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Multi-level hypothesis testing for populations of heterogeneous networks [article]

Guilherme Gomes and Vinayak Rao and Jennifer Neville
2018 arXiv   pre-print
Specifically, we propose a hierarchical Bayesian hypothesis testing framework that models each population with a mixture of latent space models for weighted networks, and then tests populations of networks  ...  Our framework is capable of population-level, entity-specific, as well as edge-specific hypothesis testing.  ...  Contributions: Our contribution is a multi-level statistical hypothesis testing framework for populations of weighted networks, concerning both the overall graph distributions, as well as two types of  ... 
arXiv:1809.02512v1 fatcat:5paemnyl5ncctc2gi2tfgvigqq

Discovery of Multi-Level Network Differences Across Populations of Heterogeneous Connectomes [article]

Vivek Gopalakrishnan, Jaewon Chung, Eric Bridgeford, Benjamin D. Pedigo, Jesús Arroyo, Lucy Upchurch, G. Allan Johnson, Nian Wang, Youngser Park, Carey E. Priebe, Joshua T. Vogelstein
2022 arXiv   pre-print
These tests facilitate simultaneous analysis of multiple connectomes across different levels of network topology, enabling the robust and reproducible discovery of hierarchical brain structures that vary  ...  In addition to explaining the theoretical foundations and guarantees of our hypothesis tests, we demonstrate their superiority over current state-of-the-art connectomics methods through extensive simulation  ...  Formulation of statistical tests for multi-level inference We introduce our k-sample hypothesis tests below in a formal statistical framework.  ... 
arXiv:2011.14990v5 fatcat:3iqzmeyikfdupfjqdierrwibrm

Impact of bandwidth for various services in heterogeneous network and quality of service via communication technologies in Malaysian higher educational

Mohd Nazri ISMAIL, Abdullah Mohd ZIN
2007 Analele Universităţii "Dunărea de Jos" Galaţi: Fascicula III, Electrotehnică, Electronică, Automatică, Informatică  
Statistical Analysis using t-test shows that implementation of high speed bandwidth for Internet (WAN) achieved significant level.  ...  Frequency test are used to analyze the various services implementation via convergence of communication technologies in heterogeneous environment for retrieving information.  ...  utilization and QoS of network are well managed for multi-service traffic. 5.  ... 
doaj:5c89e344f5b443c49b19a54f5e969540 fatcat:ebeyrug5ufacbomxzczu7c25na

Hierarchical Modular Optimization of Convolutional Networks Achieves Representations Similar to Macaque IT and Human Ventral Stream

Daniel Yamins, Ha Hong, Charles F. Cadieu, James J. DiCarlo
2013 Neural Information Processing Systems  
In this work, we construct models of the ventral stream using a novel optimization procedure for category-level object recognition problems, and produce RDMs resembling both macaque IT and human ventral  ...  for visual object recognition.  ...  The intuitive idea of the HMO optimization procedure is that a good multi-stack heterogeneous network will be found by creating mixtures of single-stack components each of which specializes in a portion  ... 
dblp:conf/nips/YaminsHCD13 fatcat:uvky7s4qffdo3ijf3uuxrq4rhm

Presenting a Conceptual Model for Systematic Structure of Production in the Light of Various Structures of Supply Chain Network

Amir Parishani
2016 Mediterranean Journal of Social Sciences  
the disturbance terms Arch test for heterogeneity of variance was used.  ...  to determine the best function that can explain better structure the Durbin-Watson test for autocorrelation test, variance inflation test to check the alignment, Jrakbra test to check the normality of  ...  test for heterogeneity of variance was used.  ... 
doi:10.5901/mjss.2016.v7n2s2p9 fatcat:fehafzbgcjcz3jeirqj6w2unqy

Exports, Foreign Direct Investment, and Productivity: Evidence from German Firm Level Data

Joachim Wagner
2005 Social Science Research Network  
This paper presents the first empirical test with German establishment level data of a hypothesis derived by Helpman, Melitz and Yeaple in a model that explains the decision of heterogeneous firms to serve  ...  Using a non-parametric test for first order stochastic dominance it is shown that, in line with this hypothesis, the productivity distribution of foreign direct investors dominates that of exporters, which  ...  CONCLUSIONS This paper presents the first empirical test with German establishment level data of a hypothesis derived by Helpman, Melitz and Yeaple (2004) in a model that explains the decision of heterogeneous  ... 
doi:10.2139/ssrn.740251 fatcat:cdos5jsu5rhd3dqqvhxql444ee

Chaotic expression dynamics implies pluripotency: when theory and experiment meet

Chikara Furusawa, Kunihiko Kaneko
2009 Biology Direct  
Testing the hypothesis: To test the hypothesis, it is crucial to measure the time course of gene expression levels at the single-cell level by fluorescence microscopy and fluorescence-activated cell sorting  ...  By analyzing the time series of single-cell-level expression data, one can distinguish whether the variation in protein expression level over time is due only to stochasticity in expression dynamics or  ...  Ohnuma for discussion. This work was also supported in part by a grant from the Global COE (Centers of Excellence) of the Ministry of Education, Culture, Sports, Science and Technology, Japan.  ... 
doi:10.1186/1745-6150-4-17 pmid:19445676 pmcid:PMC2690595 fatcat:afejeln5onbydbelnp6jrcagre

Multi-scale model of epidemic fade-out: Will local extirpation events inhibit the spread of white-nose syndrome?

Suzanne M. O'Regan, Krisztian Magori, J. Tomlin Pulliam, Marcus A. Zokan, RajReni B. Kaul, Heather D. Barton, John M. Drake
2015 Ecological Applications  
Previous studies have identified risk factors for propagation of WNS over hibernaculum and landscape scales but none of these have tested the hypothesis that separation of spatial scales and disease-induced  ...  To test this hypothesis, we developed a mechanistic multi-scale model parameterized using white-nose syndrome county and site incidence data that connects hibernaculum-level susceptible-infectious-removed  ...  We thank Drew Kramer for valuable comments and members of the Drake lab for helpful discussions. We are grateful to several anonymous reviewers for valuable comments on the manuscript.  ... 
doi:10.1890/14-0417.1 pmid:26214909 fatcat:ubd3hplgpra5pkvdxjxy3krxfy

Potential Parasite Transmission in Multi-Host Networks Based on Parasite Sharing

Shai Pilosof, Serge Morand, Boris R. Krasnov, Charles L. Nunn, Andrew J. Yates
2015 PLoS ONE  
Epidemiological networks are commonly used to explore dynamics of parasite transmission among individuals in a population of a given host species.  ...  However, many parasites infect multiple host species, and thus multi-host networks may offer a better framework for investigating parasite dynamics.  ...  We thank the CERoPath Project team for sample collection and analysis. This is publication 851 of the Mitrani Department of Desert Ecology.  ... 
doi:10.1371/journal.pone.0117909 pmid:25748947 pmcid:PMC4352066 fatcat:7b2fiorlvbas7eviumr57w4ssy

Resilience through diversity: Lost neuronal heterogeneity in human epilepsy renders networks vulnerable to synchronous transitions [article]

Scott Rich, Homeira Moradi Chameh, J&eacuter&eacutemie Lefebvre, Taufik A Valiante
2021 bioRxiv   pre-print
Mathematical analyses based in mean-field theory reveal clear distinctions in the dynamical structure of networks with low and high heterogeneity, including the presence of multi-stability and saddle-node  ...  We provide in vitro, in silico, and mathematical support for this hypothesis.  ...  We provide in vitro, in silico, and mathematical support for this hypothesis.  ... 
doi:10.1101/2021.03.02.433627 fatcat:dvdhzttjl5cuflossbgwwywjuu

Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy

Irfana Muqbil
2013 Journal of Stem Cell Research & Therapy  
The cancer stem cell (CSC) hypothesis is increasingly being accepted as a model to explain for the functional heterogeneity that is commonly observed in solid tumors.  ...  According to this hypothesis, there exists a hierarchical organization of cells within the tumor, in which a differential subpopulation of stem-like cells is responsible for sustaining and recurrence of  ...  In order to explore this hypothesis, our group recently utilized network analysis to identify the set of target genes of this multi-faceted agent.  ... 
doi:10.4172/2157-7633.s7-005 pmid:24319631 pmcid:PMC3852409 fatcat:2hft5ra2r5g5xium6zfncz4hhe

Co-evolution of conventions and networks: An experimental study

Rense Corten, Vincent Buskens
2010 Social Networks  
We study the emergence of conventions in dynamic networks experimentally.  ...  We study how macro-level outcomes of the process in terms of Pareto-efficiency and heterogeneity depend on initial conditions. Moreover, we examine the underlying processes at the microlevel.  ...  To test Hypothesis 2.1, we compare the average efficiency between risk levels.  ... 
doi:10.1016/j.socnet.2009.04.002 fatcat:ajcmabaabbhyrdoytuyzcz3zai

Habitat heterogeneity induces rapid changes in the feeding behaviour of generalist arthropod predators

Karin Staudacher, Oskar Rennstam Rubbmark, Klaus Birkhofer, Gerard Malsher, Daniela Sint, Mattias Jonsson, Michael Traugott, Rana El-Sabaawi
2018 Functional Ecology  
in the entire network) and species level (d', degree of interaction specialization at the species level).  ...  The "habitat heterogeneity hypothesis" predicts positive effects of structural complexity on species coexistence.  ...  For comparison of treatment effects at the network level and at the species level, the H 2 ' index of network specialization and the d' index of specialization were calculated, respectively (Blüthgen,  ... 
doi:10.1111/1365-2435.13028 pmid:29657351 pmcid:PMC5887929 fatcat:ulkz3eu5bjgyvloblx5yy4bn2e

Examining the Association of Religious Context with Giving to Non-Profit Organizations

Pamala Wiepking, René H. F. P. Bekkers, Una O. Osili
2014 European Sociological Review  
We test two explanations for the relationship between giving and religious heterogeneity.  ...  We find support for the minority hypothesis that people belonging to a religious minority have a higher likelihood of giving but not for the group size hypothesis that the relative size of the religious  ...  Acknowledgements The authors would like to thank David Reinstein, Maurice Gesthuizen, Pearl Dykstra, the editor of ESR, and two anonymous reviewers for helpful suggestions on an earlier version of this  ... 
doi:10.1093/esr/jcu064 fatcat:wm3wasqkmjecxkhe6gk7y7ksui

Multi-scale network biology model & the model library

Jianghui Xiong, Jianghui Xiong
2011 Nature Precedings  
individual patient Cell death/growth Level Individual Cell Data Accessible Human population (via computation) Yeast (SGA); Human cell lines; Human population The pipeline Protein Network  ...  -Annotate -Benchmark/validate -Updating -Integrating The current models used for pre-clinical drug testing Do NOT accurately predict how new treatments will act in clinical trials -Heterogeneity  ...  The Perturbation Index of pair-wise combination of lung cancer agents  ... 
doi:10.1038/npre.2011.5778.1 fatcat:ddqnpvdvxjaujftqpkall7cu2q
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