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Modular slowing of resting-state dynamic Functional Connectivity as a marker of cognitive dysfunction induced by sleep deprivation
[article]
2020
biorxiv/medrxiv
pre-print
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Dynamic Functional Connectivity (dFC) in the resting state is increasingly considered as a correlate of cognitive processing. ...
In particular, we focus on Sleep Deprivation (SD) as a reversible model of cognitive dysfunction, which has also been proposed as a cognitive challenge model of cognitive impairments arising in Alzheimer's ...
Acknowledgements DB acknowledges support from the Mission for Interdisciplinarity of the CNRS (Infiniti program 2017-2018, "BrainTime") and from the EU Innovative Training Network "i-CONN" (H2020 ITN 859937 ...
doi:10.1101/2020.01.17.910810
fatcat:btohiuclbfb4jmdimzhzp2u7yq
Psychobiology of altered states of consciousness
2013
Psychology of Consciousness
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The article reviews the current knowledge regarding altered states of consciousness (ASC) (a) occurring spontaneously, (b) evoked by physical and physiological stimulation, (c) induced by psychological ...
The neurophysiological approach revealed that the different states of consciousness are mainly brought about by a compromised brain structure, transient changes in brain dynamics (disconnectivity), and ...
In contrast, hypnotically induced hallucinations are characterized by a dynamic dissociation between frontal and parietal connectivity. ...
doi:10.1037/2326-5523.1.s.2
fatcat:3x3mzqm3cvcvfoxzhkxv5fei7a
Psychobiology of Altered States of Consciousness
2005
Psychological bulletin
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The article reviews the current knowledge regarding altered states of consciousness (ASC) (a) occurring spontaneously, (b) evoked by physical and physiological stimulation, (c) induced by psychological ...
The neurophysiological approach revealed that the different states of consciousness are mainly brought about by a compromised brain structure, transient changes in brain dynamics (disconnectivity), and ...
In contrast, hypnotically induced hallucinations are characterized by a dynamic dissociation between frontal and parietal connectivity. ...
doi:10.1037/0033-2909.131.1.98
pmid:15631555
fatcat:it3jmguevra37pcfhae7pepnui
Eyes-closed task-free electroencephalography in clinical trials for Alzheimer's disease: an emerging method based upon brain dynamics
2014
Alzheimer's Research & Therapy
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In this review, we report the EEG changes in the course of AD, including slowing of the EEG oscillations, decreased functional connectivity in the higher-frequency bands, and decline in optimal functional ...
Synaptic dysfunction accompanies Alzheimer's disease (AD) and EEG can be regarded as a potentially useful biomarker in this disease. ...
Acknowledgements The authors thank Marieke Lansbergen and John Sijben on behalf of Nutricia Research who provided feedback on the structure and coherence of the manuscript. ...
doi:10.1186/s13195-014-0086-x
pmid:25621017
pmcid:PMC4304266
fatcat:ltdtisracvakbfd2oissgozilu
Panel, Mini-panel and Study Group
2014
Neuropsychopharmacology
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Here, much interest has been devoted to functional MRI (fMRI)-based phenotypes related to the genetic risk for the disorder; in particular, functional connectivity of the DLPFC and hippocampus during working ...
association with a genome-wide supported psychosis risk variant in ITIH3/4 as well as the enrichment of gene sets and pathways involved in dopamine neurotransmission. ...
measured resting state fMRI (R-fMRI) indices of human brain function. ...
doi:10.1038/npp.2014.279
pmid:25466712
pmcid:PMC4261146
fatcat:v6fgkukh6zgtdmswrjpk46dvhi
The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives
2021
Frontiers in Psychiatry
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Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and psychosis on the other ...
However, historically, the concepts of arousal and stress have been challenging to define as measurable experimental variables. ...
In line with this, a study examining functional connectivity between the LC and SN in healthy young and older adults used regression and functional connectivity analyses on resting-state fMRI data over ...
doi:10.3389/fpsyt.2020.601519
pmid:33584368
pmcid:PMC7873441
fatcat:hfbkrasizzb3rhgrlw7igolyqe
Circadian clocks, brain function, and development
2013
Annals of the New York Academy of Sciences
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Emerging from research on circadian rhythms is a model of the interaction among genes, sleep, and the environment that converges on the circadian clock to influence susceptibility to developing psychopathology ...
Components of the molecular clock are expressed throughout the brain and are centrally poised to play an important role in brain function. ...
Acknowledgments The
Conflicts of interest Dr. Frank is a member of advisory boards for Servier, has received honoraria from Servier and Lundbeck, and royalties from Guilford Press. ...
doi:10.1111/nyas.12335
pmid:24329517
fatcat:ck54orbzy5efbndfwhsyahdzcu
EEG delta oscillations as a correlate of basic homeostatic and motivational processes
2012
Neuroscience and Biobehavioral Reviews
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Delta oscillations dominate the EEG of waking reptiles. In humans, they are prominent only in early developmental stages and during slow-wave sleep. ...
Increase of delta power has been documented in a wide array of developmental disorders and pathological conditions. ...
Acknowledgements This work was supported by a grant of the Russian Foundation for Basic Research (RFBR) no. 11-06-00041-a. ...
doi:10.1016/j.neubiorev.2011.10.002
pmid:22020231
fatcat:4unzz6glf5b7beooj67no3zpmu
ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups
2019
Neuropsychopharmacology
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Methods: Photoactivatable or "caged" dynorphin derivatives were synthesized and evaluated at heterologously expressed receptors using a functional secreted alkaline phosphatase assay in HEK293 cells and ...
The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology. ...
To assess functional connectivity, we obtained resting state fMRI scans and used a seed based approach to assess left hippocampal connectivity. ...
doi:10.1038/s41386-019-0544-z
pmid:31801977
pmcid:PMC6957922
fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups
2016
Neuropsychopharmacology
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Rita Goldstein The Icahn School of Medicine at Mount Sinai, New York, New York, United States Background: Resting-state functional connectivity has emerged as a reliable marker of abnormal brain functioning ...
Slow cortical rhythms are also observed during the waking state, as well as during sleep, suggesting widespread functional roles for this oscillation. ...
Reduced levels of RELN expression in the adult brain induce cognitive impairment and dendritic spine density deficits. ...
doi:10.1038/npp.2016.239
fatcat:wg7pyurlzvhp7bvlmlbxtkunl4
Control of Functional Connectivity in Cerebral Cortex by Basal Ganglia Mediated Synchronization
[article]
2020
arXiv
pre-print
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of cortex, synchronizing those areas and functionally connecting them. ...
and disconnect interfering activity, and recurrently process the resulting patterns of activity, channeling cognition and promoting goal [...] ...
The modularity of an individual's resting state cortical networks, measured by fMRI, has been found to be predictive of task performance as a function of task complexity, with high modularity subjects ...
arXiv:1708.00779v2
fatcat:3mbrakwdgfewpcdggox5v6mwme
Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology
2018
Journal of Alzheimer's Disease
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dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in ...
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems ...
networks as a sign of functional cortical "connectivity" [310, 312] . ...
doi:10.3233/jad-179932
pmid:29562524
pmcid:PMC6008221
fatcat:j3u6gkzfqbg47kv4o2hpkjadn4
27th Annual Computational Neuroscience Meeting (CNS*2018): Part Two
2018
BMC Neuroscience
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Acknowledgements Supported by NINDS 1 R01 NS085006 to RLC.
Acknowledgments JB was supported by NIH grant F31DC016811 to JB and JB, SC, and RG were supported by NIH R01MH1006674 to SC. ...
This work is supported by the CMBC Interdisciplinary Neuroscience Pilot Research Fund at Emory University.
Acknowledgments This work is supported by NSF grant DMS-1517085. ...
The collective dynamics of neuronal networks-responsible for the cognitive and other functions of the brain-is strongly influenced by their connection topology. ...
doi:10.1186/s12868-018-0451-y
fatcat:afgrjlnjgjarldkuwo3e2pt5sm
Poster Session II
2015
Neuropsychopharmacology
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Resting-state fMRI analyses focused on resting-state functional connectivity (RSFC) of the amygdala. ...
inhibitor (SSRI) treatment on the resting state functional connectivity (FC) of dorsal versus ventral striatum. ...
Background: Resting-state functional connectivity has recently emerged as a reliable marker of abnormal brain functioning in addiction, whereby compared to healthy controls drug users show deficits in ...
doi:10.1038/npp.2015.326
pmid:26632287
pmcid:PMC4672311
fatcat:ib64i5qmzngvxcpn5hznkcagie
From Coral to Coal
2020
Journal of Clinical & Experimental Immunology
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And for all the above, the mind-eye mirror connection which perceives and interprets, and creates a neuronal abstract substrate of bound distinct circuits that form as a whole memory, undoubtedly holds ...
All these contrasting dynamics, this vivid antithesis of an integer ecosystem to a compressed peat bog, this endless colorful miracle of delight to a blackish stratum shell of scorn, get to be defined ...
Attention is a very basic function that often is a precursor to all other neurological/cognitive functions. ...
doi:10.33140/jcei.05.06.03
fatcat:3d7r7gbo2nctjnt75w3zqescke
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