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Mindfulness is associated with psychological health and moderates pain in knee osteoarthritis

A.C. Lee, W.F. Harvey, L.L. Price, L.P.K. Morgan, N.L. Morgan, C. Wang
2017 Osteoarthritis and Cartilage  
Objective-Previous studies suggest that higher mindfulness is associated with less pain and depression. However, the role of mindfulness has never been studied in knee osteoarthritis (OA). We evaluate the relationships between mindfulness and pain, psychological symptoms, and quality of life in knee OA. Method-We performed a secondary analysis of baseline data from our randomized comparative trial in participants with knee OA. Mindfulness was assessed using the Five Facet Mindfulness
more » ... re. We measured pain, physical function, quality of life, depression, stress, and selfefficacy with commonly-used patient-reported measures. Simple and multivariable regression models were utilized to assess associations between mindfulness and health outcomes. We further tested whether mindfulness moderated the pain-psychological outcome associations. Results-Eighty patients were enrolled (60.3±10.3 years;76.3% female, body mass index: 33.0±7.1kg/m 2 ). Total mindfulness score was associated with mental (beta=1.31,95% CI: 0.68,1.95) and physical (beta=0.69,95% CI:0.06,1.31) component quality of life, self-efficacy (beta=0.22,95% CI:0.07,0.37), depression (beta=-1.15,95% CI:-1.77,-0.54), and stress (beta=-1.07,95% CI:-1.53,-0.60). Of the five facets, the Describing, Acting-with-Awareness, and Non-judging mindfulness facets had the most associations with psychological health. No significant association was found between mindfulness and pain or function (P=0.08-0.24). However, we found that mindfulness moderated the effect of pain on stress (P=0.02). Conclusion-Mindfulness is associated with depression, stress, self-efficacy, and quality of life among knee OA patients. Mindfulness also moderates the influence of pain on stress, which suggests that mindfulness may alter the way one copes with pain. Future studies examining the benefits of mind-body therapy, designed to increase mindfulness, for patients with OA are warranted.
doi:10.1016/j.joca.2016.06.017 pmid:27349461 pmcid:PMC5183521 fatcat:g74754dawvgd7o2wvpdw2jx4em

Detecting Photosymbiosis in Fossil Scleractinian Corals

Chiara Tornabene, Rowan C. Martindale, Xingchen T. Wang, Morgan F. Schaller
2017 Scientific Reports  
basic potassium persulfate solution and then converted bacterially into nitrous oxide, which can be measured for δ 15 N by gas chromatography-isotope ratio mass spectrometry (for detailed procedure see Wang  ...  A-B are modern, C is Holocene, D is Miocene, E is Oligocene, and F is Triassic in age.  ... 
doi:10.1038/s41598-017-09008-4 pmid:28842582 pmcid:PMC5572714 fatcat:zp5lp6rw5nbfvot3y7zvn5dgma

Pin1 Regulates the Dynamics of c-Myc DNA Binding To Facilitate Target Gene Regulation and Oncogenesis

A. S. Farrell, C. Pelz, X. Wang, C. J. Daniel, Z. Wang, Y. Su, M. Janghorban, X. Zhang, C. Morgan, S. Impey, R. C. Sears
2013 Molecular and Cellular Biology  
S5A to C in the supplemental material).  ...  ChIP inputs were Western blotted as in panel C.  ... 
doi:10.1128/mcb.01455-12 pmid:23716601 pmcid:PMC3719674 fatcat:d4ree45oc5flrmfdqx6mbzgr4u

Tree-structured model diagnostics for linear regression

Xiaogang Su, Chih-Ling Tsai, Morgan C. Wang
2008 Machine Learning  
If X j is discrete with values in C = {c 1 , . . . , c d }, then the form of I {x ij ∈ A} is considered for any subset A ⊂ C.  ...  To enhance diagnostic methods, we consider the tree method or recursive partitioning originated by Morgan and Sonquist (1963) .  ...  After applying the same orthogonal transformation to the response vector y, we partition the resultant vector into two components Appendix B: Derivation of the score test Let w i = I {x ij ≤ c}, n 1  ... 
doi:10.1007/s10994-008-5080-8 fatcat:ahtvglzhnvc4blpoehw6yvkiai

Protein matching with custom neural network objective functions

David S. Vogel, Eric Gottschalk, Morgan C. Wang
2004 SIGKDD Explorations  
MODIFYING THE NEURAL NETWORK C. Bishop [2] discusses various neural network objective functions. This idea was motivation to optimize a new objective function specific to this problem: GRMSE.  ... 
doi:10.1145/1046456.1046476 fatcat:tbtg4kzrungo7jz5d5vfyyfiau

Mindfulness is associated with psychological symptoms, self-efficacy, and quality of life among patients with symptomatic knee osteoarthritis

N.L. Morgan, G.L. Ransford, L.P. Morgan, J.B. Driban, C. Wang
2013 Osteoarthritis and Cartilage  
Morgan y , G.L. Ransford y , L.P. Morgan z , J.B. Driban y , C. Wang y . y Tufts Med.  ...  Hypothesized predictors of clinical response included body mass index (BMI), NZ Score, age, Kellgren score, and PHQ-9 score. c.  ... 
doi:10.1016/j.joca.2013.02.535 fatcat:yarzubdsj5b2lnwdlmsxysdjee

Probabilistic penalized principal component analysis

Chongsun Park, Morgan C. Wang, Eun Bi Mo
2017 Communications for Statistical Applications and Methods  
c n ⟩ T W T (x n − µ) + 1 2σ 2 tr ( W T W ⟨ c n c T n ⟩) } , where we have omitted terms independent of the model parameters and ⟨c n ⟩ = M −1 W T (x n − µ), ⟨ c n c T n ⟩ = σ 2 M −1 + ⟨c n ⟩⟨c n ⟩ T ,  ...  E-step E-step takes the expectation of l x,c with respect to the distribution f (c n |x n , W, σ 2 ): ⟨l x,c ⟩ = − N ∑ n=1 { p 2 ln σ 2 + 1 2 tr (⟨ c n c T n ⟩) + 1 2σ 2 (x n − µ) T (x n − µ) − 1 σ 2 ⟨  ... 
doi:10.5351/csam.2017.24.2.143 fatcat:dhvcmfj2ujbsfeqhvwbygjf33m

Protocol for Community-created Public MS/MS Reference Library Within the GNPS Infrastructure [article]

Fernando Vargas, Kelly C. Weldon, Nicole Sikora, Mingxun Wang, Zheng Zhang, Emily C. Gentry, Morgan W. Panitchpakdi, Mauricio Caraballo, Pieter C. Dorrestein, Alan K. Jarmusch
2019 bioRxiv   pre-print
(C) MASST search results page (, (3) click on the "Dataset Matches".  ...  (A) Illustrative base peak chromatogram, (B) average MS spectrum, and (C) MS/MS spectra selected by MSMS-Chooser for dethiobiotin in the positive ionization mode.  ...  Supplemental Information Protocol for Community-created Public MS/MS Reference Library Within the GNPS Infrastructure Fernando Vargas 1,2, † , Kelly C. Weldon 1,4, † , Nicole Sikora  ... 
doi:10.1101/804401 fatcat:t3wi7bpr7jaj7n2jecnu7rhkmu

Pax3 Stimulates p53 Ubiquitination and Degradation Independent of Transcription

Xiao Dan Wang, Sarah C. Morgan, Mary R. Loeken, Domingos Henrique
2011 PLoS ONE  
Pax3 (Figure 4 B, C) .  ...  (C) Indirect immunofluorescence of p53 (green) and Pax3 (red) in stage 1 and stage 3 ESC. Cells were counterstained with DAPI (blue) to visualize nuclei.  ... 
doi:10.1371/journal.pone.0029379 pmid:22216266 pmcid:PMC3247257 fatcat:dqhzly6llngbvkhkifor37prku

Lipopolysaccharide regulation of lipoprotein lipase expression in murine macrophages

M R Hill, K Kelly, X Wu, F Wanker, H Bass, C Morgan, C Wang, J M Gimble
1995 Infection and Immunity  
Thompson, and C. Webb for helpful discussions; K.  ...  Blots were hybridized overnight at 55ЊC, washed, and exposed with an intensifying screen for 1 to 7 days at Ϫ70ЊC (9, 19) . Transcriptional analysis.  ...  (C) Transcription. Nuclei isolated from J774 cells treated with 10 ng of lipopolysaccharide per ml for 0, 4, or 20 h were used in nuclear run-on experiments.  ... 
pmid:7868257 pmcid:PMC173082 fatcat:4lirdqsopjezrdpgdrbgpfusc4

Interfacial actin protrusions mechanically potentiate killing by cytotoxic T cells [article]

Fella Tamzalit, Mitchell S. Wang, Weiyang Jin, Vitaly Boyko, John M. Heddleston, Charles T. Black, Lance C. Kam, Morgan Huse
2018 bioRxiv   pre-print
Then, the average distance between every pixel in M C and the COG of M C (D C ) was determined and subsequently divided by the average distance between every pixel in M F and the COG of M C (D F ) (fig  ...  (C) Histogram showing the distribution of strong deflections as a function of radial distance from the center of the IS. N = 10 for each cell type in B and C.  ... 
doi:10.1101/443309 fatcat:niofo6ddqjgvvmke4dmlymtbaq

PICSAR: Long Noncoding RNA in Cutaneous Squamous Cell Carcinoma

Yunhai Luo, Stefanie L. Morgan, Kevin C. Wang
2016 Journal of Investigative Dermatology  
defined as noncoding genomic transcripts greater than 200 nucleotides in length, play central roles in regulating a diverse array of biological processes in both normal development and pathogenesis (Wang  ...  lncRNAs have been shown to be important regulatory molecules at many levels of gene expression, such as chromatin remodeling, transcription, stability, posttranscriptional modifications, and translation (Wang  ... 
doi:10.1016/j.jid.2016.04.013 pmid:27450499 pmcid:PMC6138452 fatcat:4ter57ntvjcmxc45fpqgp3bct4

13 C, 2 H NMR Studies of Structural and Dynamical Modifications of Glucose-Exposed Porcine Aortic Elastin

Moshe C. Silverstein, Kübra Bilici, Steven W. Morgan, Yunjie Wang, Yanhang Zhang, Gregory S. Boutis
2015 Biophysical Journal  
The 13 C cross-polarization spectra reveal a notably increased a-helical character in the alanine motifs after glucose exposure.  ...  The correlation times of tumbling motion of the 13 C-1 H internuclear vectors in the glucose-treated sample are larger than in untreated samples, pointing to their more rigid structure.  ...  C b -Phe, C b -Ile -, b-sheet/turn or RC 41.0 41.0 C b -Phe, C b -Leu b-sheet/turn, - 42.4 - C a -Gly, C b -Leu -, b-sheet/turn or RC 43.8 43.8 C a -Gly, C b -Leu -, b-sheet/turn 48.4 49.2 5 0.7 C a -  ... 
doi:10.1016/j.bpj.2015.02.005 pmid:25863067 pmcid:PMC4390820 fatcat:xntfeiewlvhoxk2f225x5kp46y

Alternative hydrogen uptake pathways suppress methane production in ruminants [article]

Chris Greening, Renae Geier, Cecilia Wang, Laura C Woods, Sergio E Morales, Michael J McDonald, Rowena Rushton-Green, Xochitl C Morgan, Satoshi Koike, Sinead C Leahy, William J Kelly, Isaac Cann (+3 others)
2018 bioRxiv   pre-print
The flow rate was 60 mL min -1 , the detector was set to 80°C, the 578 injector was set to 80°C, and the oven was set to 75°C.  ...  At mid-exponential phase, 5 mL cultures 587 were harvested by centrifugation (13,000 x g, 4°C).  ... 
doi:10.1101/486894 fatcat:cv3bx4oyi5dprdwiv52uynv4xu

Morphological profiling of tubercule bacilli identifies drug pathways of action [article]

Trever C Smith, Krista M Pullen, Michaela C Olson, Morgan E McNellis, Ian Richardson, Sophia Hu, Jonah Larkins-Ford, Xin Wang, Joel S Freundlich, D. Michael Ando, Bree Aldridge
2020 bioRxiv   pre-print
Reconstituted drugs were then aliquoted in single-use sterile tubes and stored at -20°C until use.  ...  The cells were subcultured once using fresh butyrate medium before they were aliquoted into 347 tubes (1 ml each) which were stored at -80°C until use.  ... 
doi:10.1101/2020.03.11.987545 fatcat:7uzt45pebnanbp4dp2t6decg4q
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