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Multi-Omics Model Applied to Cancer Genetics
2021
International Journal of Molecular Sciences
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In fact, it is essential to providing general theoretical information on genomics, epigenomics, and transcriptomics to understand the phases of multi-omics approach. ...
We consider how to create a multi-omics model. In the last section, we describe the new frontiers and future perspectives of this field. ...
Hypermethylation of CpG islands in the promoter region of a tumor suppressor or otherwise cancer-related gene is often associated with transcriptional silencing of the related gene. ...
doi:10.3390/ijms22115751
pmid:34072237
fatcat:xo4fgxhu5faupcvs4oi3yvbywy
The current issues and future perspective of artificial intelligence for developing new treatment strategy in non-small cell lung cancer: harmonization of molecular cancer biology and artificial intelligence
2021
Cancer Cell International
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However, integrated analysis of multi-omics data is extremely labor intensive, making the development of new analysis technology indispensable. ...
Recently, a variety of new findings have been reported based on multi-omics analysis in combination with various clinical information. ...
Acknowledgements The authors would like to thank Enago (www. enago. jp) for the English language review. ...
doi:10.1186/s12935-021-02165-7
pmid:34446006
pmcid:PMC8393743
fatcat:ksvydxnfnnehfno2qbtdeagcgm
Molecular subtyping of colorectal cancer: Recent progress, new challenges and emerging opportunities
2018
Seminars in Cancer Biology
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Also prominent in CRC are mutations in the TP53 tumor suppressor gene, which play a crucial role in cell proliferation and apoptosis [45, 46] . ...
A more precise understanding of the biological properties that distinguish patients with colorectal tumors, especially in terms of their clinical features, is a key requirement towards a more robust, targeted-drug ...
A major difference is that most sporadic MSI tumors evolve via hypermethylation of the MLH1 gene promoter, while Lynch syndrome tumors primarily acquire MSI through germline mutations in one of the MMR ...
doi:10.1016/j.semcancer.2018.05.002
pmid:29775690
pmcid:PMC6240404
fatcat:jtfffdfoznenfmigdydgekqxby
Current Insights and Advancements in Head and Neck Cancer: Emerging Biomarkers and Therapeutics with Cues from Single Cell and 3D Model Omics Profiling
2021
Frontiers in Oncology
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Bioinformatic tools are used for study of differentially expressed genes and further omics data analysis. ...
In the final analysis, this review suggests that the development of improved target-specific personalized therapies can combat HNC's global plight. ...
ACKNOWLEDGMENTS We would like to thank Souvik Sur, Ritish Syanti, Titas Mondal and Ashwani for contribution to the ideas in the manuscript. ...
doi:10.3389/fonc.2021.676948
pmid:34490084
pmcid:PMC8418074
fatcat:vv54u3q4e5f4vlha35a4bk2ma4
The Role of Network Science in Glioblastoma
2021
Cancers
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In the particular case of cancer genomics, network discovery is challenged by the multitude of available high-dimensional heterogeneous views of data. ...
Identifying the architecture of molecular GBM networks is essential to understanding the information flow and better informing drug development and pre-clinical studies. ...
cancer subtype identification from multi-omics data, which are obtained by combining features' ranking in the network and their expression variation. ...
doi:10.3390/cancers13051045
pmid:33801334
pmcid:PMC7958335
fatcat:24qpogtftvekvekcvkx6luqie4
Omics analyses provide insights to CART cell therapy resistance
2021
Journal of Translational Genetics and Genomics
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Resistance to CART cell therapy can be mediated by the cancer cells, the tumor microenvironment, or the patient's T cells. ...
In this review, we will outline lessons learned from multi-omics studies (1) to identify biomarkers of response or toxicity to CART cell therapy or (2) to develop biomarker-guided therapeutic interventions ...
It was not until the 1970s that we began to link these changes to specific genes. ...
doi:10.20517/jtgg.2021.06
fatcat:fwvsbiypfzawpf2rcozsv5qo2e
Epigenome dysregulation in cholangiocarcinoma
2018
Biochimica et Biophysica Acta - Molecular Basis of Disease
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Epigenomics is a fast-evolving field of research that has lately attracted considerable interest, mainly due to the reversibility of epigenetic marks. ...
Clinically, among solid tumors, the field is still limited. ...
This region is commonly deleted in different cancers and contains many tumor suppressor genes. ...
doi:10.1016/j.bbadis.2017.06.014
pmid:28645654
fatcat:c7lcwcicjrh2tenwguo74kzk6m
Precision Medicine: An Optimal Approach to Patient Care in Renal Cell Carcinoma
2022
Frontiers in Medicine
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Renal cell cancer (RCC) is a heterogeneous tumor that shows both intra- and inter-heterogeneity. ...
It is anticipated that combined efforts from all sectors involved will make PM accessible to RCC and other patients with cancer, making a tremendous positive leap on individualized treatment strategies ...
TABLE 1 | 1 Description of multi-omics data repositories related to cancer. ...
doi:10.3389/fmed.2022.766869
pmid:35775004
pmcid:PMC9237320
fatcat:2qy6l5ujmneedbzzcnf4lkmceu
Tumor Profiling at the Service of Cancer Therapy
2021
Frontiers in Oncology
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Cancer treatment options have evolved significantly in the past few years. ...
In this review, we will focus on how tumor profiling has evolved over the past decades to deliver more efficient and personalized treatment options, and how novel technologies can help us envisage the ...
Research on oncogenes and tumor suppressor genes (the two main types of genes in which mutations drive cancer development) has been strongly active since the first description of a cancer-causing mutation ...
doi:10.3389/fonc.2020.595613
pmid:33505911
pmcid:PMC7832432
fatcat:vvklzjond5d6fcbcnl33er6jk4
Cancer cell metabolism as new targets for novel designed therapies
2014
Future Medicinal Chemistry
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process of tumor development: the capability to sustain proliferative signaling, resistance to cell death, evasion of growth suppression, ability of replicative immortality, tumor-promoting inflammation ...
The advent of high-throughput technologies to amass an abundance of omic data, together with the development of new computational methods that allow the integration and analysis of omic data by using genome-scale ...
process of tumor development: the capability to sustain proliferative signaling, resistance to cell death, evasion of growth suppression, ability of replicative immortality, tumor-promoting inflammation ...
doi:10.4155/fmc.14.119
fatcat:cn2xqoern5do5op3bb3t4g2xda
Precision Medicine and Melanoma: Multi-Omics Approaches to Monitoring the Immunotherapy Response
2021
International Journal of Molecular Sciences
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processes underlying the biology of cancer; therefore, improving the tumor clinical management. ...
The recent multi-omics analyses (genomics, transcriptomics, proteomics, metabolomics, radiomics, etc.) and the technological evolution of data interpretation have allowed to identify and understand several ...
PTEN is an important tumor suppressor gene involved in cell growth, survival, and cell motility. ...
doi:10.3390/ijms22083837
pmid:33917181
pmcid:PMC8067863
fatcat:l273buhckbe3tkcitxmpcasfie
Knowledge-driven genomic interactions: an application in ovarian cancer
2014
BioData Mining
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Further, single-gene expression outcome prediction is limited for cancer evaluation since genes do not act in isolation, but rather interact with other genes in complex signaling or regulatory networks ...
Effective cancer clinical outcome prediction for understanding of the mechanism of various types of cancer has been pursued using molecular-based data such as gene expression profiles, an approach that ...
The results published here are in whole or part based upon data generated by The Cancer Genome Atlas pilot project established by the NCI and NHGRI. ...
doi:10.1186/1756-0381-7-20
pmid:25214892
pmcid:PMC4161273
fatcat:mx32nzzcnjdfpe3fuz3rpbb764
Molecular Classification of Renal Cell Carcinoma and Its Implication in Future Clinical Practice
2017
Kidney Cancer
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Here, we attempt to classify ccRCC based on contemporary molecular features with emphasis on their respective potential significance in clinical practice. ...
Metastatic RCC (mRCC) is lethal and refractory to conventional chemotherapeutic agents. ...
The gene set used to classify RCC tumors in ccA/ccB was then optimized and simplified by Brooks and colleagues using a centroid-based classification algorithm (called prediction analysis of microarray ...
doi:10.3233/kca-170008
pmid:30334000
pmcid:PMC6179110
fatcat:rdvdb3ivffcbdmtti6zfsccfpe
Immune-Related Mutational Landscape and Gene Signatures: Prognostic Value and Therapeutic Impact for Head and Neck Cancer
2021
Cancers
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This review aims to provide a holistic view on how the immune landscape dictates the tumor fate and vice versa, and how integrative analysis of multi-omics data contribute to our current knowledge on the ...
The availability of multi-omics data and emerging computational technologies facilitate not only a deeper understanding of the cellular composition in the tumor immune microenvironment but also enables ...
Conclusions and Perspectives The integrative analysis of multi-omics data is a powerful tool to elucidate immunerelated cellular and molecular profiles with a strong impact on cancer immune escape and ...
doi:10.3390/cancers13051162
pmid:33800421
pmcid:PMC7962834
fatcat:yak7rpzm6rbljchqjpgqfquimi
Liquid Biopsy Based Circulating Biomarkers in Metastatic Prostate Cancer
2022
Frontiers in Oncology
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castration sensitive prostate cancer (mCSPC) and castration resistant prostate cancer (mCRPC). ...
secretome from (circulating) tumor cells and tumor microenvironment in metastatic prostate cancer. ...
Job van Riet for his contribution to section 2.2 Genetic biomarkers. ...
doi:10.3389/fonc.2022.863472
pmid:35669415
pmcid:PMC9165750
fatcat:fxk6m5hvtnemlnw7zkdbsf3boy
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