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Modelling the impact of neurovascular coupling impairments on BOLD-based functional connectivity at rest

Mario E. Archila-Meléndez, Christian Sorg, Christine Preibisch
2020 NeuroImage  
The aim of our simulation study, therefore, was to investigate the influence of impaired neurovascular coupling on resting-state BOLD-FC.  ...  Functional magnetic resonance imaging (fMRI) of blood oxygenation level dependent (BOLD) signals during the resting-state is widely used to study functional connectivity (FC) of slowly fluctuating ongoing  ...  Acknowledgements The authors thank the German Research Foundation DFG [grant numbers PR 1039/6-1, SO 1336/4-1] for funding.  ... 
doi:10.1016/j.neuroimage.2020.116871 pmid:32335261 fatcat:z6xfqeigpzddxmjo2az2jmkrzq

Pathophysiological interference with neurovascular coupling - when imaging based on hemoglobin might go blind

Ute Lindauer
2010 Frontiers in Neuroenergetics  
Local activation studies as well as studies investigating functional connectivity between brain regions of the resting brain provide a rapidly increasing body of knowledge on brain function in humans and  ...  Local activation studies as well as studies investigating functional connectivity between brain regions of the resting brain provide a rapidly increasing body of knowledge on brain function in humans and  ...  Citation : Lindauer U, Dirnagl U, Füchtemeier M, Böttiger C, Offenhauser N, Leithner C and Royl G (2010) Pathophysiological interference with neurovascular coupling -when imaging based on hemoglobin  ... 
doi:10.3389/fnene.2010.00025 pmid:20953238 pmcid:PMC2955428 fatcat:4izqjunusjazvpgkwcch3nia5m

Integration of multimodal neuroimaging methods: a rationale for clinical applications of simultaneous EEG-fMRI

Vitali Paolo
2015 Functional Neurology  
Finally, the use of this approach to evaluate the functional connectivity of resting-state networks would extend the applications of EEG-fMRI to uncooperative or unconscious patients.  ...  Integration of multimodal neuroimaging methods: a rationale for clinical applications of simultaneous EEG-fMRI KEY WORDS: BOLD, epilepsy, neurovascular coupling, pre-surgical mapping, resting-state networks  ...  , and therefore able to provide only indirect information on neural activity, based on the phenomenon of "neurovascular coupling", i.e. the relationship that exists between neural activity at cellular  ... 
doi:10.11138/fneur/2015.30.1.009 fatcat:ssykgisdejh5zfz3vluaq6xi4u

Alterations in Functional Network Topology Within Normal Hemispheres Contralateral to Anterior Circulation Steno-Occlusive Disease: A Resting-State BOLD Study

Junjie Wu, Fadi Nahab, Jason W. Allen, Ranliang Hu, Seena Dehkharghani, Deqiang Qiu
2022 Frontiers in Neurology  
The purpose of this study was to assess spatially remote effects of hemodynamic impairment on functional network topology contralateral to unilateral anterior circulation steno-occlusive disease (SOD)  ...  The BOLD baseline was used to analyze network connectivity contralateral to the diseased hemispheres of SOD patients.  ...  A challenge to such paradigms, however, rests in the nature of BOLD functional network connectivity, which is influenced both by changes in neurovascular coupling and true neural connections (27, 28)  ... 
doi:10.3389/fneur.2022.780896 pmid:35392638 pmcid:PMC8980268 fatcat:e3ab2eccqbaajbv67qccqoisge

Longitudinal Multimodal fMRI to Investigate Neurovascular Changes in Spontaneously Hypertensive Rats

Andrew Crofts, Melissa Trotman-Lucas, Justyna Janus, Michael Kelly, Claire L Gibson
2020 Journal of Neuroimaging  
Here, we use a longitudinal functional MRI (fMRI) protocol to assess the impact of hypertension on neurovascular coupling in spontaneously hypertensive rats (SHRs).  ...  To further understand this, it is advantageous to study neurovascular coupling as hypertension progresses in a rodent model.  ...  in a number of brain regions in hypertensive subjects, as well as disruption to functional connectivity. 3 The mechanisms behind these changes in neurovascular coupling are currently unclear, although  ... 
doi:10.1111/jon.12753 pmid:32648648 fatcat:fvosrn6fknftbjvlz5ncpp7hfy

Neurovascular coupling in humans: Physiology, methodological advances and clinical implications

Aaron A Phillips, Franco HN Chan, Mei Mu Zi Zheng, Andrei V Krassioukov, Philip N Ainslie
2015 Journal of Cerebral Blood Flow and Metabolism  
Herein, with particular focus on humans, we review the present mechanistic understanding of neurovascular coupling and highlight current approaches to assess these responses and the application in health  ...  management of this critical physiological function.  ...  We are at an embryonic stage regarding neurovascular coupling function using an in vivo human model.  ... 
doi:10.1177/0271678x15617954 pmid:26661243 pmcid:PMC4821024 fatcat:e74fdrfokzfipndlj7grx7cjhm

Separating vascular and neuronal effects of age on fMRI BOLD signals [article]

Kamen A. Tsvetanov, Richard N.A. Henson, James B. Rowe
2020 arXiv   pre-print
We review current approaches to dissociate neuronal and vascular components of BOLD-fMRI of regional activity and functional connectivity.  ...  Accurate identification of brain function is necessary to understand the neurobiology of cognitive ageing, and thereby promote well-being across the lifespan.  ...  latencies of neuronal responses were not directly measured). 23 Dynamic causal modelling Dynamic Causal Modelling (DCM) is a model-based approach to studying brain connectivity (Friston et al., 2003  ... 
arXiv:1912.02899v2 fatcat:tq4mkl776vdzpialwczs5hgama

Neurovascular dysfunction in vascular dementia, Alzheimer's and atherosclerosis

Osman Shabir, Jason Berwick, Sheila E. Francis
2018 BMC Neuroscience  
Understanding the mechanisms of neurovascular coupling in health and disease may enable us to develop potential therapies to prevent the breakdown of neurovascular coupling in the treatment of vascular  ...  Atherosclerosis is a chronic syndrome affecting the integrity and function of major blood vessels including those that supply the brain, and it is therefore hypothesised that atherosclerosis impairs cerebral  ...  Acknowledgements I would like to thank the University of Sheffield for funding my PhD studentship as part of the Neuroimaging in Cardiovascular Disease (NICAD) Network.  ... 
doi:10.1186/s12868-018-0465-5 pmid:30333009 pmcid:PMC6192291 fatcat:v6f22goktfbmjiwtvhykjjx2vy

Aberrant Coupling Between Resting-State Cerebral Blood Flow and Functional Connectivity in Wilson's Disease

Sheng Hu, Hongli Wu, ChunSheng Xu, Anqin Wang, Yi Wang, Tongping Shen, Fangliang Huang, Hongxing Kan, Chuanfu Li
2019 Frontiers in Neural Circuits  
Functional connectivity strength (FCS) and CBF were calculated based on standard gray mask.  ...  Whether the coupling of CBF and functional connectivity is imbalanced in WD remains largely unknown.  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.  ... 
doi:10.3389/fncir.2019.00025 pmid:31057370 pmcid:PMC6482267 fatcat:4typv3s7azbtxjubokttlxb5ny

Considerations for resting state functional MRI and functional connectivity studies in rodents

Wen-Ju Pan, Jacob C. W. Billings, Joshua K. Grooms, Sadia Shakil, Shella D. Keilholz
2015 Frontiers in Neuroscience  
Resting state functional MRI (rs-fMRI) and functional connectivity mapping have become widely used tools in the human neuroimaging community and their use is rapidly spreading into the realm of rodent  ...  These types of interwoven human and animal experiments have a potentially large impact on neuroscience and clinical practice.  ...  The BOLD signal relies on consistent neurovascular coupling to represent neural activity in a reliable manner.  ... 
doi:10.3389/fnins.2015.00269 pmid:26300718 pmcid:PMC4525377 fatcat:izgtvld2k5fwdh4jdsqy63vlsm

Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and Diffusion fMRI responses in rat visual cortex [article]

Yuji Komaki, Clement Debacker, Boucif Djemai, Luisa Ciobanu, Tomokazu Tsurugizawa, Denis Le Bihan
2020 bioRxiv   pre-print
Those results further confirm the implications of astrocytes in the neurovascular coupling mechanism underlying BOLD fMRI, while DfMRI relies on other, not astrocyte-mediated mechanisms.  ...  The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation were investigated an aquaporin 4 (AQP4) channel blocker, TGN-020, acting as an  ...  Interfering with astrocyte function should, thus, impact BOLD fMRI responses, but not necessarily neural responses which have been shown to persist unaltered after neurovascular coupling inhibition [19  ... 
doi:10.1101/2020.01.24.917849 fatcat:eef76ypvhzhvxi5htjsv6eqwpy

Disturbed neurovascular coupling in type 2 diabetes mellitus patients: Evidence from a comprehensive fMRI analysis

Bo Hu, Lin-Feng Yan, Qian Sun, Ying Yu, Jin Zhang, Yu-Jie Dai, Yang Yang, Yu-Chuan Hu, Hai-Yan Nan, Xin Zhang, Chun-Ni Heng, Jun-Feng Hou (+7 others)
2019 NeuroImage: Clinical  
Previous studies presumed that the disturbed neurovascular coupling to be a critical risk factor of cognitive impairments in type 2 diabetes mellitus (T2DM), but distinct clinical manifestations were lacked  ...  Consequently, we decided to investigate the neurovascular coupling in T2DM patients by exploring the MRI relationship between neuronal activity and the corresponding cerebral blood perfusion.  ...  Acknowledgements The authors thank the clinical and the nursing team of the Endocrinology Department in Tangdu Hospital for their cooperation with work on involving participants.  ... 
doi:10.1016/j.nicl.2019.101802 pmid:30991623 pmcid:PMC6447740 fatcat:olt5qfllezhelope4p4wwtpioq

Neurovascular Coupling During Visual Stimulation in Multiple Sclerosis: A MEG-fMRI Study

Rachael Stickland, Marek Allen, Lorenzo Magazzini, Krish D. Singh, Richard G. Wise, Valentina Tomassini
2018 Neuroscience  
Here, we tested the hypothesis that neurovascular coupling is impaired in MS.  ...  Despite altered neuronal and vascular responses, neurovascular coupling appears to be preserved in MS, at least within the range of damage and disability studied here.  ...  Based on the vascular impairments reported in MS, we predicted that the MS group would have a reduced hemodynamic response to stimulation, and that neurovascular coupling in the visual cortex would be  ... 
doi:10.1016/j.neuroscience.2018.03.018 pmid:29580963 pmcid:PMC6458991 fatcat:jek4ppfx3vfsrav7adpyqrvq3q

Alcohol induced region-dependent alterations of hemodynamic response: implications for the statistical interpretation of pharmacological fMRI studies

M. Luchtmann, K. Jachau, C. Tempelmann, J. Bernarding
2010 Experimental Brain Research  
Furthermore, the present study revealed a potential pitfall associated with the statistical interpretation of pharmacological fMRI studies based on the general linear model: if the functional form of the  ...  Yet, few studies have used the blood oxygenation level dependent functional magnetic resonance imaging method (BOLD fMRI) to map how alcohol alters brain functions, as fMRI relies on neurovascular coupling  ...  on neurovascular coupling mechanisms.  ... 
doi:10.1007/s00221-010-2277-4 pmid:20502888 pmcid:PMC2885301 fatcat:iqymnqfznzaidfcljkamw25key

Imaging Functional Recovery Following Ischemic Stroke: Clinical and Preclinical fMRI Studies

Andrew Crofts, Michael E. Kelly, Claire L. Gibson
2019 Journal of Neuroimaging  
Functional magnetic resonance imaging (fMRI) studies of patients in the months and years following stroke have given some insight into how the brain recovers lost functions.  ...  Preclinical models of ischemic stroke aim to enhance understanding of the biology underlying recovery following stroke.  ...  activity and neurovascular coupling.  ... 
doi:10.1111/jon.12668 pmid:31608550 fatcat:nv5krqhjhffizdwtzkaw2ti3wm
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