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Morphological changes in secondary, but not primary, sensory cortex in individuals with life-long olfactory sensory deprivation

Moa G. Peter, Gustav Mårtensson, Elbrich M. Postma, Love Engström Nordin, Eric Westman, Sanne Boesveldt, Johan N. Lundström
2020 NeuroImage  
Our results suggest that a lifelong absence of sensory input does not necessarily lead to morphological alterations in primary sensory cortex and extend previous findings with divergent morphological alterations  ...  We detected no morphological alterations in the primary olfactory (piriform) cortex.  ...  Why are clear morphological changes in the primary sensory cortex of the absent sense reported in congenital blindness but not evident in congenital anosmia?  ... 
doi:10.1016/j.neuroimage.2020.117005 pmid:32485304 fatcat:bxiujw362vgdjcty7qmniikpli

Normal Olfactory Functional Connectivity Despite Life-Long Absence of Olfactory Experiences [article]

Moa G Peter, Peter Fransson, Gustav Martensson, Elbrich M Postma, Love Engstrom Nordin, Eric Westman, Sanne Boesveldt, Johan N Lundstrom
2020 bioRxiv   pre-print
Challenging this is the fact that individuals with congenital anosmia (life-long olfactory sensory loss) display little to no morphological changes in primary olfactory cortex.  ...  Congenital blindness is associated with atypical morphology, and functional connectivity within and from, visual cortical regions; changes that are hypothesized to originate from a life-long absence of  ...  to as secondary olfactory cortex (Lundström et al. 2011 ), but, surprisingly, it has been suggested that no morphological alterations occur within primary olfactory cortex despite a life-long absence  ... 
doi:10.1101/2020.05.21.106161 fatcat:tia5tro4gbem3ifexsvmazz5pi

Normal Olfactory Functional Connectivity Despite Lifelong Absence of Olfactory Experiences

Moa G Peter, Peter Fransson, Gustav Mårtensson, Elbrich M Postma, Love Engström Nordin, Eric Westman, Sanne Boesveldt, Johan N Lundström
2020 Cerebral Cortex  
Challenging this is the fact that individuals with congenital anosmia (lifelong olfactory sensory loss) display little to no morphological changes in the primary olfactory cortex.  ...  in functional connectivity within the olfactory cortex between individuals with congenital anosmia (n = 33) and matched controls (n = 33).  ...  to as secondary olfactory cortex (Lundström et al. 2011 ), but, surprisingly, it has been suggested that no morphological alterations occur within primary olfactory cortex despite a lifelong absence  ... 
doi:10.1093/cercor/bhaa217 pmid:32810869 pmcid:PMC7727390 fatcat:ledtykykmzcofhtegdxip5qhnq

Divergent morphological changes within the orbitofrontal cortex in individuals with congenital olfactory sensory loss [article]

Moa G Peter, Gustav Mårtensson, Elbrich M Postma, Love Engström Nordin, Eric Westman, Sanne Boesveldt, Johan N Lundström
2019 bioRxiv   pre-print
that a lifelong absence of sensory input does not necessarily lead to morphological alterations in primary sensory cortex.  ...  No structural alterations in the primary olfactory (piriform) cortex were, however, demonstrated.  ...  These divergent results in neighboring cortical areas indicate that the cerebral plasticity related to a life-long olfactory sensory deprivation cannot be explained by a simple morphological mechanism  ... 
doi:10.1101/760793 fatcat:hxlyy3do2rgazgxpggvxcd7qui

Compensatory plasticity: time matters

Latifa Lazzouni, Franco Lepore
2014 Frontiers in Human Neuroscience  
Plasticity in the blind is also accompanied with neurochemical and morphological changes; both intrinsic connectivity and functional coupling at rest are altered but are likewise dependent on different  ...  Blind individuals do as good as the sighted and even more, show superior abilities in auditory, tactile and olfactory processing.  ...  Congenitally blind activated primary and secondary olfactory areas in addition to strong activations of occipital cortex areas ; reorganization is in fact possible for odor processing.  ... 
doi:10.3389/fnhum.2014.00340 pmid:24971056 pmcid:PMC4054015 fatcat:gwbgwr525rflfcmeuxlr2hnzeu

Cortical GABAergic Interneurons in Cross-Modal Plasticity following Early Blindness

Sébastien Desgent, Maurice Ptito
2012 Neural Plasticity  
, in receptive field refinement, and in treatment of sensory information reaching the cerebral cortex.  ...  This paper attempts to highlight the links between early sensory deprivation, cortical GABAergic interneuron alterations, and cross-modal plasticity, discuss its implications, and further provide insights  ...  Long-term monocular deprivation in rats decreases the expression of CB but not CR and PV in primary visual cortex, suggesting that the CBPs-IR neuronal subpopulations may be differently affected by the  ... 
doi:10.1155/2012/590725 pmid:22720175 pmcid:PMC3377178 fatcat:oumqveggwrfxbb4sghlshy5tk4

Information Processing in the Mammalian Olfactory System

Pierre-Marie Lledo, Gilles Gheusi, Jean-Didier Vincent
2005 Physiological Reviews  
This is in agreement with other findings showing that olfactory deprivation does not cause a decrease in cell proliferation (93, 133) .  ...  The mature sensory neurons have only a limited life span of ϳ90 days (286) , but if mice are reared in a laminar flow hood to prevent rhinitis, sensory neurons can survive as long as 12 mo, close to the  ... 
doi:10.1152/physrev.00008.2004 pmid:15618482 fatcat:fpfnaknyk5bbljzjgyrgmt5nt4

Sensory Deprivation during Early Postnatal Period Alters the Density of Interneurons in the Mouse Prefrontal Cortex

Hiroshi Ueno, Shunsuke Suemitsu, Yosuke Matsumoto, Motoi Okamoto
2015 Neural Plasticity  
These results suggest that long-term sensory deprivation causes the changes of intracortical inhibitory networks in the PFC and the changes of inhibitory networks in the PFC may contribute to cross-modal  ...  Since this phenomenon is assumed to be associated with altered GABAergic inhibition in the PFC, we have tested the hypothesis that early postnatal sensory deprivation causes the changes of inhibitory neuronal  ...  In congenitally blind individuals, functional connectivity between MT/MST and dorsal lateral PFC is enhanced, but functional connectivity between MT/MST and primary auditory cortex is not enhanced.  ... 
doi:10.1155/2015/753179 pmid:26161272 pmcid:PMC4487934 fatcat:jvhdsfq3gfe3jo7j2ndllxibp4

Watching Synaptogenesis in the Adult Brain

Wolfgang Kelsch, Shuyin Sim, Carlos Lois
2010 Annual Review of Neuroscience  
With the development of several new genetic labeling and imaging techniques, the study of synapse development and integration of these new neurons into mature circuits both in vitro and in vivo is rapidly  ...  of the transient plasticity that new neurons provide toward circuit refinement and adaptation to changing environmental demands.  ...  Differentiating neurons are most susceptible to develop aberrant connectivity, and some morphological changes are seen only in new neurons generated within days of the onset of seizure, but not in neurons  ... 
doi:10.1146/annurev-neuro-060909-153252 pmid:20572770 fatcat:evt5jl3d6vguhjxuzgiyvxj64y

Genetic Increases in Olfactory Bulb BDNF Do Not Enhance Survival of Adult-Born Granule Cells

2019 Chemical Senses  
Normally ~50% of new olfactory GCs survive, but survival declines if sensory drive is reduced.  ...  OB BDNF levels were significantly higher in transgenic mice compared to controls, and this was maintained following sensory deprivation.  ...  However, consistent with prior reports of BDNF changes with olfactory sensory activity, measures in deprived WT mice showed differences between left and right OBs (Jones et al. 2007; Degano et al. 2014  ... 
doi:10.1093/chemse/bjz058 pmid:31562506 pmcid:PMC6923167 fatcat:tywwat4sbjebvkil7a2xkkt4nq

Long-term survival of olfactory sensory neurons after target depletion

Krista Sultan-Styne, Rafael Toledo, Christine Walker, Anna Kallkopf, Charles E. Ribak, Kathleen M. Guthrie
2009 Journal of Comparative Neurology  
Life-long addition and elimination of neurons within the adult olfactory epithelium and olfactory bulb allows for adaptive structural responses to sensory experience, learning, and recovery after injury  ...  The combination of increased proliferation and extended survival resulted in essentially normal numbers of new sensory neurons surviving for as long as 5 weeks, with an accompanying restoration of olfactory  ...  Long-term neuronal survival in the deprived OE. A-D.  ... 
doi:10.1002/cne.22084 pmid:19496176 pmcid:PMC2728470 fatcat:ql6aubwd4vckvao64tls3khxmu

Structural and Functional Abnormalities in the Olfactory System of Fragile X Syndrome Models

Felipe Bodaleo, Carola Tapia-Monsalves, Christian Cea-Del Rio, Christian Gonzalez-Billault, Alexia Nunez-Parra
2019 Frontiers in Molecular Neuroscience  
Individuals with FXS exhibit abnormal sensory information processing frequently leading to hypersensitivity across sensory modalities and consequently a wide array of behavioral symptoms.  ...  In this review article, we will discuss molecular, morphological and physiological aspects of the olfactory information processing in FXS models.  ...  At the neurophysiological level, long-term potentiation (LTP), a long-term change in synaptic strength involving morphological changes in dendritic spines (Nicoll, 2017) was studied in vitro in mice  ... 
doi:10.3389/fnmol.2019.00135 pmid:31191246 pmcid:PMC6548058 fatcat:q2wdlroomjadpmmjwocu4t4jny

Postnatal experience modulates functional properties of mouse olfactory sensory neurons

Jiwei He, Huikai Tian, Anderson C. Lee, Minghong Ma
2012 European Journal of Neuroscience  
However, it remains unknown how early experience shapes functional properties of individual olfactory sensory neurons (OSNs), the primary odor detectors in the nose.  ...  In the mammalian olfactory system, deprivation of the sensory inputs via neonatal, unilateral naris closure has been shown to induce structural, molecular, and functional changes from the olfactory epithelium  ...  Therefore, sensory experience in early life modulates the response kinetics of OSNs and the most consistent change is observed in the decay phase, which is slowed down by sensory deprivation.  ... 
doi:10.1111/j.1460-9568.2012.08170.x pmid:22703547 pmcid:PMC3424323 fatcat:odu7lbca25c2ffukzhtdh45kqi

Visual Cortex Plasticity: A Complex Interplay of Genetic and Environmental Influences

José Fernando Maya-Vetencourt, Nicola Origlia
2012 Neural Plasticity  
We shall also review different experimental strategies that can be used to achieve the recovery of sensory functions after long-term deprivation in humans.  ...  Here, we shall concentrate on structural and functional consequences of early sensory deprivation in the visual system and discuss how intracellular signal transduction pathways associated with experience  ...  Early deaf individuals, but not late-onset deaf subjects, actually display impairments in their ability to process language using a cochlear implant in adult life as the auditory cortex has been reshaped  ... 
doi:10.1155/2012/631965 pmid:22852098 pmcid:PMC3407658 fatcat:2kkdnvqaujd5pdqosatxazimda

Origin and function of olfactory bulb interneuron diversity

Pierre-Marie Lledo, Florian T. Merkle, Arturo Alvarez-Buylla
2008 Trends in Neurosciences  
Surprisingly, OB interneurons are generated by stem cells not only in the walls of the lateral ventricle facing the striatum but also in the rostral migratory stream and walls of the lateral ventricle  ...  In adult rodents, subventricular zone (SVZ) astrocytes (B cells) function as primary progenitors in the generation of new neurons that migrate to the olfactory bulb (OB), where they differentiate into  ...  Acknowledgments Additional references relevant to this subject are included in the cited studies; they could not be included in this review because of space limitations.  ... 
doi:10.1016/j.tins.2008.05.006 pmid:18603310 pmcid:PMC4059175 fatcat:ozrai2cw2bda7medgacq5yphta
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