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A Unique Visual Attention Profile Associated With the FMR1 Premutation

Molly Winston, Kritika Nayar, Emily Landau, Nell Maltman, John Sideris, Lili Zhou, Kevin Sharp, Elizabeth Berry-Kravis, Molly Losh
2021 Frontiers in Genetics  
Atypical visual attention patterns have been observed among carriers of the fragile X mental retardation gene (FMR1) premutation (PM), with some similarities to visual attention patterns observed in autism  ...  Results demonstrate a profile of visual attention that appears strongly associated with the FMR1 PM in women, and may constitute a meaningful biomarker.  ...  We would also like to thank Faraz Farzin for sharing of her eye tracking stimuli and assistance in creation of the protocol for collection of data pertaining to the NimStim task.  ... 
doi:10.3389/fgene.2021.591211 pmid:33633778 pmcid:PMC7901883 fatcat:pz3bovwgtre5ja6qyvylaoi3je

The Scope of Big Data in One Medicine: Unprecedented Opportunities and Challenges

Molly E. McCue, Annette M. McCoy
2017 Frontiers in Veterinary Science  
scientific approaches; (2) unbiased collection and analysis of data; and (3) a holistic understanding of biology and pathophysiology.  ...  Big data require collection and analysis of data at an unprecedented scale and represents a paradigm shift in health care, offering (1) the capacity to generate new knowledge more quickly than traditional  ...  Protein-protein interaction networks are mathematical models of the physical contacts between proteins.  ... 
doi:10.3389/fvets.2017.00194 pmid:29201868 pmcid:PMC5696324 fatcat:gbkpx2tcnnhx5n2hq6jv7oqtha

Phenome-Wide Association Studies: Embracing Complexity for Discovery

Sarah A. Pendergrass, Anurag Verma, Anna Okula, Molly A. Hall, Dana C. Crawford, Marylyn D. Ritchie
2015 Human Heredity  
, may provide additional leverage for making the most of the incredible wealth of information available for study.  ...  Greater consideration of the complexity of biological processes, using more data from the phenome, exposome, and diverse -omic resources, including considering the interplay of pleiotropy and genetic interactions  ...  Cytoscape is a software package for visualizing interaction networks (http://www.cytoscape. org/).  ... 
doi:10.1159/000381851 pmid:26201697 fatcat:eoc265qmjfamxknwjz3rlbr3gy

Rabbit Basic Science [chapter]

Molly Varga
2014 Textbook of Rabbit Medicine  
One pound (0.45 kg) of food was sent for analysis.  ...  High protein levels are not required for maintenance of unproductive pets. Grass is a source of protein and amino acids for rabbits.  ... 
doi:10.1016/b978-0-7020-4979-8.00001-7 fatcat:i6lutmgap5bvpn5ogsaje7w2qa

Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A

Poonam R. Molli, Da-Qiang Li, Rozita Bagheri-Yarmand, Suresh B. Pakala, Hiroshi Katayama, Subrata Sen, Jyoti Iyer, Jonathan Chernoff, Ming-Ying Tsai, Sujit S. Nair, Rakesh Kumar
2010 Journal of Cell Biology  
Phosphorylated histone H3 was visualized by autoradiography (top panel). Ponceau-stained blot shows equal amount of GST proteins and histone H3 used for all the reactions.  ...  Phosphorylated histone H3 was visualized by autoradiography (top panel). Ponceau-stained blot shows equal amount of GST proteins and histone H3 used for all the reactions.  ... 
doi:10.1083/jcb.200908050 pmid:20603326 pmcid:PMC2911675 fatcat:3vfu2yy4pve45b3ziq4qsrqybu

Facilitating Autism Research

Deborah Fein, Molly Helt
2017 Journal of the International Neuropsychological Society  
First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related.  ...  and correlate them with phenotypic characteristics (see Campbell, Kohane, & Kong, 2013 , for an example of exploratory analysis of biological data).  ...  to the visual periphery.  ... 
doi:10.1017/s1355617717001096 pmid:29198284 fatcat:4ce3p4axandrhbcwjrt6pgq7vm

Diminishing Risk for Age-Related Macular Degeneration with Nutrition: A Current View

Molly Schleicher, Karen Weikel, Caren Garber, Allen Taylor
2013 Nutrients  
Preventative interventions through dietary modification are attractive strategies, because they are more affordable than clinical therapies, do not require specialists for administration and many studies  ...  provide information from recent literature on the value of various nutrients, particularly omega-3 fatty acids, lower glycemic index diets and, perhaps, some carotenoids, with regard to diminishing risk for  ...  These data indicate that glycoxidative stress results in accumulation of elevated levels of intracellular glycated proteins and compromised protein editing capacities.  ... 
doi:10.3390/nu5072405 pmid:23820727 pmcid:PMC3738980 fatcat:i5gay6nhafc2jas575ichgy3ti

Digestive Disorders [chapter]

Molly Varga
2014 Textbook of Rabbit Medicine  
Unfortunately, the product has been withdrawn due to adverse drug interactions in humans.  ...  Toxin B is a potent cytotoxin that interacts synergistically with toxin A (Perkins et al., 1995) .  ... 
doi:10.1016/b978-0-7020-4979-8.00008-x fatcat:tyntqbohmvhxdoxoqkixs33gl4

Mapping Local Cytosolic Enzymatic Activity in Human Esophageal Mucosa with Porous Silicon Nanoneedles

Ciro Chiappini, Paola Campagnolo, Carina S. Almeida, Nima Abbassi-Ghadi, Lesley W. Chow, George B. Hanna, Molly M. Stevens
2015 Advanced Materials  
These fi ndings highlight a translational potential for nanoneedles as a minimally invasive exploratory tool for a more accurate selection of biopsy sites and for appropriate mapping of target areas during  ...  weight for pro-CTSB, CTSB and β-actin showing protein expression with quantifi cation for matching normal (N3) and diseased (T3) region of tissues from patient 3.  ... 
doi:10.1002/adma.201501304 pmid:26197973 pmcid:PMC4858817 fatcat:d6srx3tr5vh7phu3nagp3u2va4

Female x male and male x male interactions have limited influence on competitive fertilization in Drosophila melanogaster [article]

Stefan Lüpold, Jonathan Bradley Reil, Mollie K Manier, Valérian Zeender, John M Belote, Scott Pitnick
2019 bioRxiv   pre-print
Only the timing of female sperm ejection depended on female × male genotypic interactions.  ...  Such interactions have been identified as potential sources of genetic variation in sexually selected traits but are also expected to inhibit trait diversification.  ...  each represented 441 genotype and the female × male × male genotypic combination as random effects. 442 For each analysis, we generated a model set with all combinations of predictors and 443 interactions  ... 
doi:10.1101/702720 fatcat:nlqealrmtbdg5iaihzripvbpmm

A Unique Collaboration on a National Goal

Molly C. Dougherty
2005 Nursing Research  
This was accomplished through the use of exploratory factor analysis on a federal dataset.  ...  Exploratory factor analysis and confirmatory factor analysis (CFA) were used to examine the basic psychometric properties of the 20-item H & H scale.  ...  The goal was instrument parsimony with structure of the scale and magnitude of items determined through the factor analysis. A cutoff point of .50 was used for factor loading.  ... 
doi:10.1097/00006199-200509000-00001 pmid:16224313 fatcat:tgn47ceitfbgjgy5zomfvsfg3m

The relevance of molecular biomarkers in cervical cancer patients treated with radiotherapy

Sarah Kilic, Bernadette Cracchiolo, Molly Gabel, Bruce Haffty, Omar Mahmoud
2015 Annals of Translational Medicine  
Additional radioresistance biomarkers have been identified in exploratory experiments.  ...  PubMed was searched for studies presenting biomarkers of cervical cancer radioresistance validated in patient studies or in laboratory experimentation.  ...  whether analysis was univariate or multivariate.  ... 
doi:10.3978/j.issn.2305-5839.2015.10.18 pmid:26605307 pmcid:PMC4630546 fatcat:lag2worbjfgbdolot3b2yzr5ma

Xp11.22 deletions encompassing CENPVL1, CENPVL2, MAGED1 and GSPT2 as a cause of syndromic X-linked intellectual disability

Christina Grau, Molly Starkovich, Mahshid S. Azamian, Fan Xia, Sau Wai Cheung, Patricia Evans, Alex Henderson, Seema R. Lalani, Daryl A. Scott, Jacobus P. van Wouwe
2017 PLoS ONE  
By searching a clinical database of over 60,000 individuals referred for array-based CNV analyses and online resources, we identified four males from three families with intellectual disability, developmental  ...  The maximum region of overlap between their deletions spanned~430 kb and included two pseudogenes, CENPVL1 and CENPVL2, whose functions are not known, and two protein coding genes-the G1 to S phase transition  ...  Acknowledgments The authors thank family members for participating in this research.  ... 
doi:10.1371/journal.pone.0175962 pmid:28414775 pmcid:PMC5393878 fatcat:k4edxzgtsjaonly2eulpkjcnxi

Characterization and metabolic synthetic lethal testing in a new model of SDH-loss familial pheochromocytoma and paraganglioma

John Smestad, Oksana Hamidi, Lin Wang, Molly Nelson Holte, Fatimah Al Khazal, Luke Erber, Yue Chen, L. James Maher
2017 OncoTarget  
Finally, we perform analysis of SDHC synthetic lethality with lactate dehydrogenase A (LDHA) and pyruvate carboxylase (PCX), which are important for regeneration of NAD+ and aspartate biosynthesis, respectively  ...  SDH loss reprograms cell biology, we developed an immortalized mouse embryonic fibroblast cell line with conditional disruption of Sdhc and characterize the kinetics of Sdhc gene rearrangement, SDHC protein  ...  for downstream exploratory analysis.  ... 
doi:10.18632/oncotarget.23639 pmid:29464059 pmcid:PMC5814199 fatcat:q6orgzndrfbg5pqznoxnnzon7q

A Comprehensive Review of Experimental Rodent Models of Repeated Blast TBI

Maciej Skotak, Molly T. Townsend, Kakulavarapu V. Ramarao, Namas Chandra
2019 Frontiers in Neurology  
Typical exposure conditions are the following: (1) peak overpressure in the 27-145 kPa (4-21 psi) range, (2) number of exposures: 2 (13.9%), 3 (63.9%), 5 (16.7%), or 12 (5.6%) with a single exposure used for  ...  We performed an analysis and extracted basic parameters to capture the characteristics of the exposure conditions (the blast intensity, inter-exposure interval and the number of exposures), the age and  ...  Visual cues around the room and pre-training the animal facilitates learning the location of the escape box.  ... 
doi:10.3389/fneur.2019.01015 pmid:31611839 pmcid:PMC6776622 fatcat:44c6agu73fdozkazqhlexkr4mm
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