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Multi-vendor standardized sequence for edited magnetic resonance spectroscopy
2019
NeuroImage
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In this paper, we describe an effort to develop a new universal MEGA-PRESS sequence with HERMES functionality for the major MR vendor platforms with standardized RF pulse shapes, durations, amplitudes ...
On each platform, edited MRS experiments were conducted with the vendor-native and universal MEGA-PRESS sequences for GABA (TE = 68 ms) and Lac editing (TE = 140 ms). ...
Introduction Proton ( 1 H) magnetic resonance spectroscopy (MRS) is a non-invasive tool for measuring endogenous metabolite levels in the human brain to investigate healthy and pathological physiology ...
doi:10.1016/j.neuroimage.2019.01.056
pmid:30682536
pmcid:PMC7008948
fatcat:utn5viteb5c6xaw5xrpc3kpmc4
INSPECTOR: free software for magnetic resonance spectroscopy data inspection, processing, simulation and analysis
2021
Scientific Reports
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AbstractIn vivo magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics, allowing for non-invasive measurement and analysis of small molecules from living ...
In addition to convenience, the functionalities of INSPECTOR ensure rigorous and consistent data processing throughout multi-experiment and multi-center studies. ...
MA) as a stand-alone user-friendly software with powerful analytic capabilities for applying magnetic resonance spectroscopy data to biomedical research and ultimately clinical applications 12 . ...
doi:10.1038/s41598-021-81193-9
pmid:33483543
fatcat:vxhgbjmir5hk7isj276rks547m
Big GABA: Edited MR spectroscopy at 24 research sites
2017
NeuroImage
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Magnetic resonance spectroscopy (MRS) is the only biomedical imaging method that can noninvasively detect endogenous signals from the neurotransmitter γ-aminobutyric acid (GABA) in the human brain. ...
This large-scale multi-vendor, multi-site study seeks to better understand the factors that impact measurement outcomes of GABA-edited MRS. ...
Introduction Magnetic resonance spectroscopy (MRS) is unique amongst the neuroimaging modalities in detecting endogenous signals from complex molecules in the brain noninvasively. ...
doi:10.1016/j.neuroimage.2017.07.021
pmid:28716717
pmcid:PMC5700835
fatcat:t5ernqj6s5cdfhq2twugxt5jjm
NIfTI-MRS: A standard format for magnetic resonance spectroscopic data
[article]
2021
bioRxiv
pre-print
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NIfTI-MRS is proposed as a standard MR spectroscopy data format, which is implemented as an extension to the neuroimaging informatics technology initiative (NIfTI) format.Using this standardised format ...
The conversion software, spec2nii, currently converts fourteen formats to NIfTI-MRS, including DICOM and vendor proprietary formats.ConclusionThe proposed format aims to solve the issue of multiple data ...
Introduction Magnetic resonance spectroscopy (MRS) is a highly flexible technique which can generate a wide range of sensitive and specific imaging contrasts complementary to the typically water-derived ...
doi:10.1101/2021.11.09.467912
fatcat:tbohgeqwbjhx5i2xqnrl7jqkgi
Big GABA II: Water-referenced edited MR spectroscopy at 25 research sites
2019
NeuroImage
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Accurate and reliable quantification of brain metabolites measured in vivo using 1H magnetic resonance spectroscopy (MRS) is a topic of continued interest. ...
Data from 284 volunteers scanned across 25 research sites were collected using GABA+ (GABA + co-edited macromolecules (MM)) and MM-suppressed GABA editing. ...
Introduction In vivo 1 H magnetic resonance spectroscopy (MRS) allows noninvasive measurement of brain metabolite concentrations, but it does so only in a relative manner. ...
doi:10.1016/j.neuroimage.2019.02.059
pmid:30840905
pmcid:PMC6818968
fatcat:xgcppuidyrddhjprqf3o7pi5fm
Glutamate and glutamine: a review ofin vivoMRS in the human brain
2013
NMR in Biomedicine
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The present range of magnetic resonance spectroscopy (MRS) methods used to assess Glu and Gln, vary in approach, complexity and outcome, thus the focus of this review is on a description of MRS acquisition ...
TE-averaging sequences are not usually available from major MRI vendors but can be easily modified from standard PRESS sequence source code. ...
The implementation of very short echo time techniques requires substantial modification of standard vendor supplied localization sequences. ...
doi:10.1002/nbm.3045
pmid:24123328
pmcid:PMC3849600
fatcat:ghwxvycat5csxa5z5mlw2x3eea
Multi-center reproducibility of neurochemical profiles in the human brain at 7 T
2015
NMR in Biomedicine
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The same seven subjects were each examined twice using four different 7T MRsystems from two different vendors using an identical semi-LASER spectroscopy sequence. ...
Purpose-To harmonize data acquisition and post-processing of single voxel proton magnetic resonance spectroscopy ( 1 H-MRS) at 7 Tesla (7T), and to determine metabolite concentrations, accuracy and reproducibility ...
Acknowledgments We would like to thank the staff of all contributing institutes for their help in arranging and planning the examinations. ...
doi:10.1002/nbm.3252
pmid:25581510
pmcid:PMC4339538
fatcat:isj3y2yoabg2pb6ppvpj7p6m4a
In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism
2022
Metabolites
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Magnetic resonance spectroscopy (MRS) is a non-invasive and non-ionizing technique, enabling in vivo investigation of cardiac metabolism in normal and diseased hearts. ...
sequences. ...
as multi-voxel magnetic resonance spectroscopic imaging (MRSI) or chemical shift imaging (CSI) [13, 14] . ...
doi:10.3390/metabo12020189
pmid:35208262
pmcid:PMC8877606
fatcat:hifjisrcyfga7nwz54jbssjuv4
Osprey: Open-Source Processing, Reconstruction & Estimation of Magnetic Resonance Spectroscopy Data
[article]
2020
bioRxiv
pre-print
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Processing and quantitative analysis of magnetic resonance spectroscopy (MRS) data are far from standardized and require interfacing with third-party software. ...
Results: Osprey successfully loads, processes, models, and quantifies MRS data acquired with a variety of conventional and spectral editing techniques. ...
is a new, open-source software environment for the pre-processing, linear-combination modelling, quantification and visualization of magnetic resonance spectroscopy data. ...
doi:10.1101/2020.02.12.944207
fatcat:cb6wekhlyfetfh3a5sz24dohta
On the reproducibility of hippocampal MEGA-sLASER GABA MRS at 7T using an optimized analysis pipeline
2020
Magnetic Resonance Materials in Physics, Biology and Medicine
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The increased spectral dispersion of ultra-high-field spectroscopy allows for reproducible spectral quantification, despite a very broad line width. ...
However, the low concentration and the overlap of more prominent resonances hamper GABA quantification using MR spectroscopy. The hippocampus plays a pivotal role in neurodegeneration. ...
For the optimization process of s , two different preprocessing routines were used. Standard processing (SR) was similar to the processing applied in a recent multi-site study [18] . ...
doi:10.1007/s10334-020-00879-9
pmid:32865653
pmcid:PMC8154804
fatcat:62iphwbi6rhololh5ae4dwn5t4
NIfTI-MRS format specification
2021
Zenodo
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Data format specification for the NIfTI-MRS file format. NIfTI-MRS is a NIfTI derived format for storing magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) data. ...
Documentation for the format is available online. ...
Whilst a DICOM standard for MRS exists, it is not fully implemented by the vendors, and other DICOM 'hacks' for MRS have resulted in crucial information being stored inconsistently between vendors or contained ...
doi:10.5281/zenodo.5084789
fatcat:e4m57xnb4veo3iyzbkoweoauqa
Fully automated macromolecule suppressed single voxel glutamate spectroscopy (FAMOUS SVGS)
2016
Journal of Translational Medicine
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Methods: Here we describe a new localized proton MRS method "Fully Automated MacrOmolecUle Suppressed Single Voxel Glutamate Spectroscopy (FAMOUS SVGS)" for measuring Glu. ...
Purpose: The aim of the study was to develop and validate a new localized 1 H MRS pulse sequence and automated post-processing software for the quantification of brain Glutamate (Glu) in clinical conditions ...
Tiejun Zhao from Siemens for providing FASTMAP WIP.
Competing interests The authors declare that they have no competing interests.
Funding ...
doi:10.1186/s12967-016-0970-1
pmid:27456699
pmcid:PMC4960747
fatcat:nkxbfdzz5rb6hhw6w7dkiwu6ca
3D GABA imaging with real-time motion correction, shim update and reacquisition of adiabatic spiral MRSI
2014
NeuroImage
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Magnetic resonance spectroscopy (MRS) is the only way to measure GABA and Glu noninvasively in vivo. GABA detection is particularly challenging and requires special MRS techniques. ...
The most popular is MEscher-GArwood (MEGA) difference editing with single-voxel Point RESolved Spectroscopy (PRESS) localization. ...
Resources provided to Martinos Center by the Center for Functional Neuroimaging Technologies, P41EB015896, a P41 Regional Resource supported by the National Institute of Biomedical Imaging and Bioengineering ...
doi:10.1016/j.neuroimage.2014.09.032
pmid:25255945
pmcid:PMC4312209
fatcat:sq3d5ijqt5enrei2pbihmmcjba
Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement
2013
Journal of Cardiovascular Magnetic Resonance
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Rapid innovations in cardiovascular magnetic resonance (CMR) now permit the routine acquisition of quantitative measures of myocardial and blood T1 which are key tissue characteristics. ...
At present, ECV and native T1 mapping appear sufficiently robust for many diseases; yet more research is required before a large-scale application for clinical decision-making can be recommended. ...
Establish site normative values for the particular
set-up (vendor/field strength/magnet/contrast
regime/sequence variant and patient population
(age/gender)).
ii. ...
doi:10.1186/1532-429x-15-92
pmid:24124732
pmcid:PMC3854458
fatcat:2oosc5odgjf3dpinnhjb245fpq
Guidelines for Acquiring and Reporting Clinical Neurospectroscopy
2013
Seminars in neurology
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resonance spectroscopy (MRS) of the brain, or neurospectroscopy, has moved from the realm of academic research into that of the clinical world. ...
A standard operating procedure used across the three sites is described and high reproducibility across different platforms is shown. ...
The variance issue, in turn, has inhibited Table 1 Clinical Indications for Magnetic Resonance Spectroscopy 1. ...
doi:10.1055/s-0032-1331814
pmid:23361487
fatcat:6ukzagnqt5bghnzy4gnjhr5m6a
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