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Modeling the Tortuosity of Retinal Vessels: Does Caliber Play a Role?

E Trucco, H Azegrouz, B Dhillon
2010 IEEE Transactions on Biomedical Engineering  
We suggest in this paper that curvature may not be the only quantity involved in modeling tortuosity, and that vessel thickness, or caliber, may also play a role.  ...  The tortuosity of retinal blood vessels is a diagnostic parameter assessed by ophthalmologists on the basis of examples and experience; no quantitative model is specified in clinical practice.  ...  ACKNOWLEDGMENT The authors would like to thank Optos plc, C. Buchanan, D. Cairns, P. Wilson, J. Ellis, and T. McGillivray for support and helpful discussions.  ... 
doi:10.1109/tbme.2010.2050771 pmid:20515707 fatcat:txadbhyogvcknplmvsx3j5wo5u

Vessel Evaluation in Patients with Primary Open-Angle Glaucoma, Normal Tension Glaucoma and Healthy Controls

Constanze Kortuem, Johannes Dietter, Yagmur Bozkurt, Friederike Charlotte Kortuem, Annegret Abaza, Siegfried Wahl, Iliya V Ivanov, Marius Ueffing, Bogomil Voykov
2021 Clinical Ophthalmology  
Based on a retrospective analysis of fundus photographs, specific retinal vasculature features of the retinal vasculature display significant alterations associated with NTG and POAG.  ...  The primary endpoint was the change in CRAE, CRVE, AVR, fractal dimension and tortuosity of the retinal vasculature from baseline, retrospectively analyzed from 2011 to 2017 at the University Eye Hospital  ...  Part of the work concerning the development of algorithms for fundus analysis was supported by a grant of the Charlotte and Tistou Kerstan Foundation.  ... 
doi:10.2147/opth.s320505 pmid:34707346 pmcid:PMC8544789 fatcat:b2foytykg5bwphpcssqqelag7i

Method for quantitative assessment of retinal vessel tortuosity in optical coherence tomography angiography applied to sickle cell retinopathy

Maziyar M. Khansari, William O'Neill, Jennifer Lim, Mahnaz Shahidi
2017 Biomedical Optics Express  
In the current study, a quantitative vessel tortuosity index (VTI) based on a combination of local and global centerline features is presented.  ...  The results demonstrate that the proposed method shows promise for detection of increased tortuosity in vessels due to retinal disorders.  ...  Nevertheless, their method does not consider the magnitude of the curve, which plays an important role in clinical evaluation of vessel tortuosity.  ... 
doi:10.1364/boe.8.003796 pmid:28856050 pmcid:PMC5560841 fatcat:3sufsziudvhodjpif7cn7lza5y

FABC: Retinal Vessel Segmentation Using AdaBoost

C A Lupascu, D Tegolo, E Trucco
2010 IEEE Transactions on Information Technology in Biomedicine  
This paper presents a method for automated vessel segmentation in retinal images.  ...  The algorithm was tested on the public digital retinal images for vessel extraction (DRIVE) set, frequently used in the literature and consisting of 40 manually labeled images with gold standard.  ...  These results suggest that the quality of the vasculature maps provided by FABC should be adequate for the clinical tasks targeted by other methods [e.g., estimation of caliber, tortuosity, and retinal  ... 
doi:10.1109/titb.2010.2052282 pmid:20529750 fatcat:kylwhw3rprenjo2xwnisqdy5fy

Relationship of Retinal Vascular Tortuosity with the Neuroretinal Rim: The Singapore Malay Eye Study

Victor Koh, Carol Yim-lui Cheung, Yingfeng Zheng, Tien Yin Wong, Wanling Wong, Tin Aung
2010 Investigative Ophthalmology and Visual Science  
To describe the association of retinal vascular tortuosity, measured quantitatively, with the neuroretinal rim. METHODS.  ...  The temporal-inferior region of the neuroretinal rim was most strongly associated with retinal vascular tortuosity. CONCLUSIONS.  ...  pressure may play a role in the pathogenesis of glaucomatous optic neuropathy. 4,18 -20 These findings lend support to a vascular etiology for glaucoma. 9, 21 Tortuosity, or curvature, of the retinal  ... 
doi:10.1167/iovs.09-5008 pmid:20207964 fatcat:g2qfz67bffhublnrp2ilt4xa6e

Dynamic Responses in Retinal Vessel Caliber With Flicker Light Stimulation and Risk of Diabetic Retinopathy and Its Progression

Laurence S. Lim, Lieng H. Ling, Peng Guan Ong, Wallace Foulds, E. Shyong Tai, Tien Yin Wong
2017 Investigative Ophthalmology and Visual Science  
Dynamic responses in retinal vessel caliber with flicker light stimulation and risk of diabetic retinopathy and its progression. Invest Ophthalmol Vis Sci. PURPOSE.  ...  This study investigated the associations between the responses of retinal vessels to flickering light and the incidence and progression of diabetic retinopathy (DR). METHODS.  ...  It should also be noted that while the DVA provides data on vessel caliber, it does not give an accurate indication of blood flow.  ... 
doi:10.1167/iovs.16-21008 pmid:28460046 fatcat:rjvu6vxlfvbtbffaztzp3mpek4

Vascular Patterning as Integrative Readout of Complex Molecular and Physiological Signaling by VESsel GENeration Analysis

Mark Lagatuz, Ruchi J. Vyas, Marina Predovic, Shiyin Lim, Nicole Jacobs, Miguel Martinho, Hamed Valizadegan, David Kao, Nikunj Oza, Corey A. Theriot, Susana B. Zanello, Giovanni Taibbi (+12 others)
2021 Journal of Vascular Research  
Upon input of a binary vascular image, automated output includes informative vascular maps and quantification of parameters such as tortuosity, fractal dimension, vessel diameter, area, length, number,  ...  In vivo experimental examples described here include vascular response to keratinocyte growth factor, a novel vessel tortuosity factor; angiogenic inhibition in humanized tumor xenografts by the anti-angiogenesis  ...  The opinions expressed in this report are the authors' own and do not reflect the view of NASA, the Substance Abuse and Mental Health Services Administration, the Department of Health and Human Services  ... 
doi:10.1159/000514211 pmid:33839725 fatcat:pvglvmgshrfpfbggwh2oe3iwoa

Detection of blood vessels in retinal images using two-dimensional matched filters

S. Chaudhuri, S. Chatterjee, N. Katz, M. Nelson, M. Goldbaum
1989 IEEE Transactions on Medical Imaging  
In this paper, we address the problem of detecting blood vessels in retinal images.  ...  The gray-level profile of the cross section of a blood vessel is approximated by a Gaussian shaped curve.  ...  ACKNOWLEDGMENT The authors would like to thank T. Clark for his help in obtaining the images used in this research.  ... 
doi:10.1109/42.34715 pmid:18230524 fatcat:a5ibar575bhxlgwvidmcn2n324

Retinal vessel segmentation based on Fully Convolutional Neural Networks

Américo Oliveira, Sérgio Pereira, Carlos A. Silva
2018 Expert systems with applications  
The retinal vascular condition is a reliable biomarker of several ophthalmologic and cardiovascular diseases, so automatic vessel segmentation may be crucial to diagnose and monitor them.  ...  width and direction of the vessel structure in the retina.  ...  The morphological characteristics of the retinal vasculature, such as angles, branching patterns, length, width, and tortuosity, can play a crucial role in assisting cardiologists and ophthalmologists  ... 
doi:10.1016/j.eswa.2018.06.034 fatcat:llcgdvpw6vbidktls3wg6zjbdm

A prospective case-control study to investigate retinal microvascular changes in acute dengue infection

Petrina Tan, David C. Lye, Tun Kuan Yeo, Carol Y. Cheung, Tun-Linn Thein, Joshua G. Wong, Rupesh Agrawal, Ling-Jun Li, Tien-Yin Wong, Victor C. Gan, Yee-Sin Leo, Stephen C. Teoh
2015 Scientific Reports  
A spectrum of quantitative retinal microvascular parameters (retinal vascular caliber, fractal dimension, tortuosity and branching angle) was measured using a semi-automated computer-based program.  ...  Resolution of acute dengue coincided with decrease in retinal vascular calibers and venular fractal dimension.  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
doi:10.1038/srep17183 pmid:26603217 pmcid:PMC4658599 fatcat:7q3raf6wenduto7dfoosdufbt4

Computational assessment of the retinal vascular tortuosity integrating domain-related information

L. Ramos, J. Novo, J. Rouco, S. Romeo, M. D. Álvarez, M. Ortega
2019 Scientific Reports  
The retinal vascular tortuosity presents a valuable potential as a clinical biomarker of many relevant vascular and systemic diseases.  ...  between arteries and veins, the distance to the optic disc, the distance to the fovea, and the vessel caliber.  ...  Acknowledgements This work is supported by Instituto de Salud Carlos II, Government of Spain, and the European Regional Development Fund (ERDF) of the European Union (EU) through the DTS18/00136 research  ... 
doi:10.1038/s41598-019-56507-7 pmid:31882964 pmcid:PMC6934469 fatcat:7i347sumqrdfrfyib3v2gxovpy

Imaging the eye and its relevance to diabetes care

Nicola Quinn, Alicia Jenkin, Chris Ryan, Andrzej Januszewski, Tunde Peto, Laima Brazionis
2020 Journal of Diabetes Investigation  
In a clinical research context, retinal vasculature analyses using semi-automated software in many populations have identified associations between retinal vessel geometry, such as vessel caliber, and  ...  As yet, the value of retinal vessel geometry and corneal confocal microscopy measures at an individual level is uncertain.  ...  This proposed algorithm might play an important role in future studies for the establishment of normative values for caliber measurements 49 .  ... 
doi:10.1111/jdi.13462 pmid:33190401 fatcat:qgfkabhns5g4jniaapyxwww4we

Investigation of Bilateral Similarity in Central Retinal Blood Vessels

Sangeeta Biswas, Johan Rohdin, Andrii Kavetskyi, Gabriel Saraiva, Angkan Biswas, Martin Drahansky
2021 IEEE Access  
ACKNOWLEDGMENT This work was supported by the project Reliable, Secure, and Efficient Computer Systems, FIT-S-20-6427.  ...  IMPORTANCE OF CRBVS The CRBVs play an essential role in our vision.  ...  of vessels; vessel pattern close to the empty space (i.e., macula); curvature of the thickest/thicker vessel(s) considering straightness and tortuosity (or waviness) of the vessel(s); the density of vessels  ... 
doi:10.1109/access.2021.3074514 fatcat:a56gmv6z7rcjlhtgceee5kz56m

Retinal vessel segmentation using multiwavelet kernels and multiscale hierarchical decomposition

Yangfan Wang, Guangrong Ji, Ping Lin, Emanuele Trucco
2013 Pattern Recognition  
Finally, we obtain a binary map of the vasculature by locally adaptive thresholding, generating a threshold surface based on the vessel edge information extracted by the previous processes.  ...  Noise removal and vessel localization are achieved by a multiscale hierarchical decomposition of the normalized enhanced image.  ...  ET is partially supported by the Scottish Northern Research Partnership. We thank Adri a Perez Rovira and the VAMPIRE group for their suggestions and help.  ... 
doi:10.1016/j.patcog.2012.12.014 fatcat:2qqj3omkbvfojjkxp6rk5ezvbe

Retinal Microvasculature as a Model to Study the Manifestations of Hypertension

C. Y.-l. Cheung, M. K. Ikram, C. Sabanayagam, T. Y. Wong
2012 Hypertension  
Retinal Vascular Changes as a Model to Study Early Correlates of Hypertension Role of Microcirculation in the Pathogenesis of Hypertension The microcirculation plays a critical role in the pathophysiology  ...  Nevertheless, the measurement of retinal vascular caliber from photographs largely reflects the width of the red blood cell column (ie, internal lumen diameter), 21 and it does not capture vessel wall  ... 
doi:10.1161/hypertensionaha.111.189142 pmid:23045470 fatcat:recy3egn2rgmbjpmeg4ygptjdq
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