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Pathophysiology of Retinal Vein Occlusions
[chapter]
2012
Retinal Vein Occlusions
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Oxygen Exchange in the Retina and Autoregulation The retina exhibits the high rates of glycolysis necessary for the active transport of ions that generate gradients subserving neuronal action potentials ...
There are oxygen gradients within the retina. • The oxygen tension is highest adjacent to retinal arteries and lowest adjacent to retinal veins. ...
doi:10.1007/978-1-4614-3439-9_2
fatcat:f7wloukcgbfmjla7wvr332ed6m
Modelling of hydrogen diffusion in the retina
2020
ANZIAM Journal
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Modeling Hydrogen clearance from the retina. ANZIAM J. 59:281–292, 2018. doi:10.1017/S1446181117000426 A. B. Friedland. A mathematical model of transmural transport of oxygen to the retina. Bull. ...
Choroidal regulation of oxygen supply to the guinea pig retina. In A. G. Hudetz, and D. F. Bruley (Eds.), Oxygen Transport to Tissue XX, pp. 385–389. Springer, 1998. doi:10.1007/978-1-4615-4863-8 ...
This small Peclet number is equivalent to a large α in the 1D model. Here, the diffusion term plays a vital role in the transport of the hydrogen. ...
doi:10.21914/anziamj.v61i0.14995
fatcat:jd3e3gf545da7at3a6mrlmi6he
Mathematical methods for modeling the microcirculation
2017
AIMS Biophysics
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vascular networks, solute transport and delivery to the surrounding tissue, and vessel wall mechanics under passive and active stimuli. ...
The microcirculation plays a major role in maintaining homeostasis in the body. Alterations or dysfunctions of the microcirculation can lead to several types of serious diseases. ...
Models of gas transport in the retinal tissue Several models have been developed to estimate oxygen profiles in the avascular region of the retina (outer retina). ...
doi:10.3934/biophy.2017.3.362
fatcat:nnsrh43egvhb3jzi3h3mm52lgm
Dynamics of angiogenesis during murine retinal development: a coupled in vivo and in silico study
2012
Journal of the Royal Society Interface
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factor (PDGF)-A results in the formation of a dense scaffold on the surface of the inner retina. ...
An experimentally informed, two-dimensional hybrid partial differential equation-discrete model is derived to track the outward migration of individual astrocyte and endothelial tip cells in response to ...
The authors gratefully acknowledge financial support from the BBSRC grant nos. BB/F002254/1 and BB/F002807/1. ...
doi:10.1098/rsif.2012.0067
pmid:22438490
pmcid:PMC3405746
fatcat:ohpsdvrnkfer7odw3n3ivv5bda
Mathematical Modeling of Oxygen Transport in theEye
2012
Applied Mathematics
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A simp le mathemat ical model for the steady state oxygen distribution in the eye has been developed. ...
The results of the model may contribute when axial diffusion is impo rtant and when it can be neglected. ...
In order to study the effect ofvarious parameters on the oxygen transport phenomena the model considers: ⅰ Oxygen transport in the retinal tissue ⅱ Oxygen transport within the retinal cap illary The model ...
doi:10.5923/j.am.20120204.01
fatcat:fgvezbrt4ba4bi3he5wln2yqby
Theoretical Analysis of Oxygen Consumption by Vascular Walls Exposed to Hemodynamic Stress in the Human Retinal Microvascular Network
2010
Transactions of Japanese Society for Medical and Biological Engineering
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The rates at which endothelial and smooth muscle cells in vessel walls should consume oxygen during blood transport along the length of a microvascular network are highly controversial. ...
We examined the arteriovenous distribution of oxygen consumption by a microvessel wall exposed to circumferential wall stress and fluid shear stress. ...
, and oxygen content of blood and tissue, within the microvascular networks of the human retina. ...
doi:10.11239/jsmbe.48.482
fatcat:jmrb3c76nvcyxk67zacb5m3yye
The eye, the kidney and microcirculation
2010
Nephrology, Dialysis and Transplantation
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The mammalian retina has been found to possess an unusually high rate of glycolysis [7] and oxygen consumption [8] , with this activity fuelling the active transport processes that maintain the ionic ...
Bayliss was the first to describe the myogenic constriction of arterioles when transmural pressure is elevated [2] . ...
doi:10.1093/ndt/gfq425
pmid:20628181
fatcat:l2dk6z7cy5gxhb7gaf7tjmsu5m
A Hybrid Discrete-Continuum Mathematical Model of Pattern Prediction in the Developing Retinal Vasculature
2012
Bulletin of Mathematical Biology
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Prior to birth, astrocytes migrate from the optic nerve over the surface of the inner retina in response to a chemotactic gradient of PDGF-A, formed at an earlier stage by migrating retinal ganglion cells ...
The model of the functional vasculature is informed by a range of morphological and molecular data obtained over a period of several days, from 6 days prior to birth to approximately 8 days after birth ...
Acknowledgements The authors gratefully acknowledge financial support from the BBSRC: Grant # BB/F002254/1 and BB/F002807/1. ...
doi:10.1007/s11538-012-9754-9
pmid:22829182
fatcat:zyp6meahefdejekkyigqeac4py
Effects of Changes in the Apparent Viscosity of Blood with Vessel Size on Retinal Microcirculation:Significance of the Fåhraeus-Lindqvist Effect
2011
Transactions of Japanese Society for Medical and Biological Engineering
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The purpose of this study was to quantitatively assess the influence of the Fåhraeus-Lindqvist effect on the microcirculation in the arteriovenous network of the human retina. ...
The efficiency of blood transport to tissues in the microvascular bed, which was evaluated in terms of the inverse of the mechanical energy cost of the product of the driving pressure and blood flow, was ...
This rheological property of blood in the macrocirculation with respect to the maximum transport of oxygen is evaluated in terms of the ratio of oxygen transport to blood viscosity [2] ; by definition ...
doi:10.11239/jsmbe.49.533
fatcat:yzmswpftdnh2feh74eqcj4uwze
Mathematical Modeling of Flow and Diffusion in the Lens of the Eye
2021
Journal of Scientific Research and Reports
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The model takes into account the transport of oxygen by diffusion and consumption of oxygen is assumed to follow the Michaelis- Menten's kinetics. ...
The prime objective of the present study is to investigate the effect of model parameters: the Michaelis- Menten's kinetic constant and maximum rate of consumption on the partial pressure of oxygen in ...
Aspect of European Journal of Pharmaceutical
Science. 2008;32:175-182.
3.
Avtar R, Tandon D. Modelling the
Transmural Transport of Oxygen to the
Retina." ...
doi:10.9734/jsrr/2021/v27i930433
fatcat:xadpgd25jvclzalkfrf5hfp53u
Microvascular oxygen tension in the rat mesentery
2008
American Journal of Physiology. Heart and Circulatory Physiology
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Capillaries appear to be the primary site of oxygen delivery to the tissue in the mesenteric microcirculation. ...
In light of the present results, previously reported data concerning oxygen consumption in the mesenteric microcirculation can be explained as artifacts of accumulated oxygen consumption due to the application ...
modeling (36, 39, 40, 42) . ...
doi:10.1152/ajpheart.00861.2007
pmid:17951364
fatcat:cvwqjprk4bhshn5qdz7jml3g6i
The pathogenesis of diabetic retinopathy: old concepts and new questions
2002
Eye (London. 1987)
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More recently, focus has been directed to the molecular basis of the disease process in diabetic retinopathy. ...
factor) together with specific receptors and obligate components of the signal transduction pathway needed to support them. ...
Acknowledgements The authors' research referred to in this review was funded by The Wellcome Trust and the British Diabetic Association. ...
doi:10.1038/sj.eye.6700133
pmid:12032713
fatcat:eytecfxzxbfc5bm5ir56jwrjc4
Ciliary blood flow and aqueous humor production
2011
Progress in retinal and eye research
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Aqueous humor production is a metabolically active process sustained by the delivery of oxygen and nutrients and removal of metabolic waste by the ciliary circulation. ...
The results also show that the plateau portion of the relationship shifts up or down depending on the level of secretory stimulation or inhibition, and that oxygen is one critical factor provided by ciliary ...
Sincere appreciation is expressed to Ms Alma Maldonado for her technical contributions and performance of many of the experiments. ...
doi:10.1016/j.preteyeres.2010.08.001
pmid:20801226
pmcid:PMC3010334
fatcat:dons4kwnhjarjezc7ob5k3b65e
Hyperspectral Computed Tomographic Imaging Spectroscopy of Vascular Oxygen Gradients in the Rabbit Retina In Vivo
2011
PLoS ONE
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Application of this method to animal models of retinal vascular disease and clinical subjects will provide useful and novel information about retinal vascular disease and physiology. ...
Up to 76 spectral measurements can be made in only a few milliseconds and used to quantify the oxygen saturation within the retinal vessels over a 10-15 degree field. ...
In this paper, we implement the HCTIS to measure hemoglobin oxygen gradients within the microvasculature of the retina in vivo. ...
doi:10.1371/journal.pone.0024482
pmid:21931729
pmcid:PMC3172231
fatcat:jbl4e2ccxvgdle5uiifhkyn6me
Biofluid modeling of the coupled eye-brain system and insights into simulated microgravity conditions
2019
PLoS ONE
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These findings indicate that the particular anatomical architecture of venous drainage in the retina may be one of the reasons why most of the SANS alterations are not observed in the retina but, rather ...
To this end, we propose a reduced (0-dimensional) mathematical model of fluid flow in the eyes and brain, which is embedded into a simplified whole-body circulation model. ...
Acknowledgments This work has been partially supported by the award NSF DMS-1853222/1853303, the Chair Gutenberg funds of the Cercle Gutenberg (France) and the Labex IRMIA and the IdEx Unistra (University ...
doi:10.1371/journal.pone.0216012
pmid:31412033
pmcid:PMC6693745
fatcat:4e6b5yjsj5g2jewbwjl4nfltkm
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