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Modeling the competition between lung metastases and the immune system using agents

Marzio Pennisi, Francesco Pappalardo, Ariannna Palladini, Giordano Nicoletti, Patrizia Nanni, Pier-Luigi Lollini, Santo Motta
2010 BMC Bioinformatics  
To help to address this problem, MetastaSim, a hybrid Agent Based -ODE model for the simulation of the vaccineelicited immune system response against lung metastases in mice is presented.  ...  These results can be then used and verified in future "in vivo" experiments, and their outcome can be used to further improve and refine the model.  ...  General description of the MetastaSim computational model The MetastaSim model uses an agent based approach to simulate the main features of the immune system.  ... 
doi:10.1186/1471-2105-11-s7-s13 pmid:21106120 pmcid:PMC2957681 fatcat:pc6cmfirfncuxkz7bplhztpzs4

Toll-like receptor-5 agonist, entolimod, suppresses metastasis and induces immunity by stimulating an NK-dendritic-CD8+T-cell axis

Craig M. Brackett, Bojidar Kojouharov, Jean Veith, Kellee F. Greene, Lyudmila G. Burdelya, Sandra O. Gollnick, Scott I. Abrams, Andrei V. Gudkov
2016 Proceedings of the National Academy of Sciences of the United States of America  
Used as a single agent in murine colon and mammary metastatic cancer models, entolimod rapidly induces CXCL9 and -10 that support homing of blood-borne CXCR3-expressing NK cells to the liver predominantly  ...  effects in several tumor models (19-23), including mouse models of liver metastases (24-26).  ...  , whereas the 4T1 model develops both liver and lung metastases.  ... 
doi:10.1073/pnas.1521359113 pmid:26831100 pmcid:PMC4763744 fatcat:dbhi6qxyvrga7c6x5dzi6gd6cu

The RANK–RANKL axis: an opportunity for drug repurposing in cancer?

S. Peters, P. Clézardin, I. Márquez-Rodas, D. Niepel, C. Gedye
2019 Clinical and Translational Oncology  
Here, we review the role of RANK/RANKL in tumourigenesis, including effects on tumour initiation, progression and metastasis and consider the impact of RANK/RANKL on tumour immunology and immune evasion  ...  Finally, we look briefly at ongoing trials and future opportunities for therapeutic synergy when combining denosumab with anti-cancer agents such as immune checkpoint inhibitors.  ...  UK); development of subsequent drafts in collaboration with the authors, assembling tables and figures, copyediting and fact checking was provided by Louise Niven, DPhil at Aspire Scientific (Bollington  ... 
doi:10.1007/s12094-018-02023-5 pmid:30656607 fatcat:ekqrb6sjcfa6fjy6xaa3sz3wga

Innovative Therapeutic Strategies for Effective Treatment of Brain Metastases

Malcolm Lim, Simon Puttick, Zachary Houston, Kristofer Thurecht, Priyakshi Kalita-de Croft, Stephen Mahler, Stephen Rose, Rosalind Jeffree, Roberta Mazzieri, Riccardo Dolcetti, Sunil Lakhani, Jodi Saunus
2019 International Journal of Molecular Sciences  
Brain metastases are also highly adapted to their microenvironment, with complex cross-talk between the tumor, the stroma and the neural compartments driving speciation and drug resistance.  ...  The factors limiting intracranial efficacy of existing agents are both physiological and molecular in nature.  ...  We would also like to acknowledge Sebastian Brandner, Adrienne Flanagan and Parmjit Jat, who provided the human tumor tissue microarray used to make Figure 2 .  ... 
doi:10.3390/ijms20061280 fatcat:zwqmlggceba77krba2hnwbx2re

Perioperative analgesia and its influence on cancer outcomes

Natasha Parrott, Judith Tomlinson
2020 Digestive Medicine Research  
and analgesic drugs used.  ...  This may be linked to the creation of an environment that promotes cancer cell growth and potentially propagation of metastases, through the surgical stress response, seeding of cancer cells, and the anesthetic  ...  Animal models have shown a dosedependent increase in tumor-cell retention and metastases in those with breast, lung and colon cancer that were given dexmedetomidine (30) .  ... 
doi:10.21037/dmr-20-45 fatcat:iiwbvpcrfvar5i5aj5ahoqebza

The Abscopal Effect of Radiation Therapy: What Is It and How Can We Use It in Breast Cancer?

Zishuo I. Hu, Heather L. McArthur, Alice Y. Ho
2017 Current Breast Cancer Reports  
However, with the continued development and use of immunotherapy strategies incorporating radiotherapy with targeted immunomodulators and immune checkpoint blockade, the abscopal effect is becoming increasingly  ...  The abscopal effect refers to the ability of localized radiation to trigger systemic antitumor effects.  ...  With broader use of targeted immunotherapy agents such as the checkpoint inhibitors, TLR agonists, and cytokines in combination with RT to stimulate the immune system, however, the abscopal effect is likely  ... 
doi:10.1007/s12609-017-0234-y pmid:28344743 pmcid:PMC5346418 fatcat:ob4vjhoyu5fydd2bicqqco2kwm

A Novel Antagonist of the Immune Checkpoint Protein Adenosine A2a Receptor Restores Tumor-Infiltrating Lymphocyte Activity in the Context of the Tumor Microenvironment

Melanie Mediavilla-Varela, Julio Castro, Alberto Chiappori, David Noyes, Dalia C. Hernandez, Bertrand Allard, John Stagg, Scott J. Antonia
2017 Neoplasia: An International Journal for Oncology Research  
METHODS: We developed a novel A2aR antagonist (PBF-509) and tested its antitumor response in vitro, in a mouse model, and in non-small cell lung cancer patient samples.  ...  CONCLUSIONS: Our studies demonstrate that inhibition of the A2aR using the novel inhibitor PBF-509 could lead to novel immunotherapeutic strategies in non-small cell lung cancer.  ...  Recently, immunotherapy with agents preventing the binding of the immune checkpoint PD-1 to its ligand PD-L1 was found to be efficacious in lung cancer.  ... 
doi:10.1016/j.neo.2017.02.004 pmid:28582704 pmcid:PMC5458644 fatcat:uld5uhqdybfgfgscqostzxiyzq

The renin-angiotensin system and malignancy

E. I. Ager, J. Neo, C. Christophi
2008 Carcinogenesis  
The local RAS appears to influence tumour growth and metastases and there is evidence of tissue-and tumour-specific differences.  ...  The renin-angiotensin system (RAS) is usually associated with its systemic action on cardiovascular homoeostasis.  ...  Candesartan, an AT1R antagonist, reduced tumour-related angiogenesis and the number of lung metastases in a murine Lewis lung cancer model (47) and, when explanted into nude mice, inhibited tumour-associated  ... 
doi:10.1093/carcin/bgn171 pmid:18632755 fatcat:ji5fsjajfnhbfofwrmn77cgagy

The Antidiabetic Agent Acarbose Improves Anti-PD-1 and Rapamycin Efficacy in Preclinical Renal Cancer

Rachael M. Orlandella, William J. Turbitt, Justin T. Gibson, Shannon K. Boi, Peng Li, Daniel L. Smith, Lyse A. Norian
2020 Cancers  
Combining acarbose with either anti-PD-1 or the mammalian target of rapamycin inhibitor, rapamycin, significantly reduced lung metastases relative to control mice on the same therapies.  ...  Here, we examined acarbose, an alpha-glucosidase inhibitor and antidiabetic agent, in a preclinical model of metastatic kidney cancer.  ...  Our study concurs with and expands upon these findings by using an orthotopic renal tumor model and quantifying spontaneous lung metastases in response to combinatorial administration of acarbose with  ... 
doi:10.3390/cancers12102872 pmid:33036247 pmcid:PMC7601245 fatcat:elkboiq7jfgobkp54uzphgohju

The optimism surrounding stereotactic body radiation therapy and immunomodulation

Hannah Tharmalingam, Peter J. Hoskin
2017 Chinese Clinical Oncology  
However, due to the immunosuppressive nature of non-irradiated sites of metastases, radiotherapy alone is seldom sufficient to induce the systemic response required for distant tumour rejection.  ...  In addition to its direct cytotoxicity, radiation and in particular SABR has powerful immunomodulatory effects resulting in immunogenic cell death and potentiation of the anti-tumour immune response.  ...  Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ... 
doi:10.21037/cco.2017.05.01 pmid:28917247 fatcat:caytz5z24berfla6xvyqrel2vu

The role of the immune system in brain metastasis

Adam T Leibold, Gina N Monaco, Mahua Dey
2019 Current Neurobiology  
We performed a comprehensive review of the literature to outline the molecular mechanisms of immunosuppression used by tumors and how the immune system interacts with the central nervous system to facilitate  ...  In this review paper we define the central role of the immune system in the development of brain metastases.  ...  Acknowledgements Authors would like to thank Christopher Brown MS for his help with the figure illustrations. Funding This work was supported by NINDS K08NS092895 grant (MD).  ... 
pmid:31097897 pmcid:PMC6513348 fatcat:cmotwofrsvcofb42g6obhzl5lu

Analysis of vaccine's schedules using models

F. Pappalardo, S. Motta, P.-L. Lollini, E. Mastriani
2006 Cellular Immunology  
We present a further, yet important, step in applying Catania Mouse Model & simulator (SimTriplex) of immune system response to vaccination.  ...  In particular we show that, as immune response can induce toxicity, one can calibrate the vaccine administrations in such a way to avoid toxicity effects, keeping immunoprevention from cancer.  ...  PLL acknowledges financial support from the University of Bologna, the Department of Experimental Pathology (''Pallotti'' fund), MIUR and the Italian Association for Cancer Research (AIRC).  ... 
doi:10.1016/j.cellimm.2007.03.002 pmid:17442286 fatcat:jmumqu3da5ehlclh7on5clk4g4

Interleukin-1 and cancer progression: the emerging role of interleukin-1 receptor antagonist as a novel therapeutic agent in cancer treatment

Anne M Lewis, Sheelu Varghese, Hui Xu, H Richard Alexander
2006 Journal of Translational Medicine  
The protein has been shown to decrease tumor growth, angiogenesis, and metastases in murine xenograft models.  ...  Our focus in this review is to summarize the known data on the role of IL-1 in tumor progression and metastasis and the use of IL-1 inhibition as a novel therapeutic approach in the treatment of solid  ...  Acknowledgements SV, HX, and HRA were supported in part by the funds from the Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland.  ... 
doi:10.1186/1479-5876-4-48 pmid:17096856 pmcid:PMC1660548 fatcat:w6pjk6mqhnfsjilxq57dde7e2u

Multiscale Agent-Based and Hybrid Modeling of the Tumor Immune Microenvironment

Kerri-Ann Norton, Chang Gong, Samira Jamalian, Aleksander Popel
2019 Processes  
In this review, we summarize the state of the art in the applications of agent-based models (ABM) and hybrid modeling to the tumor immune microenvironment and cancer immune response, including immunotherapy  ...  We review models focusing on intra-tumor heterogeneity, particularly on interactions between cancer cells and stromal cells, including immune cells, the role of tumor-associated vasculature in the immune  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/pr7010037 pmid:30701168 pmcid:PMC6349239 fatcat:gnzbrq55crh43ethwn7olrlkmu

Patient-derived xenograft (PDX) models, applications and challenges in cancer research

Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mahshid Saleh, Hamid Asadzadeh Aghdaei, Kaveh Baghaei
2022 Journal of Translational Medicine  
Therefore, they are used in many studies, such as the development of anti-cancer drugs, co-clinical trials, personalized medicine, immunotherapy, and PDX biobanks.  ...  Patient-derived xenograft models are created by tumor tissue engraftment. These models accurately represent the biology and heterogeneity of different cancers and recapitulate tumor microenvironment.  ...  CDX model won the competition between the CDX and GEMME models because of its availability and is still the first choice in many studies.  ... 
doi:10.1186/s12967-022-03405-8 pmid:35538576 pmcid:PMC9088152 fatcat:5myihhkynrfq5hk7jk3xqxnojq
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