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Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

Kalina Andrysiak, Jacek Stępniewski, Józef Dulak
<span title="2021-02-24">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/vzoeefih5ne67lh2qmgxzke42m" style="color: black;">Pflügers Archiv: European Journal of Physiology</a> </i> &nbsp;
This paper is an overview of possible use of cardiomyocytes and other cardiac cell types derived from hiPSC as in vitro models of heart in drug research area prepared on the basis of latest scientific  ...  Furthermore, heart-on-a-chip technology has recently become an increasingly popular tool, as it implements controllable culture conditions, application of various stimulations and continuous parameters  ...  Abnormalities in calcium dynamics trigger myocardial dysfunction and heart failure.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00424-021-02536-z">doi:10.1007/s00424-021-02536-z</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33629131">pmid:33629131</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8245367/">pmcid:PMC8245367</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5z7y7uhq7vd6vkha7pl6xf2a5u">fatcat:5z7y7uhq7vd6vkha7pl6xf2a5u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718111128/https://link.springer.com/content/pdf/10.1007/s00424-021-02536-z.pdf?error=cookies_not_supported&amp;code=f84ce5de-72d8-43dc-8f4e-68cdfc717ebb" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/bc/7c/bc7c698dc247fc6fb4fbfb985f2968719b600003.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00424-021-02536-z"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8245367" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Regenerative abilities of mesenchymal stem cells through mitochondrial transfer

Swati Paliwal, Rituparna Chaudhuri, Anurag Agrawal, Sujata Mohanty
<span title="2018-03-30">2018</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3t63hhfz45hilghgy2elkdj3dq" style="color: black;">Journal of Biomedical Science</a> </i> &nbsp;
In this review, we have discussed the phenomenon of mitochondrial transfer from MSCs to neighboring stressed cells, and how this aids in cellular repair and regeneration of different organs such as lung  ...  The potential scope of mitochondrial transfer in providing novel therapeutic strategies for treatment of various pathophysiological conditions has also been discussed.  ...  Acknowledgements We thank Sonali Rawat for contribution to diagrammatic representation of mitochondrial transfer in Fig. 2 and Fig. 3 of this review.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12929-018-0429-1">doi:10.1186/s12929-018-0429-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29602309">pmid:29602309</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5877369/">pmcid:PMC5877369</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3lzz65bdxbgvpn6ilh4b7z23wa">fatcat:3lzz65bdxbgvpn6ilh4b7z23wa</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191013055138/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5877369&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ff/91/ff91469fe9c39855a456c65c008bc0384232aa44.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12929-018-0429-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5877369" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Elisa Giacomelli, Viviana Meraviglia, Giulia Campostrini, Amy Cochrane, Xu Cao, Ruben W.J. van Helden, Ana Krotenberg Garcia, Maria Mircea, Sarantos Kostidis, Richard P. Davis, Berend J. van Meer, Carolina R. Jost (+17 others)
<span title="2020-05-20">2020</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/euej5flie5ggvpdbpf3spvvcw4" style="color: black;">Cell Stem Cell</a> </i> &nbsp;
Here, we showed that tri-cellular combinations of hiPSC-derived CMs, cardiac fibroblasts (CFs), and cardiac endothelial cells also enhance maturation in easily constructed, scaffold-free, three-dimensional  ...  Scaled production of thousands of hiPSC-MTs was highly reproducible across lines and differentiated cell batches.  ...  MTs were stimulated at their averaged spontaneous beating frequency. After 4 calcium transients, stimulation was stopped and 50 mM caffeine added immediately and directly to the culture medium.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.stem.2020.05.004">doi:10.1016/j.stem.2020.05.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32459996">pmid:32459996</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7284308/">pmcid:PMC7284308</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xc7mhbr2sjaolmxbfxx44zyudu">fatcat:xc7mhbr2sjaolmxbfxx44zyudu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210715093731/https://ris.utwente.nl/ws/files/249973372/1_s2.0_S1934590920302022_main.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a1/b1/a1b16f3ae0f5d0be6529938ee88219abad74ef23.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.stem.2020.05.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284308" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Contribution of Impaired Mitochondrial Autophagy to Cardiac Aging: Mechanisms and Therapeutic Opportunities

D. Dutta, R. Calvani, R. Bernabei, C. Leeuwenburgh, E. Marzetti
<span title="2012-04-12">2012</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zo5fftfyifagxbgtfyochmz3im" style="color: black;">Circulation Research</a> </i> &nbsp;
The progressive decline of cardiomyocyte mitochondrial function is considered a major mechanism underlying heart senescence.  ...  The present review illustrates the putative mechanisms whereby alterations in the autophagic removal of damaged mitochondria intervene in the process of cardiac aging and in the pathogenesis of specific  ...  Acknowledgment The authors recognize that not all of the excellent scientific work in this area could be included or cited because of the vast literature on the subject and space limitations.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/circresaha.111.246108">doi:10.1161/circresaha.111.246108</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22499902">pmid:22499902</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3353545/">pmcid:PMC3353545</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/foxc5op2snbrfdp727p4rlvtti">fatcat:foxc5op2snbrfdp727p4rlvtti</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190304221413/http://pdfs.semanticscholar.org/c1f5/4a80fba0d9408fe0d10163962a41f67f4651.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c1/f5/c1f54a80fba0d9408fe0d10163962a41f67f4651.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1161/circresaha.111.246108"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353545" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Biology on a Chip: Microfabrication for Studying the Behavior of Cultured Cells

Nianzhen Li, Anna Tourovskaia, Albert Folch
<span title="">2003</span> <i title="Begell House"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/c57mcoupfjgsjgze7rf25dv5ga" style="color: black;">Critical reviews in biomedical engineering</a> </i> &nbsp;
In addition, microtechnology is conceptually well suited for the development of fast, low-cost in vitro systems that allow for high-throughput culturing and analysis of cells under large numbers of conditions  ...  Here we review a variety of applications of microfabrication in cell culture studies, with an emphasis on the biology of various cell types.  ...  Planar MEAs have been used to stimulate and monitor physical beating of cultured cardiomyocytes.²³⁰ Denyer et al.²³¹ studied the suitability of cardiac myocytes cultured over MEAs for a pharmacological  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1615/critrevbiomedeng.v31.i56.20">doi:10.1615/critrevbiomedeng.v31.i56.20</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/15139302">pmid:15139302</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3848900/">pmcid:PMC3848900</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/pll5kozdwbdpnezbvlyr32kn4i">fatcat:pll5kozdwbdpnezbvlyr32kn4i</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170810065431/http://faculty.washington.edu/afolch/Folch_2003_CritRevBMEng.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/33/ea/33ea8ea0d1ea41b7b0f91d317c88fd836885007c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1615/critrevbiomedeng.v31.i56.20"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848900" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity

Jinxia Wei, Simiao Fan, Hongxin Yu, Lexin Shu, Yubo Li
<span title="2021-11-13">2021</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fiqgu2g3kfawzan3zs5ni7lrfy" style="color: black;">Drug Design, Development and Therapy</a> </i> &nbsp;
The identified targets were analysed from the perspective of multilevel and multidimensional bioinformatics through a network integration method.  ...  Furthermore, cytosolic phospholipase A2 (cPLA2) is the upstream signal protein of PTGS2, and it is a key enzyme in the metabolism of arachidonic acid during an inflammatory response.  ...  GO analysis divides gene function into three cultured at 37 °C for 4 h.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/dddt.s335461">doi:10.2147/dddt.s335461</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34803375">pmid:34803375</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8599306/">pmcid:PMC8599306</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/6x2wjmi3azhs7jkhfgzohhcy64">fatcat:6x2wjmi3azhs7jkhfgzohhcy64</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211127053746/https://www.dovepress.com/getfile.php?fileID=75806" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4e/c3/4ec3bb7917a99c5c99e4e016ec30dd5327a3808d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/dddt.s335461"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599306" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Molecular pathways of oestrogen receptors and β-adrenergic receptors in cardiac cells: Recognition of their similarities, interactions and therapeutic value

J.O. Machuki, H.Y. Zhang, S.E. Harding, H. Sun
<span title="2017-10-30">2017</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/i6pkaytoi5b35f3tbhyfeegymi" style="color: black;">Acta Physiologica</a> </i> &nbsp;
In addition, we explore the relevance of these interactions to cell physiology, drugs (especially bblockers and calcium channel blockers) and cardioprotection.  ...  compared to that of pre-menopausal women. 1 In addition, development of CVDs in men occurs at a relatively young age, while the risk of CVDs in women accelerates after menopause. 1 These observations  ...  This phenomenon is referred to as calcium-induced calcium release. The resultant Ca 2+ transient activates the myofilament protein troponin C turning on cardiomyocyte contraction.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/apha.12978">doi:10.1111/apha.12978</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28994249">pmid:28994249</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5813217/">pmcid:PMC5813217</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/on2iusxltjepxcas2xaau2a3y4">fatcat:on2iusxltjepxcas2xaau2a3y4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426202945/http://spiral.imperial.ac.uk/bitstream/10044/1/61638/4/Molecular%20pathways%20of%20oestrogen%20receptors%20and%20%ce%b2-adrenergic%20receptors%20in%20cardiac%20cells%3a%20Recognition%20of%20their%20similarities%2c%20interactions%20and%20therapeutic%20value.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b9/93/b99360347e99bf01be79d7e632ed3f21f343fffb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1111/apha.12978"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813217" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Nanotopography-guided tissue engineering and regenerative medicine

Hong Nam Kim, Alex Jiao, Nathaniel S. Hwang, Min Sung Kim, Do Hyun Kang, Deok-Ho Kim, Kahp-Yang Suh
<span title="">2013</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xkqdyiaizzcpfbssudcavryixa" style="color: black;">Advanced Drug Delivery Reviews</a> </i> &nbsp;
In this review, we provide an extensive analysis of recent efforts to mimic functional nanostructures in vitro for improved tissue engineering and regeneration of injured and damaged tissues.  ...  Brain tissue is an electro-active tissue in which information and stimulation received from the eyes, ears and skin are processed through the relay of signals by neurons.  ...  (F) Action potential propagation analysis of NRVMs cultured on flat and anisotropic nanopatterns.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.addr.2012.07.014">doi:10.1016/j.addr.2012.07.014</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22921841">pmid:22921841</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5444877/">pmcid:PMC5444877</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/e62tlaasgjbq7nny5uv5thohgu">fatcat:e62tlaasgjbq7nny5uv5thohgu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206003414/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5444877&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/59/3d/593dac731b8e0256ecb4dac14b89b764828aa536.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.addr.2012.07.014"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5444877" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Late Sodium Current of the Heart: Where Do We Stand and Where Are We Going?

Balázs Horváth, Norbert Szentandrássy, János Almássy, Csaba Dienes, Zsigmond Máté Kovács, Péter P. Nánási, Tamas Banyasz
<span title="2022-02-15">2022</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/lecpmp3vs5hulh3xiqgqnyhrge" style="color: black;">Pharmaceuticals</a> </i> &nbsp;
Even though the role of late sodium current in shaping action potential under physiologic circumstances is debated, it's unquestioned role in arrhythmogenesis keeps it in the focus of research.  ...  Despite the increasing body of accumulating information on the subject, our understanding of its role in normal or pathologic states is not complete.  ...  First, they showed that specific Na v 1.8 inhibitors reduce ATX-II stimulated late sodium current in wild-type, but not in SCN10A -/cardiomyocytes.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ph15020231">doi:10.3390/ph15020231</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/35215342">pmid:35215342</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8879921/">pmcid:PMC8879921</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/b3thnpnmtndrdlqzd7fk3kwxfm">fatcat:b3thnpnmtndrdlqzd7fk3kwxfm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220425005622/https://mdpi-res.com/d_attachment/pharmaceuticals/pharmaceuticals-15-00231/article_deploy/pharmaceuticals-15-00231-v3.pdf?version=1645513112" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/13/f5/13f53bd06782318afe2bdce6448707d4971a68f5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/ph15020231"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8879921" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Synergy Between Intercellular Communication and Intracellular Ca2+ Handling in Arrhythmogenesis

Etienne Boileau, Christopher H. George, Dimitris Parthimos, Alice N. Mitchell, Sabina Aziz, Perumal Nithiarasu
<span title="2015-01-06">2015</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/imwgooosl5b4lgzai3w2my5g5y" style="color: black;">Annals of Biomedical Engineering</a> </i> &nbsp;
2+ dynamics.  ...  Entrainment phenomena are shown to be linked to both intracellular Ca 2+ and coupling-specific dynamics in a synergistic manner.  ...  The authors also acknowledge the financial support provided by the Sêr Cymru National Research Network in Advanced Engineering and Materials.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10439-014-1243-x">doi:10.1007/s10439-014-1243-x</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25558847">pmid:25558847</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/t3mlb5zjjfdbnefldcndf52sai">fatcat:t3mlb5zjjfdbnefldcndf52sai</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180722190611/http://orca.cf.ac.uk/91868/1/Synergy_between_intercellular_communication_and_intracellular_Ca2%2B_handling_in_arrhythmogenesis%20FINAL%20REVISED.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/41/77/4177aa9374d340bf1275f0c150abd691132d5744.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10439-014-1243-x"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Advances in tissue engineering through stem cell-based co-culture

Nikolaos K. Paschos, Wendy E. Brown, Rajalakshmanan Eswaramoorthy, Jerry C. Hu, Kyriacos A. Athanasiou
<span title="2014-02-03">2014</span> <i title="Wiley"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ywdsfxmslzakzkbaopeg3wgjba" style="color: black;">Journal of Tissue Engineering and Regenerative Medicine</a> </i> &nbsp;
Three types of cell-cell interactions take place in co-culture: cell-cell adhesion, Figure 3 . An example of indirect co-culture system.  ...  Their incorporation into coculture systems seems to be important in the creation of complex tissues or organs. In this review, critical aspects of stem cell use in co-culture systems are discussed.  ...  Acknowledgement This work was funded in part by the California Institute for Regenerative Medicine (CIRM) grant #TR3-05709.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/term.1870">doi:10.1002/term.1870</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24493315">pmid:24493315</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/akqlf2cqsvadzhbsua33737e3u">fatcat:akqlf2cqsvadzhbsua33737e3u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180724052714/https://cloudfront.escholarship.org/dist/prd/content/qt0h521096/qt0h521096.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6f/e0/6fe069cb463d777b176bf2d9173201fdce930ec2.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/term.1870"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a>

Speaker Abstracts

<span title="">2000</span> <i title="Rockefeller University Press"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2yuph7umhbeorelyupdudpow5y" style="color: black;">The Journal of General Physiology</a> </i> &nbsp;
As long as the concentration of nutrient molecules in the culture medium is significantly higher than in the periplasm near the transporters, the diffusive flux ⌽ can meet the requirements for unhibited  ...  Fick's equation relates the difference in concentration of a species of molecules in the external space and in the periplasmic space with their flux ⌽ across the OM: ⌬ c и P ϭ ⌽ .  ...  Adult rat cardiomyocytes were harvested and suspended in culture media with FDP and spiked with 0.1 Ci 14 C-FDP.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1085/jgp.116.1.1a">doi:10.1085/jgp.116.1.1a</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/267kjtssujhffkp5efmntt7nn4">fatcat:267kjtssujhffkp5efmntt7nn4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180720120454/http://jgp.rupress.org/content/jgp/116/1/1a.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ac/af/acaf9e800bb39459d7513ef051053eacc398d94d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1085/jgp.116.1.1a"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Energy metabolism in nuclear reprogramming

Clifford DL Folmes, Timothy J Nelson, Andre Terzic
<span title="">2011</span> <i title="Future Medicine Ltd"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4qnglatiwfdvznlhdbzx52atda" style="color: black;">Biomarkers in Medicine</a> </i> &nbsp;
An alternative to ESCs was introduced with the realization that fibroblasts and, in general, somatic tissue could be reprogrammed back to the pluripotent ground state by transduction of a set of stemness  ...  Therefore, mitochondrial biogenesis and energy metabolism comprise a vital axis for biomarker discovery, intimately reflecting the molecular dynamics fundamental for the resetting and redirection of cell  ...  Several studies have taken advantages of metabolomic footprinting analysis to monitor stem cell maintenance in response to different culture conditions.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/bmm.11.87">doi:10.2217/bmm.11.87</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22103608">pmid:22103608</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3477517/">pmcid:PMC3477517</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/buncdmvorbcvbm5ufrz6323rki">fatcat:buncdmvorbcvbm5ufrz6323rki</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200206024743/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3477517&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1a/08/1a08ca46a3248fbca4b1e23660902172e35f134a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2217/bmm.11.87"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3477517" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Molecular Basis of Atrial Fibrillation Initiation and Maintenance

Kira Beneke, Cristina E. Molina
<span title="2021-03-23">2021</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/7tlmrxth7rdppg7b76pc7rnpf4" style="color: black;">Hearts</a> </i> &nbsp;
Over the past decades, research in appearance and progression of this arrhythmia have turned into significant advances in its management.  ...  Here, we review recent advances in molecular and cellular basis for AF initiation, maintenance and progression.  ...  Adult-specific removal of Tbx5 caused AF in mice and cardiomyocytes from this model revealed a multilevel gene regulatory network activated by TBX5 and repressed by PITX2 linking seven GWAS AF loci, including  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/hearts2010014">doi:10.3390/hearts2010014</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/h4q45obxz5bpfjm7ekawzdqtxi">fatcat:h4q45obxz5bpfjm7ekawzdqtxi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210325150809/https://res.mdpi.com/d_attachment/hearts/hearts-02-00014/article_deploy/hearts-02-00014-v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ba/3e/ba3ec665763be615b9f4846ad47c39815a8005aa.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/hearts2010014"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a>

Integrative and theoretical research on the architecture of a biological system and its disorder

Shinichi Uchida, Yoshiyuki Asai, Yoshiaki Kariya, Kunichika Tsumoto, Hiroshi Hibino, Masashi Honma, Takeshi Abe, Fumiaki Nin, Yasutaka Kurata, Kazuharu Furutani, Hiroshi Suzuki, Hiroaki Kitano (+2 others)
<span title="2019-03-13">2019</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fa3hsv3nebaifgtk2k2u2w7zqi" style="color: black;">Journal of Physiological Sciences</a> </i> &nbsp;
The topics included reactions of drugs, ion-transport architecture in an epithelial system, multi-omics in renal disease, cardiac electrophysiological systems, and a software platform for computer simulation  ...  In this review article these authors have summarized recent achievements in the field and discuss next-generation studies on health and disease.  ...  calcium concentration dynamics shown in the center panel.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12576-019-00667-8">doi:10.1007/s12576-019-00667-8</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/in2rjtpv4jhlznih5j4y3dzpr4">fatcat:in2rjtpv4jhlznih5j4y3dzpr4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190502230319/https://link.springer.com/content/pdf/10.1007%2Fs12576-019-00667-8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/20/be/20be261dc0a7ceb4529af9f795cffe9a07772b67.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s12576-019-00667-8"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>
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