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Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA–DTI working group
2013
NeuroImage
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As part of an ENIGMA-DTI working group, we analyzed high-resolution FA images from multiple imaging sites across North America, Australia, and Europe, to address the challenge of harmonizing imaging data ...
The ENIGMA (Enhancing NeuroImaging Genetics through Meta-Analysis) Consortium was set up to analyze brain measures and genotypes from multiple sites across the world to improve the power to detect genetic ...
This work from the ENIGMA-DTI working group lays the foundation to select phenotypes for large future multi-site joint-analytic genetic association studies with DTI data. ...
doi:10.1016/j.neuroimage.2013.04.061
pmid:23629049
pmcid:PMC3729717
fatcat:j4q3mc76wzbazexgmsz7xybx3a
Genetics of the Connectome and the ENIGMA Project
[chapter]
2016
Micro-, Meso- and Macro-Connectomics of the Brain
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At the time of writing, ENIGMA involves over 500 scientists from 185 institutions worldwide, working together on around 30 projects to discover factors that may help or harm the brain. ...
Here we give an overview of a worldwide effort, called the ENIGMA Consortium (http://enigma.ini.usc.edu), which unites scientists worldwide to determine how variants in our genetic code influence the brain ...
ENIGMA's working groups, such as the ENIGMA-DTI and EEG working groups, among others. ...
doi:10.1007/978-3-319-27777-6_10
fatcat:dubvdtd4frftblsfki3fcsgvxy
Altered White Matter Microstructural Organization in Post-Traumatic Stress Disorder across 3,049 Adults: Results from the PGC-ENIGMA PTSD Consortium
[article]
2019
bioRxiv
pre-print
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In an effort to find reliable effects, we present a multi-cohort analysis of dMRI metrics across 3,049 individuals from 28 cohorts currently participating in the PGC-ENIGMA PTSD working group (a joint ...
partnership between the Psychiatric Genomics Consortium and the Enhancing NeuroImaging Genetics through Meta-Analysis consortium). ...
Multi-site
genetic analysis of diffusion images and voxelwise heritability analysis: A pilot project of the
ENIGMA-DTI working group. ...
doi:10.1101/677153
fatcat:3uzwtu6zwrforacronrlofa35i
Peak width of skeletonized mean diffusivity (PSMD) as marker of widespread white matter tissue damage in multiple sclerosis
2019
Multiple Sclerosis and Related Disorders
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DTI data were obtained from a total of 20,005 individuals aged 46 18.1 to 92.6 years and analyzed with the same pipeline for computing DTI metrics. ...
Here, we gathered and meta-analyzed 43 cross-sectional diffusion tensor imaging (DTI) data from 10 population-based cohort studies 44 in order to establish the time course of white matter water diffusion ...
Multi-site genetic analysis of diffusion 498 images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI working group. Brouwer RM, Curran JE, de Zubicaray GI, et al. ...
doi:10.1016/j.msard.2018.11.011
fatcat:7dnedeu5xnezvc2byiipp3jiem
White matter brain aging In Relationship to Schizophrenia and Its Cognitive Deficit
[article]
2020
bioRxiv
pre-print
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We used machine learning model to predict individual age from diffusion tensor imaging features and calculated the delta age (Δage) as the difference between predicted and chronological age. ...
Followed feature selection, a machine learning model was trained with fractional anisotropy values in 34 of 43 tracts on a training set consisted of 107 healthy controls (HC). ...
Multi-site genetic analysis 1 of diffusion images and voxelwise heritability analysis: A pilot project of the ENIGMA-DTI 2 working group. ...
doi:10.1101/2020.10.19.344879
fatcat:bsg542pfzzd6tjkt4uhpwndd6u
BDNF Serum Levels are Associated With White Matter Microstructure in Schizophrenia - A Pilot Study
2020
Frontiers in Psychiatry
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We investigated a possible correlation between BDNF serum levels, fiber tract architecture, and regional grey matter volumes in 19 schizophrenia patients and a gender- and age-matched control group. ...
These findings of our pilot study are encouraging leads for future research in larger samples. ...
Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. ...
doi:10.3389/fpsyt.2020.00031
pmid:32153434
pmcid:PMC7046752
fatcat:fmziftkeqjcoxicdi4mhzneue4
Lessons to be learned: how a comprehensive neurobiological framework of atypical reading development can inform educational practice
2016
Current Opinion in Behavioral Sciences
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This work was funded by 1R01HD065762 and 1R01HD067312 (NICHD), the William Hearst Fund, Harvard Catalyst (5UL1RR025758), the Charles Hood foundation and a pilot grant from Boston Children's Hospital (all ...
Acknowledgments We thank Nikola Nowack, Meaghan Mauer, Talia Raney, Udani Sandanayaka, and Jennifer Zuk for their assistance with the manuscript. ...
Multi-site genetic analysis of diffusion images and voxelwise heritability analysis: a pilot project of the ENIGMA-DTI working group. Neuroimage. 2013; 81:455-469. [PubMed: 23629049] 25. ...
doi:10.1016/j.cobeha.2016.05.006
pmid:27766284
pmcid:PMC5066307
fatcat:cqk5nnw4nbccpdvmtm4g7kidxm
ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups
2019
Neuropsychopharmacology
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The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology. ...
Conclusions: The combination of photoactivatable neuropeptides and genetically-encoded optical neuropeptide sensors enable experiments into the spatiotemporal dynamics of neuropeptidergic signaling in ...
This promising line of research has led to the creation of the ENIGMA Brain Age working group, part of the broader ENIGMA network, an international collaboration of imaging genomics. ...
doi:10.1038/s41386-019-0544-z
pmid:31801977
pmcid:PMC6957922
fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
Panel and Study Groups
2013
Neuropsychopharmacology
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A number of these changes are associated with genetic variation some of which are associated with increased risk for schizophrenia. ...
Although the expression in GAD67 expression is probably one of the most replicated findings to date, there have been relatively few studies of this finding with respect to genetic variation or brain development ...
Conclusions: We also report updates from the ENIGMA schizophrenia and bipolar working groups, that have uncovered unsuspected patterns in disease profiles, by integrating neuroimaging and genetics on a ...
doi:10.1038/npp.2013.278
fatcat:expu2u3f3reypazj7tt7jhybfa
ACNP 57th Annual Meeting: Poster Session III
2018
Neuropsychopharmacology
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Diffusion tensor imaging (DTI) showed that higher SASP index was related to lower FA and higher mean diffusivity in specific brain tracts (e.g., the cingulate bundle [FA, r = -0.15, p = 0.04; MD, r = 0.50 ...
SASP biomarkers were derived from proteomic panel measured by multiplex immunoassay, and the SASP index was derived the regression analysis from a previously published study. ...
Methods: This study used multi-site, multimodal imaging (diffusion MRI, dMRI, and structural MRI, sMRI) with a cohort of 52 controls and 147 MDD patients. ...
doi:10.1038/s41386-018-0268-5
fatcat:wiooxnisvfhovadauljiso4ie4
ACNP 55th Annual Meeting: Poster Session III
2016
Neuropsychopharmacology
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In our presentation last year at the ACNP, we reported a) the pharmacological characterization of the COX-1 and COX-2 radioligands using in vitro enzymatic assays in monkey and human blood, and b) initial ...
We injected a total dose of 10 μg of LPS at a concentration of 1 μg/μl, and an Neuropsychopharmacology (2016) 41, S455-S630 ...
We collected multi-shell diffusion imaging magnetic resonance imaging (dMRI) imaging before and after the set of infusions on a Siemens Prisma scanner with the following parameters: 1.5mm3 voxel, 30 direction ...
doi:10.1038/npp.2016.242
fatcat:4efd43swjbboranfrcs3pp32h4
ACNP 59th Annual Meeting: Poster Session I
2020
Neuropsychopharmacology
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This work contributes to the understanding of noradrenergic drugs as therapeutic aids for PTSD patients. ...
Neurochemical analyses were performed on the brains of postnatal offspring using high-performance liquid chromatography and protein concentration analysis. ...
DTI was processed using ENIGMA-DTI analysis pipeline to measure whole-brain and regional white matter fractional anisotropy (FA) values in 24 tracts. ...
doi:10.1038/s41386-020-00890-7
pmid:33279934
pmcid:PMC7735198
fatcat:mqfz5f66vfbuvdbnrj7b2jt334