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Modeling brain dynamics after tumor resection using The Virtual Brain [article]

Hannelore Aerts, Michael Schirner, Thijs Dhollander, Ben Jeurissen, Eric Achten, Dirk Van Roost, Petra Ritter, Daniele Marinazzo
2019 bioRxiv   pre-print
Based on these findings, we perform the first "virtual neurosurgery" analyses to evaluate the potential of brain network modeling in predicting brain dynamics after tumor resection.  ...  However, brain network models first have to be validated, before they can be used to predict brain dynamics.  ...  network modeling to predict brain dynamics after tumor resection.  ... 
doi:10.1101/752931 fatcat:sp6prz5eqngrxhgzafrg3qy36y

Virtual brain tumours (gliomas) enhance the reality of medical imaging and highlight inadequacies of current therapy

K R Swanson, E C Alvord, J D Murray
2002 British Journal of Cancer  
Not surprisingly, recurrences develop at or near the edge of the resection bed even after extensive surgical resection or local irradiation.  ...  The virtual human brain depicts the anatomic distribution of gray and white matter, allowing modeling of the differential motility of glioma cells in the two tissues, which has been reported to be biologically  ...  Not surprisingly, recurrences develop at or near the edge of the resection bed even after extensive surgical resection or local irradiation.  ... 
doi:10.1038/sj.bjc.6600021 pmid:11857005 pmcid:PMC2746525 fatcat:xxe3xx5varhkdhhw5iv6zzmmxa

Use of virtual magnetic resonance imaging to compensate for brain shift during image-guided surgery: illustrative case

John T. Kim, Long Di, Arnold B. Etame, Sarah Olson, Michael A. Vogelbaum, Nam D. Tran
2022 Journal of Neurosurgery: Case Lessons  
safe resection of malignant brain tumors.  ...  BACKGROUND Maximal safe resection is the paramount objective in the surgical management of malignant brain tumors. It is facilitated through use of image-guided neuronavigation.  ...  An updated virtual iMRI data set was generated and used to compensate for brain shift and aid in complete resection of the brainstem tumor.  ... 
doi:10.3171/case21683 pmid:35733635 pmcid:PMC9204912 fatcat:u36qcdgkhrcdfgikoukm7lwqgu

Assessing performance of augmented reality-based neurosurgical training

Wei-Xin Si, Xiang-Yun Liao, Yin-Ling Qian, Hai-Tao Sun, Xiang-Dong Chen, Qiong Wang, Pheng Ann Heng
2019 Visual Computing for Industry, Biomedicine, and Art  
In addition, the simulator provides bimanual haptic interaction in a holographic environment to mimic real brain tumor resection.  ...  We propose a registration method for precise mapping of the virtual and real information.  ...  Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.  ... 
doi:10.1186/s42492-019-0015-8 pmid:32240415 fatcat:q6tymlo24bghdbqbqo57uvugee

Modeling of Retraction and Resection for Intraoperative Updating of Images

Michael I. Miga, David W. Roberts, Francis E. Kennedy, Leah A. Platenik, Alex Hartov, Karen E. Lunn, Keith D. Paulsen
2001 Neurosurgery  
Surgical procedures involving the retraction of tissue and the resection of a left frontoparietal tumor were simulated computationally, and the simulations were used to update the preoperative image volume  ...  A new approach to account for brain shift, using computational methods driven by sparsely available operating room (OR) data, has been augmented with techniques for modeling tissue retraction and resection  ...  AnalyzeAVW software was provided in collaboration with the Mayo Foundation.  ... 
doi:10.1097/00006123-200107000-00012 pmid:11440463 fatcat:yvcyeva6t5fejhceut33yiwdju

Modeling of Retraction and Resection for Intraoperative Updating of Images

Michael I. Miga, David W. Roberts, Francis E. Kennedy, Leah A. Platenik, Alex Hartov, Karen E. Lunn, Keith D. Paulsen
2001 Neurosurgery  
Surgical procedures involving the retraction of tissue and the resection of a left frontoparietal tumor were simulated computationally, and the simulations were used to update the preoperative image volume  ...  A new approach to account for brain shift, using computational methods driven by sparsely available operating room (OR) data, has been augmented with techniques for modeling tissue retraction and resection  ...  AnalyzeAVW software was provided in collaboration with the Mayo Foundation.  ... 
doi:10.1227/00006123-200107000-00012 fatcat:plyk45pgcbgktng3rn7ubaxm7a

A systematic review of virtual reality for the assessment of technical skills in neurosurgery

Justin Chan, Dhiraj J. Pangal, Tyler Cardinal, Guillaume Kugener, Yichao Zhu, Arman Roshannai, Nicholas Markarian, Aditya Sinha, Anima Anandkumar, Andrew Hung, Gabriel Zada, Daniel A. Donoho
2021 Neurosurgical Focus  
Examining volume of resection demonstrated that attending surgeons removed less simulated tumor but preserved more normal tissue than trainees.  ...  OBJECTIVE Virtual reality (VR) and augmented reality (AR) systems are increasingly available to neurosurgeons.  ...  studies measured volume of blood lost during a virtual brain tumor resection using the NeuroVR system (Supplemental Table 5 ). 12,14, 25,3 3, 34,37 Experimental designs of included studies limit the  ... 
doi:10.3171/2021.5.focus21210 pmid:34333472 fatcat:wwjcznbfxnbdpahnyam6ha2ttm

Current Practice in Preoperative Virtual and Physical Simulation in Neurosurgery

Elisa Mussi, Federico Mussa, Chiara Santarelli, Mirko Scagnet, Francesca Uccheddu, Rocco Furferi, Yary Volpe, Lorenzo Genitori
2020 Bioengineering  
Therefore, the main aim of the paper is to take into account the literature best practices and to describe the current workflow and methodology used to standardize the pre-operative virtual and physical  ...  In brain tumor surgery, an appropriate and careful surgical planning process is crucial for surgeons and can determine the success or failure of the surgery.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/bioengineering7010007 pmid:31947718 fatcat:q6ykybfbovdbvku7eh5dguhvwa

The Evolution of Mathematical Modeling of Glioma Proliferation and Invasion

Hana L.P. Harpold, Ellsworth C. Alvord, Kristin R. Swanson
2007 Journal of Neuropathology and Experimental Neurology  
This review presents a history of the use of mathematical modeling in the study of the proliferative-invasive growth of gliomas, illustrating the progress made in understanding the in vivo dynamics of  ...  Together, these efforts have extended our knowledge and insight into in vivo brain tumor growth dynamics that should enhance current diagnoses and treatments.  ...  In order to accurately analyze the dynamics of the model in heterogeneous brain tissue, a detailed description of grey and white matter distribution in the brain was required.  ... 
doi:10.1097/nen.0b013e31802d9000 pmid:17204931 fatcat:a46xtlqfvvbcrepgsf3mzq36hm

Virtual and real brain tumors: using mathematical modeling to quantify glioma growth and invasion

Kristin R. Swanson, Carly Bridge, J.D. Murray, Ellsworth C. Alvord
2003 Journal of the Neurological Sciences  
We begin with a model of untreated gliomas and continue with models of polyclonal gliomas following chemotherapy or surgical resection.  ...  Over the last 10 years increasingly complex mathematical models of cancerous growths have been developed, especially on solid tumors, in which growth primarily comes from cellular proliferation.  ...  [11] suggested that brain tumors behave as complex dynamic and self-organizing biosystems and used computer visualizations and simulations involving cellular automata and agent-based modeling and image  ... 
doi:10.1016/j.jns.2003.06.001 pmid:14607296 fatcat:mnk7hg6d7fblvbskuxqhlrmhty

Virtual Reality Simulation of Robotic Transsphenoidal Brain Tumor Resection: Evaluating Dynamic Motion Scaling in a Master-Slave System

Saúl A. Heredia-Pérez, Kanako Harada, Miguel A. Padilla-Castañeda, Murilo Marques-Marinho, Jorge A. Márquez-Flores, Mamoru Mitsuishi
2018 International Journal of Medical Robotics and Computer Assisted Surgery  
It used position-based dynamics to allow soft-tissue deformation and resection with haptic feedback; dynamic motion scaling control was also incorporated into the simulator.  ...  A virtual reality simulator, developed to perform the transsphenoidal resection of pituitary gland tumours, tested the usability of robotic interfaces and control algorithms.  ...  The deformable behaviour of the soft tissue, including membranes, tumour, and brain, was modelled using position-based dynamics, allowing for real-time tissue resection.  ... 
doi:10.1002/rcs.1953 pmid:30117272 pmcid:PMC6587960 fatcat:i4cty3oitfh5bmqwuiybnlaqsm

Treatment-related uptake of O-(2-[18F]fluoroethyl)-L-tyrosine and L-[methyl-3H]-methionine after tumor resection in rat glioma models

Stefanie Geisler, Carina Stegmayr, Nicole Niemietz, Philipp Lohmann, Marion Rapp, Gabriele Stoffels, Antje Willuweit, Norbert Galldiks, Christian P Filss, Michael Sabel, Heinz H. Coenen, N. Jon Shah (+1 others)
2019 Journal of Nuclear Medicine  
Methods: F98 or GS-9L rat gliomas were implanted into the brain of 64 rats. Tumors were resected after 1 wk of tumor growth, and sham surgery was performed in an additional 10 animals.  ...  Tracer uptake was quantified by lesion-to-brain ratios (L/B) at the rim of the resection cavity (considered treatment-related uptake) and in residual or recurrent tumor tissue.  ...  RESULTS Treatment-Related Tracer Uptake After Surgical Intervention The mean values of L/B and T/B at different time points after tumor resection in the 2 tumor models and on brain resection in control  ... 
doi:10.2967/jnumed.119.225680 pmid:30850492 fatcat:g6io5wcutzbx3pjasrqx2aivba

Abstracts DGMKG-DGNC-DGPRÄC-DGKCH

2022 Innovative Surgical Science  
Conclusion: The quantitative proteome analysis with modified aptamers is feasible and may be used to develop precise serum marker to predict tumor occurrence, progression and recurrence in OSCC.  ...  Slow Off-rate Modified aptamers as modified DNA aptamers as used in the SOMAScan® (Somalogic, Boulder, USA) with high affinity and high specificity to the respective proteins, may overcome current limitation  ...  Conclusion: The lack of masseter co-activation with smile predicts a lack of spontaneous involuntary smile after dynamic smile reconstruction using the masseteric nerve.  ... 
doi:10.1515/iss-2022-2005 fatcat:rcrdth7nufgxpo433ogjq7howe

Predicting the Location of Glioma Recurrence after a Resection Surgery [chapter]

Erin Stretton, Emmanuel Mandonnet, Ezequiel Geremia, Bjoern H. Menze, Hervé Delingette, Nicholas Ayache
2012 Lecture Notes in Computer Science  
We propose a method for estimating the location of glioma recurrence after surgical resection.  ...  This method consists of a pipeline including the registration of images at different time points, the estimation of the tumor infiltration map, and the prediction of tumor regrowth using a reaction-diffusion  ...  This work was partially supported by the Care4me ITEA2 project and ERC MedYMA. A big thank you to Maxime Sermesant, Jatin Relan and Gregoire Malandain for their support.  ... 
doi:10.1007/978-3-642-33555-6_10 fatcat:rotf5iuigrgv5dsop7e2adwati

Modeling Brain Dynamics in Brain Tumor Patients Using the Virtual Brain

Hannelore Aerts, Michael Schirner, Ben Jeurissen, Dirk Van Roost, Eric Achten, Petra Ritter, Daniele Marinazzo
2018 eNeuro  
To this end, we simulated large-scale brain dynamics in 25 human brain tumor patients and 11 human control participants using The Virtual Brain, an open-source neuroinformatics platform.  ...  Presurgical planning for brain tumor resection aims at delineating eloquent tissue in the vicinity of the lesion to spare during surgery.  ...  Results Model fit of personalized virtual brain models In this study, we simulated large-scale brain dynamics in brain tumor patients and control subjects using the Reduced Wong-Wang model (Deco et  ... 
doi:10.1523/eneuro.0083-18.2018 pmid:29911173 pmcid:PMC6001263 fatcat:3xf7yekac5hutatlv6sno3eaym
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