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Multi-modal Validation Framework of Mitral Valve Geometry and Functional Computational Models [chapter]

Sasa Grbic, Thomas F. Easley, Tommaso Mansi, Charles H. Bloodworth, Eric L. Pierce, Ingmar Voigt, Dominik Neumann, Julian Krebs, David D. Yuh, Morten O. Jensen, Dorin Comaniciu, Ajit P. Yoganathan
2015 Lecture Notes in Computer Science  
Computational models of the mitral valve (MV) exhibit significant potential for patient-specific surgical planning.  ...  The validation of the underlying models will enhance modeling accuracy and confidence in the simulated results.  ...  Conclusion We extended the framework in [1] for validating geometrical and functional models of the mitral valve (MV) by utilizing a controlled in-vitro setup.  ... 
doi:10.1007/978-3-319-14678-2_25 fatcat:2p7ygormjvdmncintytljj3tu4

Multi-modal Pipeline for Comprehensive Validation of Mitral Valve Geometry and Functional Computational Models [chapter]

Dominik Neumann, Sasa Grbic, Tommaso Mansi, Ingmar Voigt, Jean-Pierre Rabbah, Andrew W. Siefert, Neelakantan Saikrishnan, Ajit P. Yoganathan, David D. Yuh, Razvan Ioan Ionasec
2014 Lecture Notes in Computer Science  
Computational models of valve function have been developed for these purposes.  ...  As a first step towards this aim, we propose an integrated pipeline for the validation of MV geometry and function models estimated in ex-vivo TEE data with respect to ex-vivo microCT data.  ...  Conclusion We proposed a novel complete pipeline for validating geometrical and functional models of the mitral valve utilizing a controlled ex-vivo setup capable of acquiring both high-resolution ex-vivo  ... 
doi:10.1007/978-3-642-54268-8_22 fatcat:jbuesfdnobhdlmdz5quudrnpla

Patient-Specific Modeling of the Heart: Applications to Cardiovascular Disease Management [chapter]

Razvan Ionasec, Ingmar Voigt, Viorel Mihalef, Saša Grbić, Dime Vitanovski, Yang Wang, Yefeng Zheng, Joachim Hornegger, Nassir Navab, Bogdan Georgescu, Dorin Comaniciu
2010 Lecture Notes in Computer Science  
We are developing patient-specific cardiac models, estimated from available multi-modal images, to enable advanced clinical applications for the management of cardiovascular disease.  ...  For emerging percutaneous and minimal invasive valve interventions, cardiac surgeons and interventional cardiologists can substantially benefit from automated patient selection and virtual valve implantation  ...  We developed a novel patient-specific modeling framework of the complete heart from multi-modal cardiac images to facilitate the management of cardiovascular disease.  ... 
doi:10.1007/978-3-642-15835-3_2 fatcat:343rbbpwhzcs5ebgo23eymutbq

Modelling mitral valvular dynamics-current trend and future directions

Hao Gao, Nan Qi, Liuyang Feng, Xingshuang Ma, Mark Danton, Colin Berry, Xiaoyu Luo
2017 International Journal for Numerical Methods in Biomedical Engineering  
Computational modelling aims to understand the biomechanics of human mitral valve and could lead to the development of new treatment, prevention and diagnosis of mitral valve diseases.  ...  However, the interest in mitral valve modelling is growing, and the sophistication level is increasing with the advanced development of computational technology and imaging tools.  ...  clinical imaging, lack of computational power, and complexity in multi-physics modelling.  ... 
doi:10.1002/cnm.2858 pmid:27935265 pmcid:PMC5697636 fatcat:hj2dlzlbknatlhd5sbllxqj5mm

Papillary Muscle Segmentation from a Multi-atlas Database: A Feasibility Study [chapter]

Benedetta Biffi, Maria A. Zuluaga, Sébastien Ourselin, Andrew M. Taylor, Silvia Schievano
2016 Lecture Notes in Computer Science  
Mitral valve regurgitation replacement could be benefited by the use of pre-surgical 3D models that would allow the clinician to better understand the patient's structural and functional information before  ...  Within the context of mitral valve planning, the papillary muscles represent an ideal landmark set as they can be clearly identified in both modalities.  ...  Mitral valve regurgitation replacement could be benefited by the use of pre-surgical 3D models that would allow the clinician to better understand the patient's structural and functional information before  ... 
doi:10.1007/978-3-319-28712-6_9 fatcat:nksfdybtojaqrbbkh42w3hzrwm

Fully automatic segmentation of the mitral leaflets in 3D transesophageal echocardiographic images using multi-atlas joint label fusion and deformable medial modeling

A.M. Pouch, H. Wang, M. Takabe, B.M. Jackson, J.H. Gorman, R.C. Gorman, P.A. Yushkevich, C.M. Sehgal
2014 Medical Image Analysis  
Comprehensive visual and quantitative analysis of in vivo human mitral valve morphology is central to the diagnosis and surgical treatment of mitral valve disease.  ...  population of subjects with normal valve morphology and mitral valve disease.  ...  ), the National Institutes of Health AG037376 from the NIA, and a grant from the Penn-Pfizer Alliance (10295).  ... 
doi:10.1016/j.media.2013.10.001 pmid:24184435 pmcid:PMC3897209 fatcat:4njupgibgzfjfj6jclamyjbyfy

Spatiotemporal Segmentation and Modeling of the Mitral Valve in Real-Time 3D Echocardiographic Images [chapter]

Alison M. Pouch, Ahmed H. Aly, Eric K. Lai, Natalie Yushkevich, Rutger H. Stoffers, Joseph H. Gorman, Albert T. Cheung, Joseph H. Gorman, Robert C. Gorman, Paul A. Yushkevich
2017 Lecture Notes in Computer Science  
The framework integrates multi-atlas label fusion and template-based medial modeling to generate quantitatively descriptive models of valve dynamics.  ...  As a step towards filling this knowledge gap, we present a novel framework for 4D segmentation and geometric modeling of the mitral valve in real-time 3D echocardiography (rt-3DE).  ...  Acknowledgments This work was funded by the National Institutes of Health: EB017255 and HL103723. Spatiotemporal Segmentation and Modeling of the Mitral Valve 753  ... 
doi:10.1007/978-3-319-66182-7_85 pmid:29285527 pmcid:PMC5743331 fatcat:meyjxndp5nanlfc4wufs2hqcmi

Morphologica l and Functional Modeling of the Heart Valves and Chambers [chapter]

Razvan Ioan Ionasec, Dime Vitanovski, Dorin Comaniciu
2011 Patient-Specific Modeling in Tomorrow's Medicine  
An integrated model of the four heart valves and chambers is introduced, which captures a large spectrum of morphologic, dynamic and pathologic variations.  ...  In this chapter we present a comprehensive framework for the patient-specific modeling of the valvular apparatus and heart chambers from multimodal cardiac images.  ...  At the center of the proposed approach is the dynamic valvular model introduced in section 2, which captures comprehensive patient-specific information of the morphology and functions from multi-modal  ... 
doi:10.1007/8415_2011_94 fatcat:ixrpdisqovgfdhchscvfwehp3e

Segmentation of the Aortic Valve Apparatus in 3D Echocardiographic Images: Deformable Modeling of a Branching Medial Structure [chapter]

Alison M. Pouch, Sijie Tian, Manabu Takabe, Hongzhi Wang, Jiefu Yuan, Albert T. Cheung, Benjamin M. Jackson, Joseph H. Gorman, Robert C. Gorman, Paul A. Yushkevich
2015 Lecture Notes in Computer Science  
3D echocardiographic (3DE) imaging is a useful tool for assessing the complex geometry of the aortic valve apparatus.  ...  However, its application to the entire aortic valve apparatus is limited since the structure has a branching medial geometry that cannot be explicitly parameterized in the original cm-rep framework.  ...  Acknowledgement This work was supported by the National Institutes of Health: HL119010, HL103723, and EB014346.  ... 
doi:10.1007/978-3-319-14678-2_20 pmid:26247062 pmcid:PMC4523230 fatcat:d7jsfpsi7zathofsttwwuswmre

A Framework for the Systematic Characterization of the Aortic Valve Complex by Real-Time Three Dimensional Echocardiography: Implications for Transcatheter Aortic Valve Replacement [chapter]

Daniel Zalkind, Michael Kim, Ernesto E.
2013 Hot Topics in Echocardiography  
LV and right ventricular dimensions and function, aortic regurgitation, and the structure and function of the other valves should be evaluated.  ...  Comparison of aortic root dimensions and geometries before and after transcatheter aortic valve implantation byand -dimensional tranesophageal echocardiography and multislice computed tomography.  ... 
doi:10.5772/56021 fatcat:w7msvfeyfffd3mlqoo34ts2o7m

A workflow for patient-specific fluid–structure interaction analysis of the mitral valve: A proof of concept on a mitral regurgitation case

Benedetta Biffi, Maurizio Gritti, Agata Grasso, Elena G. Milano, Marianna Fontana, Hamad Alkareef, Joseph Davar, Paramijit Jeetley, Carol Whelan, Sarah Anderson, Donatella Lorusso, Emilie Sauvage (+3 others)
2019 Medical Engineering and Physics  
Patient-specific computational models of the MV could provide a personalised understanding of MV mechanics, dysfunctions and possible interventions.  ...  The mechanics of the mitral valve (MV) are the result of the interaction of different anatomical structures complexly arranged within the left heart (LH), with the blood flow.  ...  The views expressed in this publication are those of the authors and not necessarily those of the National Health Service, the National Institute for Health Research or the Department of Health.  ... 
doi:10.1016/j.medengphy.2019.09.020 pmid:31653498 fatcat:kzoeuhrd5bhg5hnyuy65h4ycpu

Fluid-structure interactions of the mitral valve and left heart: Comprehensive strategies, past, present and future

Daniel R. Einstein, Facundo Del Pin, Xiangmin Jiao, Andrew P. Kuprat, James P. Carson, Karyn S. Kunzelman, Richard P. Cochran, Julius M. Guccione, Mark B. Ratcliffe
2010 International Journal for Numerical Methods in Biomedical Engineering  
The remodeling that occurs after a posterolateral myocardial infarction can alter mitral valve function by creating conformational abnormalities in the mitral annulus and in the posteromedial papillary  ...  in four broad categories: data collection, geometry, fluid-structure interaction and validation.  ...  Acknowledgments Research funded by the National Heart and Blood Institute Awards 5R01HL077921-03 and 1R01-HL084431-01A1 and 1RO1-HL073598-01A.  ... 
doi:10.1002/cnm.1280 pmid:20454531 pmcid:PMC2864615 fatcat:pafjz2oce5gujd5wdwa36t4euy

New insights into mitral heart valve prolapse after chordae rupture through fluid–structure interaction computational modeling

Andrés Caballero, Wenbin Mao, Raymond McKay, Charles Primiano, Sabet Hashim, Wei Sun
2018 Scientific Reports  
In this study, a fluid-structure interaction (FSI) modeling framework is implemented to investigate the impact of chordae rupture on the left heart (LH) dynamics and severity of MR.  ...  Mitral valve (MV) dynamics depends on a force balance across the mitral leaflets, the chordae tendineae, the mitral annulus, the papillary muscles and the adjacent ventricular wall.  ...  Acknowledgements This work was supported in part by the NIH HL104080 and HL127570 grants. Andrés Caballero is in part supported by a Fulbright-Colciencias Fellowship.  ... 
doi:10.1038/s41598-018-35555-5 pmid:30470812 pmcid:PMC6251907 fatcat:7ros42p3pvfnflyotz6oflmazi

Automated Segmentation and Geometrical Modeling of the Tricuspid Aortic Valve in 3D Echocardiographic Images [chapter]

Alison M. Pouch, Hongzhi Wang, Manabu Takabe, Benjamin M. Jackson, Chandra M. Sehgal, Joseph H. Gorman, Robert C. Gorman, Paul A. Yushkevich
2013 Lecture Notes in Computer Science  
Towards this goal, this work integrates template-based medial modeling and multi-atlas label fusion techniques to automatically delineate and quantitatively describe aortic leaflet geometry in 3D echocardiographic  ...  Given the importance of imagebased morphological assessment in the diagnosis and surgical treatment of aortic valve disease, there is considerable need to develop a standardized framework for 3D valve  ...  This research was supported by an American Heart Association pre-doctoral fellowship (10PRE3510014) and the National Institutes of Health: HL063954, HL073021, and HL103723 from the NHLBI; AG037376 from  ... 
doi:10.1007/978-3-642-40811-3_61 fatcat:ew4jhcgjorbnvc7ytksv3ce5re

Fast image-based mitral valve simulation from individualized geometry

Pierre-Frederic Villard, Peter E. Hammer, Douglas P. Perrin, Pedro J. del Nido, Robert D. Howe, Loughlin Clive
2018 International Journal of Medical Robotics and Computer Assisted Surgery  
Methods: We present a method to semi-automatically build a mitral valve computational model from micro CT (computed tomography) scans: after manually picking chordae fiducial points, the leaflets are segmented  ...  Results: We validate our method on three explanted porcine hearts and show that our model predicts the closed valve surface with point-to-surface error of appoximately 1mm, a reasonable coaptation surface  ...  [6] , the authors extracted the valve anatomy from a multi-slice CT scan of a human subject. The geometry included the mitral valve leaflets, the papillary muscles and 21 chordae.  ... 
doi:10.1002/rcs.1880 pmid:29356304 fatcat:nmjjmjuwyfaelaz5ike34td2ny
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