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Extramedullary plasmacytoma (EMP) is a rare form of plasma cell neoplasm that originates from B lymphocytes. It accounts for only 4% of all plasma cell disorders. We present two cases of EMP that were diagnosed in two different locations. The first case is a 55-yearold presented with epistaxis and sinusoidal polyps. Histologic examination disclosed plasmacytoma. The second case is a 69-year-old patient presented with upper airway obstruction caused by laryngeal mass and histologic examinationdoi:10.14740/jmc3179 fatcat:ykutzsk7qfdtpe7hjttdrg5ob4
more »... vealed plasmacytoma of the larynx. Our cases are unique in their presentation and anatomic locations. To our knowledge, sinusoidal and laryngeal occurrences of the disease are only reported in a handful of cases. Both cases were treated mainly with radiotherapy. The postoperative phase was uneventful.
Deforestation Around the World [Working Title]
Deforestation is one of the most pressing environmental issues that the world is facing currently. It is the conversion of forested land to non-forested land by humans. Deforestation occurs when a land dominated by naturally occurring trees is converted to provide certain services in response to the human demand. The indiscriminate felling of trees has resulted in a reduction of 3.16% in the global forest cover from 1990 to 2015. Although India has seen an increment in the total forest cover ofdoi:10.5772/intechopen.85804 fatcat:wxgqkxdldja4fkawsuqdqjg4z4
more »... ca. 1%, still there are certain regions in the country that have sought a decrease in the forest cover. The main reasons attributed to the reduction in forest cover are shifting cultivation, rotational felling, other biotic pressures, diversion of forest lands for developmental activities, etc. Continuous illicit cutting of trees has impacted the microclimatic conditions, hydrological cycle, soil quality, biodiversity, etc. of the country, thereby making the country more vulnerable for any uneventful happening. Sustainable forest management practices, alternatives for shifting cultivation, promotion of plantation outside the forest and the usage of certified forest products, etc. are some of the measures that can be adopted to curb the rate of deforestation.
Paul A, Dutta PK, Khan ML, Das AK. 2019. Rhododendrons: A major resource of fuelwood in high altitude region of Arunachal Himalaya, India. Biodiversitas 20: 2628-2635. ...doi:10.13057/biodiv/d200927 fatcat:e6clab77tnc3hji46nyut5ezgm
Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cells are being derived from other ethnic groups. Here we describe for the first time the establishment of a naturally transformed breast cancer cell line, KAIMRC1 from an Arab woman of age 62 suffering from stage IIB breast cancer (T2N1M0). Moreover, we have characterized these cells for thedoi:10.1186/s12885-017-3812-5 pmid:29187162 pmcid:PMC5707794 fatcat:xqvbyyv6x5hi3peejsw4i2244m
more »... biological and molecular markers, induction of MAPK pathways as well as its response to different commercially available drugs and compounds. Methods: Breast cancer tissue sections were minced and cultured in media for several weeks. KAIMRC1 cells were successfully isolated from one of the primary breast tumor tissue cultures without any enzymatic digestion. To study the growth characteristics of the cells, wound healing assay, clonogenic assay, cell proliferation assays and live cell time-lapse microscopy was performed. Karyotyping, Immunophenotyping and molecular pathway specific compound treatment was also performed. A selective breast cancer gene expression panel was used to identify genes involved in the signal transduction dysregulation and malfunction of normal biological processes during breast carcinogenesis. Results: These cells are ER/PR-positive and HER2-negative. The epithelial nature of these cells was confirmed by flow cytometry analysis using epithelial cell markers. They are cuboidal in shape and relatively smaller in size as compared to established cell lines, MCF-7, MDA MB-231 and the normal breast cell line, MCF-10A. In normal cell culture conditions these cells showed the capability of growing both in monolayer as well as in 3-D conformation. They showed a doubling time in vitro of approximately 24 h. They exhibit a modal karyotype of 58-63,X with abnormalities in a couple of chromosomes. KAIMRC1 cells were found to be more responsive to drug treatment in vitro in comparison to the established MDA MB-231 and MCF-7 cell lines. Conclusions: In conclusion we have isolated and characterized a new naturally immortalized breast cell line, KAIMRC1 with a potential to play a key role in opening up novel avenues towards the understanding of breast carcinoma.
Copyright © 2018 Singh, Sharma, Ghosh, Kumar and Khan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). ...doi:10.3389/fchem.2018.00548 pmid:30519555 pmcid:PMC6258793 fatcat:2iu5eiqbjbedrgkljzqug3nscm
Rhabdomyosarcoma (RMS) is a malignant soft-tissue tumor mainly seen in the pediatric population. Here, we describe a case of an aggressive sinonasal RMS with distant metastasis in an adult patient. A 51-year-old male presented to the otolaryngology clinic with a unilateral painless neck mass and nasal obstruction. A flexible transnasal endoscope showed a huge fungating mass obstructing more than 80% of the right nasal cavity. A contrasted computed tomography (CT) scan of the paranasal sinusesdoi:10.7759/cureus.25886 pmid:35844319 pmcid:PMC9278485 fatcat:ldeh46jpyvbydh6krfiz23y4ym
more »... owed an enhancing soft-tissue density mass involving the right nasal cavity. A biopsy revealed RMS, an embryonal variant. The patient responded well to chemoradiotherapy but later developed spinal metastasis and cord compression. He was admitted for palliative care but died due to cardiopulmonary arrest 10 months after diagnosis. A high index of clinical suspicion for malignancy is required in adult patients with unilateral nasal symptoms.
The mixed metal oxides Bi2MoO6 and La-doped Bi2MoO6 were prepared by the sol–gel method. Then, varying quantities of the as-prepared mixed metal oxides were blended with graphene oxide (GO), employing sonication, to obtain Bi2MoO6/GO (BM/GO) and La-Bi2MoO6/GO (LBM/GO) nanocomposites. These prepared materials were characterized by different techniques such as thermal gravimetric analysis (TGA), X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), X-ray photoelectron spectroscopy (XPS),doi:10.3390/met11040559 fatcat:ttx635hkjnbmxni6lcm33vyfxa
more »... electron microscope (SEM), and transmission electron microscopy (TEM). Dielectric properties were studied by using a precision impedance analyzer. Dielectric constant and loss tan of the synthesized composites were studied as a function of frequency by using a precision impedance analyzer. Overall, the dielectric constant (ɛ') observed for the LBM/GO composites was higher than that of BM/GO.
Anxiety among children has increased in recent years. Culturally adapted questionnaires developed to measure the level of anxiety are the best screening instruments for the general population. This study describes the scientific translation and adaptation of the Spence Children's Anxiety Scale (SCAS) into the Malay language.Method: The process of scientific translation of this selfreport instrument followed the guidelines of the Task Force for Translation and Cultural Adaptation of thedoi:10.1590/2237-6089-2014-0038 pmid:25860565 fatcat:4wzpcsznvzcrzdb7zhquawlnd4
more »... onal Society for Pharmacoeconomics and Outcomes Research (ISPOR).Results: The Malay version and its adaptation for a new cultural context are described.Conclusion: The Malay version achieved the aims of the original version and its conceptual and operational equivalence. It may be used as the first Malay instrument to measure anxiety among children in research and in clinical and community settings.
Gymnocladus assamicus is a critically endangered tree species endemic to Northeast India, and shows sexual dimorphism with male and hermaphrodite flowers on separate trees. We studied phenology, reproductive biology and mating system of the species. The flowers are small, tubular, odorless and last for about 96 hours. Pollen grains in both morphs were viable and capable of fertilization leading to fruit and seed set. Scanning electron micrographs revealed morphologically similar pollen in bothdoi:10.1371/journal.pone.0087287 pmid:24586267 pmcid:PMC3938411 fatcat:yqxk3i4qkzdftg3ymrdmq36vki
more »... ale and hermaphrodite flowers. The fruit set in open pollinated flowers was 43.61 percent, while controlled autogamous and geitonogamous pollinations yielded 76.81 and 65.58 percent fruit set respectively. Xenogamous pollinations between male and hermaphrodite flowers resulted in 56.85 percent fruit set and pollinations between hermaphrodite flowers yielded 67.90 percent fruit set. This indicates a functionally androdioecious mating system and pollination limited fruit set in G. assamicus. Phylogenetic analyses of Gymnocladus and the sister genus Gleditsia are needed to assess if the androdioecious mating system in G. assamicus evolved from dioecy as a result of selection for hermaphrodites for reproductive assurance during colonization of pollination limited high altitude ecosystems.
The integration of ecological and atmospheric characteristics for biodiversity management is fundamental for long-term ecosystem conservation and drafting forest management strategies, especially in the current era of climate change. The explicit modelling of regional ecological responses and their impact on individual species is a significant prerequisite for any adaptation strategy. The present study focuses on predicting the regional distribution of Rhododendron arboreum, a medicinal plantdoi:10.3390/rs13163284 fatcat:fzw7cvthwbc4lcgc4zlaeckkau
more »... ecies found in the Himalayan region. Advanced Species Distribution Models (SDM) based on the principle of predefined hypothesis, namely BIOCLIM, was used to model the potential distribution of Rhododendron arboreum. This hypothesis tends to vary with the change in locations, and thus, robust models are required to establish nonlinear complex relations between the input parameters. To address this nonlinear relation, a class of deep neural networks, Convolutional Neural Network (CNN) architecture is proposed, designed, and tested, which eventually gave much better accuracy than the BIOCLIM model. Both of the models were given 16 input parameters, including ecological and atmospheric variables, which were statistically resampled and were then utilized in establishing the linear and nonlinear relationship to better fit the occurrence scenarios of the species. The input parameters were mostly acquired from the recent satellite missions, including MODIS, Sentinel-2, Sentinel-5p, the Shuttle Radar Topography Mission (SRTM), and ECOSTRESS. The performance across all the thresholds was evaluated using the value of the Area Under Curve (AUC) evaluation metrics. The AUC value was found to be 0.917 with CNN, whereas it was 0.68 with BIOCLIM, respectively. The performance evaluation metrics indicate the superiority of CNN for species distribution over BIOCLIM.
The Eastern Himalayan region of Northeast (NE) India is home to a large number of indigenous rice varieties, which may serve as a valuable genetic resource for future crop improvement to meet the ever-increasing demand for food production. However, these varieties are rapidly being lost due to changes in land-use and agricultural practices, which favor agronomically improved varieties. A detailed understanding of the genetic structure and diversity of indigenous rice varieties is crucial fordoi:10.1186/2193-1801-2-228 pmid:23741655 pmcid:PMC3667383 fatcat:np5m5avwqfaffdp6tlnbknnlfy
more »... icient utilization of rice genetic resources and for developing suitable conservation strategies. To explore the genetic structure and diversity of rice varieties in NE India, we genotyped 300 individuals of 24 indigenous rice varieties representing sali, boro, jum and glutinous types, 5 agronomically improved varieties, and one wild rice species (O. rufipogon) using seven SSR markers. A total of 85 alleles and a very high level of gene diversity (0.776) were detected among the indigenous rice varieties of the region. Considerable level of genetic variation was found within indigenous varieties whereas improved varieties were monoporphic across all loci. The comparison of genetic diversity among different types of rice revealed that sali type possessed the highest gene diversity (0.747) followed by jum (0.627), glutinous (0.602) and boro (0.596) types of indigenous rice varieties, while the lowest diversity was detected in agronomically improved varieties (0.459). The AMOVA results showed that 66% of the variation was distributed among varieties indicating a very high level of genetic differentiation in rice varieties in the region. Two major genetically defined clusters corresponding to indica and japonica groups were detected in rice varieties of the region. Overall, traditionally cultivated indigenous rice varieties in NE India showed high levels of genetic diversity comparable to levels of genetic diversity reported from wild rice populations in various parts of the world. The efforts for conservation of rice germplasm in NE India should consider saving rice varieties representing different types with specific emphasis given to sali and jum types. The protection against the loss of vast genetic diversity found in indigenous rice varieties in NE India is crucial for maintaining future food security in the changing world.
Herein, a systematic study of the enhanced physicochemical properties of lanthanide doped (La-doped) bismuth molybdate (Bi2MoO6) is performed. For this purpose, Bi2MoO6 and La-doped Bi2MoO6 were prepared by the sol-gel method. BiCl3, Na2MoO4·2H2O, and LaCl3·7H2O were taken as the main precursors while sodium dodecyl sulfate was used as a surfactant. Both Bi2MoO6 and La-doped Bi2MoO6 were calcined at 650 °C for 2 h. These prepared materials were characterized by spectroscopic techniques such asdoi:10.3390/ma13010035 pmid:31861758 pmcid:PMC6981540 fatcat:iogc74bmxben3bids2u4cvwa6e
more »... V–VIS, FT-IR, XRD, photoluminescence, XPS, along with other techniques such as SEM, TEM, TGA, etc. The investigation of luminescence behavior revealed that the La-doped Bi2MoO6 nanocomposite exhibited much greater luminescence compared to the undoped Bi2MoO6. The photocatalytic behavior of the prepared materials was explored by studying the degradation of methylene blue (MB) at room temperature. The degradation of MB with Bi2MoO6 and La-doped bismuth molybdate were observed to be 68% and 75% @ 45 s, respectively, indicating an enhancement of catalytic performance due to the La doping.
Mohamed Latif Khan is a professor, his field of research interest is the evaluation on the regeneration status of forest trees, exploration on germplasm of bamboo and cane, conservation of endangered plant ... Khan on Primula species of Arunachal Pradesh. Dr. ...doi:10.11609/jott.o3721.6788-95 fatcat:uqeo7n743rbhdi6nyihay2haha
Crocus sativus, a medicinally important herbaceous plant, has been traditionally used to cure coughs, colds, insomnia, cramps, asthma, and pain. Moreover, the therapeutic applications of saffron include its immunomodulatory and anticancer properties. The current experimental analysis was performed to explore the potential nutraceutical efficacy of corm, leaf, petal, and stigma of saffron ethanolic extracts as analgesic, anti-inflammatory, anticoagulant, and antidepressant using hot plate,doi:10.3390/plants9111414 pmid:33105854 pmcid:PMC7690613 fatcat:a5byb7bksnglbhmixgditgistq
more »... eenan-induced paw edema, capillary tube and forced swim test, respectively in mice. The results indicated that among all the extracts, stigma ethanolic extract (SEE) represented maximum latency activity (72.85%) and edema inhibition (77.33%) followed by petal ethanolic extract (PEE) with latency activity and edema inhibition of 64.06 and 70.50%, respectively. Corm ethanolic extract (CEE) and leaf ethanolic extract (LEE) displayed mild analgesic activity of 22.40% and 29.07%, respectively. Additionally, LEE (53.29%) and CEE (47.47%) exhibited mild to moderate response against inflammation. The coagulation time of SEE (101.66 s) was almost equivalent to the standard drug, aspirin (101.66 s), suggesting a strong anticoagulant effect followed by PEE (86.5 s). LEE (66.83 s) represented moderate inhibitory effect on coagulation activity while CEE (42.83 s) showed neutral effect. Additionally, PEE and SEE also expressed itself as potential antidepressants with immobility time ≤76.66 s, while CEE (96.50 s) and LEE (106.83 s) indicated moderate to mild antidepressant efficacy. Based on the in vivo activities, saffron extract, particularly SEE and PEE, can be used as a potential nutraceutical and therapeutic agent due to its significant pharmacological activities.
Lipoid proteinosis (LP) is a rare autosomal-recessive disease characterized by the deposition of hyaline material infiltrating multiple body organs, including the larynx. The possible clinical presentations are wide-ranging. Laryngeal involvement results in dysphonia that is noted at birth or infantile years. The diagnosis is based on histological findings, and the management options vary depending on the severity of the symptoms. In this paper, we report an unusual case of LP with laryngealdoi:10.1093/jscr/rjac360 pmid:35999820 pmcid:PMC9392577 fatcat:tis4klv46zcevhaj3ra2qjoyee
more »... olvement in an adult patient, along with a review of current literature.
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