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Modeling of region-specific fMRI BOLD neurovascular response functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials
2008
NeuroImage
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To explain these differences, the BOLD neurovascular response function was modeled. ...
The response of the rat visual system to flashes of blue light has been studied by blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI). ...
Acknowledgements This work was supported by grants EB000215, EB000215-S1, and GM56398 from the National Institutes of Health, and DABK39-03-C-0058 from the Counterdrug Technology Assessment Center, Office ...
doi:10.1016/j.neuroimage.2008.02.022
pmid:18406628
pmcid:PMC2483240
fatcat:vzrxxcjb4vef5m6y3ptmd66kpa
Mapping the functional network of medial prefrontal cortex by combining optogenetics and fMRI in awake rats
2015
NeuroImage
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Here we combined optogenetic stimulation and functional magnetic resonance imaging (opto-fMRI) to reveal the network of brain regions functionally activated by mPFC outputs in awake rodents. ...
Given its vital importance, investigating the function of individual mPFC circuits in animal models has provided critical insight into the neural basis underlying different behaviors and psychiatric conditions ...
the National Institute of Neurological Disorders and Stroke. ...
doi:10.1016/j.neuroimage.2015.05.036
pmid:26002727
pmcid:PMC4512884
fatcat:4ojeclql2zf4bahgeezwvipxsi
Functional magnetic resonance imaging in chronic ischaemic stroke
2016
Philosophical Transactions of the Royal Society of London. Biological Sciences
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Indeed, the perceived clinical potential of BOLD fMRI remains unrealized. In this review, we focus on the application of fMRI to studies of brain function in the chronic stage of stroke progression. ...
Despite its potential as a sensitive non-invasive in vivo marker of brain function that may aid in the development of new treatments, blood oxygenation level-dependent (BOLD) functional magnetic resonance ...
doi:10.1098/rstb.2015.0353
pmid:27574307
pmcid:PMC5003855
fatcat:qv4wou6p7vdvlolbhdgznpykou
Coupling Mechanism and Significance of the BOLD Signal: A Status Report
2014
Annual Review of Neuroscience
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The blood-oxygen-level-dependent (BOLD) signal, detected in fMRI, reflects changes in deoxyhemoglobin driven by localized changes in brain blood flow and blood oxygenation, which are coupled to underlying ...
Functional magnetic resonance imaging (fMRI) provides a unique view of the working human mind. ...
The author acknowledges support from NINDS 1R01NS063226, ...
doi:10.1146/annurev-neuro-071013-014111
pmid:25032494
pmcid:PMC4147398
fatcat:yrptkxd6xbhubgu3bpnco4xbua
Neurovascular and neurometabolic couplings in dynamic calibrated fMRI: transient oxidative neuroenergetics for block-design and event-related paradigms
2010
Frontiers in Neuroenergetics
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Functional magnetic resonance imaging (fMRI) with blood-oxygenation level dependent (BOLD) contrast is an important tool for mapping brain activity. ...
Interest in quantitative fMRI has renewed awareness in importance of oxidative neuroenergetics, as reflected by cerebral metabolic rate of oxygen consumption ( ), CMR O 2 for supporting brain function. ...
In each case, the comparison showed that the residual "noise" in modeling was smaller than the measurement uncertainty. ...
doi:10.3389/fnene.2010.00018
pmid:20838476
pmcid:PMC2936934
fatcat:kq73jrpmhvbozdilpxqxxaojxa
Quantitative basis for neuroimaging of cortical laminae with calibrated functional MRI
2013
Proceedings of the National Academy of Sciences of the United States of America
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Results During forepaw stimulation in the rat we measured dynamic responses of BOLD, CBV, and CBF at 11.7 T with different fMRI methods and then combined these data to calibrate the fMRI signal to calculate ...
that changes in cerebral metabolic rate of oxygen consumption (CMR O2 ) can be calculated with a biophysical model of BOLD (6). ...
This work was supported by National Institutes of Health Grants R01 MH-067528 and P30 NS-052519 (to F.H.), R01 AG-034953 (to D.L.R.), and R01 NS-066974 (to H.B.). ...
doi:10.1073/pnas.1307154110
pmid:23980158
pmcid:PMC3773779
fatcat:5zopaejiufg63mltccnmaqp6ti
Resting-state hemodynamics are spatiotemporally coupled to synchronized and symmetric neural activity in excitatory neurons
2016
Proceedings of the National Academy of Sciences of the United States of America
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In stimulus-evoked studies, the positive fMRI blood oxygen level-dependent (BOLD) signal corresponds to a decrease in [HbR] caused by a local increase in blood flow leading to over-oxygenation of the region ...
In resting-state fMRI, hemodynamic fluctuations have been found to exhibit patterns of bilateral synchrony, with correlated regions inferred to have functional connectivity. ...
(iii) The analysis approach used here assumed a neurovascular coupling model in which neural events would (directly or indirectly) evoke a stereotyped Δ[HbT] response, a model with a strong physiological ...
doi:10.1073/pnas.1525369113
pmid:27974609
pmcid:PMC5206542
fatcat:woxqfamtubfuhnwfpq3fhvnouq
Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal
2017
NeuroImage
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Here, we review work showing that neurovascular coupling and brain circuit function in the awake animal are profoundly different from those in the anesthetized state. ...
While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function. ...
NZ is supported by R01MH098003 from the National Institute of Mental Health and R01NS085200 from the National Institute of Neurological Disorders and Stroke. ...
doi:10.1016/j.neuroimage.2016.11.069
pmid:27908788
pmcid:PMC5526447
fatcat:apmur7ojhbasrgexfswze6lhme
Imaging Neurovascular Function and Functional Recovery after Stroke in the Rat Striatum Using Forepaw Stimulation
2014
Journal of Cerebral Blood Flow and Metabolism
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This study shows that fMRI signals could differ significantly from LFP and that the observed negative CBV response has potential to serve as a marker for striatal functional integrity in rats. ...
with LFP (r ¼ 0.04), demonstrating that the negative striatal CBV response is not originated from net regional inhibition. ...
In normal rats, neurovascular fMRI of the striatum in normal and stroke rats Y-YI Shih et al function in the cortex and the striatum was evaluated by correlating CBV fMRI response with LFP results. ...
doi:10.1038/jcbfm.2014.103
pmid:24917039
pmcid:PMC4158660
fatcat:oeov6zfbjrhmlkd2242m6dkhbm
Spatial contribution of hippocampal BOLD activation in high-resolution fMRI
2019
Scientific Reports
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Here, we take advantage of these two benefits to investigate the spatial characteristics of the hippocampal activation in a rat model before and after changing the hippocampal plasticity by long-term potentiation ...
We found that the hippocampal BOLD signals evoked by electrical stimulation at the perforant pathway increased more at the radiatum layer of the hippocampal CA1 region than at the pyramidal cell layer. ...
Acknowledgements The authors acknowledge funding from Louis-Jeantet and Louis D. Foundations (DLB) and CEA bottom-up programme (LC). YA thanks B. Djemai for support with general animal handling. ...
doi:10.1038/s41598-019-39614-3
pmid:30816226
pmcid:PMC6395694
fatcat:q54phw6tdbhibbfw3ehc2omsvq
Pitfalls in fMRI
2009
European Radiology
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Several different techniques allow a functional assessment of neuronal activations by magnetic resonance imaging (fMRI). ...
Consequently, the term 'fMRI' is often used synonymously with BOLD imaging. ...
Acknowledgements We thank Georg Homola for assisting with data analyses and figure generations. Andreas Bartsch's work has been generously facilitated by the Vera and Volker Doppelfeld Foundation. ...
doi:10.1007/s00330-009-1456-9
pmid:19504107
fatcat:dnd7t5ite5dj3fjm7rlm4hi2dm
Remote Changes in Cortical Excitability after Experimental Traumatic Brain Injury and Functional Reorganization
2018
Journal of Neurotrauma
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We used the adult rat controlled cortical impact injury model to study the ipsilesional forelimb map evoked by electrical stimulation of the affected limb, as well as the contralesional forelimb map evoked ...
The results show a transient trans-hemispheric shift in the ipsilesional cortical map as indicated by fMRI, remote contralesional increases in cortical excitability that occur in spatially similar regions ...
The project described was also supported in part CORTICAL EXCITABILITY AND FUNCTIONAL REORGANIZATION ...
doi:10.1089/neu.2017.5536
pmid:29717625
pmcid:PMC6196752
fatcat:ox6doxo7cbfqnbkxkkozytukfe
Spontaneous activity changes in large-scale cortical networks in older adults couple to distinct hemodynamic morphology
[article]
2020
bioRxiv
pre-print
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These results demonstrate the potential of our integrated EEG/fMRI analysis for making inferences about neural and vascular processes in higher-level cognitive networks in healthy and at-risk populations ...
In the default mode network, the HDR pattern in our sample of older adults was associated with a structural surrogate marker of general cerebrovascular deterioration and predicted temporal disruption in ...
a potential role of such activity states in reducing the cost of brain 7 function during resting state. ...
doi:10.1101/2020.05.05.079749
fatcat:3af4lpkngngwlhawcswjxq47bi
Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal
[article]
2016
bioRxiv
pre-print
Preserved Fulltext
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Here, we review work showing that neurovascular coupling and brain circuit function in the awake animal are profoundly different from those in the anesthetized state. ...
While there has been extensive study of neurovascular coupling in anesthetized animal models, anesthesia causes large disruptions of brain metabolism, neural responsiveness and cardiovascular function. ...
In the resting state, fMRI (termed resting-state fMRI or rsfMRI) measures resting-state functional connectivity (RSFC) between brain regions by quantifying the temporal synchronization of spontaneously ...
doi:10.1101/077024
fatcat:brk3y6diibfd7lpycygudr4sl4
BOLD-fMRI in the mouse auditory pathway
2018
NeuroImage
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2019 pre-print arXiv:1903.08565v1 fatcat:kt7zjwye3vhpflg2n5w2pvclau
Given the importance of the mouse model in plasticity studies, animal models, and optogenetics, and fMRI's potential to map dynamic responses to specific cues, this first fMRI study of the mouse auditory ...
Indeed, fMRI has been previously used to characterize the auditory pathway in humans and in rats. ...
Chronic functions in rat brain reveals residual differences that correlate with the differences in regional evoked potentials. Neuroimage 41, 525-534. ...
doi:10.1016/j.neuroimage.2017.10.027
pmid:29050909
fatcat:r34y6vj3araz5pllne4f4bhnmq
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