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Modeling Within-Host Effects of Drugs on Plasmodium falciparum Transmission and Prospects for Malaria Elimination
2014
PLoS Computational Biology
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Here, we report a mechanistic, within-host mathematical model that uses pharmacokinetic (PK) and pharmacodynamic (PD) data to simulate the effects of artemisinin-based combination therapies (ACTs) on Plasmodium ...
Prospects for elimination in much of Sub-Saharan Africa appear far less favorable currently, due to high rates of infection and less frequent and less rapid treatment. ...
Author Contributions Conceived and designed the experiments: GLJ PWG SIH DLS DAF. Performed the experiments: GLJ PWG SIH. Analyzed the data: GLJ PWG SIH DLS DAF. Wrote the paper: GLJ DLS DAF. ...
doi:10.1371/journal.pcbi.1003434
pmid:24465196
pmcid:PMC3900379
fatcat:zeybqozye5hb5aenrzegcg7nwa
Plasmodium vivax Vaccine Research: Insights from Colombian Studies
2011
American Journal of Tropical Medicine and Hygiene
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of P. falciparum infections than P. vivax . 1 Within one year of initiating these control methods, P. falciparum was eliminated; however, it took five years to eliminate P. vivax . 1 The Vanuatu experience ...
Transmission of P. vivax thus can occur before drug treatment is clinically indicated and initiated. ...
Disclaimer: Authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or the stated policy of the World Health Organization. ...
doi:10.4269/ajtmh.2011.09-0781
pmid:21292871
pmcid:PMC3032483
fatcat:ntekcgpb6fe5xhw264sx3axyme
Malaria Parasites in the Asymptomatic: Looking for the Hay in the Haystack
2016
Trends in Parasitology
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With malaria elimination back on the international agenda, programs face the challenge of targeting all Plasmodium infections, not only symptomatic cases. ...
Here we review our current knowledge on the determinants leading to Plasmodium falciparum symptomless infections. ...
Surveillance tools based on these factors might guide the selection of the most effective elimination strategies to target the asymptomatic reservoir of malaria transmission. protein that epigenetically ...
doi:10.1016/j.pt.2015.11.015
pmid:26708404
fatcat:so43xdxxzfgzdghr7y7qlqfv54
Bridging the Knowledge Gap in Transmission-Blocking Immunity to Malaria: Deciphering Molecular Mechanisms in Mosquitoes
2016
Advances in Infectious Diseases
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This review highlights the role of anti-malarial immune responses to antigen-specific targets for designing effective vaccines against the sexual stages of Plasmodium that occur within the invertebrate ...
The artificial blocking of transmission of the Plasmodium parasite between hosts from human to Anopheles mosquito, and vice versa, is crucial to restricting the spread of disease. ...
A compounding factor is that mixed infections of P. falciparum and P. vivax can take place within the one host [10] . ...
doi:10.4236/aid.2016.62005
fatcat:kuw3w2qkgnh7bpfk3qqpvr4w2m
Toward silencing the burden of malaria: progress and prospects for RNAi-based Approaches
2006
BioTechniques
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Toward silencing the burden of malaria: progress and prospects for RNAi-based approaches Anthony E. ...
However, little information on the function of different Plasmodium proteins is available, slowing the identification of appropriate therapeutic targets and hence the development of effective drugs for ...
doi:10.2144/000112117
fatcat:j3bo4v6qnzhw3dd4gzp6jfdaji
malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication
2017
PLoS Medicine
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These advances have once again put malaria elimination on the agenda. ...
For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission. ...
Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study. ...
doi:10.1371/journal.pmed.1002455
pmid:29190291
pmcid:PMC5708606
fatcat:mvseyprjtbhgdnr2s6boxqdpra
Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials
2010
Pharmaceuticals
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This review examines the properties of existing and prospective drugs, mechanisms of action, counter-indications and their potential role in regional malaria elimination efforts. ...
Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes. ...
Although the focus is on drugs active against P. falciparum, drugs shown to be efficacious against P. vivax gametocytes or those of murine and simian models of malaria are also considered, as they may ...
doi:10.3390/ph4010044
fatcat:6qwekjsktjfgdg3hrotc25hcpa
Malaria parasite clearance
2017
Malaria Journal
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Pharmacokinetic-pharmacodynamic modelling of anti-malarial drug effects on parasite clearance has proved useful in predicting therapeutic responses and in dose-optimization. ...
Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes. ...
Acknowledgements I am very grateful to my colleagues for their advice.
Competing interests The authors declare that they no competing interests.
Funding I am a Wellcome Trust Principal Fellow. ...
doi:10.1186/s12936-017-1731-1
pmid:28231817
pmcid:PMC5324257
fatcat:tyxzycxi4zcrjpgawqifpwz7im
The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study
2018
Lancet. Infectious Diseases (Print)
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The importance of such asymptomatic plasmodium infections in malaria transmission is probably related to their duration and density. ...
Interpretation Persistent largely asymptomatic P vivax and P falciparum infections are common in this area of low seasonal malaria transmission. ...
We thank the study participants for their willingness to attend the repeated study visits and donate blood samples and the study staff for their dedication to collect samples and follow up the study participants ...
doi:10.1016/s1473-3099(18)30046-x
pmid:29398388
pmcid:PMC5910058
fatcat:ej3ogpmpgjbklobfzixoyamrfy
Metabolomics in the fight against malaria
2014
Memórias do Instituto Oswaldo Cruz
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High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium life cycle and the downstream ramifications on the host's metabolism, pathogenesis ...
relevant for identifying new drug targets or intervention strategies. ...
ACKNOWLEDGEMENTS To Esmeralda Meyer, for her critical review of the paper, and the MaHPIC team and scientific community, for insights and inspiration. ...
doi:10.1590/0074-0276140043
pmid:25185001
pmcid:PMC4156452
fatcat:pbhvfq5qofgn5oquucysyowzki
Targeting apicoplasts in malaria parasites
2012
Expert opinion on therapeutic targets
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Eliminating gametocytes does not directly impact clinical symptoms but drugs targeting this stage are important tools for reducing malaria transmission. ...
These topics will only be touched on here. There are three prospective roles for anti-malarial compounds: prophylactic, therapeutic and transmission blocking. ...
doi:10.1517/14728222.2013.739158
pmid:23231425
fatcat:y6jgr2thubc2voeq5h5rujglxi
Global Epidemiology of Plasmodium vivax
2016
American Journal of Tropical Medicine and Hygiene
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Without strategies accounting for these P. vivax-specific characteristics, progress toward elimination of endemic malaria transmission will be substantially impeded. ...
Plasmodium vivax is the most widespread human malaria, putting 2.5 billion people at risk of infection. ...
Acknowledgments: We acknowledge Ric Price for his input on chloroquine resistance, Michael White for his discussions on case estimates, and Joshua Longbottom, Maria Devine, and Alexander Rhodes for comments ...
doi:10.4269/ajtmh.16-0141
pmid:27402513
pmcid:PMC5198891
fatcat:k4tivp2hl5aexbfojkbotr445u
Repurposing Drugs to Fight Hepatic Malaria Parasites
2020
Molecules
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Repositioning existing compounds may constitute a faster solution to the current gap of prophylactic and therapeutic drugs that act on Plasmodium parasites, overall contributing to the global effort of ...
Despite achievements in the treatment of this devastating disease, there is still an urgent need for the discovery of new drugs that tackle infection by Plasmodium parasites. ...
Acknowledgments: The authors kindly acknowledge Thomas Hanscheid for valuable insights and fruitful discussions.
Conflicts of Interest: The authors declare no conflict of interest. ...
doi:10.3390/molecules25153409
pmid:32731386
fatcat:ynhixbqblreyhbqk6lmyabza74
Plasmodium knowlesi malaria: current research perspectives
2018
Infection and Drug Resistance
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The zoonotic nature of this infection hinders malaria elimination efforts. ...
Current studies do not provide sufficient data for an effective control program. ...
Acknowledgments
Disclosure The authors report no conflicts of interest in this work. ...
doi:10.2147/idr.s148664
pmid:30127631
pmcid:PMC6089103
fatcat:j7iq2pojxfc2fmgwzbpnpgoi7e
Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations
2009
Malaria Journal
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, Plasmodium falciparum transmission, in part due to carriage of latematuring gametocytes that remain post-treatment. ...
Effective malaria control has successfully reduced the malaria burden in many countries, but to eliminate malaria, these countries will need to further improve their control efforts. ...
Plowe (Department of Medicine, University of Maryland, Baltimore) for helping to review the manuscript. ...
doi:10.1186/1475-2875-8-159
pmid:19604346
pmcid:PMC2718908
fatcat:64lxj4ls2vaj7gbc2qwdzfgdta
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