43,694 Hits in 11.4 sec

A systematic approach for the accurate non-invasive estimation of blood glucose utilizing a novel light-tissue interaction adaptive modelling scheme

V O Rybynok, P A Kyriacou
2007 Journal of Physics, Conference Series  
This approach is based on spectroscopic techniques and a new adaptive modelling scheme.  ...  a scheme has the capability of extracting accurately the concentration of glucose from a complex biological media.  ...  In its roots this equation is a solution of a linear integral of the light intensity losses occurring during light propagation along the straight line through the sample.  ... 
doi:10.1088/1742-6596/85/1/012033 fatcat:hq7h3pf4pngtddz6vkd7rqau2u

Novel Optics-Based Approaches for Cardiac Electrophysiology: A Review

M. Caroline Müllenbroich, Allen Kelly, Corey Acker, Gil Bub, Tobias Bruegmann, Anna Di Bona, Emilia Entcheva, Cecilia Ferrantini, Peter Kohl, Stephan E. Lehnart, Marco Mongillo, Camilla Parmeggiani (+5 others)
2021 Frontiers in Physiology  
The physics of light interaction with cardiac tissue is detailed and associated challenges with the use of optical sensors and actuators are presented.  ...  The recent advent of optogenetics opens up new possibilities for regional and tissue-level electrophysiological control and hold promise for future novel clinical applications.  ...  The degree to which light slows while propagating through a medium is quantified by the refractive index of the media, which reports the ratio of speed of light in a vacuum (the only place where zero scattering  ... 
doi:10.3389/fphys.2021.769586 pmid:34867476 pmcid:PMC8637189 fatcat:v72js6yjobetvbg7jdrjtza6y4

Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues

Malek Kammoun, Redouane Ternifi, Vincent Dupres, Philippe Pouletaut, Sandra Même, William Même, Frederic Szeremeta, Jessem Landoulsi, Jean-Marc Constans, Frank Lafont, Malayannan Subramaniam, John R. Hawse (+1 others)
2019 Scientific Reports  
At present, there is a lack of well-validated protocols that allow for the analysis of the mechanical properties of muscle and tendon tissues.  ...  Therefore, we sought to develop novel protocols for the characterization of mechanical properties in musculotendinous tissues using atomic force microscopy (AFM) and ultrasound elastography.  ...  Acknowledgements This work was carried out and funded in the framework of the Labex MS2T.  ... 
doi:10.1038/s41598-019-44053-1 pmid:31118478 pmcid:PMC6531478 fatcat:5skb3ieowzdlpldelul6isjf5e

Modeling and numerical simulation of light propagation through biological tissue with implanted structures

Chintha Chamalie Handapangoda
The outcome of this stage was an efficient algorithm for solving the transient photon transport equation (PTE), which governs light propagation through tissue.  ...  In stage 1, a technique for simulating laser pulse propagation through tissue, which addresses some of the drawbacks of existing methods, was developed.  ...  A number of researchers have been working on modeling light propagation through biological tissue, as well as through tissue with inhomogeneities.  ... 
doi:10.4225/03/587c04bcdc2eb fatcat:ukg2hpnlorek7gw7h5vd6sblhe

A Novel Approach for the Utilization of Biocellulose Nanofibres in Polyurethane Nanocomposites for Potential Applications in Bone Tissue Implants

Faiz Khan, Yaser Dahman
2012 Designed Monomers and Polymers  
Acknowledgements This work was financially supported by Agriculture and Agri-Food Canada through the Agricultural Bioproducts Innovation Network (ABIN) in addition to Ryerson University in Toronto, Canada  ...  Their PU was composed of aliphatic diisocyanates and PLC diols with a biologically active chain extender with a HS/SS ratio of 60%.  ...  [65] designed a nanocomposite membrane composed of MWNT/chitosan. This novel nanocomposite was characterized by FT-IR and X-ray diffraction.  ... 
doi:10.1163/156855511x606119 fatcat:fh7xau75qbbo5nd33xriewiakm

A Novel Approach for Protein Structure Prediction [article]

Saurabh Sarkar, Prateek Malhotra, Virender Guman
2012 arXiv   pre-print
This signifies the importance of protein secondary structures as the main hidden controlling factors due to which we observe a particular amino acid sequence.  ...  The idea of this project is to study the protein structure and sequence relationship using the hidden markov model and artificial neural network.  ...  This action potential then propagates away from the soma, down the axon. The output signal leaves the neuron through the axonal endings.  ... 
arXiv:1206.3509v1 fatcat:pwjphhcaw5akjofrojt4jzxiu4

Stimulating electrode Design for Implantable Sub Retina Research Application: A Novel Approach

T Alavanthar, V Ellappan
2018 International Journal of Engineering & Technology  
In this design, a mathematical model is created to investigate for the all above said factors which influence implants positioned at internal surface of the retinal tissue.  ...  The basic elemental methods of charge injection by the stimulation electrode to tissue are pointed out. A prologue on the developments of vision implants and electrode characteristics were presented.  ...  The electrode capacitance model An ionic charge flow takes place between biological tissue and stimulating electrode. The charge flow process is modeled through faradic and non-faradic mechanisms.  ... 
doi:10.14419/ijet.v7i2.24.12509 fatcat:n4trs66virgazai753zv5whqem

Dual metabolomics: A novel approach to understanding plant–pathogen interactions

J. William Allwood, Andrew Clarke, Royston Goodacre, Luis A.J. Mur
2010 Phytochemistry  
A plant cell-pathogen co-culture based approach has been developed where the plant and pathogen cells are separated after 12 h of co-culture via differential filtering and centrifugation.  ...  We propose that this system will enable the metabolomic profiling of the separated host and pathogen (i.e. 'dual metabolomics') and will facilitate the modelling of reciprocal responses.  ...  BBSRC) for contributing to the support of this project.  ... 
doi:10.1016/j.phytochem.2010.01.006 pmid:20138320 fatcat:pydvpqxecndlto3az7dlsqdm2i

Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases

Valentina Paloschi, Maria Sabater-Lleal, Heleen Middelkamp, Aisen Vivas, Sofia Johansson, Andries van der Meer, Maria Tenje, Lars Maegdefessel
2021 Cardiovascular Research  
These organ models will provide an important asset for future approaches to personalized cardiovascular medicine and improved patient care.  ...  The development of organs-on-chip has revolutionized in vitro cell culture experiments by allowing a better mimicry of human physiology and pathophysiology that has consequently led researchers to gain  ...  Conflict of Interest The authors declare no conflict of interest.  ... 
doi:10.1093/cvr/cvab088 pmid:33729461 pmcid:PMC8683705 fatcat:7gxpoxgqmzf35h5kkvjrms7shu

Fiber length profiling: A novel approach to structural brain organization

Claude J. Bajada, Jan Schreiber, Svenja Caspers
2019 NeuroImage  
We posit that these maps are a novel way of differentiating between 'local modules' that have restricted connections to 'neighboring' areas and 'functional integrators' that have more far reaching connectivity  ...  They form patterns where certain areas have a high density of fibers of a specific length while other areas have very low density.  ...  The work received funding through the Initiative and Networking Fund of the Helmholtz Association (SC).  ... 
doi:10.1016/j.neuroimage.2018.10.070 pmid:30399419 fatcat:wvju4j5j6nccfdjzf4um7d3yuy


2022 International Journal of Applied Pharmaceutics  
The purpose of the present review is to focus on several innovative approaches, viz., the development of novel ocular drug delivery systems including liposomes, niosomes, nano-wafers, cubosomes, microneedles  ...  Conveying the therapeutic agent to the human eye has been a struggling task for formulators and scientists because of the complicated arrangement of the eye.  ...  Novel approaches for ocular drug delivery Liposomes They are lipid-containing vesicular structures made of phospholipid bilayers entrapping an aqueous core [9] .  ... 
doi:10.22159/ijap.2022v14i3.44045 fatcat:png6mqifgja5rig6hhkd5e4tmm

A Novel Data-Mining Approach Systematically Links Genes to Traits

2005 PLoS Biology  
In a new study, Peer Bork and a team of bioinformatics-savvy molecular biologists tested a new approach to extracting biologically meaningful information from the massive MEDLINE database.  ...  This excitation propagates upwards to higher processing areas in a bottom-up activation process, but the model also includes, critically, top-down connections that can amplify incoming inputs.  ...  A group of neurons within the DLPT, for example, showed distinct bursts of activity just before muscle twitching.  ... 
doi:10.1371/journal.pbio.0030166 fatcat:d3v44dbzq5ebjgatgwgdobajia

Novel approaches to in vitro transgenesis

A. Adamson, D. Jackson, J. R. E. Davis
2010 Journal of Endocrinology  
The study of gene expression is a major focus in biological research and is recognised to be critical for our understanding of physiological and pathophysiological processes.  ...  We also discuss novel approaches that combine some of the above techniques, generating increasingly complex but physiologically accurate expression systems.  ...  We thank Dr D G Spiller for critical reading of the manuscript and comments.  ... 
doi:10.1677/joe-10-0417 pmid:21134989 fatcat:sjsgmxqea5ct5g7mz7euqujzby

On a Novel Approach to Compton Scattered Emission Imaging

Mai K. Nguyen, Tuong T. Truong, Clemence Driol, Habib Zaidi
2009 IEEE Transactions on Nuclear Science  
Data is acquired by a stationary collimated gamma camera under the form of compounded conical projections of the activity density function.  ...  However, despite many innovative contributions, this topic still pose a formidable mathematical and technical challenge.  ...  Then we show how they are actually used through a mathematical modeling of image formation by a new invertible Radon transform.  ... 
doi:10.1109/tns.2009.2018106 fatcat:ka6vwy6benfgzb5bynulqqvsay

Transient micro-elastography: A novel non-invasive approach to measure liver stiffness in mice

Cécile Bastard
2011 World Journal of Gastroenterology  
The novel probe was validated in a classical fibrosis model (CCl4) and in a transgenic murine model of systemic amyloidosis.  ...  CONCLUSION: Here, we have established the first non-invasive approach to measure LS in mice, and have successfully validated it in two murine models of high LS.  ...  The method is illustrated in a model of CCl4 induced liver fibrosis and also in an amyloidosis model.  ... 
doi:10.3748/wjg.v17.i8.968 pmid:21448348 pmcid:PMC3057158 fatcat:2eof7mmv3ncxvobeebsshaj5b4
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