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Modular slowing of resting-state dynamic Functional Connectivity as a marker of cognitive dysfunction induced by sleep deprivation [article]

Diego Lombardo, Catherine Casse-Perrot, Jean-Philippe Ranjeva, Arnaud Le Troter, Maxime Guye, Jonathan Wirsich, Pierre Payoux, David Bartres-Faz, Regis Bordet, Jill C Richardson, Olivier Felician, Viktor Jirsa (+3 others)
2020 biorxiv/medrxiv   pre-print
Dynamic Functional Connectivity (dFC) in the resting state is increasingly considered as a correlate of cognitive processing.  ...  In particular, we focus on Sleep Deprivation (SD) as a reversible model of cognitive dysfunction, which has also been proposed as a cognitive challenge model of cognitive impairments arising in Alzheimer's  ...  Acknowledgements DB acknowledges support from the Mission for Interdisciplinarity of the CNRS (Infiniti program 2017-2018, "BrainTime") and from the EU Innovative Training Network "i-CONN" (H2020 ITN 859937  ... 
doi:10.1101/2020.01.17.910810 fatcat:btohiuclbfb4jmdimzhzp2u7yq

Psychobiology of altered states of consciousness

Dieter Vaitl, Niels Birbaumer, John Gruzelier, Graham A. Jamieson, Boris Kotchoubey, Andrea Kübler, Ute Strehl, Dietrich Lehmann, Wolfgang H. R. Miltner, Thomas Weiss, Ulrich Ott, Gebhard Sammer (+3 others)
2013 Psychology of Consciousness  
The article reviews the current knowledge regarding altered states of consciousness (ASC) (a) occurring spontaneously, (b) evoked by physical and physiological stimulation, (c) induced by psychological  ...  The neurophysiological approach revealed that the different states of consciousness are mainly brought about by a compromised brain structure, transient changes in brain dynamics (disconnectivity), and  ...  In contrast, hypnotically induced hallucinations are characterized by a dynamic dissociation between frontal and parietal connectivity.  ... 
doi:10.1037/2326-5523.1.s.2 fatcat:3x3mzqm3cvcvfoxzhkxv5fei7a

Psychobiology of Altered States of Consciousness

Dieter Vaitl, Niels Birbaumer, John Gruzelier, Graham A. Jamieson, Boris Kotchoubey, Andrea Kübler, Dietrich Lehmann, Wolfgang H. R. Miltner, Ulrich Ott, Peter Pütz, Gebhard Sammer, Inge Strauch (+3 others)
2005 Psychological bulletin  
The article reviews the current knowledge regarding altered states of consciousness (ASC) (a) occurring spontaneously, (b) evoked by physical and physiological stimulation, (c) induced by psychological  ...  The neurophysiological approach revealed that the different states of consciousness are mainly brought about by a compromised brain structure, transient changes in brain dynamics (disconnectivity), and  ...  In contrast, hypnotically induced hallucinations are characterized by a dynamic dissociation between frontal and parietal connectivity.  ... 
doi:10.1037/0033-2909.131.1.98 pmid:15631555 fatcat:it3jmguevra37pcfhae7pepnui

Eyes-closed task-free electroencephalography in clinical trials for Alzheimer's disease: an emerging method based upon brain dynamics

Elisabeth CW van Straaten, Philip Scheltens, Alida A Gouw, Cornelis J Stam
2014 Alzheimer's Research & Therapy  
In this review, we report the EEG changes in the course of AD, including slowing of the EEG oscillations, decreased functional connectivity in the higher-frequency bands, and decline in optimal functional  ...  Synaptic dysfunction accompanies Alzheimer's disease (AD) and EEG can be regarded as a potentially useful biomarker in this disease.  ...  Acknowledgements The authors thank Marieke Lansbergen and John Sijben on behalf of Nutricia Research who provided feedback on the structure and coherence of the manuscript.  ... 
doi:10.1186/s13195-014-0086-x pmid:25621017 pmcid:PMC4304266 fatcat:ltdtisracvakbfd2oissgozilu

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Here, much interest has been devoted to functional MRI (fMRI)-based phenotypes related to the genetic risk for the disorder; in particular, functional connectivity of the DLPFC and hippocampus during working  ...  association with a genome-wide supported psychosis risk variant in ITIH3/4 as well as the enrichment of gene sets and pathways involved in dopamine neurotransmission.  ...  measured resting state fMRI (R-fMRI) indices of human brain function.  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives

Jennifer A. Ross, Elisabeth J. Van Bockstaele
2021 Frontiers in Psychiatry  
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and psychosis on the other  ...  However, historically, the concepts of arousal and stress have been challenging to define as measurable experimental variables.  ...  In line with this, a study examining functional connectivity between the LC and SN in healthy young and older adults used regression and functional connectivity analyses on resting-state fMRI data over  ... 
doi:10.3389/fpsyt.2020.601519 pmid:33584368 pmcid:PMC7873441 fatcat:hfbkrasizzb3rhgrlw7igolyqe

Circadian clocks, brain function, and development

Ellen Frank, Michelle M. Sidor, Karen L. Gamble, Chiara Cirelli, Katherine M. Sharkey, Nathaniel Hoyle, Liat Tikotzky, Lisa S. Talbot, Michael J. McCarthy, Brant P. Hasler
2013 Annals of the New York Academy of Sciences  
Emerging from research on circadian rhythms is a model of the interaction among genes, sleep, and the environment that converges on the circadian clock to influence susceptibility to developing psychopathology  ...  Components of the molecular clock are expressed throughout the brain and are centrally poised to play an important role in brain function.  ...  Acknowledgments The Conflicts of interest Dr. Frank is a member of advisory boards for Servier, has received honoraria from Servier and Lundbeck, and royalties from Guilford Press.  ... 
doi:10.1111/nyas.12335 pmid:24329517 fatcat:ck54orbzy5efbndfwhsyahdzcu

EEG delta oscillations as a correlate of basic homeostatic and motivational processes

Gennady G. Knyazev
2012 Neuroscience and Biobehavioral Reviews  
Delta oscillations dominate the EEG of waking reptiles. In humans, they are prominent only in early developmental stages and during slow-wave sleep.  ...  Increase of delta power has been documented in a wide array of developmental disorders and pathological conditions.  ...  Acknowledgements This work was supported by a grant of the Russian Foundation for Basic Research (RFBR) no. 11-06-00041-a.  ... 
doi:10.1016/j.neubiorev.2011.10.002 pmid:22020231 fatcat:4unzz6glf5b7beooj67no3zpmu

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Methods: Photoactivatable or "caged" dynorphin derivatives were synthesized and evaluated at heterologously expressed receptors using a functional secreted alkaline phosphatase assay in HEK293 cells and  ...  The kinetics of dynorphin signal activation, duration and spread were characterized in striatum using a combination of photorelease, sensor imaging and electrophysiology.  ...  To assess functional connectivity, we obtained resting state fMRI scans and used a seed based approach to assess left hippocampal connectivity.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y

ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups

2016 Neuropsychopharmacology  
Rita Goldstein The Icahn School of Medicine at Mount Sinai, New York, New York, United States Background: Resting-state functional connectivity has emerged as a reliable marker of abnormal brain functioning  ...  Slow cortical rhythms are also observed during the waking state, as well as during sleep, suggesting widespread functional roles for this oscillation.  ...  Reduced levels of RELN expression in the adult brain induce cognitive impairment and dendritic spine density deficits.  ... 
doi:10.1038/npp.2016.239 fatcat:wg7pyurlzvhp7bvlmlbxtkunl4

Control of Functional Connectivity in Cerebral Cortex by Basal Ganglia Mediated Synchronization [article]

Daniel Pouzzner
2020 arXiv   pre-print
of cortex, synchronizing those areas and functionally connecting them.  ...  and disconnect interfering activity, and recurrently process the resulting patterns of activity, channeling cognition and promoting goal [...]  ...  The modularity of an individual's resting state cortical networks, measured by fMRI, has been found to be predictive of task performance as a function of task complexity, with high modularity subjects  ... 
arXiv:1708.00779v2 fatcat:3mbrakwdgfewpcdggox5v6mwme

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman (+32 others)
2018 Journal of Alzheimer's Disease  
dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in  ...  The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems  ...  networks as a sign of functional cortical "connectivity" [310, 312] .  ... 
doi:10.3233/jad-179932 pmid:29562524 pmcid:PMC6008221 fatcat:j3u6gkzfqbg47kv4o2hpkjadn4

27th Annual Computational Neuroscience Meeting (CNS*2018): Part Two

2018 BMC Neuroscience  
Acknowledgements Supported by NINDS 1 R01 NS085006 to RLC. Acknowledgments JB was supported by NIH grant F31DC016811 to JB and JB, SC, and RG were supported by NIH R01MH1006674 to SC.  ...  This work is supported by the CMBC Interdisciplinary Neuroscience Pilot Research Fund at Emory University. Acknowledgments This work is supported by NSF grant DMS-1517085.  ...  The collective dynamics of neuronal networks-responsible for the cognitive and other functions of the brain-is strongly influenced by their connection topology.  ... 
doi:10.1186/s12868-018-0451-y fatcat:afgrjlnjgjarldkuwo3e2pt5sm

Poster Session II

2015 Neuropsychopharmacology  
Resting-state fMRI analyses focused on resting-state functional connectivity (RSFC) of the amygdala.  ...  inhibitor (SSRI) treatment on the resting state functional connectivity (FC) of dorsal versus ventral striatum.  ...  Background: Resting-state functional connectivity has recently emerged as a reliable marker of abnormal brain functioning in addiction, whereby compared to healthy controls drug users show deficits in  ... 
doi:10.1038/npp.2015.326 pmid:26632287 pmcid:PMC4672311 fatcat:ib64i5qmzngvxcpn5hznkcagie

From Coral to Coal

2020 Journal of Clinical & Experimental Immunology  
And for all the above, the mind-eye mirror connection which perceives and interprets, and creates a neuronal abstract substrate of bound distinct circuits that form as a whole memory, undoubtedly holds  ...  All these contrasting dynamics, this vivid antithesis of an integer ecosystem to a compressed peat bog, this endless colorful miracle of delight to a blackish stratum shell of scorn, get to be defined  ...  Attention is a very basic function that often is a precursor to all other neurological/cognitive functions.  ... 
doi:10.33140/jcei.05.06.03 fatcat:3d7r7gbo2nctjnt75w3zqescke
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