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Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group

Neda Jahanshad, Peter V. Kochunov, Emma Sprooten, René C. Mandl, Thomas E. Nichols, Laura Almasy, John Blangero, Rachel M. Brouwer, Joanne E. Curran, Greig I. de Zubicaray, Ravi Duggirala, Peter T. Fox (+19 others)
2013 NeuroImage  
As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data  ...  The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic  ...  This work from the ENIGMA-DTI working group lays the foundation to select phenotypes for large future multi-site joint-analytic genetic association studies with DTI data.  ... 
doi:10.1016/j.neuroimage.2013.04.061 pmid:23629049 pmcid:PMC3729717 fatcat:j4q3mc76wzbazexgmsz7xybx3a

Genetics of the Connectome and the ENIGMA Project [chapter]

Paul M. Thompson, Derrek P. Hibar, Jason L. Stein, Gautam Prasad, Neda Jahanshad
2016 Micro-, Meso- and Macro-Connectomics of the Brain  
At the time of writing, ENIGMA involves over 500 scientists from 185 institutions worldwide, working together on around 30 projects to discover factors that may help or harm the brain.  ...  Here we give an overview of a worldwide effort, called the ENIGMA Consortium (http://enigma.ini.usc.edu), which unites scientists worldwide to determine how variants in our genetic code influence the brain  ...  ENIGMA's working groups, such as the ENIGMA-DTI and EEG working groups, among others.  ... 
doi:10.1007/978-3-319-27777-6_10 fatcat:dubvdtd4frftblsfki3fcsgvxy

Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium [article]

Emily Dennis, Seth E Disner, Negar Fani, Lauren E Salminen, Mark Logue, Emily K Clarke-Rubright, Courtney C Haswell, Christopher Averill, Lee A Baugh, Jessica Bomyea, Steven E Bruce, Jiook Cha (+95 others)
2019 bioRxiv   pre-print
In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,049 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint  ...  partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium).  ...  Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group.  ... 
doi:10.1101/677153 fatcat:3uzwtu6zwrforacronrlofa35i

Peak width of skeletonized mean diffusivity (PSMD) as marker of widespread white matter tissue damage in multiple sclerosis

C. Vinciguerra, A. Giorgio, J. Zhang, I. Di Donato, M.L. Stromillo, R. Tappa Brocci, A. Federico, M.T. Dotti, N. De Stefano
2019 Multiple Sclerosis and Related Disorders  
DTI data were obtained from a total of 20,005 individuals aged 46 18.1 to 92.6 years and analyzed with the same pipeline for computing DTI metrics.  ...  Here, we gathered and meta-analyzed 43 cross-sectional diffusion tensor imaging (DTI) data from 10 population-based cohort studies 44 in order to establish the time course of white matter water diffusion  ...  Multi-site genetic analysis of diffusion 498 images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group. Brouwer RM, Curran JE, de Zubicaray GI, et al.  ... 
doi:10.1016/j.msard.2018.11.011 fatcat:7dnedeu5xnezvc2byiipp3jiem

White matter brain aging In Relationship to Schizophrenia and Its Cognitive Deficit [article]

Jingtao Wang, Peter Kochunov, Hemalatha Sampath, Kathryn S. Hatch, Meghann C. Ryan, Fuzhong Xue, Jahanshad Neda, Thompson Paul, Britta Hahn, James Gold, James Waltz, L. Elliot Hong (+1 others)
2020 bioRxiv   pre-print
We used machine learning model to predict individual age from diffusion tensor imaging features and calculated the delta age (Δage) as the difference between predicted and chronological age.  ...  Followed feature selection, a machine learning model was trained with fractional anisotropy values in 34 of 43 tracts on a training set consisted of 107 healthy controls (HC).  ...  Multi-site genetic analysis 1 of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI 2 working group.  ... 
doi:10.1101/2020.10.19.344879 fatcat:bsg542pfzzd6tjkt4uhpwndd6u

BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study

Christine Hammans, Kristina Neugebauer, Vinod Kumar, Lea Mevissen, Melanie A. Sternkopf, Ana Novakovic, Tobias Wensing, Ute Habel, Ted Abel, Thomas Nickl-Jockschat
2020 Frontiers in Psychiatry  
We investigated a possible correlation between BDNF serum levels, fiber tract architecture, and regional grey matter volumes in 19 schizophrenia patients and a gender- and age-matched control group.  ...  These findings of our pilot study are encouraging leads for future research in larger samples.  ...  Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data.  ... 
doi:10.3389/fpsyt.2020.00031 pmid:32153434 pmcid:PMC7046752 fatcat:fmziftkeqjcoxicdi4mhzneue4

Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice

Ola Ozernov-Palchik, Xi Yu, Yingying Wang, Nadine Gaab
2016 Current Opinion in Behavioral Sciences  
This work was funded by 1R01HD065762 and 1R01HD067312 (NICHD), the William Hearst Fund, Harvard Catalyst (5UL1RR025758), the Charles Hood foundation and a pilot grant from Boston Children's Hospital (all  ...  Acknowledgments We thank Nikola Nowack, Meaghan Mauer, Talia Raney, Udani Sandanayaka, and Jennifer Zuk for their assistance with the manuscript.  ...  Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage. 2013; 81:455-469. [PubMed: 23629049] 25.  ... 
doi:10.1016/j.cobeha.2016.05.006 pmid:27766284 pmcid:PMC5066307 fatcat:cqk5nnw4nbccpdvmtm4g7kidxm

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  Conclusions: The combination of photoactivatable neuropeptides and genetically-encoded optical neuropeptide sensors enable experiments into the spatiotemporal dynamics of neuropeptidergic signaling in  ...  This promising line of research has led to the creation of the ENIGMA Brain Age working group, part of the broader ENIGMA network, an international collaboration of imaging genomics.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

Panel and Study Groups

2013 Neuropsychopharmacology  
A number of these changes are associated with genetic variation some of which are associated with increased risk for schizophrenia.  ...  Although the expression in GAD67 expression is probably one of the most replicated findings to date, there have been relatively few studies of this finding with respect to genetic variation or brain development  ...  Conclusions: We also report updates from the ENIGMA schizophrenia and bipolar working groups, that have uncovered unsuspected patterns in disease profiles, by integrating neuroimaging and genetics on a  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

ACNP 57th Annual Meeting: Poster Session III

2018 Neuropsychopharmacology  
Diffusion tensor imaging (DTI) showed that higher SASP index was related to lower FA and higher mean diffusivity in specific brain tracts (e.g., the cingulate bundle [FA, r = -0.15, p = 0.04; MD, r = 0.50  ...  SASP biomarkers were derived from proteomic panel measured by multiplex immunoassay, and the SASP index was derived the regression analysis from a previously published study.  ...  Methods: This study used multi-site, multimodal imaging (diffusion MRI, dMRI, and structural MRI, sMRI) with a cohort of 52 controls and 147 MDD patients.  ... 
doi:10.1038/s41386-018-0268-5 fatcat:wiooxnisvfhovadauljiso4ie4

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial  ...  We injected a total dose of 10 μg of LPS at a concentration of 1 μg/μl, and an Neuropsychopharmacology (2016) 41, S455-S630  ...  We collected multi-shell diffusion imaging magnetic resonance imaging (dMRI) imaging before and after the set of infusions on a Siemens Prisma scanner with the following parameters: 1.5mm3 voxel, 30 direction  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

ACNP 59th Annual Meeting: Poster Session I

2020 Neuropsychopharmacology  
This work contributes to the understanding of noradrenergic drugs as therapeutic aids for PTSD patients.  ...  Neurochemical analyses were performed on the brains of postnatal offspring using high-performance liquid chromatography and protein concentration analysis.  ...  DTI was processed using ENIGMA-DTI analysis pipeline to measure whole-brain and regional white matter fractional anisotropy (FA) values in 24 tracts.  ... 
doi:10.1038/s41386-020-00890-7 pmid:33279934 pmcid:PMC7735198 fatcat:mqfz5f66vfbuvdbnrj7b2jt334