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Role of iron deficiency anemia in the propagation of beta thalssemia gene

Muhammad Usman, Moinuddin Moinuddin, Syed Azhar Ahmed
2011 The Korean Journal of Hematology  
The diagnostic criterion for beta thalassemia trait (BTT) is elevated Hb-A2 levels. Iron deficiency anemia (IDA) reduces the synthesis of Hb-A2, resulting in reduced Hb-A2 levels, so patients with co-pathological conditions BTT with IDA, may have a normal level of Hb-A2. Many socio-economic factors like unawareness, poor diagnostic facilities, and cost of molecular diagnosis (for screening purposes) result in interpretation of these subjects as normal. Methods Venous blood samples from 200
more » ... ried females having a family history of thalassemia were collected, and basic hematological parameters, hemoglobin electrophoresis, and molecular analysis for beta thalassemia were done. Patients with IDA and patients with co-pathological conditions BTT and IDA were treated with oral iron. These subjects were then followed for a period of 20 weeks. Results Of the 200 females, 34 were found to be anemic. Hemoglobin electrophoresis identified 16 of these patients as BTT. Molecular analysis of all patients confirmed this diagnosis, but identified 8 additional patients with BTT. Eight patients that were not detected with hemoglobin electrophoresis were found to have co-pathology of BTT with IDA. Conclusion Patients with the co-pathological condition BTT with IDA may be interpreted as being normal, as they have normal Hb-A2 levels. These misdiagnosed subjects when marry with BTT have the potential to produce beta thalassemia major in offspring. This is one of the factors playing a major role in the propagation of beta thalassemia gene in Pakistani population, and become a serious hindrance for the thalassemia prevention program in Pakistan.
doi:10.5045/kjh.2011.46.1.41 pmid:21461303 pmcid:PMC3065626 fatcat:buootwltgzagzktlfj6jsdpora

Vegetation type of highly disturbed forests around Murree, Pakistan

Afsheen KHAN, Moinuddin AHMED, Farid AHMED, Rafat SAEED, Faheem SIDDIQUI
2020 Turkish Journal of Biodiversity  
Ahmed (1988) , Ahmed et al. (1990a Ahmed et al. ( , b, 1991 Ahmed et al. ( , 2010 , Ahmed & Naqvi (2005) , Hussain & Badshah (1998) , Wahab et al. (2008) , Siddiqui et al. (2009) , Khan et al. (2010a  ...  Pinus wallichiana populated forests were also been reported by various workers (Ahmed et al., 1989 (Ahmed et al., , 1990a (Ahmed et al., , b, 1991 (Ahmed et al., , 2006 Wahab et al., 2008 and Siddiqui  ... 
doi:10.38059/biodiversity.708154 fatcat:yidsrazeubeczgfc7cmmswgsse


Farooq Ahmed, Ravindra G Devani, Mohammed Moinuddin, Mohd. Ashfaq Ahmed
2018 Journal of Evidence Based Medicine and Healthcare  
Farooq Ahmed, H. No. 2-909/43/2/58, Farooq Manzil Bare Hills, Ganesh Nagar, Ring Road, Gulbarg-585105.  ... 
doi:10.18410/jebmh/2018/205 fatcat:xxpkd6phajgbfmnsklz3vlgd2y

Diagnosis of Genial Tuberculosis by PCR and other conventional methods

Adneen Moureen, Syed Moinuddin Satter, Ahmed Abu Saleh, Parveen Fatema, Sharmeen Ahmed
2017 Bangladesh Journal of Medical Microbiology  
<p>Female Genital Tuberculosis is a unique diagnostic challenge among the infertile population in countries where TB poses a high epidemiological risk. Early diagnosis and effective management is crucial to secure the reproductive organs from irretrievable damage. This cross sectional study was done between April 2011 to March 2012 in the Department of Microbiology and Immunology, Bangabandhu Sheikh Mujib Medical University in collaboration with National Tuberculosis Reference Laboratory and TB
more » ... laboratory of International Centre for Diarrhoeal Disease Research, Bangladesh to compare the different laboratory tests on endometrial tissue for the diagnosis of genital tuberculosis. Laparoscopic endometrial tissue biopsies of 91 infertile women with clinical suspicion of Genital Tuberculosis were subjected to AFB smear microscopy, culture in Lowenstein Jensen media, histopathology and PCR assay. Two primers - mpt64, IS6110 were used as target for Mycobacterial DNA. Among the endometrial tissue samples of 91 infertile cases, AFB smear was positive in 43 (47%) cases, 8 (7.6%) cases was positive in culture; while PCR was positive in 36 (42.4%) cases. None of the cases were positive for epithelioid granulomatous lesions. PCR was found positive in 33% of smear negative cases and 35% of culture negative cases while PCR was found negative in 53.4% of smear positive cases and 12.5% of culture positive cases. Use of both AFB smear microscopy and PCR assay enhances the detection rate of GTB.</p><p>Bangladesh J Med Microbiol 2014; 08 (02): 03-07</p>
doi:10.3329/bjmm.v8i2.31083 fatcat:oh7tnvuwqjbgnlixnxd32siax4

Atrial fibrillation after Coronary Artery Bypass Surgery with and without Cardiopulmonary Bypass

Md Rezaul Karim, Tawfiq Ahmed, Shahriar Moinuddin, Tariq Ahmed Chowdhury, Moshfequre Rahman Khan
2018 Cardiovascular Journal  
<p><strong>Background:</strong>Atrial fibrillation <strong>(</strong>AF) is the most common postoperative supraventricular arrhythmi. 20% to 40% of patients have AF after coronary artery bypass operation (CABG).Arrhythmia of all grades may occur due to cardiopulmonary bypass (CPB) and injuries inflicted during operativeprocedures. Thus it has been proposed that CABG surgery would be safer if CPB could be avoided.</p><p><strong>Methods:</strong>Total 60 patients who underwentCABG were selected
more » ... r the study and divided in two groups. Group A: 30 patients with Off-pump CABG (OPCAB) and Group B: 30 patients with On-pump CABG. 12 lead ECG was done at morning on the day of surgery, after surgery &amp; when any arrhythmia are noted for at least 7days. Morbidity of patients like arrhythmia and hospital mortality were recorded and compared during the first week after surgery.</p><p><strong>Results:</strong>Off-pump group (group- A) had less incidence of post-operative AF than on-pump group(group-B) (10% vs 40%). Postoperative blood requirement,total operative time, the period of mechanical ventilation,ICU stay and total postoperative hospital stayis significantly shorter in off-pump than in on-pump group of patients.</p><p><strong>Conclusion: </strong>This study clearly demonstrates that off pump CABG procedure is associated with less incidence of AF. Therefore OPCAB procedure for myocardial revascularization is clearly justified whenever feasible.</p><p>Cardiovasc. j. 2018; 10(2): 171-179</p>
doi:10.3329/cardio.v10i2.36288 fatcat:lbi45q5pdndpjlz63dci3fbn4u

Ever-increasing Caesarean section and its economic burden in Bangladesh

Mohammad Rifat Haider, Mohammad Masudur Rahman, Md. Moinuddin, Ahmed Ehsanur Rahman, Shakil Ahmed, M. Mahmud Khan, Eric Brian Faragher
2018 PLoS ONE  
Cesarean Section (CS) delivery has been increasing rapidly worldwide and Bangladesh is no exception. In Bangladesh, the CS rate has increased from about 3% in 2000 to about 24% in 2014. This study examines trend in CS in Bangladesh over the last fifteen years and implications of this increasing CS rates on health care expenditures.
doi:10.1371/journal.pone.0208623 pmid:30532194 pmcid:PMC6287834 fatcat:2opkaorfonclhaddd4zegbcghm

Study of contents of inguinal hernia in girls

Kishor Mankar, Nandkishor Shinde, Mohammed Moinuddin, Ashfaq Ahmed
2019 International Surgery Journal  
Inguinal hernia in females is relatively uncommon as compared to males. In female patients, the hernial sac contains one ovary in approximately 15–20% of cases, and some also contain a fallopian tube. This study was done to know the contents in inguinal hernia in girls.Methods: A prospective study on eight girls with inguinal hernia presenting between January 2016 to December 2018, presented with swelling in inguinal region. Physical examination in all girls was done followed by ultrasonogram
more » ... know the content of inguinal hernia. All patients underwent surgical exploration.Results: Among 8 girls with inguinal hernia, 2 (25%) girls had bilateral inguinal hernia, 4(50%) girls had right and 2 (25%) girls had left sided inguinal hernia. Ultrasonogram showed 2 girls with bilateral inguinal hernia had intestines as content on both sides. 3 girls had intestines, one (10%) girl had omentum and 2 (20%) girls had ovary as content of hernia sac. On surgical exploration one girl had omentum, one had ovary, two had intestine as hernial sac content. Two girls with irreducible hernia had omentum and ovary respectively as hernial content. In all girls after reduction of content, herniotomy was done.Conclusions: Surgical repair should be done at diagnosis in all girls presenting with inguinal hernia in view of high incidence of incarceration of ovary and tubes. Sac must be opened and its contents examined before it is tied off and excised.
doi:10.18203/2349-2902.isj20191266 fatcat:qlxcql6aynbh3p7r5uhlfalfdu

Predicting Power Electronics Device Reliability under Extreme Conditions with Machine Learning Algorithms [article]

Carlos Olivares, Raziur Rahman, Christopher Stankus, Jade Hampton, Andrew Zedwick, Moinuddin Ahmed
2021 arXiv   pre-print
Power device reliability is a major concern during operation under extreme environments, as doing so reduces the operational lifetime of any power system or sensing infrastructure. Due to a potential for system failure, devices must be experimentally validated before implementation, which is expensive and time-consuming. In this paper, we have utilized machine learning algorithms to predict device reliability, significantly reducing the need for conducting experiments. To train the models, we
more » ... ve tested 224 power devices from 10 different manufacturers. First, we describe a method to process the data for modeling purposes. Based on the in-house testing data, we implemented various ML models and observed that computational models such as Gradient Boosting and LSTM encoder-decoder networks can predict power device failure with high accuracy.
arXiv:2107.10292v1 fatcat:kezf24zgpbgzhg3arcnmrzij44

Evaluation of Neurocognitive Dysfunction after Coronary Artery Bypass Surgery

Tawfiq Ahmed, Md Rezaul Karim, Jahangir Haider Khan, Shahriar Moinuddin
2018 Cardiovascular Journal  
<p><strong>Objective</strong>: The Neurological injury is an important complication after coronary artery bypass surgery (CABG). The incidence of neurocognitive impairment after cardiac surgery varies from 20% to 80%. In this study we tried to analyze this difference of neurologic dysfunction between On-pump CABG and Off-pump CABG (OPCAB).</p><p><strong>Methods</strong>:This is a case control study done in National Institute of Cardiovascular Disease (NICVD), Dhaka during the period of July
more » ... to June 2014. Sixty Patients with Ischemic heart disease were the study population. Group- A includes 30 patients underwent on pump CABG, Group-B 30 patients underwent OPCAB. All the patients of both the groups were followed up to 2 month's postoperatively to find out any neurological and neurocognitive dysfunctionby observing motor function, sensory function,Mini Mantel state (MMS) Examination, orientation, memory, attention and calculation, recall and language test.</p><p><strong>Results: </strong>Neurocognitive dysfunction in the early postoperative period is significantly different among the groups.Neurocognitive dysfunction was more in Group A in comparison to Group B, On 3rd and 8th POD the MINI Mental Scores were found to be significantly lower in On-pump group than those in Off-pump group (22.0 ± 5.28 vs. 25.67 ± 3.34, p = 0.002 and 25.93 ± 3.11 vs. 26.63 ± 2.50, p = 0.023 respectively).This neurocognitive dysfunction gradually improved by the end of two month postoperative period. Only 6.66% patient in Group-A was found neurocognitically dysfunctional and was referred to neurophysician for further treatment. In case of OPCAB Group, no patient suffered fromneuorocognitive dysfunction.</p><p><strong>Conclusion</strong>: This study has convincingly shown cardio-pulmonary bypass (CPB) has had detrimental effect on neurocognitive function in patients who underwent CABG.</p><p>Cardiovasc. j. 2018; 10(2): 186-193</p>
doi:10.3329/cardio.v10i2.36290 fatcat:y7wap2ta5vgyhms5eui4clw6ca

Antiprotozoal activities of Vincetoxicum stocksii and Carum copticum

Arsala Mansoor, Mohammad Ali Ibrahim, Mudassir Asrar Zaidi, Moinuddin Ahmed
2011 Bangladesh Journal of Pharmacology  
doi:10.3329/bjp.v6i1.8442 fatcat:ne7konlk35c7tpq7hdvis7ebca

Device-level vacuum packaged uncooled microbolometer on a polyimide substrate

Moinuddin Ahmed, Donald P. Butler, Zeynep Celik-Butler
2016 Infrared physics & technology  
In addition to those features, the microbolometers on polyimide were fabricated utilizing a new release layer technology as discussed by Ahmed et al.  ... 
doi:10.1016/j.infrared.2016.09.011 fatcat:e5rfkknsevdrnnhfucxaphz7lq

The dendroclimatic potential of conifers from northern Pakistan

Moinuddin Ahmed, Jonathan Palmer, Nasrullah Khan, Muhammad Wahab, Pavla Fenwick, Jan Esper, Ed Cook
2011 Dendrochronologia  
et al., 1990a (Ahmed et al., ,b, 1991 .  ...  Ahmed and Sarangzai (1991a,b) and Ahmed et al. (2009a) estimated age and growth rates of various conifer species.  ... 
doi:10.1016/j.dendro.2010.08.007 fatcat:7zelngf2ovagbpp67c5jyz6bfy

Micro-scale Spatial Clustering of Cholera Risk Factors in Urban Bangladesh

Qifang Bi, Andrew S. Azman, Syed Moinuddin Satter, Azharul Islam Khan, Dilruba Ahmed, Altaf Ahmed Riaj, Emily S. Gurley, Justin Lessler, Edward T. Ryan
2016 PLoS Neglected Tropical Diseases  
Close interpersonal contact likely drives spatial clustering of cases of cholera and diarrhea, but spatial clustering of risk factors may also drive this pattern. Few studies have focused specifically on how exposures for disease cluster at small spatial scales. Improving our understanding of the micro-scale clustering of risk factors for cholera may help to target interventions and power studies with cluster designs. We selected sets of spatially matched households (matched-sets) near cholera
more » ... ase households between April and October 2013 in a cholera endemic urban neighborhood of Tongi Township in Bangladesh. We collected data on exposures to suspected cholera risk factors at the household and individual level. We used intra-class correlation coefficients (ICCs) to characterize clustering of exposures within matched-sets and households, and assessed if clustering depended on the geographical extent of the matched-sets. Clustering over larger spatial scales was explored by assessing the relationship between matched-sets. We also explored whether different exposures tended to appear together in individuals, households, and matched-sets. Household level exposures, including: drinking municipal supplied water (ICC = 0.97, 95%CI = 0.96, 0.98), type of latrine (ICC = 0.88, 95%CI = 0.71, 1.00), and intermittent access to drinking water (ICC = 0.96, 95%CI = 0.87, 1.00) exhibited strong clustering within matched-sets. As the geographic extent of matched-sets increased, the concordance of exposures within matched-sets decreased. Concordance between matched-sets of exposures related to water supply was elevated at distances of up to approximately 400 meters. Household level hygiene practices were correlated with infrastructure shown to increase cholera risk. Cooccurrence of different individual level exposures appeared to mostly reflect the differing domestic roles of study participants. Strong spatial clustering of exposures at a small spatial scale in a cholera endemic population suggests a possible role for highly targeted interventions. Studies with cluster designs in areas with strong spatial clustering of exposures should increase sample size to account for the correlation of these exposures. PLOS Neglected Tropical Diseases | While clustering of cholera incidence had been previously described, the relative role of similar risk behaviors versus transmission dynamics is not well understood. We explored how risk factors for cholera clustered at the sub-community scale, and found significant more correlation in risk behaviors among spatially matched households than the community as a whole. We found clustering of single risk factors, and co-occurrence of different risk factors. Our results indicated that the distribution of risk behaviors may play a role in the clustering of cholera cases at very small (e.g., <100m) spatial scales. This had implications for spatially matched study designs, which may be overmatching on some exposures. It also may lead us to rethink targeted interventions, suggesting a role for more intensive highly targeted interventions as a supplement to more generalized campaigns.
doi:10.1371/journal.pntd.0004400 pmid:26866926 pmcid:PMC4750854 fatcat:c6unrus2ezhnphkcvqvpjuz64m

Impact of maternal and neonatal health initiatives on inequity in maternal health care utilization in Bangladesh

Mohammad Rifat Haider, Mohammad Masudur Rahman, Md. Moinuddin, Ahmed Ehsanur Rahman, Shakil Ahmed, M. Mahmud Khan, Mahfuzar Rahman
2017 PLoS ONE  
Despite remarkable progress in maternal and child health, inequity persists in maternal care utilization in Bangladesh. Government of Bangladesh (GOB) with technical assistance from United Nation Population Fund (UNFPA), United Nation Children's Fund (UNICEF) and World Health Organization (WHO) started implementing Maternal and Neonatal Health Initiatives in selected districts of Bangladesh (MNHIB) in 2007 with an aim to reduce inequity in healthcare utilization. This study examines the effect
more » ... f MNHIB on inequity in maternal care utilization. Method Two surveys were carried out in four districts in Bangladesh-baseline in 2008 and end-line in 2013. The baseline survey collected data from 13,206 women giving birth in the preceding year and in end-line 7,177 women were interviewed. Inequity in maternal healthcare utilization was calculated pre and post-MNHIB using rich-to-poor ratio and concentration index. Results Mean age of respondents were 23.9 and 24.6 years in 2008 and 2013 respectively. Utilization of pregnancy-related care increased for all socioeconomic strata between these two surveys. The concentration indices (CI) for various maternal health service utilization in 2013 were found to be lower than the indices in 2008. However, in comparison to contemporary BDHS data in nearby districts, MNHIB was successful in reducing inequity in receiving ANC from a trained provider (CI: 0.337 and 0.272), institutional delivery (CI: 0.435 in 2008 to 0.362 in 2013), and delivery by skilled personnel (CI: 0.396 and 0.370).
doi:10.1371/journal.pone.0181408 pmid:28742825 pmcid:PMC5526556 fatcat:uwwdudlzafddpdesmdmvav52se

Determinants of caesarean section in Bangladesh: Cross-sectional analysis of Bangladesh Demographic and Health Survey 2014 Data

Mohammad Masudur Rahman, Mohammad Rifat Haider, Md. Moinuddin, Ahmed Ehsanur Rahman, Shakil Ahmed, M. Mahmud Khan, Mahfuzar Rahman
2018 PLoS ONE  
Caesarean section (CS) has been on the rise worldwide and Bangladesh is no exception. In Bangladesh, the CS rate, which includes both institutional and community-based deliveries, has increased from about 3% in 2000 to about 24% in 2014. This study examines the association of reported complications around delivery and socio-demographic, healthcare and spatial characteristics of mothers with CS, using data from the latest Bangladesh Demographic and Health Survey (BDHS). Methods The study is
more » ... on data from the 2014 BDHS. BDHS is a nationally representative survey which is conducted periodically and 2014 is the latest of the BDHS conducted. Data collected from 4,627 mothers who gave birth in health care institutions in three years preceding the survey were used in this study. Results Average age of the mothers was 24.6 years, while their average years of schooling were 3.2. Factors like mother being older, obese, residing in urban areas, first birth, maternal perception of large newborn size, husband being a professional, had higher number of antenatal care (ANC) visits, seeking ANC from private providers, and delivering in a private facility were statistically associated with higher rates of CS.
doi:10.1371/journal.pone.0202879 pmid:30208058 pmcid:PMC6135390 fatcat:i64qo2xkxjcati57buzmidxudi
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