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Noladin Ether Acts on Trabecular Meshwork Cannabinoid (CB1) Receptors to Enhance Aqueous Humor Outflow Facility
2006
Investigative Ophthalmology and Visual Science
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The effects of noladin ether on aqueous humor outflow facility were measured in a porcine anterior-segmentperfused organ culture model. ...
The data also show that noladin ether-induced enhancement of outflow facility is mediated through the trabecular meshwork CB1 receptor, with an involvement of p42/44 MAP kinase signaling pathway and changes ...
meshwork to increase aqueous humor outflow. ...
doi:10.1167/iovs.05-0729
pmid:16639008
fatcat:o4xvrpabxbdevecvoxrt37auuu
A two-phase model for the aqueous outflow through the trabecular meshwork
2016
International Journal of Applied Mathematical Research
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A two-phase steady-state model for the percolation of aqueous humor through the trabecular meshwork (TM) in eye has been developed. ...
Both the rings are assumed to be made up of homogeneous, isotropic, viscoelastic material swollen with continuously flowing aqueous humor through the tissue with different structural properties. ...
The outflow of aqueous humor through the trabecular meshwork occurs under the pressure differential across the meshwork. ...
doi:10.14419/ijamr.v5i2.5763
fatcat:2xzn4utbp5hrtl72xu4vaeq6ty
Aqueous outflow: Segmental and distal flow
2014
Journal of cataract and refractive surgery
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A prominent risk factor of primary open-angle glaucoma is ocular hypertension, a pathologic state caused by impaired outflow of aqueous humor through the trabecular meshwork within the iridocorneal angle ...
The conventional pathway, which regulates approximately 85% of aqueous outflow, refers to the flow of aqueous humor through the trabecular meshwork (TM), Schlemm canal, collector channels, and episcleral ...
In this review, aqueous humor outflow within the trabecular meshwork and distal segments of the outflow pathway will be discussed. ...
doi:10.1016/j.jcrs.2014.06.020
pmid:25088623
pmcid:PMC4151118
fatcat:fob25reghzen3kalqshnkagcvq
Serum proteins and aqueous outflow resistance in bovine eyes
1993
Investigative Ophthalmology and Visual Science
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Modeling studies confirm that plasma-derived proteins in the aqueous humor of the trabecular meshwork can generate a significant fraction of aqueous outflow resistance. ...
The proximity of the protein entry point to the trabecular meshwork suggests that the protein content of the aqueous humor in the trabecular meshwork might be much higher than previously suggested. ...
results not only provide a physical basis for the wash-out effect, but also show that aqueous outflow resistance can be generated by proteins in the aqueous humor as they pass through the trabecular meshwork ...
pmid:8258512
fatcat:fnuacnrz5nejffytl2t76hk5gu
CB2 Cannabinoid Receptors in Trabecular Meshwork Cells Mediate JWH015-Induced Enhancement of Aqueous Humor Outflow Facility
2005
Investigative Ophthalmology and Visual Science
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A porcine anterior segment perfused organ culture model was used to measure the effects of JWH015 on aqueous humor outflow facility. ...
To study the effects of JWH015, a CB2-selective agonist, on aqueous humor outflow facility, to investigate whether functional CB2 cannabinoid receptors are expressed in trabecular meshwork cells, and to ...
The maintenance of IOP depends on a dynamic balance between the secretion of aqueous humor by the ciliary body and the outflow of aqueous humor through the trabecular meshwork and uveoscleral route. ...
doi:10.1167/iovs.04-0651
pmid:15914613
fatcat:r22wb7ckrvedtmzbvsybwdgmq4
The Effects of Prostaglandin Analogs on Intraocular Pressure in Human Eye for Open Angle Glaucoma
2020
VOLUME-8 ISSUE-10, AUGUST 2019, REGULAR ISSUE
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And it is connected by trabecular meshwork. The inner layer of the canal's wall has been assumed as permeable. And the aqueous humor drains into the canal through this porous tissue wall. ...
The eye keeps on making aqueous humor in the ciliary body and it passes through the trabecular meshwork into the scheme of the canal, the key drainage from the eye and it finally goes to the "collector ...
characteristics of aqueous humor flow and a simple mathematical framework for describing the aqueous outflow through trabecular meshwork have been studied. ...
doi:10.35940/ijitee.a8195.1210220
fatcat:barympx5qzfwll46cg5iniq55q
Primary Open-Angle Glaucoma
2012
American Journal of Pathology
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The authors provide one of the few mouse models that can be used to study the early stages of POAG and demonstrate a central role for CTGF in regulating aqueous outflow resistance by trabecular meshwork ...
meshwork to maintain a healthy level of aqueous outflow resistance. ...
doi:10.1016/j.ajpath.2012.03.011
pmid:22525463
pmcid:PMC3378912
fatcat:cgneubi2nfcmvlnex6ajfbbiqu
Understanding Trabecular Meshwork Physiology: A Key to the Control of Intraocular Pressure?
2003
Physiology
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The trabecular meshwork is a tissue located in the anterior chamber angle of the eye, and it is a crucial determinant of intraocular pressure values because of its resistance to the evacuation of aqueous ...
humor from the eye. ...
On this route, aqueous humor exits the eye through a well-structured tissue called the trabecular meshwork (TM). ...
doi:10.1152/nips.01443.2003
pmid:14500801
fatcat:xv7x6wphlzfhfortiqdc3nhghu
Rho- Kinase Inhibitor Y-27632 Decreases the Thickness of Trabecular Meshwork in Juvenile Rats Mod-el Injected with Sodium Hyaluronate
2018
Journal of Tropical Life Science
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Most glaucoma drugs lower the intraocular pressure (IOP) by decreasing the aqueous humor production and increasing the outflow through uveoscleral pathway. ...
None of these drugs work mainly on increasing outflow through the trabecular pathway. ...
Trabecular meshwork tissue is recognized to have the highest responsibility in regulating aqueous humor outflow as conventional pathway. ...
doi:10.11594/jtls.08.02.13
fatcat:lf7uqsvqnnclredehj2etlqtfq
Surgery on the Trabecular Meshwork: Histopathological Evidence
2015
Current Journal of Glaucoma Practice with DVD
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Juxtacanalicular (JXT) trabecular meshwork and endothelial lining of Schlemm's canal have been cited as the loci of aqueous outflow resistance, both in a normal as well as a glauco matous eye. ...
In this review, we attempt to understand the currently available surgical modalities in light of the available histo pathological evi dence, regarding localization of outflow resistance. ...
part the trabecular meshwork that is mainly involved in aqueous outflow resistance (inner wall of SC and the adjacent trabecular meshwork), while leaving intact the innermost trabecular meshwork layers ...
doi:10.5005/jp-journals-10008-1184
pmid:26997835
pmcid:PMC4750027
fatcat:ysq6gviimjc5dbtdowu6sivv74
Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction
2008
Survey of ophthalmology
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Prostaglandin receptors and their associated mRNAs have been located in the trabecular meshwork, ciliary muscle, and sclera providing evidence that endogenous prostaglandins have a functional role in aqueous ...
A consistent finding is a substantial increase in uveoscleral outflow and a less consistent finding is an increase in trabecular outflow facility. ...
IOP usually is reduced by slowing the production rate of aqueous humor, by decreasing the resistance to flow through the trabecular meshwork, by increasing drainage through the uveoscleral outflow pathway ...
doi:10.1016/j.survophthal.2008.08.010
pmid:19038618
pmcid:PMC2727743
fatcat:46na4wdj5ja3vbwaeqam3osgfm
Aqueous Humor Dynamics: A Review~!2010-03-03~!2010-06-17~!2010-09-02~!
2010
Open Ophthalmology Journal
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proteins, such as cochlin, obstruct the aqueous humor outflow through the TM. ...
The two main structures related to aqueous humor dynamics are the ciliary body and the trabecular meshwork (TM). ...
bypass outflow resistance by shunting aqueous humor through or around the trabecular meshwork. ...
doi:10.2174/1874364101004010052
pmid:21293732
pmcid:PMC3032230
fatcat:t54hbzeod5fgbcksde3blwg63u
Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma
2017
The Yale Journal of Biology and Medicine
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pathway to increase aqueous humor outflow. ...
In recent years, the scientific and medical community has seen encouraging development of novel classes of drugs for primary OAG, the majority of which lower IOP by targeting the trabecular meshwork outflow ...
aqueous humor outflow through the trabecular meshwork outflow pathway [51] [52] [53] [54] . ...
pmid:28356898
pmcid:PMC5369028
fatcat:253vim743ndyzjv52fbmlrzmmu
Review Of Applied Mathematical Models For Describing The Behaviour Of Aqueous Humor In Eye Structures
2015
International Journal of Applied Mechanics and Engineering
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The proposed model may be used for modeling the flow of the aqueous humor through the trabecular meshwork. The trabecular meshwork is modeled as an array of rectilinear parallel capillary tubes. ...
In the paper, currently used methods for modeling the flow of the aqueous humor through eye structures are presented. ...
of the aqueous humor from the eye, t F -the outflow of the aqueous humor through the trabecular meshwork, u F -the outflow of the aqueous humor through the sclera, tot C , pp C -total conductance of the ...
doi:10.1515/ijame-2015-0049
fatcat:lgt35xjxjngi7ndpqxszegency
NGenetics and Environmental Stress Factor Contributions to Anterior Segment Malformations and Glaucoma
[chapter]
2013
Glaucoma - Basic and Clinical Aspects
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The majority of the aqueous humor will be drained from the eye via the trabecular pathway through the trabecular meshwork (TM) and Schlemm's canal. ...
Trabecular meshwork and aqueous humor outflow pathway Aqueous humor is a colourless and transparent fluid that makes contact with various structures in both the anterior and posterior chambers of the eye ...
The majority of the aqueous humor will be drained from the eye via the trabecular pathway through the trabecular meshwork (TM) and Schlemm's canal. ...
doi:10.5772/54653
fatcat:dggylyy7jzaoddhr5xczzyi2ay
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