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A soft wearable robot for tremor assessment and suppression

J.A. Gallego, E. Rocon, J. Ibanez, J.L. Dideriksen, A.D. Koutsou, R. Paradiso, M.B. Popovic, J.M. Belda-Lois, F. Gianfelici, D. Farina, D.B. Popovic, M. Manto (+2 others)
2011 2011 IEEE International Conference on Robotics and Automation  
First results demonstrate the performance of the TREMOR neurorobot as a novel means of assessing and attenuating pathological tremors.  ...  In this context, this paper presents the concept design, development, and preliminary validation of a soft wearable robot for tremor assessment and suppression.  ...  allowing for tremor attenuation.  ... 
doi:10.1109/icra.2011.5979639 dblp:conf/icra/GallegoRIDKPPBGFPMDP11 fatcat:uw5cw5usijb35k44thlpnu4gam

Adenosine is crucial for deep brain stimulation–mediated attenuation of tremor

Lane Bekar, Witold Libionka, Guo-Feng Tian, Qiwu Xu, Arnulfo Torres, Xiaohai Wang, Ditte Lovatt, Erika Williams, Takahiro Takano, Jurgen Schnermann, Robert Bakos, Maiken Nedergaard
2007 Nature Medicine  
Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating tremor and other movement disorders 1-3 .  ...  Intrathalamic infusion of A1 receptor agonists directly reduces tremor, whereas adenosine A1 receptor-null mice show involuntary movements and seizure at stimulation intensities below the therapeutic level  ...  Deep brain stimulation (DBS) is a widely used neurosurgical approach to treating tremor and other movement disorders [1] [2] [3] .  ... 
doi:10.1038/nm1693 pmid:18157140 fatcat:vqpiycazwzaq5j3phsuy4paxee

Novel Functional MRI Task for Studying the Neural Correlates of Upper Limb Tremor

Frederique M. C. Boonstra, Thushara Perera, Gustavo Noffs, Cassandra Marotta, Adam P. Vogel, Andrew H. Evans, Helmut Butzkueven, Bradford A. Moffat, Anneke van der Walt, Scott C. Kolbe
2018 Frontiers in Neurology  
Tremor of the upper limbs is a disabling symptom that is present during several neurological disorders and is currently without treatment.  ...  However, no adequately or standardized protocols for fMRI exists at present. Here we present a novel, online available fMRI task that could be used to assess the in vivo pathology of tremor.  ...  Tremor is one of the most common movement disorders and is a symptom of many neurological disorders including PD, ET, and MS (37, 38) .  ... 
doi:10.3389/fneur.2018.00513 pmid:30013508 pmcid:PMC6036145 fatcat:aiykppvwxbcyrnk64p4jtetfny

Diagnosis and therapy of functional tremor a systematic review illustrated by a case report

Michael Bartl, Rebekka Kewitsch, Mark Hallett, Martin Tegenthoff, Walter Paulus
2020 Neurological Research and Practice  
Background Diagnosis of functional movement disorders and specifically functional tremor (FT) (representing 50% of them) remains demanding.  ...  Additionally, due to heterogeneity of the disorders, structured concepts and guidelines for diagnosis and therapy are difficult to establish.  ...  Acknowledgements We thank the patient for the support and the possibility to publish the case report.  ... 
doi:10.1186/s42466-020-00073-1 pmid:33324935 pmcid:PMC7713151 fatcat:vaibc7csnvcxrj2ep7ss2i74py

Bioinformatic Approaches Used in Modelling Human Tremor

Manto Mario, Grimaldi Giuliana, Lorivel Thomas, Farina Dario, Popovic Lana, Conforto Silvia, D'Alessio Tommaso, Belda-Lois Juan-Manuel, Pons Jose-Luis, Rocon Eduardo
2009 Current Bioinformatics  
Tremor is a common movement disorder, for which pharmacological and neurophysiological models have been developed these last 3 decades, and which is at the frontier of biology, health sciences and computer  ...  In particular, algorithms for instantaneous assessments of oscillations and direct online cancellations have been suggested.  ...  A novel technique for the study of tremor was presented.  ... 
doi:10.2174/157489309788184747 fatcat:kts5h6kgxzchfb6ejxgiprl4jy

Acute effects of thalamic deep brain stimulation and thalamotomy on sensorimotor cortex local field potentials in essential tremor

Ellen L. Air, Elena Ryapolova-Webb, Coralie de Hemptinne, Jill L. Ostrem, Nicholas B. Galifianakis, Paul S. Larson, Edward F. Chang, Philip A. Starr
2012 Clinical Neurophysiology  
Following thalamotomy, theta and beta (13-30 Hz) was increased in M1. Induction of postural tremor reduced M1 theta, alpha and beta activity compared to the resting state.  ...  for therapeutic efficacy.  ...  Acknowledgments This study was supported by the NIH (R01 NS069779 to P.A.S.) and an educational grant for fellowship training to Dr. Air from Medtronic Inc. Dr. Air receives consulting fees from St.  ... 
doi:10.1016/j.clinph.2012.04.020 pmid:22633916 pmcid:PMC3577937 fatcat:m2mkui25hfhtpipcooi5wfrole

Substantia Nigra Volume Dissociates Bradykinesia and Rigidity from Tremor in Parkinson's Disease: A 7 Tesla Imaging Study

Kathleen L. Poston, Matthew A. I. Ua Cruadhlaoich, Laura F. Santoso, Jeffrey D. Bernstein, Tian Liu, Yi Wang, Brian Rutt, Geoffrey A. Kerchner, Michael M. Zeineh
2020 Journal of Parkinson's Disease  
Non-invasive in vivo 7.0T QSM may serve as a biomarker in longitudinal studies of SN atrophy and in studies of people at risk for developing PD.  ...  In postmortem analysis of late stage Parkinson's disease (PD) neuronal loss in the substantial nigra (SN) correlates with the antemortem severity of bradykinesia and rigidity, but not tremor.  ...  CONFLICTS OF INTEREST Dr. Poston has received consulting fees from Allergan and Curasen, and research grants from Sanofi. Dr. Wang has share ownership in Medimagemetric LLC to disclose. Dr.  ... 
doi:10.3233/jpd-191890 pmid:32250317 fatcat:7icogvpgwbe7fjkt3pjmweea3m

On-Off Tremor Suppression Orthosis with Electromagnetic Brake

Gil Herrnstadt, Carlo Menon
2013 International Journal of Mechanical Engineering and Mechatronics  
Pathological tremor is a common neurological movement disorder characterized by involuntary rhythmic oscillation of body parts.  ...  A MEMS gyro signal is processed to assess the tremor component. The system successfully reduces tremor amplitude with over 88% of tremor signal power reduction.  ...  Acknowledgements This work is supported by the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC) and the International Essential Tremor  ... 
doi:10.11159/ijmem.2013.002 fatcat:wk24ygzbrzhtlijw4tl7ur6vby

How to Tackle Tremor – Systematic Review of the Literature and Diagnostic Work-Up

A. W. G. Buijink, M. F. Contarino, J. H. T. M. Koelman, J. D. Speelman, A. F. van Rootselaar
2012 Frontiers in Neurology  
Tremor is the most prevalent movement disorder in clinical practice.  ...  Studies that were included investigated the value and/or usability of diagnostic tests for tremor.  ...  However, this has not been assessed for differentiating ET from PD. Also, the effect of a levodopa trial on tremor has not been assessed separately.  ... 
doi:10.3389/fneur.2012.00146 pmid:23109928 pmcid:PMC3478569 fatcat:go5pach4zzdjpfhq4wms5bzc2e

Principles of Electrophysiological Assessments for Movement Disorders

Kai-Hsiang Stanley Chen, Robert Chen
2020 Journal of Movement Disorders  
Electrophysiological studies can provide objective and quantifiable assessments of movement disorders.  ...  They are useful in the diagnosis of hyperkinetic movement disorders, particularly tremors and myoclonus.  ...  In this review, we will outline the basic settings and techniques used in electrophysiological studies for movement disorders, data analysis techniques and the typi-cal response patterns corresponding  ... 
doi:10.14802/jmd.19064 pmid:31986867 pmcid:PMC6987526 fatcat:uux2nof5m5c6reuot3ytb6q4xy

A neuroprosthesis for tremor management through the control of muscle co-contraction

Juan Álvaro Gallego, Eduardo Rocon, Juan Manuel Belda-Lois, José Luis Pons
2013 Journal of NeuroEngineering and Rehabilitation  
Pathological tremor is the most prevalent movement disorder.  ...  Results: The neuroprosthesis attained significant attenuation of tremor (p < 0.001), and reduced its amplitude up to a 52.33 ± 25.48%.  ...  A more profound investigation of this phenomenon is needed, and would require from the integration of electromyographic (EMG) recordings and advanced signal processing techniques-to remove the artifacts  ... 
doi:10.1186/1743-0003-10-36 pmid:23587119 pmcid:PMC3661364 fatcat:fgn44fy2nfbgjkj5th7n3ktuqa

DIMETER: A Haptic Master Device for Tremor Diagnosis in Neurodegenerative Diseases

Roberto González, Antonio Barrientos, Jaime del Cerro, Benito Coca
2014 Sensors  
In this study, a device based on patient motion capture is developed for the reliable and non-invasive diagnosis of neurodegenerative diseases.  ...  Here, we first present a literature review of the methods used to detect and evaluate tremor; then, we describe the DIMETER device in terms of the software and hardware used and the battery of tests developed  ...  Acknowledgments The authors would like to thank the doctors who participated in the study for their cooperation and support during the tests, especially Carlos Magariños, Roberto Figueiras (Ramon y Cajal  ... 
doi:10.3390/s140304536 pmid:24608001 pmcid:PMC4003956 fatcat:srah4p7ofjevjhum2ayv3wk7fa

Evaluation of movement and brain activity

Mark Hallett, Lourdes M. DelRosso, Rodger Elble, Raffaele Ferri, Fay B. Horak, Stephan Lehericy, Martina Mancini, Masao Matsuhashi, Riki Matsumoto, Muthuraman Muthuraman, Jan Raethjen, Hiroshi Shibasaki
2021 Clinical Neurophysiology  
Clinical neurophysiology studies can contribute important information about the physiology of human movement and the pathophysiology and diagnosis of different movement disorders.  ...  This review, initiating a series of articles on this topic, focuses on the methods and techniques.  ...  Acknowledgements Some sections of the article are similar to the corresponding sections in the Handbook of Clinical Neurophysiology, Volume 1 (Hallett, 2003) , since this is intended to be an update of  ... 
doi:10.1016/j.clinph.2021.04.023 pmid:34488012 pmcid:PMC8478902 fatcat:lxtcdawk4ngqblxy5plaig355q

Clinical Intervention Using Focused Ultrasound (FUS) Stimulation of the Brain in Diverse Neurological Disorders

Hongchae Baek, Daniel Lockwood, Emily Jo Mason, Emmanuel Obusez, Matthew Poturalski, Richard Rammo, Sean J. Nagel, Stephen E. Jones
2022 Frontiers in Neurology  
Various surgical techniques and pharmaceutical treatments have been developed to improve the current technologies of treating brain diseases.  ...  It can deliver acoustic energy through the physical barrier of the brain and eliminate abnormal brain cells to treat patients with Parkinson's disease and essential tremor.  ...  ACKNOWLEDGMENTS We thank Megan Griffiths for editorial review.  ... 
doi:10.3389/fneur.2022.880814 pmid:35614924 pmcid:PMC9124976 fatcat:h5g4ro2fbfdwhc63hpcvtr6soa

Anaesthesia and deep brain stimulation

Barkha Bindu, Parmod Bithal
2016 Journal of Neuroanaesthesiology and Critical Care  
AbstractDeep brain stimulation (DBS) is becoming an increasingly popular minimally invasive surgical procedure for various movement disorders, especially Parkinson's disease.  ...  This review article discusses the surgical procedure of DBS, devices currently available, perioperative anaesthetic concerns and techniques, effect of anaesthetic drugs on microelectrode recordings and  ...  In 1975, the concept of stimulation rather than ablation of deep brain structures for treatment of movement disorders emerged. DBS was first developed in 1987 by Professor and Neurosurgeon Dr.  ... 
doi:10.4103/2348-0548.190064 fatcat:wk5fgcue3vdpjcpte3qzjnwgu4
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