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Noladin Ether Acts on Trabecular Meshwork Cannabinoid (CB1) Receptors to Enhance Aqueous Humor Outflow Facility

Ya Fatou Njie, Akhilesh Kumar, Zhuanhong Qiao, Lichun Zhong, Zhao-Hui Song
2006 Investigative Ophthalmology and Visual Science  
The effects of noladin ether on aqueous humor outflow facility were measured in a porcine anterior-segmentperfused organ culture model.  ...  The data also show that noladin ether-induced enhancement of outflow facility is mediated through the trabecular meshwork CB1 receptor, with an involvement of p42/44 MAP kinase signaling pathway and changes  ...  meshwork to increase aqueous humor outflow.  ... 
doi:10.1167/iovs.05-0729 pmid:16639008 fatcat:o4xvrpabxbdevecvoxrt37auuu

A two-phase model for the aqueous outflow through the trabecular meshwork

Ram Avtar, Swati Srivastava
2016 International Journal of Applied Mathematical Research  
A two-phase steady-state model for the percolation of aqueous humor through the trabecular meshwork (TM) in eye has been developed.  ...  Both the rings are assumed to be made up of homogeneous, isotropic, viscoelastic material swollen with continuously flowing aqueous humor through the tissue with different structural properties.  ...  The outflow of aqueous humor through the trabecular meshwork occurs under the pressure differential across the meshwork.  ... 
doi:10.14419/ijamr.v5i2.5763 fatcat:2xzn4utbp5hrtl72xu4vaeq6ty

Aqueous outflow: Segmental and distal flow

Swarup S. Swaminathan, Dong-Jin Oh, Min Hyung Kang, Douglas J. Rhee
2014 Journal of cataract and refractive surgery  
A prominent risk factor of primary open-angle glaucoma is ocular hypertension, a pathologic state caused by impaired outflow of aqueous humor through the trabecular meshwork within the iridocorneal angle  ...  The conventional pathway, which regulates approximately 85% of aqueous outflow, refers to the flow of aqueous humor through the trabecular meshwork (TM), Schlemm canal, collector channels, and episcleral  ...  In this review, aqueous humor outflow within the trabecular meshwork and distal segments of the outflow pathway will be discussed.  ... 
doi:10.1016/j.jcrs.2014.06.020 pmid:25088623 pmcid:PMC4151118 fatcat:fob25reghzen3kalqshnkagcvq

Serum proteins and aqueous outflow resistance in bovine eyes

M Johnson, H Gong, T F Freddo, N Ritter, R Kamm
1993 Investigative Ophthalmology and Visual Science  
Modeling studies confirm that plasma-derived proteins in the aqueous humor of the trabecular meshwork can generate a significant fraction of aqueous outflow resistance.  ...  The proximity of the protein entry point to the trabecular meshwork suggests that the protein content of the aqueous humor in the trabecular meshwork might be much higher than previously suggested.  ...  results not only provide a physical basis for the wash-out effect, but also show that aqueous outflow resistance can be generated by proteins in the aqueous humor as they pass through the trabecular meshwork  ... 
pmid:8258512 fatcat:fnuacnrz5nejffytl2t76hk5gu

CB2 Cannabinoid Receptors in Trabecular Meshwork Cells Mediate JWH015-Induced Enhancement of Aqueous Humor Outflow Facility

Lichun Zhong, Lijun Geng, YaFatou Njie, Wenke Feng, Zhao-Hui Song
2005 Investigative Ophthalmology and Visual Science  
A porcine anterior segment perfused organ culture model was used to measure the effects of JWH015 on aqueous humor outflow facility.  ...  To study the effects of JWH015, a CB2-selective agonist, on aqueous humor outflow facility, to investigate whether functional CB2 cannabinoid receptors are expressed in trabecular meshwork cells, and to  ...  The maintenance of IOP depends on a dynamic balance between the secretion of aqueous humor by the ciliary body and the outflow of aqueous humor through the trabecular meshwork and uveoscleral route.  ... 
doi:10.1167/iovs.04-0651 pmid:15914613 fatcat:r22wb7ckrvedtmzbvsybwdgmq4

The Effects of Prostaglandin Analogs on Intraocular Pressure in Human Eye for Open Angle Glaucoma

Shabab Akbar, Sapna Ratan Shah
And it is connected by trabecular meshwork. The inner layer of the canal's wall has been assumed as permeable. And the aqueous humor drains into the canal through this porous tissue wall.  ...  The eye keeps on making aqueous humor in the ciliary body and it passes through the trabecular meshwork into the scheme of the canal, the key drainage from the eye and it finally goes to the "collector  ...  characteristics of aqueous humor flow and a simple mathematical framework for describing the aqueous outflow through trabecular meshwork have been studied.  ... 
doi:10.35940/ijitee.a8195.1210220 fatcat:barympx5qzfwll46cg5iniq55q

Primary Open-Angle Glaucoma

Andrew W. Taylor
2012 American Journal of Pathology  
The authors provide one of the few mouse models that can be used to study the early stages of POAG and demonstrate a central role for CTGF in regulating aqueous outflow resistance by trabecular meshwork  ...  meshwork to maintain a healthy level of aqueous outflow resistance.  ... 
doi:10.1016/j.ajpath.2012.03.011 pmid:22525463 pmcid:PMC3378912 fatcat:cgneubi2nfcmvlnex6ajfbbiqu

Understanding Trabecular Meshwork Physiology: A Key to the Control of Intraocular Pressure?

Artur Llobet, Xavier Gasull, Arcadi Gual
2003 Physiology  
The trabecular meshwork is a tissue located in the anterior chamber angle of the eye, and it is a crucial determinant of intraocular pressure values because of its resistance to the evacuation of aqueous  ...  humor from the eye.  ...  On this route, aqueous humor exits the eye through a well-structured tissue called the trabecular meshwork (TM).  ... 
doi:10.1152/nips.01443.2003 pmid:14500801 fatcat:xv7x6wphlzfhfortiqdc3nhghu

Rho- Kinase Inhibitor Y-27632 Decreases the Thickness of Trabecular Meshwork in Juvenile Rats Mod-el Injected with Sodium Hyaluronate

Wino Vierlia, Lely Wulandari, Hidayat Sujuti, Ma'sum Effendi
2018 Journal of Tropical Life Science  
Most glaucoma drugs lower the intraocular pressure (IOP) by decreasing the aqueous humor production and increasing the outflow through uveoscleral pathway.  ...  None of these drugs work mainly on increasing outflow through the trabecular pathway.  ...  Trabecular meshwork tissue is recognized to have the highest responsibility in regulating aqueous humor outflow as conventional pathway.  ... 
doi:10.11594/jtls.08.02.13 fatcat:lf7uqsvqnnclredehj2etlqtfq

Surgery on the Trabecular Meshwork: Histopathological Evidence

Shibal Bhartiya, Parul Ichhpujani, Tarek Shaarawy, Tanuj Dada, Tarek Shaarawy
2015 Current Journal of Glaucoma Practice with DVD  
Juxtacanalicular (JXT) trabecular meshwork and endothelial lining of Schlemm's canal have been cited as the loci of aqueous outflow resistance, both in a normal as well as a glauco matous eye.  ...  In this review, we attempt to understand the currently available surgical modalities in light of the available histo pathological evi dence, regarding localization of outflow resistance.  ...  part the trabecular meshwork that is mainly involved in aqueous outflow resistance (inner wall of SC and the adjacent trabecular meshwork), while leaving intact the innermost trabecular meshwork layers  ... 
doi:10.5005/jp-journals-10008-1184 pmid:26997835 pmcid:PMC4750027 fatcat:ysq6gviimjc5dbtdowu6sivv74

Update on the Mechanism of Action of Topical Prostaglandins for Intraocular Pressure Reduction

Carol B. Toris, B'Ann T. Gabelt, Paul L. Kaufman
2008 Survey of ophthalmology  
Prostaglandin receptors and their associated mRNAs have been located in the trabecular meshwork, ciliary muscle, and sclera providing evidence that endogenous prostaglandins have a functional role in aqueous  ...  A consistent finding is a substantial increase in uveoscleral outflow and a less consistent finding is an increase in trabecular outflow facility.  ...  IOP usually is reduced by slowing the production rate of aqueous humor, by decreasing the resistance to flow through the trabecular meshwork, by increasing drainage through the uveoscleral outflow pathway  ... 
doi:10.1016/j.survophthal.2008.08.010 pmid:19038618 pmcid:PMC2727743 fatcat:46na4wdj5ja3vbwaeqam3osgfm

Aqueous Humor Dynamics: A Review~!2010-03-03~!2010-06-17~!2010-09-02~!

Manik Goel
2010 Open Ophthalmology Journal  
proteins, such as cochlin, obstruct the aqueous humor outflow through the TM.  ...  The two main structures related to aqueous humor dynamics are the ciliary body and the trabecular meshwork (TM).  ...  bypass outflow resistance by shunting aqueous humor through or around the trabecular meshwork.  ... 
doi:10.2174/1874364101004010052 pmid:21293732 pmcid:PMC3032230 fatcat:t54hbzeod5fgbcksde3blwg63u

Novel Pharmacologic Candidates for Treatment of Primary Open-Angle Glaucoma

Louise J Lu, James C Tsai, Ji Liu
2017 The Yale Journal of Biology and Medicine  
pathway to increase aqueous humor outflow.  ...  In recent years, the scientific and medical community has seen encouraging development of novel classes of drugs for primary OAG, the majority of which lower IOP by targeting the trabecular meshwork outflow  ...  aqueous humor outflow through the trabecular meshwork outflow pathway [51] [52] [53] [54] .  ... 
pmid:28356898 pmcid:PMC5369028 fatcat:253vim743ndyzjv52fbmlrzmmu

Review Of Applied Mathematical Models For Describing The Behaviour Of Aqueous Humor In Eye Structures

M. Dzierka, P. Jurczak
2015 International Journal of Applied Mechanics and Engineering  
The proposed model may be used for modeling the flow of the aqueous humor through the trabecular meshwork. The trabecular meshwork is modeled as an array of rectilinear parallel capillary tubes.  ...  In the paper, currently used methods for modeling the flow of the aqueous humor through eye structures are presented.  ...  of the aqueous humor from the eye, t F -the outflow of the aqueous humor through the trabecular meshwork, u F -the outflow of the aqueous humor through the sclera, tot C , pp C -total conductance of the  ... 
doi:10.1515/ijame-2015-0049 fatcat:lgt35xjxjngi7ndpqxszegency

NGenetics and Environmental Stress Factor Contributions to Anterior Segment Malformations and Glaucoma [chapter]

Yoko A., Michael A.
2013 Glaucoma - Basic and Clinical Aspects  
The majority of the aqueous humor will be drained from the eye via the trabecular pathway through the trabecular meshwork (TM) and Schlemm's canal.  ...  Trabecular meshwork and aqueous humor outflow pathway Aqueous humor is a colourless and transparent fluid that makes contact with various structures in both the anterior and posterior chambers of the eye  ...  The majority of the aqueous humor will be drained from the eye via the trabecular pathway through the trabecular meshwork (TM) and Schlemm's canal.  ... 
doi:10.5772/54653 fatcat:dggylyy7jzaoddhr5xczzyi2ay
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