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Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients

Mireille Nieuwenhuis, Hugo G. Schnack, Neeltje E. van Haren, Julia Lappin, Craig Morgan, Antje A. Reinders, Diana Gutierrez-Tordesillas, Roberto Roiz-Santiañez, Maristela S. Schaufelberger, Pedro G. Rosa, Marcus V. Zanetti, Geraldo F. Busatto (+8 others)
2017 NeuroImage  
Please cite this article as: Nieuwenhuis, M., et al., Multi-center MRI prediction models: Predicting sex and illness course in first episode psychosis patients, NeuroImage (2016), http://dx.  ...  The multi-center sample included brain structural MRI scans from 256 males and 133 females patients with first episode psychosis, acquired in five centers: University Medical Center Utrecht (The Netherlands  ...  Acknowledgements The Melbourne research was supported by grants from the National Health and Medical Research Council of Australia (Program Grants, IDs: 350241; 566529  ... 
doi:10.1016/j.neuroimage.2016.07.027 pmid:27421184 pmcid:PMC5193177 fatcat:6jvib2nm2bgpdiamc7gbo42kmu

Psychosis in Women: Time for Personalized Treatment

Marianna Mazza, Emanuele Caroppo, Domenico De Berardis, Giuseppe Marano, Carla Avallone, Georgios D. Kotzalidis, Delfina Janiri, Lorenzo Moccia, Alessio Simonetti, Eliana Conte, Giovanni Martinotti, Luigi Janiri (+1 others)
2021 Journal of Personalized Medicine  
The great variability in clinical onset, illness course, and response to pharmacological and psychosocial treatment is in great part gender-related.  ...  of the staging model of psychosis onset.  ...  It is widely recognized that schizophrenia and first-episode psychosis may show great variability in clinical onset, illness course, and response to pharmacological and psychosocial treatment [2] .  ... 
doi:10.3390/jpm11121279 pmid:34945748 pmcid:PMC8705671 fatcat:vlbaicmzk5emtnatkw6mq25uim

Prediction of Individual Differences from Neuroimaging Data

Vince D. Calhoun, Stephan M. Lawrie, Janaina Mourao-Miranda, Klaas E. Stephan
2017 NeuroImage  
Niewenhuys et al targets the important question whether multi-center structural brain imaging data can help predicting illness course in first episode psychosis patients.  ...  While predicting sex from brain structure was possible with high accuracy, illustrating the potential of the approach, predicting illness course proved to be more challenging.  ...  Moreover, they report a remarkable correspondence between representations in the layers of the model and in dorsal stream areas.  ... 
doi:10.1016/j.neuroimage.2016.12.012 pmid:28011043 pmcid:PMC5761318 fatcat:k7oahczrozbltgcqadbft7cxqm

Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning

A E Lyall, O Pasternak, D G Robinson, D Newell, J W Trampush, J A Gallego, M Fava, A K Malhotra, K H Karlsgodt, M Kubicki, P R Szeszko
2017 Molecular Psychiatry  
Free Water Imaging is a novel diffusion magnetic reasonance imaging (MRI) method that is able to separate changes affecting the extracellular space from those that reflect changes in neuronal cells and  ...  A previous Free Water Imaging study in schizophrenia identified significantly Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research  ...  The primary goal of the current study was to investigate whether increases in extracellular FW would be observed among patients experiencing a first episode of psychosis studied early in the course of  ... 
doi:10.1038/mp.2017.43 pmid:28348381 pmcid:PMC5617750 fatcat:dl4gcjjlgfft3pea2mry2peyli

First-episode psychosis research in India: A review

Vijaya Raghavan, Greeshma Mohan, Seema Jaiswal, Thara Rangaswamy
2018 Indian Journal Of Mental Health And Neurosciences  
Methods: A Boolean search of articles published from January 1990 to March 2018 in electronic database of PubMed and Google Scholar was carried out and original research studies done on first-episode psychosis  ...  With the growth of early intervention services for psychosis worldwide, it is imperative to understand the current knowledge on first-episode psychosis (FEP) from Indian context.  ...  ACKNOWLEDGEMENTS Post-Doctoral support is by the Fogarty International Training Program in Chronic Non-Communicable Diseases and Disorders at the University of Florida, Grant # 1D43TW009120 (L.  ... 
doi:10.32746/ijmhns.2018.v1.i1.2 fatcat:fxdefrs3b5ecblxukdzwydv2fy

Recent Advances and Future Directions in Brain MR Imaging Studies in Schizophrenia: Toward Elucidating Brain Pathology and Developing Clinical Tools

Shinsuke Koike, Akiko Uematsu, Daiki Sasabayashi, Norihide Maikusa, Tsutomu Takahashi, Kazutaka Ohi, Shinichiro Nakajima, Yoshihiro Noda, Yoji Hirano
2021 Magnetic Resonance in Medical Sciences  
In the future, we believe that combining a high-quality human MRI dataset with genetic data, randomized controlled trials, and MRI for non-human primates and animal models will enable us to understand  ...  In addition, compared to the disease and participant factors, machine and imaging protocol differences could affect MRI signals, which should be addressed in multi-site studies.  ...  This study was also supported by UTokyo Center for Integrative Science of Human Behavior (CiSHuB) and the World Premier International-International Research Center for Neurointelligence (WPI-IRCN).  ... 
doi:10.2463/mrms.rev.2021-0050 fatcat:x2cxiwkrsjazneezm2dyatoqm4

10–14 April, Orlando, Florida: A summary of topics and trends

Luis Alameda, Abhishekh Ashok, Suzanne Avery, Ali Bani-Fatemi, Susan Berkhout, Mike Best, Kelsey Bonfils, Marco Colizzi, Maria Dauvermann, Stefan Du Plessis, Dominic Dwyer, Emily Eisner (+27 others)
2019 Psychiatry Research  
The Schizophrenia International Research Society (SIRS) recently held its first North American congress, which took place in Orlando, Florida from 10-14 April 2019.  ...  A collection of these reports is summarized and presented below and highlights the main themes and topics that emerged during the congress.  ...  The findings suggest that the connectivity of these networks is preserved in first episode psychosis, but markedly reduced in patients with chronic illness.  ... 
doi:10.1016/j.psychres.2019.112672 pmid:31780184 fatcat:t5abnoixhfdkdb45olhmlxk3nq

Fronto-Parietal Gray Matter Volume Loss Is Associated with Decreased Working Memory Performance in Adolescents with a First Episode of Psychosis

Marta Rapado-Castro, Mara Villar-Arenzana, Joost Janssen, David Fraguas, Igor Bombin, Josefina Castro-Fornieles, Maria Mayoral, Ana González-Pinto, Elena de la Serna, Mara Parellada, Dolores Moreno, Beatriz Paya (+4 others)
2021 Journal of Clinical Medicine  
We aimed to assess this relationship in a subsample of 33 adolescents with first-episode EOP and 47 matched controls over 2 years.  ...  Studies examining longitudinal brain changes and cognitive performance in psychosis lend support for an altered development of high-order cognitive functions, which parallels progressive gray matter (GM  ...  Science and Innovation (Instituto de Salud Carlos III), co-financed by EDRF funds from the EU, and the Fundación Alicia Koplowitz AG-P is employed by the University of the Basque Country and has been  ... 
doi:10.3390/jcm10173929 pmid:34501377 fatcat:n4n2xgyt4vcdbey2arpfwnvpty

Classifying Schizophrenia Using Multimodal Multivariate Pattern Recognition Analysis: Evaluating the Impact of Individual Clinical Profiles on the Neurodiagnostic Performance

Carlos Cabral, Lana Kambeitz-Ilankovic, Joseph Kambeitz, Vince D. Calhoun, Dominic B. Dwyer, Sebastian von Saldern, Maria F. Urquijo, Peter Falkai, Nikolaos Koutsouleris
2016 Schizophrenia Bulletin  
in patients with SZ and healthy controls (HC).  ...  In addition the results of RS based moderator analysis showed that age of patients, as well as their age at the illness onset were the most important clinical features.  ...  Acknowledgments In addition, we are thankful that Carlos Cabral and Lana Kambeitz-Ilankovic were supported in the analysis and writing of this manuscript through the EU-FP7 project PRONIA ("Personalised  ... 
doi:10.1093/schbul/sbw053 pmid:27460614 pmcid:PMC4960438 fatcat:lopn66ff7jgo5n6c2s6uo4awzm

Precision Nomothetic Medicine in Depression Research: A New Depression Model, and New Endophenotype Classes and Pathway Phenotypes, and A Digital Self

Michael Maes
2022 Journal of Personalized Medicine  
and medical treatments to endophenotype subgroups of depressed patients in order to achieve the best clinical outcome for each individual.  ...  Machine learning approaches, such as soft independent modeling of class analogy (SIMCA) and pathway analysis, were introduced in depression research in the 1990s (Maes et al.) to construct neuroimmune  ...  Conflicts of Interest: The author has no conflict of interest with any commercial or other association in connection with the submitted article.  ... 
doi:10.3390/jpm12030403 pmid:35330403 pmcid:PMC8955533 fatcat:ufeyv24gezgoxlneoummknweki

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge
2021 Antioxidants  
Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes occur many years before the first episode of schizophrenia; these are not reversible after the illness onset.  ...  We propose in-vivo GSH quantification for patient selection in forthcoming antioxidant trials in psychosis.  ...  recruitment for the data reported in Figure 1 .  ... 
doi:10.3390/antiox10111703 pmid:34829575 pmcid:PMC8615159 fatcat:rdpymsl6qrcklgtbm4otnqtuau

A multivariate neuromonitoring approach to neuroplasticity-based computerized cognitive training in recent onset psychosis

Shalaila S. Haas, Linda A. Antonucci, Julian Wenzel, Anne Ruef, Bruno Biagianti, Marco Paolini, Boris-Stephan Rauchmann, Johanna Weiske, Joseph Kambeitz, Stefan Borgwardt, Paolo Brambilla, Eva Meisenzahl (+5 others)
2020 Neuropsychopharmacology  
in recent onset psychosis (ROP) patients.  ...  This model was out-of-sample cross-validated in the ROP patients from the CCT trial to assess associations between rsFC pattern change, cognitive gains and SP during CCT.  ...  Clinical recruitment and data preprocessing for this project have been carried out in the scope of the doctoral thesis of SSH at Ludwig Maximilian University and International Max Planck Research School  ... 
doi:10.1038/s41386-020-00877-4 pmid:33027802 fatcat:jorql52aabbhfayimdnfxk3gze

Research in people with psychosis risk syndrome: a review of the current evidence and future directions

Christoph U. Correll, Marta Hauser, Andrea M. Auther, Barbara A. Cornblatt
2010 Journal of Child Psychology and Psychiatry and Allied Disciplines  
The chronic illness course in most individuals, greater treatment responsiveness during the first episode, progressive grey matter decline during early disease stages, and retrospective accounts of "prodromal  ...  of illness; 5) follow-up of patients who developed schizophrenia despite early interventions and comparison of illness trajectories with patients who did not receive early interventions; 6) characterization  ...  The chronic and relapsing illness course in most individuals with schizophrenia, greater treatment responsiveness during the first episode of psychosis, documented progressive grey matter decline during  ... 
doi:10.1111/j.1469-7610.2010.02235.x pmid:20214698 pmcid:PMC3085111 fatcat:burp3hgblrfbpggp6s7wvmybbq

7th European Conference on Schizophrenia Research: Time for precision medicine?

2019 European Archives of Psychiatry and Clinical Neuroscience  
Apathy is present in individuals at risk for psychosis, early onset schizophrenia, first episode psychosis (FEP) and during the following course of illness.  ...  Included in this pool of patients are clinical high-risk states to multi-episode course of the disease. A.  ...  first episode psychosis.  ... 
doi:10.1007/s00406-019-01045-6 fatcat:4tbfk4p4yngqto7uxhrdczle54

The 4th Schizophrenia International Research Society Conference, 5–9 April 2014, Florence, Italy: A summary of topics and trends

Olukayode Abayomi, Davide Amato, Candace Bailey, Byron Bitanihirwe, Lynneice Bowen, Shimon Burshtein, Alexis Cullen, Montserrat Fusté, Ana P. Herrmann, Babak Khodaie, Sanja Kilian, Qortni A. Lang (+19 others)
2014 Schizophrenia Research  
Anne O'Shea collected the reports and put them in to one manuscript in order and organized the references. Dr. DeLisi then edited the manuscript for accuracy, language and scholarship.  ...  In addition, the following report provides an overview of the conference for those who were present, but could not participate in all sessions, and those who did not have the opportunity to attend, but  ...  Acknowledgments The information in this report and the accuracy of each statement were the sole responsibility of each rapporteur and based on personal interpretation of what was heard.  ... 
doi:10.1016/j.schres.2014.08.032 pmid:25306204 pmcid:PMC4394607 fatcat:lhwpf5jvd5g2hlsutb44qojrvi
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