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Preservation of retinotopic map in retinal degeneration

John Xie, Gene-Jack Wang, Lindy Yow, Mark S. Humayun, James D. Weiland, Carlos J. Cela, Hossein Jadvar, Gianluca Lazzi, Elona Dhrami-Gavazi, Stephen H. Tsang
2012 Experimental Eye Research  
light and transcorneal electrical stimulation (TcES) in five subjects with retinal degeneration (RD) who have had more than ten years of light-perceptiononly best visual acuity and five age-matched normal-sighted  ...  All subjects underwent quantitative PET with FDG as the metabolic tracer during stimulation of the right eye under both light stimulation condition and transcorneal electrical stimulation (TcES) using  ...  Acknowledgements Funding/Support: This research was supported in part by the US Department of Energy under grant DE-FC02-04ER63735, and in part by the National Science Foundation under grant CBET-0917458  ... 
doi:10.1016/j.exer.2012.03.017 pmid:22685713 pmcid:PMC4310463 fatcat:46eumr2q7famvllpbchaslhvky

Neural responses elicited by electrical stimulation of the retina

Shih-Jen Chen, Manjunatha Mahadevappa, Roberto Roizenblatt, James Weiland, Mark Humayun
2006 Transactions of the American Ophthalmological Society  
Three biological models of retinal degeneration are compared: normal and rd1 mouse, normal and RCD1 dog, and human with retinitis pigmentosa.  ...  To study electrically elicited responses (EERs) that are produced by epiretinal stimulation of normal and degenerated retina.  ...  Shimazu and associates 12 suggested that ON bipolar cells are stimulated during the delivery of transcorneal electrical stimuli in normal cat.  ... 
pmid:17471346 pmcid:PMC1809925 fatcat:tqscvqduibfblenkzoyla5d7ey

Electrical stimulation — a therapeutic strategy for retinal and optic nerve disease?

Florian Gekeler, Karl Ulrich Bartz-Schmidt
2012 Graefe's Archives for Clinical and Experimental Ophthalmology  
Electrical stimulation of the visual system was re-discovered in the 1970s for elicitation of visual percepts, or phosphenes, by supra-threshold stimulation [2] .  ...  Current status and perspective While data from laboratory animals with different disease models show a clear beneficial effect of electrical stimulation on the retina and optic nerve, data from human trials  ... 
doi:10.1007/s00417-012-1930-y pmid:22282217 fatcat:tnjfpmrxzrginbz4rorcf4gdqq

Flexible Polyimide Microelectrodes Array for Transcorneal Electrical Stimulation

Luis Niño de-Rivera, Fidel W. Pérez-Tovar, Jorge Santiago Amaya, Félix Gil Carrasco
2015 Journal of Biomedical Science and Engineering  
Acknowledgements This paper was carried out by the support of the National Science Council and Technology of México, CON-ACyT, Hospital Dr. Luis Sánchez Bulnes.  ...  (APCM, México), Instittuto Politécnico Nacional, IPN) and the Instituto Nacional de Astrofísica, Optica y Electrónica (INAOE, Mexico) who helped in FAB facilities.  ...  Transcorneal Electrical Stimulation (TES) has an effect on the survival of axotomised retinal ganglion cells and on phosphene sensation when the cornea is properly stimulated [1] .  ... 
doi:10.4236/jbise.2015.88051 fatcat:lctmeu77pvhxdhdoiqbjgsstgi

Non-invasive current stimulation in vision recovery: a review of the literature

Cecilia Perin, Barbara Vigano', Daniele Piscitelli, Barbara Maria Matteo, Roberto Meroni, Cesare Giuseppe Cerri
2019 Restorative Neurology and Neuroscience  
In the first group, repetitive transorbital alternating current stimulation (rtACS) reached level A recommendation, and transcorneal electrical stimulation (tcES) reached level C.  ...  Numerous studies have been carried out in order to unveil the effects of electrical stimulation (ES) as a useful tool for rehabilitation for different visual conditions and pathologies.  ...  Disclosure of interest The authors report no conflicts of interest  ... 
doi:10.3233/rnn-190948 pmid:31884495 fatcat:p4h3zwhqcrgxvbnyyqhia7nwci

Excitation of the Pre-frontal and Primary Visual Cortex in Response to Transcorneal Electrical Stimulation in Retinal Degeneration Mice

Stephen K. Agadagba, Xin Li, Leanne Lai Hang Chan
2020 Frontiers in Neuroscience  
We recorded spontaneous electrocorticogram (ECoG) neural activity in prefrontal cortex and primary visual cortex in a mouse model of retinitis pigmentosa (RP) after prolonged (5-day) transcorneal electrical  ...  The aim of the study is to investigate the effect of applying a prolonged electrical stimulation on the eye of rd mice with various stimulation frequencies, in awake and anesthetized brain states.  ...  Transcorneal Electrical Stimulation Transcorneal electrical stimulation is a technique that has been reported to treat various ophthalmological diseases in humans such as Stargardt's disease, Best dystrophy  ... 
doi:10.3389/fnins.2020.572299 pmid:33162879 pmcid:PMC7584448 fatcat:6xnzx6yotbdlthhpcgsd46rxvy

Phosphene Thresholds Elicited by Transcorneal Electrical Stimulation in Healthy Subjects and Patients with Retinal Diseases

Lubka Naycheva, Andreas Schatz, Tobias Röck, Gabriel Willmann, André Messias, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, Florian Gekeler
2012 Investigative Ophthalmology and Visual Science  
Acknowledgments The authors thank technicians Ulrike Fuchs, Katharina Endress, and Susanne Kramer for performance of excellent examinations and Laura Stecher for help in data entry.  ...  lymphoma-2 (BCL-2), 47 BAX, or some tumor necrosis factor genes. 48 Transcorneal electrical stimulation (TES) on humans with longstanding retinal artery occlusion, 49 nonarteritic anterior ischemic  ...  In those studies electrical stimulation for eliciting phosphenes is applied in a different manner: transcorneal, 19,20 suprachoroidal, 21 transscleral, 22 epiretinal, [23] [24] [25] and subretinal  ... 
doi:10.1167/iovs.12-9612 pmid:23049087 fatcat:zrd4uz66krenrffw2u5liulwqe

Pulsed Electrical Stimulation of the Human Eye Enhances Retinal Vessel Reaction to Flickering Light

Stefanie Freitag, Alexander Hunold, Matthias Klemm, Sascha Klee, Dietmar Link, Edgar Nagel, Jens Haueisen
2019 Frontiers in Human Neuroscience  
In three DVA measurements, three stimulus conditions were investigated: flicker light stimulation (FLS); electrical stimulation (ES); simultaneous electrical and flicker light stimulation (ES+FLS).  ...  Recent studies indicate therapeutic benefits of electrical stimulation in cases of specific ophthalmic diseases that are associated with dysfunctional ocular microcirculation.  ...  ACKNOWLEDGMENTS The authors thank Sophia Wunder and Gernot Enders for performing parts of the examinations.  ... 
doi:10.3389/fnhum.2019.00371 pmid:31695600 pmcid:PMC6817672 fatcat:6im3yqim3rdtbfjuizkljrvvqy

The Use of Electrotherapeutics in Ophthalmology

Kieu-Yen Luu, Min Zhao, Mark J. Mannis
2019 American Journal of Ophthalmology  
While many early therapeutic uses of electricity did not produce effective and replicable results, studies on electrical stimulation of the eye provided the foundation for the development of clinically  ...  We reviewed historical journals, articles, and books discussing the use of electricity and electrotherapeutics in ophthalmology.  ...  Electric stimulation of the cornea, lens, choroid, and retina have proved efficacious for the development of devices such as iontophoresis, transcorneal electrical stimulation (TES), the Argus II epiretinal  ... 
doi:10.1016/j.ajo.2019.11.011 pmid:31738895 pmcid:PMC7949834 fatcat:tcpxarb7lva6bjrn5eiod3abli

Neuroprotective strategies for retinal disease

Machelle T. Pardue, Rachael S. Allen
2018 Progress in retinal and eye research  
In addition, we review rehabilitative methods that increase endogenous repair mechanisms, including exercise and electrical stimulation therapies.  ...  retina thus far, both in animals and in humans; and discuss considerations when translating each treatment to the clinic and to the retina, including which therapies show the most promise for each retinal  ...  Acknowledgments Funding sources Pardue and Allen Page 35  ... 
doi:10.1016/j.preteyeres.2018.02.002 pmid:29481975 pmcid:PMC6081194 fatcat:6muffpzt5nh77bpolhkm4z3gpe

Optical Imaging of Visual Cortical Responses Evoked by Transcorneal Electrical Stimulation With Different Parameters

Zengguang Ma, Pengjia Cao, Pengcheng Sun, Liming Li, Yiliang Lu, Yan Yan, Yao Chen, Xinyu Chai
2014 Investigative Ophthalmology and Visual Science  
Optical imaging of visual cortical responses evoked by transcorneal electrical stimulation with different parameters. Invest Ophthalmol Vis Sci. 2014;55:5320-5331.  ...  Acknowledgments The authors thank Wei Wang (at Institute of Neuroscience, CAS) for useful comments on the manuscript.  ...  The use of phosphenes evoked by transcorneal electrical stimulation (TcES) has been proposed as a means of residual visual function evaluation and candidate selection before implantation of retinal prostheses  ... 
doi:10.1167/iovs.14-14600 pmid:25082881 fatcat:rq4pkrhl7jgavfdix7jo5ik3ti

Effect of Electrical Stimulation on Ocular Cells: A Means for Improving Ocular Tissue Engineering and Treatments of Eye Diseases

Fatemeh Sanie-Jahromi, Ali Azizi, Sahar Shariat, Mohammadkarim Johari, Milena Raffi
2021 BioMed Research International  
One of the most important biophysical factors to make this happen is noninvasive electrical stimulation (ES) to target ocular cells that may preserve vision in multiple retinal and optic nerve diseases  ...  Initially, we summarized the current literature on the in vitro and in vivo effects of ES on ocular cells and then we provided the clinical studies describing the effect of ES on ocular complications.  ...  Acknowledgments The authors would like to thank the directors of Shiraz University of Medical Sciences for supporting this research.  ... 
doi:10.1155/2021/6548554 pmid:34840978 pmcid:PMC8612806 fatcat:7unl6nkmanhuzemvflnlyuashm

Transcorneal Electrical Stimulation for Patients with Retinitis Pigmentosa: A Prospective, Randomized, Sham-Controlled Exploratory Study

Andreas Schatz, Tobias Röck, Lubka Naycheva, Gabriel Willmann, Barbara Wilhelm, Tobias Peters, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, André Messias, Florian Gekeler
2011 Investigative Ophthalmology and Visual Science  
Acknowledgments The authors thank Klaus Dietz, head emeritus of the Institute of Biometry in Medicine (University of Tübingen, Germany), for indispensable initial support in evaluating the data and using  ...  the statistical models for this study; technicians Ulricke Kessler, Katharina Endress,  ...  in several ocular diseases in humans and in animal models (see the introduction).  ... 
doi:10.1167/iovs.10-6932 pmid:21467183 fatcat:w3toky5rojcmjcyibrk3qbqnsm

Electrical Stimulation of Cranial Nerves in Cognition and Disease

Devin Adair, Dennis Truong, Zeinab Esmaeilpour, Nigel Gebodh, Helen Borges, Libby Ho, J. Douglas Bremner, Bashar W. Badran, Vitaly Napadow, Vincent P. Clark, Marom Bikson
2020 Brain Stimulation  
Because cranial nerves determine and modulate brain function, invasive and non-invasive cranial nerve electrical stimulation methods have applications in the clinical, behavioral, and cognitive domains  ...  Much prior cranial nerve stimulation work was conceptually limited to the production of sensory perception, with individual titration of intensity based on the level of perception and tolerability.  ...  Noninvasive electrical stimulation in human subjects has produced changes in EEG recordings without behavioral percepts [19] .  ... 
doi:10.1016/j.brs.2020.02.019 pmid:32289703 pmcid:PMC7196013 fatcat:fcec2w46njgbvktujshfs2rhra

Indirect traumatic optic neuropathy

Eric L. Singman, Nitin Daphalapurkar, Helen White, Thao D. Nguyen, Lijo Panghat, Jessica Chang, Timothy McCulley
2016 Military Medical Research  
Research in this field will likely require the development of robust databases to identify patients with ITON and follow related outcomes, in addition to both in-vivo animal and virtual human models to  ...  study the mechanisms of damage and potential therapies.  ...  Authors' contributions All authors reviewed articles, drafted the manuscript, participated in its design and reviewed and approved the manuscript. ELS and TM conceptualized the review.  ... 
doi:10.1186/s40779-016-0069-2 pmid:26759722 pmcid:PMC4709956 fatcat:p6jyhdauhra7zibysvjsdheq7q
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