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Modeling of tumor conspicuity in hepatic CT images: combined compartment and vascular models

J. Bezy-Wendling, M. Kretowski, P. Coupe
2004 2nd IEEE International Symposium on Biomedical Imaging: Macro to Nano (IEEE Cat No. 04EX821)  
The aim of this work is to simulate dynamic CT scan of the liver, in normal tissue and in a hypervascular tumor.  ...  Two models are developed: a physiological vascular model for the main vessels, until arterioles and venules, and a compartment model for parenchyma enhancement.  ...  In conclusion, combining these two models, one for the macrovascular trees, and the second one for microvessels, provide a realistic model of dynamic hepatic enhancement in CT.  ... 
doi:10.1109/isbi.2004.1398570 fatcat:bukfn5mednf6lezbikf7h7yx3e

Perfusion magnetic resonance imaging of the liver

Choon Hua Thng
2010 World Journal of Gastroenterology  
In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and  ...  of antiangiogenic therapy, evaluating tumor viability after anticancer therapy or ablation, and diagnosis of liver cirrhosis and its severity.  ...  Septian Hartono (National Cancer Centre, Singapore) and Dr. Keiko Miyazaki (Institute of Cancer Research, UK) for their valuable assistance in the preparation of the manuscript.  ... 
doi:10.3748/wjg.v16.i13.1598 pmid:20355238 pmcid:PMC2848368 fatcat:y5pvxoix3zddpgizp3kxsyxm4a

Hepatic tumor enhancement in computed tomography: combined models of liver perfusion and dynamic imaging

Johanne Bézy-Wendling, Marek Kretowski, Yan Rolland
2003 Computers in Biology and Medicine  
It relies on two models: (1) a vascular model, based on physiological rules, is used to generate the 3D hepatic vascular network; (2) the physical process of CT acquisition allows to synthesize timed-stamped  ...  The coupled models are used to simulate the enhancement of a hyper-vascular tumor at di erent acquisition times, showing a maximum conspicuity during the arterial phase. ?  ...  It has been showed that the combined models of liver perfusion and dynamic CT can reproduce several signiÿcant features of vascular pathological disturbances, and associated image modiÿcations.  ... 
doi:10.1016/s0010-4825(02)00056-2 pmid:12485631 fatcat:mbtchbwuavamta5mkm4uftjz2i

Simulation of Biphasic CT Findings in Hepatic Cellular Carcinoma by a Two-Level Physiological Model

Marek Kretowski, Johanne Bezy-Wendling, Pierrick Coupe
2007 IEEE Transactions on Biomedical Engineering  
Our approach results from the combination of a macroscopic model, providing simulation of the growth and pathological modifications of vascular network, and a microvascular model, based on compartmental  ...  In this paper, we present a two-level physiological model that is able to reflect morphology and function of vascular networks, in clinical images.  ...  Herndon and T. R. Gowrishankar for advice and discussion. ACKNOWLEDGMENT The authors would like to thank Prof. J.-L. Coatrieux for his support and inspiring discussions.  ... 
doi:10.1109/tbme.2006.888834 pmid:17355068 pmcid:PMC1959472 fatcat:uvm7rnqmnzhyniaytmvu25g5bq

Computed Tomography Imaging of Solid Tumors Using a Liposomal-Iodine Contrast Agent in Companion Dogs with Naturally Occurring Cancer

Ketan B. Ghaghada, Amy F. Sato, Zbigniew A. Starosolski, John Berg, David M. Vail, Bing Xu
2016 PLoS ONE  
Results Liposomal-I resulted in significant (p < 0.05) enhancement and uniform opacification of the vascular compartment.  ...  Conventional contrast-enhanced CT imaging was performed in a subset of dogs, 90 minutes prior to administration of Liposomal-I.  ...  Peter Working and Ms. Linda Kinney for assistance with study planning and animal protocols. Author Contributions  ... 
doi:10.1371/journal.pone.0152718 pmid:27031614 pmcid:PMC4816501 fatcat:lf67xxjnw5buzisara3el3iki4

Imaging of HCC—Current State of the Art

Christina Schraml, Sascha Kaufmann, Hansjoerg Rempp, Roland Syha, Dominik Ketelsen, Mike Notohamiprodjo, Konstantin Nikolaou
2015 Diagnostics  
Cone beam CT can provide a three-dimensional analysis of the liver with tumor and vessel characterization comparable to cross-sectional imaging so that this technique is gaining an increasing role in the  ...  tomography (CT) techniques for imaging in HCC.  ...  for diagnosis of HCC, based on a combination of imaging and laboratory findings [13] .  ... 
doi:10.3390/diagnostics5040513 pmid:26854169 pmcid:PMC4728473 fatcat:dt2l5jtbk5h67awwqhkxcwk5za

Recent Advances in CT and MR Imaging for Evaluation of Hepatocellular Carcinoma

Jeong Min Lee, Jeong-Hee Yoon, Ijin Joo, Hyun Sik Woo
2012 Liver Cancer  
In this review, we discuss the role of CT and MRI in the diagnosis and staging of HCC, recent technological advances, and the strengths and limitations of these imaging modalities.  ...  A variety of imaging modalities are currently used in evaluating patients with suspected HCC; these include ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), nuclear medicine, and  ...  Tissue enhancement can be divided into two phases: that of the intravascular compartment and that of the extravascular compartment. By obtaining a series of CT images in 9 .  ... 
doi:10.1159/000339018 pmid:24159569 pmcid:PMC3747553 fatcat:6ws3pvjp6bgjritlqcfqw4p6w4

Radiological biomarkers for assessing response to locoregional therapies in hepatocellular carcinoma: From morphological to functional imaging

Xiao-Dan Ye, Zuguo Yuan, Jian Zhang, Zheng Yuan
2017 Oncology Reports  
Functional imaging (such as perfusion and diffusion imaging, PET-CT/MR and MR spectroscopy) has the potential to be a promising technique for assessment of HCC response to LRTs.  ...  Assessment of imaging response is essential in the management of HCC for determining efficacy of therapy and as a surrogate marker for improved survival.  ...  Acknowledgements This study was supported by the National Natural Science Foundation of China (No. 81301262, 81571629 and 81301218).  ... 
doi:10.3892/or.2017.5420 pmid:28184942 fatcat:2ybyim3pebfy5j6gpj7arniqey

Non-invasive diagnostic imaging of colorectal liver metastases

Pier Paolo Mainenti
2015 World Journal of Radiology  
Nowadays, multiple non-invasive imaging modalities are available and those have a pivotal role in the workup of patients with CRLMs.  ...  Colorectal cancer is one of the few malignant tumors in which synchronous or metachronous liver metastases [colorectal liver metastases (CRLMs)] may be treated with surgery.  ...  [81] ; and (3) metabolic monitoring of the tumor response to the therapy [82] . 18 F-FDG-PET/MRI As stated above, both PET and CT show a few limitations in the evaluation of liver lesions; recently  ... 
doi:10.4329/wjr.v7.i7.157 pmid:26217455 pmcid:PMC4506934 fatcat:c5ngrw2xtzbnvkwjula7fs65b4

CT Perfusion of the Liver: Principles and Applications in Oncology

Se Hyung Kim, Aya Kamaya, Jürgen K. Willmann
2014 Radiology  
In this review, basic principles, current acquisition protocols, and pharmacokinetic models used for CT perfusion imaging of the liver are described.  ...  perfusion has now reached technical maturity, allowing for its use in assessing tumor vascularity in larger-scale prospective clinical trials.  ...  For liver CT perfusion, one of the three methods-including model-free maximum slope method, compartment model-based method, and distributed parameter model-based method-or their combination can be used  ... 
doi:10.1148/radiol.14130091 pmid:25058132 pmcid:PMC4263626 fatcat:us3akc3zezb2nmranr5lduum4i

ESGAR 2015 Book of Abstracts

2015 Insights into Imaging  
Conclusion: The arterial and portal venous vascularity of the liver can be evaluated independently and quantitatively using compartment model analysis of IVCED-CT which can be equivalent to IACE-CT.  ...  Kadoya; Matsumoto/JP Purpose: To evaluate arterial and portal venous vascularity of the liver independently using compartment model analysis of intravenous contrast-enhanced dynamic CT (IVCED-CT).Material  ...  Kim; Seoul/KR Purpose: To describe the image findings, clinical course, and implications of sloughing of biliary tumor thrombi of HCC after chemoembolization.  ... 
doi:10.1007/s13244-015-0412-2 pmid:26104122 pmcid:PMC4485664 fatcat:pgp6jvdjkjho5mbxei2gi5lvja

Tumor models and specific contrast agents for small animal imaging in oncology

Yicheng Ni, Huaijun Wang, Feng Chen, Junjie Li, Frederik DeKeyzer, Yuanbo Feng, Jie Yu, Hilde Bosmans, Guy Marchal
2009 Methods  
and how to apply such models in imaging-based research studies.  ...  Despite the widespread use of various imaging modalities in clinical and experimental oncology without or with combined application of commercially available nonspecific contrast agents (CAs), development  ...  Leuven Molecular Small Animal Imaging Center (KUL EF/05/08) and Hefboomproject HB/08/009, Industrieel Onderzoeksfonds K.U. Leuven.  ... 
doi:10.1016/j.ymeth.2009.03.014 pmid:19328231 fatcat:22imvvcqtjcotex223zha2eype

ESGAR 2018 Book of Abstracts

2018 Insights into Imaging  
Results: 2-compartment model ranked first in both datasets.  ...  Lower energy levels and iodine density images increase pancreatic tumor conspicuity on rapid kV-switching dual energy CT S. Aslan, M.S. Nural, İ.  ... 
doi:10.1007/s13244-018-0634-1 pmid:29845588 pmcid:PMC5974953 fatcat:6az3dgaqwzekpp6u7hl3dfsy4u

ESGAR 2014 Book of Abstracts

2014 Insights into Imaging  
Associations between tumor size, vascularity, homogeneity, growth type, presence of metastases and vascular invasion at CT were evaluated with Fisher's and t tests.  ...  The purpose of this study was to asses prediction capability of nonlinear compartment model analysis of gadoxetate disodium-enhanced MR imaging for histological grade of hepatocellular carcinoma (HCC).  ... 
doi:10.1007/s13244-014-0341-5 pmid:24938542 pmcid:PMC4070181 fatcat:l62zgmms2rdyxpqfq33cznyqmu

ESGAR 2016 Book of Abstracts

2016 Insights into Imaging  
Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.  ...  The 'ESGAR -THE EUROPEAN SOCIETY OF GASTROINTESTINAL AND ABDOMINAL RADIOLOGY' (or) 'ESGAR 2016 -27th ESGAR Annual Meeting and Postgraduate Course' is accredited by the European Accreditation Council for  ...  DCE-MRI data were analysed using modelfree parameters and pharmacokinetic modeling (liver: dual-input single compartment model, spleen: Tofts model). MRI parameters were correlated with HVPG.  ... 
doi:10.1007/s13244-016-0502-9 pmid:27222054 pmcid:PMC4896868 fatcat:rrqwumuca5emlp6dyyvgqyo6ni
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