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TWAIL (Milletlerarası Hukuka Üçüncü Dünya Yaklaşımları) Nedir?

Makau Mutua, Muhammed Beheşti Aydoğan, Muharrem Çelik
2020 Public and Private International Law Bulletin  
Üçüncü Dünya toplumları arasında geniş bir çeşitlilik olsa da Üçüncü Dünya terimi, direniş ve kurtuluşa yönelik stratejik bir paradigmanın parçası olarak tarihselleşmiştir. 32 Bu nedenle "Üçüncü Dünya"  ...  Ayrıca Üçüncü Dünya devleti olmak ve bunun şartları ile milletlerarası hukuk arasındaki sorunlu etkileşim ve Üçüncü Dünya'nın Batı'ya süregelen bağımlılığını araştırmaktadır.  ... 
doi:10.26650/ppil.2020.40.1.0034 fatcat:7lpeqvwg6jdoxh2xvinmpswree

Left Sided Acute Appendicitis in Pregnant Woman: A Case Report

Muhammed Zübeyr Üçüncü, Merve Müge Üçüncü
2016 Turkish Journal of Colorectal Disease  
Zübeyr Üçüncü, Design: Merve Müge Üçüncü, Data Collection or Processing: Merve Müge Üçüncü, Analysis or Interpretation: Merve Müge Üçüncü, Literature Search: Muhammed Zübeyr Üçüncü, Writing: Muhammed  ...  Zübeyr Üçüncü.  ... 
doi:10.4274/tjcd.08860 fatcat:53blvxf5sjejxga47e47porb34

Design of Photosensitizing Agents for Targeted Antimicrobial Photodynamic Therapy

Maxime Klausen, Muhammed Ucuncu, Mark Bradley
2020 Molecules  
Photodynamic inactivation of microorganisms has gained substantial attention due to its unique mode of action, in which pathogens are unable to generate resistance, and due to the fact that it can be applied in a minimally invasive manner. In photodynamic therapy (PDT), a non-toxic photosensitizer (PS) is activated by a specific wavelength of light and generates highly cytotoxic reactive oxygen species (ROS) such as superoxide (O2−, type-I mechanism) or singlet oxygen (1O2*, type-II mechanism).
more » ... Although it offers many advantages over conventional treatment methods, ROS-mediated microbial killing is often faced with the issues of accessibility, poor selectivity and off-target damage. Thus, several strategies have been employed to develop target-specific antimicrobial PDT (aPDT). This includes conjugation of known PS building-blocks to either non-specific cationic moieties or target-specific antibiotics and antimicrobial peptides, or combining them with targeting nanomaterials. In this review, we summarise these general strategies and related challenges, and highlight recent developments in targeted aPDT.
doi:10.3390/molecules25225239 pmid:33182751 pmcid:PMC7696090 fatcat:sxt5k4kdmngqdgk6sdyomrugsq

Evaluation Knowledge, Attitude, and Behaviour for Breast Cancer among Young Women Living in Two Different Habitats of Turkey

Muhammed Zübeyr Üçüncü, Merve Müge Üçüncü, Dilek Toprak
2018 Asian Pacific Journal of Cancer Prevention  
Breast cancer is the most frequently diagnosed cancer among women in Turkey and worldwide, and is ranked as the second-leading cause of death in women after lung cancer. Early diagnosis of breast cancer is possible, and breast cancer is included in cancer-screening programs in Turkey. The aim of this study was to evaluate the knowledge, attitude, and behaviour of young women (older than 20 years of age) on breast self-examination and breast cancer screening methods, and to determine the effect
more » ... f sociodemographic characteristics. Methods: A total of 489 patients were included in the study. The mean age of participants was 36.53 ± 11.22 years. 346 (70.8%) of the participants were married. The study was a cross-sectional, non-randomized study in public health. The participants in this study were women over 20 years old, who presented to Arnavutkoy State Hospital General surgery policlinic and Sisli Hamidiye Etfal Family Medicine policlinic. Results: The rate and duration of breastfeeding were higher among participants living in rural areas than those living in urban areas (p<0.001) The awareness of breast cancer increased as the level of education increased (p<0.001). Having a family history of a high incidence of breast cancer significantly increased the rate of breast self examination practice by 1.93 fold (p=0.016). Conclusion: Breast Cancer is a disease that can be treated 100 % with early diagnosis. Primary care physicians especially works in lower socioeconomic conditions have to tell the importance of early diagnosis of breast cancer, and properly explain breast self examination and other screening tools.
doi:10.31557/apjcp.2018.19.11.3179 pmid:30486608 fatcat:rfgp7qh6vzetlojawmupljktaa

Our Therapeutic Approach to Idiopathic Granulomatous Mastitis

Süleyman Bademler, Muhammed Zubeyr Ucuncu
2018 Anadolu Kliniği Tıp Bilimleri Dergisi  
Aim: Granulomatous mastitis is a rare disease of the breast. Initial findings during admission can be mistaken for breast cancer. In this study, we aimed to present our experience with idiopathic granulomatous mastitis (IGM). Materials and Methods: Patients who had been treated and followed up after a diagnosis of GM at the surgical clinic of the Istanbul University Institute of Oncology between 2007 and 2017 were categorized into two groups: those who had received steroid treatment only (Group
more » ... 1), and those who had received steroids in combination with surgical treatment (Group 2). The groups were compared in terms of clinical and demographic characteristics and recurrence rates. Findings: We included a total of seventy-nine patients in our study. The mean patient age was 36.41±6.93 years and the mean follow-up 57.34±20.39 months. There was no significant difference between the two groups in terms of mean age, age at menarche, maternal age at first delivery, and the side involved (right, left, bilateral). The disease had recurred in 19 patients in Group 1 while no recurrence had been observed in Group 2 (p=0.001). Discussion and Conclusion: IGM is a disease that is rare but easily mistakable for breast cancer. The diagnosis necessitates confirmation through a biopsy. Steroid therapy combined with surgery can be the first choice in the treatment of this disease, on which no consensus has yet been reached. Such combination is capable of reducing recurrence rates.
doi:10.21673/anadoluklin.418775 fatcat:u5vbhwxh6bhnrfuslnktofiz2q

Wash‐free , peptide‐based fluorogenic probes for microbial imaging

Assel Baibek, Muhammed Üçüncü, Elizabeth A. Blackburn, Mark Bradley, Annamaria Lilienkampf
2020 Peptide Science  
Peptides with pan-antimicrobial affinity were synthesized and decorated with environmentally sensitive fluorophores nitrobenzoxadiazole (green) and merocyanine (red). The labeling efficacies against a range of clinically relevant fungal and Gram-negative and positive bacterial species (Candida albicans, Escherichia coli, and Staphylococcus aureus) were explored. The fluorogenic probes containing exclusively L or D-amino acids showed rapid and efficient labeling of all microbial species, whereas
more » ... probes with a mixture of L or D-amino acids failed to label fungi or bacteria,
doi:10.1002/pep2.24167 fatcat:tml5b52vqfbmbpcfmvhywu22uq

0-6 YAŞ GRUBU ÇOCUĞU OLAN ANNELERİN EV KAZALARI VE KORUNMA YOLLARI KONUSUNDAKİ BİLGİ, TUTUM VE DAVRANIŞLARI İLE SOSYODEMOGRAFİK ÖZELLİKLERİN BUNA ETKİSİ

Müge Üçüncü, Muhammed Üçüncü, Dilek Toprak
2019 İstanbul Tıp Fakültesi Dergisi  
ÖZET Amaç: Çocuk ölümleri arasında kazalar giderek önemli bir sorun olmaya başlamıştır. Bu çalışmada, 0-6 yaş grubu çocuğu olan annelerin çocukların ev kazalarını bilme ve bu kazalardan korunma yolları konusunda bilgi ve tutumlarının değerlendirilmesini amaçladık. Gereç ve Yöntem: Prospektif, tek merkezli, tanımlayıcı-analitik olarak yapılan çalışmamıza Şubat-Mart 2016 tarihleri arasında Şişli Hamidiye Etfal Eğitim ve Araştırma Hastanesi Aile Hekimliği Polikliniği'ne başvuran 217 kişi dahil
more » ... di. Tarafımızdan hazırlanan anket formu birebir görüşülerek dolduruldu. SPSS 19,0 programında analizler yapıldı. Bulgular: Çalışmamıza katılan annelerin yaş ortalaması 33,32±5,64 idi. Eğitim seviyesi yüksek olan ve gelir düzeyi yüksek olan annelerin ev kazaları bilme durumları daha fazlaydı (p<0,001, p<0,001). Ev içerisinde yaşayan kişi ve çocuk sayısı arttıkça annelerin ev kazalarını bilme ve güvenlik önlemi alma durumları azalmaktaydı. Güvenlik önlemleri tanılama ölçeğinden 35 yaş altı, eğitim seviyesi yüksek ve tek çocuğu olan anneler daha fazla puan almıştı (p=0,005, p=0,009, p=0,017). Sonuç: Ev kazaları kaynaklı ölüm ve sakatlıkların artması nedeniyle bu konuda toplumsal bilinçlenme ve işbirliği şarttır. Ebeveynlerin, özellikle de annelerin, kazalardan korunma konusunda bilgilendirilmesi ve çocuklarına verecekleri eğitim, kazalardan korunma konusunda desteklenmesi büyük önem arz etmektedir. Anahtar Kelimeler: Çocuklarda ev kazaları, güvenlik önlemleri, birinci basamak ABSTRACT Objective: Accidents have become an increasingly important cause of child deaths in both developed and developing countries. In this study, we aimed to evaluate the knowledge and attitudes of mothers of children in the the 0-6 age group on ways of protecting them accidents at home. Material and Methods: A prospective, single-center, descriptive-analytical study was conducted between February 2016 and March 2016. The study included 217 people at Şişli Hamidiye Etfal Training and Research Hospital Family Medicine Polyclinic. Results: The average age of mothers in our study was 33.32±5.64 years. Mothers with higher levels of education and with high incomes were found to have more knowledge about home accidents (p<0.001, p<0.001). As the number of children and people living in the house increased, the mother's knowledge of home accidents and security precautions decreased. Mothers aged ≥35 years with a high educational level who had one child scored more points on the Scale of Recognizing Security Measures (p=0.005, p=0.009, p=0.017). Conclusion: Social awareness and business cooperation should be raised in the prevention of home accidents. Parents' knowledge of precautions against accidents -especially mothers who spend most of their time with children -and the education they give their children is key for protection against accidents.
doi:10.26650/iuitfd.2018.0011 fatcat:rzuyogayn5gyjk7j6aajjw5o2a

A Ratiometric Fluorescent Probe for Gold and Mercury Ions

Muhammed Üçüncü, Erman Karakuş, Mustafa Emrullahoğlu
2015 Chemistry - A European Journal  
Af luorescent probe that displays ar atiometric fluorescence response towardsg old and mercury ions has been devised. Emittinga tarelativelyl onger wavelength, the conjugatedf orm of the fluorescent dye transformsi n the presence of the gold or mercury ions into an ew dye, the molecular structure of which lacks the conjugation and consequently emits at ad istinctly shorter wavelength.
doi:10.1002/chem.201502411 pmid:26227744 fatcat:usbpikrdrfh4hcua7w7gvqg6ca

Dyeing Fungi: Amphotericin B Based Fluorescent Probes for Multiplexed Imaging

Assel Baibek, Muhammed Üçüncü, Bryn Short, Gordon Ramage, Annamaria Lilienkampf, Mark Bradley
2021 Chemical Communications  
The clinically used antifungal polyene Amphotericin B was conjugated, via the mycosamine and the aglycon moieties, to fluorophores. The Cy5 conjugated probe showed selective labelling of fungi in the presence...
doi:10.1039/d0cc08177a pmid:33491716 fatcat:mwmse7mnovcofiyxpqmebgaqiq

Our Experience with Desmoid Tumors

Metin Keskin, Muhammed Zübeyr Üçüncü, Ecem Memişoğlu, Adem Bayraktar, Emre Balık, Mehmet Türker Bulut
2016 Turkish Journal of Colorectal Disease  
Zübeyr Üçüncü, Metin Keskin, Literatür Arama: Metin Keskin, Muhammed Zübeyr Üçüncü, Adem Bayraktar, Yazan: Metin Keskin, Muhammed Zübeyr Üçüncü, Ecem Memişoğlu.  ...  Balık, Türker Bulut, Konsept: Metin Keskin, Emre Balık, Türker Bulut, Dizayn: Metin Keskin, Emre Balık, Türker Bulut, Veri Toplama veya İşleme: Ecem Memişoğlu, Adem Bayraktar, Analiz veya Yorumlama: Muhammed  ... 
doi:10.4274/tjcd.25993 fatcat:xorrbinqszd7pngrozbq6abdoq

Beklenmedik bir klinik görüntü ile ortaya çıkan tiroid bezi primer skuamöz hücreli karsinomu

Korhan Kılıç, Muhammed Sedat Sakat, Harun Üçüncü
2019 Ege Tıp Dergisi  
doi:10.19161/etd.416023 fatcat:h3nwtscnqvhqzfqbijht73jcve

Multifunctional, Histidine-tagged Polymers: Antibody Conjugation and Signal Amplification

Yichuan Zhang, Alessia Gambardella, Muhammed Üçüncü, Jin Geng, Jessica Clavadetscher, Mark Bradley, Annamaria Lilienkampf
2020 Chemical Communications  
A polymer scaffold, with multiple reactive centres, was synthesised by RAFT polymerisation and conjugated to the antibody Herceptin. A hexahistidine RAFT agent enabled the rapid and simple purification of polymer–protein...
doi:10.1039/d0cc04591h pmid:33084632 fatcat:kegi6p3vuffmdesuooak5y6l4q

A BODIPY aldoxime-based chemodosimeter for highly selective and rapid detection of hypochlorous acid

Mustafa Emrullahoğlu, Muhammed Üçüncü, Erman Karakuş
2013 Chemical Communications  
A BODIPY-based fluorescent probe integrated with an aldoxime unit shows a remarkable fluorescence "turn-on" response to hypochlorous acid (HOCl). The oxidative dehydrogenation of BODIPY aldoxime by HOCl results in a distinct fluorescence enhancement as well as a change in color from red to orange.
doi:10.1039/c3cc44463e pmid:23887624 fatcat:tldiqntipjdxdmpektahcioovq

Clinical Significance of Serum Membrane-Bound Mucin-2 Levels in Breast Cancer

Suleyman Bademler, Alisan Zirtiloglu, Murat Sari, Muhammed Ucuncu, Elif Dogru, Senem Karabulut
2019 Biomolecules  
This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and the relationship with tumour progression and known prognostic parameters. We enrolled 127 female patients with histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 levels were measured by the enzyme-linked immunosorbent assay (ELISA) method and compared with those of 40 age and sex-matched healthy controls. Median age of
more » ... sis was 50 (range: 26–78). Twenty-eight (22%) patients were metastatic and the most frequent site of metastasis was bone (n = 17, 61%). The median serum MUC2 level of BC patients was significantly higher than that of the controls (198 vs. 54 ng/mL, p < 0.001). There was no significant difference between patients and controls according to known disease-related clinicopathological or laboratory parameters (p > 0.05). Serum MUC2 levels were not associated with survival (p = 0.65). Although serum MUC2 levels might have a diagnostic role, their predictive and prognostic role in survival in BC patients was not detected. Serum levels of MUC2 should be investigated for diagnostic or screening purposes on a larger scale.
doi:10.3390/biom9020040 pmid:30682816 pmcid:PMC6406351 fatcat:vetdtttfirg67cita447hl5lyq

Diagnostic and Prognostic Significance of Carboxypeptidase A4 (CPA4) in Breast Cancer

Suleyman Bademler, Muhammed Zubeyr Ucuncu, Ceren Tilgen Vatansever, Murat Serilmez, Hakan Ertin, Hasan Karanlık
2019 Biomolecules  
Recent research focused on prolonged survival has suggested that carboxypeptidase A4 (CPA4) plays a role in both tumor microenvironment formation and distant metastasis in cancer. In some patients, serum and expression (mRNA) levels of CPA4 have been found to be correlated with the aggressiveness and progression of the disease. Accordingly, we conducted a first study to investigate the diagnostic and prognostic significance of CPA4 in the case of breast cancer (BC), the most common form of
more » ... nancy in women. The study included a total of 50 patients with BC and 20 healthy women as the control group. The participants' serum CPA4 levels were determined by the ELISA test, and, for assessment of CPA4 mRNA, we used the PCR method. The serum CPA4 (p = 0.001) and CPA4 mRNA (p = 0.015) levels were found to be statistically significantly higher in the controls, compared to the patient group. When the results of patient group were statistically analyzed based on subgrouping by tumor characteristics, the measured CPA4 mRNA levels showed significant difference with respect to the molecular subtype (p = 0.006), pN status (p = 0.023), and pathological stage (p = 0.039), while the serum CPA4 measurements differed significantly in terms of pathological type only (p = 0.024). We conclude that CPA4 is diagnostically and prognostically not futile when used in combination with the other considerations and measurements in breast cancer.
doi:10.3390/biom9030103 pmid:30875843 pmcid:PMC6468575 fatcat:zjpxm3omgvb5nnj7gmxzqjkapq
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