific manner with functioning  ...  Brain morphometry in these regions was then correlated with cognitive functioning in each of the domains in the prHD group using random forest methods.  ...  In an early study of 15 prHD individuals that used whole-brain voxel-based morphometry (VBM) (Rosas et al. 2005) , linear regression analyses revealed that Verbal Fluency, Stroop Interference, and SDMT  ... 
doi:10.1002/brb3.185 pmid:24653952 pmcid:PMC3937704 fatcat:fbw5b7vtjna7bomowoc4ebikqi

Neuroanatomic markers of post-traumatic epilepsy based on magnetic resonance imaging and machine learning [article]

Haleh Akrami, Richard M Leahy, Andrei Irimia, Paul E Kim, Christianne Heck, Anand Joshi
2020 medRxiv   pre-print
Although post-traumatic epilepsy (PTE) is a common complication of traumatic brain injury (TBI), the relationship between these conditions is unclear, early PTE detection and prevention being major unmet  ...  We performed tensor-based morphometry to analyze brain shape changes associated with TBI and to derive imaging features for statistical group comparison.  ...  Tensor-Based Morphometry Reveals Volumetric Deficits in Moderate=Severe Pediatric Traumatic Brain Injury.  ... 
doi:10.1101/2020.07.22.20160218 fatcat:jnmy6whrtbfpzkbfrpl3yvmj4m

Translational neuroimaging in mild traumatic brain injury

Tim L. T. Wiegand, Nico Sollmann, Elena M. Bonke, Kosisochukwu E. Umeasalugo, Kristen R. Sobolewski, Nikolaus Plesnila, Martha E. Shenton, Alexander P. Lin, Inga K. Koerte
2021 Journal of Neuroscience Research  
Traumatic brain injuries (TBIs) are common with an estimated 27.1 million cases per year. Approximately 80% of TBIs are categorized as mild TBI (mTBI) based on initial symptom presentation.  ...  Advanced neuroimaging has the potential to characterize brain morphometric, microstructural, biochemical, and metabolic abnormalities following mTBI.  ...  T2-weighted MRI performed 14 days after repeated mTBI revealed cortical atrophy. Specifically, cortical thickness directly below the impact zone was reduced by up to 46%.  ... 
doi:10.1002/jnr.24840 pmid:33789358 fatcat:hze44hwaevdibjuo3xoqejsave

Strategy-based reasoning training modulates cortical thickness and resting-state functional connectivity in adults with chronic traumatic brain injury

Kihwan Han, Rebecca A. Davis, Sandra B. Chapman, Daniel C. Krawczyk
2017 Brain and Behavior  
K E Y W O R D S functional connectivity, magnetic resonance imaging, morphometry, plasticity, rehabilitation, traumatic brain injury  ...  Methods: Sixty individuals with chronic traumatic brain injury (TBI) were randomized into either strategy-based (N = 31) or knowledge-based (N = 29) training for 8 weeks.  ...  | INTRODUCTION A traumatic brain injury (TBI) is caused by external force (e.g., blast or fall) to the head, leading to disruptions in brain structure and function.  ... 
doi:10.1002/brb3.687 pmid:28523229 pmcid:PMC5434192 fatcat:5ise3xj3vvboxiiflosonxemce

Axonal integrity predicts cortical reorganisation following cervical injury

Patrick Freund, Claudia A Wheeler-Kingshott, Zoltan Nagy, Nikos Gorgoraptis, Nikolaus Weiskopf, Karl Friston, Alan J Thompson, Chloe Hutton
2012 Journal of Neurology, Neurosurgery and Psychiatry  
in the CST are related to cross-sectional spinal cord area and cortical reorganisation of the sensorimotor system in subjects with traumatic SCI.  ...  Traumatic spinal cord injury (SCI) leads to disruption of axonal architecture and macroscopic tissue loss with impaired information flow between the brain and spinal corddthe presumed basis of ensuing  ...  In the present study, we used DTI data from the same cohort to investigate microstructural changes in the CST using voxel-based morphometry of cranial DTI data (FA, AD, RD and mean diffusivity (MD)).  ... 
doi:10.1136/jnnp-2011-301875 pmid:22492214 pmcid:PMC3348614 fatcat:jqy5uc3m6batrkjuljiwg7evzy

Volumetric and shape analyses of subcortical structures in United States service members with mild traumatic brain injury

David F. Tate, Benjamin S. C. Wade, Carmen S. Velez, Ann Marie Drennon, Jacob Bolzenius, Boris A. Gutman, Paul M. Thompson, Jeffrey D. Lewis, Elisabeth A. Wilde, Erin D. Bigler, Martha E. Shenton, John L. Ritter (+1 others)
2016 Journal of Neurology  
Mild traumatic brain injury (mTBI) is a significant health concern. The majority who sustain mTBI recover, although ~20 % continue to experience symptoms that can interfere with quality of life.  ...  In this study, subcortical shape and volume in 76 Service Members with mTBI was compared to 59 Service Members with orthopedic injury (OI) and 17 with post-traumatic stress disorder (PTSD) only.  ...  This work is supported in part by the Defense and Veterans Brain Injury Centers, the Telemedicine and Advanced Technology Research Center (TATRC) at the U.S.  ... 
doi:10.1007/s00415-016-8236-7 pmid:27435967 pmcid:PMC5564450 fatcat:kjjv5kxlcrdpfpns3upbi4czb4
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