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Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus

Basilis Zikopoulos, Helen Barbas, Bernhard Baune
2007 PLoS ONE  
One circuit originated from the neurochemical group of parvalbumin-positive thalamic neurons and projected focally through large terminals to the middle cortical layers, resembling 'drivers' in sensory  ...  The largely parallel thalamo-cortical pathways terminated among distinct and laminar-specific neurochemical classes of inhibitory neurons that differ markedly in inhibitory control.  ...  John Fiala for assistance in adapting the free 3D-reconstruction software he developed, Dr. Ron Killiany for MRI and surgical assistance, Ms. Maria Medalla, Ola Alade and Mrs.  ... 
doi:10.1371/journal.pone.0000848 pmid:17786219 pmcid:PMC1952177 fatcat:djfgf2euhzgl7dx4ej7jrdcmlm

Thalamo-Cortical Disruption Contributes to Short-Term Memory Deficits in Patients with Medial Temporal Lobe Damage

Natalie L. Voets, Ricarda A. L. Menke, Saad Jbabdi, Masud Husain, Richard Stacey, Katherine Carpenter, Jane E. Adcock
2015 Cerebral Cortex  
These findings identify thalamo-cortical disruption as a potential mechanism contributing to STM deficits in the context of MTL damage.  ...  Aberrant thalamo-cortical connectivity in the epileptic hemisphere was mirrored in a loss of behavioral association with STM performance specifically in patients with hippocampal atrophy.  ...  Effect of Hippocampal Atrophy on Thalamo-Cortical Interaction Both secondary deafferentation of thalamic connections from an atrophic hippocampus and propagation of epileptic activity could in theory contribute  ... 
doi:10.1093/cercor/bhv109 pmid:26009613 pmcid:PMC4816801 fatcat:sgrh66tm7bewlopk4uznq7blri

The Mediodorsal Thalamus: An Essential Partner of the Prefrontal Cortex for Cognition

Sébastien Parnaudeau, Scott S. Bolkan, Christoph Kellendonk
2018 Biological Psychiatry  
Elevated activity is dependent on local cortical connectivity as well as on thalamo-cortical input (Right).  ...  the possibility of a general dysfunction of thalamo-cortical circuits(98,108).  ... 
doi:10.1016/j.biopsych.2017.11.008 pmid:29275841 pmcid:PMC5862748 fatcat:iovbl2ffs5eylkeuom6w2xyhqq

Intralaminar and medial thalamic influence on cortical synchrony, information transmission and cognition

Yuri B. Saalmann
2014 Frontiers in Systems Neuroscience  
The intralaminar and medial thalamic nuclei are part of the higher-order thalamus, which receives little sensory input, and instead forms extensive cortico-thalamo-cortical pathways.  ...  Such a thalamic-mediated synchronization mechanism may give rise to large-scale integration of information across multiple cortical circuits, consequently influencing the level of arousal and consciousness  ...  influence on the cortex.  ... 
doi:10.3389/fnsys.2014.00083 pmid:24847225 pmcid:PMC4023070 fatcat:b7pglfcbsbewxkbu65qqtspjt4

Open and closed loops: A computational approach to attention and consciousness

Sabrina Trapp, Henning Schroll, Fred H Hamker
2012 Advances in Cognitive Psychology  
Within recent years, researchers have proposed the independence of attention and consciousness on both empirical and conceptual grounds.  ...  However, the elusive nature of these constructs complicates progress in the investigation of their interaction.  ...  In this model, top-down signals influence the neural dynamics of a network consisting of areas V4 and ITC as well as prefrontal areas including the frontal eye field.  ... 
doi:10.2478/v10053-008-0096-y pmid:23853675 pmcid:PMC3709102 fatcat:dcc6f4eslfavfmmc7onq4psrj4

The cortico-basal ganglia integrative network: The role of the thalamus

Suzanne N. Haber, Roberta Calzavara
2009 Brain Research Bulletin  
Tract-tracing and physiological experiments have indicated a general topographic organization of the cortical-BG-thalamic loops and supported a model of BG function based on parallel and segregated pathways  ...  These terminals can influence different functional cortical areas that, in turn, project to the striatum and back to the thalamus.  ...  In contrast to the topographically specific thalamo-cortical projections to middle layers, the more widespread, diffuse terminals in layer I are in a position to modulate neuronal activity from all cortical  ... 
doi:10.1016/j.brainresbull.2008.09.013 pmid:18950692 pmcid:PMC4459637 fatcat:vhoulm4qhbctlmcpiwnc47t3hm

The Neurofunctional Model of Consciousness: The Physiological Interconnectivity of Brain Networks [chapter]

Umberto León-Domínguez
2020 Neural Connectivity [Working Title]  
The model poses a theoretical evidenced-based framework that organizes the brain journey of neural information flow from the ascending reticular activating system and non-specific thalamic nuclei, to cortical  ...  These inter-connected brain networks can be divided within three hierarchical and inter-connected "functional neural loops": (1) the "brainstem-thalamic neural loop" for arousal, (2) the "thalamo-cortical  ...  Conflict of interest The authors have no conflict of interest to declare. Neural Connectivity  ... 
doi:10.5772/intechopen.94221 fatcat:ss23xikn7ffglfriwota3qskzy

Associative Learning Beyond the Medial Temporal Lobe: Many Actors on the Memory Stage

Giulio Pergola, Boris Suchan
2013 Frontiers in Behavioral Neuroscience  
We then focus on the clinical and neuroimaging evidence available on thalamo-prefrontal and thalamo-retrosplenial networks.  ...  Among these areas, the thalamus, the retrosplenial cortex, and the prefrontal cortices have been consistently related to episodic memory performance.  ...  Therefore this nucleus is in the place to switch between patterns of thalamic electrophysiological activity, by selectively inhibiting the thalamo-cortical projections (Crick, 1984) .  ... 
doi:10.3389/fnbeh.2013.00162 pmid:24312029 pmcid:PMC3832901 fatcat:rdq5rups55eudijgsd4kb6ecbm

What Is the Evidence for Inter-laminar Integration in a Prefrontal Cortical Minicolumn?

Ioan Opris, Stephano Chang, Brian R. Noga
2017 Frontiers in Neuroanatomy  
Inter-laminar minicolumnar activity previously recorded from the dorsolateral prefrontal cortex (dlPFC) of nonhuman primates, trained in a visual delay match-to-sample (DMS) task, was re-assessed from  ...  The integration hypothesis posits that perceptual and behavioral signals are integrated within the prefrontal cortical interlaminar microcircuits.  ...  the thalamo-cortical projection in the cortico-striatal-thalamo-cortical loop.  ... 
doi:10.3389/fnana.2017.00116 pmid:29311848 pmcid:PMC5735117 fatcat:nzd6jcbmnvc2bhecnnyzankqya

The Role of the Cerebellum in the Pathophysiology of Parkinson's Disease

Mechelle M. Lewis, Shawna Galley, Samantha Johnson, James Stevenson, Xuemei Huang, Martin J. McKeown
2013 Canadian Journal of Neurological Sciences  
Nevertheless recent discoveries in anatomical connections linking the basal ganglia and the cerebellum have led to a re-examination of the role of the cerebellum in the pathophysiology of PD.  ...  This review summarizes the role of the cerebellum in explaining many curious features of PD: the significant variation in disease progression between individuals; why severity of dopaminergic deficit correlates  ...  , that the role of the striatothalamo-cortical and cerebello-thalamo-cortical circuits in externally and internally guided tasks is influenced by many factors (e.g., study paradigm, aspect of movement  ... 
doi:10.1017/s0317167100014232 fatcat:skqa3m5lcjbrvmr6e4vwp36nfi

Testing Proposed Neuronal Models of Effective Connectivity Within the Cortico-basal Ganglia-thalamo-cortical Loop During Loss of Consciousness

Julia Sophia Crone, Evan Scott Lutkenhoff, Branden Joseph Bio, Steven Laureys, Martin Max Monti
2016 Cerebral Cortex  
Specifically, we assess the fit of each model to the dynamic change in effective connectivity between specific cortical and subcortical regions at different consecutive levels of propofol-induced sedation  ...  Rather, the data show that loss of consciousness, at least in the context of propofol-induced sedation, is marked by a breakdown of corticopetal projections from the globus pallidus.  ...  Qiu et al. (2010) stress the importance of direct cortical projections from the globus pallidus because lesions to the thalamus do not affect cortical activity in the rodent model (Vanderwolf and Stewart  ... 
doi:10.1093/cercor/bhw112 pmid:27114177 fatcat:7gkfnwcbcvbvrfyp6ktgaa23ba

Wait and see

C.H.M Brunia, G.J.M van Boxtel
2001 International Journal of Psychophysiology  
Slow cortical potentials are the result of concerted activity in a number of cerebral networks, in which the thalamus forms a crucial node.  ...  The CNV reflects the preparation of a signaled movement and the simultaneous anticipatory attention for the imperative stimulus.  ...  Acknowledgements The authors thank David LaBerge, Fernando Lopes da Silva and Henk Groenewegen for their very valuable comments upon an earlier version of this paper.  ... 
doi:10.1016/s0167-8760(01)00179-9 pmid:11742685 fatcat:vdqjrgtvnreddaffrpzjdrktr4

The super-learning hypothesis: integrating learning processes across cortex, cerebellum and basal ganglia

Daniele Caligiore, Michael A. Arbib, R. Chris Miall, Gianluca Baldassarre
2019 Neuroscience and Biobehavioral Reviews  
the activity of thalamo-D.  ...  predominant influence of intrinsic activity (Hasselmo, 1995) .  ... 
doi:10.1016/j.neubiorev.2019.02.008 fatcat:d24m6yc355e6hhvr54p34p5vze

Parkinson's disease as a system-level disorder

Daniele Caligiore, Rick C Helmich, Mark Hallett, Ahmed A Moustafa, Lars Timmermann, Ivan Toni, Gianluca Baldassarre
2016 npj Parkinson's Disease  
Possible future therapies based on this different view of the disease are discussed.  ...  This single area perspective gives a restricted clinical picture and limits therapeutic approaches because it ignores the influence of altered interactions between the basal ganglia and other cerebral  ...  ), which allows the BG to influence the excitability of the thalamo-cortical system through Cer.  ... 
doi:10.1038/npjparkd.2016.25 pmid:28725705 pmcid:PMC5516580 fatcat:lj3h57ew35auvnqkoh2chi3uf4

Thalamocortical connectivity in major depressive disorder

Elliot C. Brown, Darren L. Clark, Stefanie Hassel, Glenda MacQueen, Rajamannar Ramasubbu
2017 Journal of Affective Disorders  
We did control for these potential confounding effects by including scanner as a variable of no interest in our model, however we cannot completely rule out possible influences this may have had on the  ...  In two separate studies, one using the ketamine model of psychosis, and another in autism, hyperconnectivity of both thalamo-temporal and thalamo-somatosensory circuits were found (Höflich et al., 2015b  ... 
doi:10.1016/j.jad.2017.04.004 pmid:28407555 fatcat:wxtwxihtzreg5nloe5btfgdcw4
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