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Genetically engineered neural transmission

J H Son, T H Joh
1997 Molecular Psychiatry  
To probe the biological consequences of defective or altered neural transmission, various genetically engineered transgenic mouse models have been developed, together with conventional pharmacological  ...  In conjunction with pharmacological manipulation, these sophisticated genetic manipulations of neural transmission will provide new tools to control neural transmission in both normal and pathophysiological  ...  In the mouse model lackthe recently developed genetic approach to study neuing the dopamine transporter, the released dopamine ral transmission in vivo.  ... 
doi:10.1038/sj.mp.4000181 pmid:9154215 fatcat:5omnwe4ganaohp2dzzvbfebnmi

Is Axonal Degeneration a Key Early Event in Parkinson's Disease?

Zuzanna Kurowska, Jeffrey H. Kordower, A. Jon Stoessl, Robert E. Burke, Patrik Brundin, Zhenyu Yue, Scott T. Brady, Jeffrey Milbrandt, Bruce D. Trapp, Todd B. Sherer, Satish Medicetty
2016 Journal of Parkinson's Disease  
A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport  ...  We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23 rd , 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge  ...  The other authors declare no potential conflict of interest.  ... 
doi:10.3233/jpd-160881 pmid:27497486 fatcat:tot6w6xdkzcuzlnbh3ca4zmt54

General summary

J Licinio, R Lisman
1997 Molecular Psychiatry  
Defective or altered neural Studies of the potential role of the dopamine D 1 transmission is thought to occur in neuropsychiatric receptor gene in addictive behaviors and neurodegenerative illnesses.  ...  Moreimplicated a role of the dopamine D 2 receptor gene over, recently developed molecular genetic techniques (DRD2) in addictive behaviors, no comparable studies make it possible to induce either a gene  ... 
doi:10.1038/sj.mp.4000234 fatcat:2ilpukkt5jbtbe7nomrovekjwu

Identifying the molecular basis of inhibitory control deficits in addictions: neuroimaging in non-human primates

Stephanie M Groman, J David Jentsch
2013 Current Opinion in Neurobiology  
Evidence indicates that dysfunction of the dopamine system can be both a cause and consequence of stimulant use and that this bi-directional relationship may be mediated by the ability of individuals to  ...  In addition to providing evidence that many of the neural alterations detected in stimulant-dependent individuals can emerge solely through experience with drugs, these studies have identified potential  ...  Acknowledgments This article is dedicated to the memory of Jacob P. Waletzky and recognizes the unwavering commitment of his family to supporting addiction science research.  ... 
doi:10.1016/j.conb.2013.03.001 pmid:23528268 pmcid:PMC3731407 fatcat:aneylv74yjgobflofnfilere5m

Animal Models of Attention-Deficit/Hyperactivity Disorder

Yosefu Arime, Yumiko Kubo, Ichiro Sora
2011 Biological and Pharmaceutical Bulletin  
These animal models are valuable tools for investigating molecular, cellular, and behavioral mechanisms as well as the neural development and circuit mechanisms of AD/HD.  ...  Here, we review the recent literature on animal models of AD/HD and discuss their advantages and limitations.  ...  by methylphenidate in caudate were associated with symptoms of inattention. 50) Animal models are valuable tools for investigating molecular, cellular, and behavioral mechanisms as well as the neural  ... 
doi:10.1248/bpb.34.1373 pmid:21881220 fatcat:emtm3u2cdzgzzdry4ymc6rbzxe

Molecular imaging and neural networks in impulse control disorders in Parkinson's disease

I. Aracil-Bolaños, A.P. Strafella
2016 Parkinsonism & Related Disorders  
Dopaminergic changes, such as increased dopamine release, reduced dopamine transporter activity and other changes, have been shown to be a consistent feature of ICDs in PD.  ...  Impulse control disorders (ICDs) may arise in Parkinson's disease (PD) in relation to the use of dopamine agonists (DA). A dysfunction of reward circuits is considered the main underlying mechanism.  ...  Acknowledgments This work was supported by Canadian Institutes of Health Research (MOP 136778). A.P.S is supported by the Canada Research Chair program.  ... 
doi:10.1016/j.parkreldis.2015.08.003 pmid:26298389 pmcid:PMC4874782 fatcat:6kusm7kr2jd75ogljhukot4vzy

Page 365 of Alcoholism Vol. 24, Issue 3 [page]

2000 Alcoholism  
Taken together, our findings suggest that the dopami- nergic system involved with DA transporter is a key of neural substrate for alcohol action on the CNS during the course of alcohol tolerance.  ...  REFERENCES Cevelli O (1995) Molecular biology of the dopamine receptor subtypes, in Psychopharmacology: The Fourth Generation of Progress (Bloom FE, Kupfer DJ eds), pp155-162, Raven Press, New York.  ... 

Extinction Learning and Adult Neurogenesis

Richard M Cleva, Kelly C Wischerath, M Foster Olive
2010 Neuropsychopharmacology  
This molecular model, thus, explains how even short-term exposure to 'the fast food lifestyle' creates a vicious cycle of disordered eating that cements pathological changes in dopamine signaling leading  ...  molecular regulators of AHN.  ... 
doi:10.1038/npp.2010.152 pmid:21116254 pmcid:PMC3055521 fatcat:pq34h2g65zfqnpkw6dldfdbo6e

The cybrid model of sporadic Parkinson's disease

Patricia A. Trimmer, James P. Bennett
2009 Experimental Neurology  
We have extensively studied the cytoplasmic hybrid ("cybrid") model of sPD in which donor mtDNA's are introduced into and expressed in neural tumor cells with identical nuclear genetic and environmental  ...  Parkinson's disease (PD) is the eponym attached to the most prevalent neurodegenerative movement disorder of adults, derived from observations of an early nineteenth century physician and paleontologist  ...  of Virginia ADRAF, and the D.  ... 
doi:10.1016/j.expneurol.2009.03.016 pmid:19328199 pmcid:PMC2735256 fatcat:jqe6hdop55f67cj67cpolvleqy

DeepGraphMol, a multi-objective, computational strategy for generating molecules with desirable properties: a graph convolution and reinforcement learning approach [article]

Yash Khemchandani, Steve O'Hagan, Soumitra Samanta, Neil Swainston, Timothy J Roberts, Danushka Bollegala, Douglas B Kell
2020 bioRxiv   pre-print
We provide an example based on the binding potency of small molecules to dopamine transporters.  ...  Since the experimentally obtained property scores are recognised as having potentially gross errors, we adopted a robust loss for the model.  ...  Acknowledgments The work of SS and DBK is supported as part of EPSRC grant EP/S004963/1 (SuSCoRD).  ... 
doi:10.1101/2020.05.25.114165 fatcat:zfhmrsx6mzaibb4d626gkous5q

Page 71 of Psychological Abstracts Vol. 83, Issue 1 [page]

1996 Psychological Abstracts  
Nestler “Norepinephrine and Serotonin Transporters: Molecular Tar- gets of Antidepressant Drugs” © Eric L. Barker and Randy D.  ...  Sesack “Development of Mesencephalic Dopamine Neurons in the Nonhuman Primate: Relationship to Survival and Growth Following Neural Transplantation” © John R. Sladek, Jr., Barbara Blanchard, T. J.  ... 

Page 1217 of The Journal of Neuroscience Vol. 24, Issue 5 [page]

2004 The Journal of Neuroscience  
Although our understanding of the ecological and evolutionary significance of foraging behavior has advanced considerably, the neural and molecular mechanisms underlying this behavior are largely unknown  ...  The Journal of Neuroscience, February 4, 2004 + 24(5):1217-1225 * 1217 Cellular/Molecular Dopamine and Glutamate Control Area-Restricted Search Behavior in Caenorhabditis elegans Thomas Hills, Penelope  ... 

A Novel Bio-Psychosocial-Behavioral Treatment Model in Schizophrenia

Yong-Ku Kim, Joonho Choi, Seon-Cheol Park
2017 International Journal of Molecular Sciences  
This model can be understood from the viewpoint of neurodevelopment and neural circuitry and should include the staging care, personalized care, preventive care, reducing the cognitive deficits, and reducing  ...  Because the focus of the most common antipsychotic medications is on dopamine, which is associated with positive symptoms, there is an unmet need for patients with negative symptoms.  ...  All authors read and approved the final manuscript. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/ijms18040734 pmid:28358303 pmcid:PMC5412320 fatcat:x2lgscqsqbfkpjutjs7jwdabji

Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

M Kathleen Borland, Patricia A Trimmer, Jeremy D Rubinstein, Paula M Keeney, KP Mohanakumar, Lei Liu, James P Bennett
2008 Molecular Neurodegeneration  
Rostral progression into substantia nigra with death of dopamine neurons produces the motor impairment phenotype that yields a clinical diagnosis.  ...  The vast majority of Parkinson's disease occurs sporadically, and current models of sporadic Parkinson's disease (sPD) can utilize directly infused or systemic neurotoxins.  ...  Acknowledgements Supported by NIH-NS39788 and the D. Loy Stewart Research Fund.  ... 
doi:10.1186/1750-1326-3-21 pmid:19114014 pmcid:PMC2631511 fatcat:i3glgrb6pvasbeht6esrmp6x6a

Toward a Molecular Understanding of Psychostimulant Actions Using Genetically Engineered Dopamine Receptor Knockout Mice as Model Systems

Jianhua Zhang, Ming Xu
2001 Journal of Addictive Diseases  
We have used the gene targeting technology to generate dopamine D1 and D3 receptor knockout mice and used these mice as model systems to gain a molecular understanding of acute effects of psychostimulants  ...  The use of a combined approach involving behavioral, electro-physiological as well as molecular studies has allowed us to define initially the roles of dopamine D1 and D3 receptors in the acute effects  ...  The main mechanism of terminating the dopamine actions is the reuptake of the neurotransmitter through the dopamine transporter expressed in the presynaptic nerve terminals. 4 Five dopamine receptor  ... 
doi:10.1300/j069v20n03_02 pmid:11681595 fatcat:sz3mdwsjj5ggvdgr367orfhy2a
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