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Modeling Within-Host Effects of Drugs on Plasmodium falciparum Transmission and Prospects for Malaria Elimination

Geoffrey L. Johnston, Peter W. Gething, Simon I. Hay, David L. Smith, David A. Fidock, Neil M. Ferguson
2014 PLoS Computational Biology  
Here, we report a mechanistic, within-host mathematical model that uses pharmacokinetic (PK) and pharmacodynamic (PD) data to simulate the effects of artemisinin-based combination therapies (ACTs) on Plasmodium  ...  Prospects for elimination in much of Sub-Saharan Africa appear far less favorable currently, due to high rates of infection and less frequent and less rapid treatment.  ...  Author Contributions Conceived and designed the experiments: GLJ PWG SIH DLS DAF. Performed the experiments: GLJ PWG SIH. Analyzed the data: GLJ PWG SIH DLS DAF. Wrote the paper: GLJ DLS DAF.  ... 
doi:10.1371/journal.pcbi.1003434 pmid:24465196 pmcid:PMC3900379 fatcat:zeybqozye5hb5aenrzegcg7nwa

Plasmodium vivax Vaccine Research: Insights from Colombian Studies

Falgunee K. Parekh, Vasee S. Moorthy
2011 American Journal of Tropical Medicine and Hygiene  
of P. falciparum infections than P. vivax . 1 Within one year of initiating these control methods, P. falciparum was eliminated; however, it took five years to eliminate P. vivax . 1 The Vanuatu experience  ...  Transmission of P. vivax thus can occur before drug treatment is clinically indicated and initiated.  ...  Disclaimer: Authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or the stated policy of the World Health Organization.  ... 
doi:10.4269/ajtmh.2011.09-0781 pmid:21292871 pmcid:PMC3032483 fatcat:ntekcgpb6fe5xhw264sx3axyme

Malaria Parasites in the Asymptomatic: Looking for the Hay in the Haystack

Beatriz Galatas, Quique Bassat, Alfredo Mayor
2016 Trends in Parasitology  
With malaria elimination back on the international agenda, programs face the challenge of targeting all Plasmodium infections, not only symptomatic cases.  ...  Here we review our current knowledge on the determinants leading to Plasmodium falciparum symptomless infections.  ...  Surveillance tools based on these factors might guide the selection of the most effective elimination strategies to target the asymptomatic reservoir of malaria transmission. protein that epigenetically  ... 
doi:10.1016/j.pt.2015.11.015 pmid:26708404 fatcat:so43xdxxzfgzdghr7y7qlqfv54

Bridging the Knowledge Gap in Transmission-Blocking Immunity to Malaria: Deciphering Molecular Mechanisms in Mosquitoes

Sandeep Satapathy, Andrew W. Taylor-Robinson
2016 Advances in Infectious Diseases  
This review highlights the role of anti-malarial immune responses to antigen-specific targets for designing effective vaccines against the sexual stages of Plasmodium that occur within the invertebrate  ...  The artificial blocking of transmission of the Plasmodium parasite between hosts from human to Anopheles mosquito, and vice versa, is crucial to restricting the spread of disease.  ...  A compounding factor is that mixed infections of P. falciparum and P. vivax can take place within the one host [10] .  ... 
doi:10.4236/aid.2016.62005 fatcat:kuw3w2qkgnh7bpfk3qqpvr4w2m

Toward silencing the burden of malaria: progress and prospects for RNAi-based Approaches

Anthony E. Brown, Flaminia Catteruccia
2006 BioTechniques  
Toward silencing the burden of malaria: progress and prospects for RNAi-based approaches Anthony E.  ...  However, little information on the function of different Plasmodium proteins is available, slowing the identification of appropriate therapeutic targets and hence the development of effective drugs for  ... 
doi:10.2144/000112117 fatcat:j3bo4v6qnzhw3dd4gzp6jfdaji

malERA: An updated research agenda for diagnostics, drugs, vaccines, and vector control in malaria elimination and eradication

2017 PLoS Medicine  
These advances have once again put malaria elimination on the agenda.  ...  For areas where local elimination has been recently achieved, understanding which measures are needed to maintain elimination is necessary to prevent rebound and the reestablishment of transmission.  ...  Potential for reduction of burden and local elimination of malaria by reducing Plasmodium falciparum malaria transmission: a mathematical modelling study.  ... 
doi:10.1371/journal.pmed.1002455 pmid:29190291 pmcid:PMC5708606 fatcat:mvseyprjtbhgdnr2s6boxqdpra

Blocking Plasmodium falciparum Malaria Transmission with Drugs: The Gametocytocidal and Sporontocidal Properties of Current and Prospective Antimalarials

Anthony E. Kiszewski
2010 Pharmaceuticals  
This review examines the properties of existing and prospective drugs, mechanisms of action, counter-indications and their potential role in regional malaria elimination efforts.  ...  Drugs that kill or inhibit the sexual stages of Plasmodium could potentially amplify or synergize the impact of other interventions by blocking transmission to mosquitoes.  ...  Although the focus is on drugs active against P. falciparum, drugs shown to be efficacious against P. vivax gametocytes or those of murine and simian models of malaria are also considered, as they may  ... 
doi:10.3390/ph4010044 fatcat:6qwekjsktjfgdg3hrotc25hcpa

Malaria parasite clearance

Nicholas J. White
2017 Malaria Journal  
Pharmacokinetic-pharmacodynamic modelling of anti-malarial drug effects on parasite clearance has proved useful in predicting therapeutic responses and in dose-optimization.  ...  Following anti-malarial drug treatment asexual malaria parasite killing and clearance appear to be first order processes.  ...  Acknowledgements I am very grateful to my colleagues for their advice. Competing interests The authors declare that they no competing interests. Funding I am a Wellcome Trust Principal Fellow.  ... 
doi:10.1186/s12936-017-1731-1 pmid:28231817 pmcid:PMC5324257 fatcat:tyxzycxi4zcrjpgawqifpwz7im

The persistence and oscillations of submicroscopic Plasmodium falciparum and Plasmodium vivax infections over time in Vietnam: an open cohort study

Thuy-Nhien Nguyen, Lorenz von Seidlein, Tuong-Vy Nguyen, Phuc-Nhi Truong, Son Do Hung, Huong-Thu Pham, Tam-Uyen Nguyen, Thanh Dong Le, Van Hue Dao, Mavuto Mukaka, Nicholas PJ Day, Nicholas J White (+3 others)
2018 Lancet. Infectious Diseases (Print)  
The importance of such asymptomatic plasmodium infections in malaria transmission is probably related to their duration and density.  ...  Interpretation Persistent largely asymptomatic P vivax and P falciparum infections are common in this area of low seasonal malaria transmission.  ...  We thank the study participants for their willingness to attend the repeated study visits and donate blood samples and the study staff for their dedication to collect samples and follow up the study participants  ... 
doi:10.1016/s1473-3099(18)30046-x pmid:29398388 pmcid:PMC5910058 fatcat:ej3ogpmpgjbklobfzixoyamrfy

Metabolomics in the fight against malaria

Jorge L Salinas, Jessica C Kissinger, Dean P Jones, Mary R Galinski
2014 Memórias do Instituto Oswaldo Cruz  
High-resolution metabolomics can shed new light on the intricacies of host-parasite interactions in each stage of the Plasmodium life cycle and the downstream ramifications on the host's metabolism, pathogenesis  ...  relevant for identifying new drug targets or intervention strategies.  ...  ACKNOWLEDGEMENTS To Esmeralda Meyer, for her critical review of the paper, and the MaHPIC team and scientific community, for insights and inspiration.  ... 
doi:10.1590/0074-0276140043 pmid:25185001 pmcid:PMC4156452 fatcat:pbhvfq5qofgn5oquucysyowzki

Targeting apicoplasts in malaria parasites

Christopher D Goodman, Geoffrey I McFadden
2012 Expert opinion on therapeutic targets  
Eliminating gametocytes does not directly impact clinical symptoms but drugs targeting this stage are important tools for reducing malaria transmission.  ...  These topics will only be touched on here. There are three prospective roles for anti-malarial compounds: prophylactic, therapeutic and transmission blocking.  ... 
doi:10.1517/14728222.2013.739158 pmid:23231425 fatcat:y6jgr2thubc2voeq5h5rujglxi

Global Epidemiology of Plasmodium vivax

Rosalind E. Howes, Katherine E. Battle, Kamini N. Mendis, David L. Smith, Richard E. Cibulskis, J. Kevin Baird, Simon I. Hay
2016 American Journal of Tropical Medicine and Hygiene  
Without strategies accounting for these P. vivax-specific characteristics, progress toward elimination of endemic malaria transmission will be substantially impeded.  ...  Plasmodium vivax is the most widespread human malaria, putting 2.5 billion people at risk of infection.  ...  Acknowledgments: We acknowledge Ric Price for his input on chloroquine resistance, Michael White for his discussions on case estimates, and Joshua Longbottom, Maria Devine, and Alexander Rhodes for comments  ... 
doi:10.4269/ajtmh.16-0141 pmid:27402513 pmcid:PMC5198891 fatcat:k4tivp2hl5aexbfojkbotr445u

Repurposing Drugs to Fight Hepatic Malaria Parasites

Diana Fontinha, Isabel Moules, Miguel Prudêncio
2020 Molecules  
Repositioning existing compounds may constitute a faster solution to the current gap of prophylactic and therapeutic drugs that act on Plasmodium parasites, overall contributing to the global effort of  ...  Despite achievements in the treatment of this devastating disease, there is still an urgent need for the discovery of new drugs that tackle infection by Plasmodium parasites.  ...  Acknowledgments: The authors kindly acknowledge Thomas Hanscheid for valuable insights and fruitful discussions. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/molecules25153409 pmid:32731386 fatcat:ynhixbqblreyhbqk6lmyabza74

Plasmodium knowlesi malaria: current research perspectives

Amirah Amir, Fei Wen Cheong, Jeremy Ryan de Silva, Jonathan Wee Kent Liew, Yee Ling Lau
2018 Infection and Drug Resistance  
The zoonotic nature of this infection hinders malaria elimination efforts.  ...  Current studies do not provide sufficient data for an effective control program.  ...  Acknowledgments Disclosure The authors report no conflicts of interest in this work.  ... 
doi:10.2147/idr.s148664 pmid:30127631 pmcid:PMC6089103 fatcat:j7iq2pojxfc2fmgwzbpnpgoi7e

Optimally timing primaquine treatment to reduce Plasmodium falciparum transmission in low endemicity Thai-Myanmar border populations

Saranath Lawpoolsri, Eili Y Klein, Pratap Singhasivanon, Surapon Yimsamran, Nipon Thanyavanich, Wanchai Maneeboonyang, Laura L Hungerford, James H Maguire, David L Smith
2009 Malaria Journal  
, Plasmodium falciparum transmission, in part due to carriage of latematuring gametocytes that remain post-treatment.  ...  Effective malaria control has successfully reduced the malaria burden in many countries, but to eliminate malaria, these countries will need to further improve their control efforts.  ...  Plowe (Department of Medicine, University of Maryland, Baltimore) for helping to review the manuscript.  ... 
doi:10.1186/1475-2875-8-159 pmid:19604346 pmcid:PMC2718908 fatcat:64lxj4ls2vaj7gbc2qwdzfgdta
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