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Transition from adolescent to adult services in haemophilia

Steve Chaplin
2016 The Journal of Haemophilia Practice  
Two trials have assessed the impact of a transition intervention on outcomes including self-management and transition.  ...  when it comes to transfer, but do it during a time of stability Gray et al, 2015 [83] Inflammatory bowel disease Data-driven assessment (e.g.  ... 
doi:10.17225/jhp00059 fatcat:u2j733oqlrg2xd3r6mec5t74ui

Almanac 2014: Cardiomyopathies

Oliver P Guttmann, Saidi A Mohiddin, Perry M Elliott
2015 Cardiologia Croatica  
A study of 603 patients over three decades gives evidence for the impact of clinical guidelines on morbidity and mortality.  ...  aetiology driven therapy.  ... 
doi:10.15836/ccar.2014.543 fatcat:gqkgdhgfjzgx7aa4frtdkrzhr4

Almanac 2014: cardiomyopathies

Oliver P. Guttmann, Saidi A. Mohiddin, Perry M. Elliott
2015 Cor et Vasa  
A study of 603 patients over three decades gives evidence for the impact of clinical guidelines on morbidity and mortality.  ...  aetiology driven therapy.  ... 
doi:10.1016/j.crvasa.2015.01.002 fatcat:g3xhetzcnrbv5jzahbt4dj2n4i

Almanac 2014: cardiomyopathies

Oliver P Guttmann, Saidi A Mohiddin, Perry M Elliott
2014 Heart  
An important innovation since the last Almanac is the development of more sophisticated models for predicting adverse clinical events. Oliver P Guttmann et al.  Oliver P Guttmann et al.  ...  Almanac 2014: cardiomyopathies Oliver P Guttmann et al.  ...  A study of 603 patients over three decades gives evidence for the impact of clinical guidelines on morbidity and mortality.  ... 
doi:10.1136/heartjnl-2013-305420 pmid:25906005 fatcat:fzfan62fozdwfj4qcudj7sprhi

Oxidative Stress and Cellular Response to Doxorubicin: A Common Factor in the Complex Milieu of Anthracycline Cardiotoxicity

Donato Cappetta, Antonella De Angelis, Luigi Sapio, Lucia Prezioso, Michela Illiano, Federico Quaini, Francesco Rossi, Liberato Berrino, Silvio Naviglio, Konrad Urbanek
2017 Oxidative Medicine and Cellular Longevity  
This phenomenon translates into anthracycline cardiotoxicity that is a serious problem in the growing population of paediatric and adult cancer survivors.  ...  and often severe cardiomyopathy experienced by otherwise successfully treated oncologic patients.  ...  Although the evidence of benefits in a rat model of DOX-induced cardiotoxicity in rats were shown [136] , a randomized controlled trial conducted on paediatric patients treated with cisplatin and DOX  ... 
doi:10.1155/2017/1521020 pmid:29181122 pmcid:PMC5664340 fatcat:q5pvwus5efcn7mrbewef75xxru

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

Jens Cosedis Nielsen, Yenn‐Jiang Lin, Marcio Jansen de Oliveira Figueiredo, Alireza Sepehri Shamloo, Alberto Alfie, Serge Boveda, Nikolaos Dagres, Dario Di Toro, Lee L. Eckhardt, Kenneth Ellenbogen, Carina Hardy, Takanori Ikeda (+39 others)
2020 Journal of Arrhythmia  
clinical reassessment may be needed every 4-6 months to optimize risk re-assessment. 11-13 As the CHA 2 DS 2 -VASc is a cluster of common cardiovascular risk factors, it is predictive of death, cardiovascular  ...  Tests that are difficult to reproduce, subject to technical failures, or difficult to interpret are likely to impact patient care as a consequence of a primary failure to produce a definitive and actionable  ...  using a concealed accessory pathway.  ... 
doi:10.1002/joa3.12338 pmid:32782627 pmcid:PMC7411224 fatcat:3eicl6dqefbjjbr4ivo5sugpj4

The 'Digital Twin' to enable the vision of precision cardiology

2020 European Heart Journal  
the pathways to restore health by model predictions.  ...  The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead.  ...  Early components of the digital twin are already making a clinical impact.  ... 
doi:10.1093/eurheartj/ehaa159 pmid:32128588 pmcid:PMC7774470 fatcat:rw6pikgtvjbdhn7pjzkog5ywgq

The Health Care Transition of Youth With Liver Disease Into the Adult Health System

Pietro Vajro, Björn Fischler, Patrizia Burra, Dominique Debray, Antal Dezsofi, Salvatore Guercio Nuzio, Nedim Hadzic, Loreto Hierro, Joerg Jahnel, Thierry Lamireau, Patrick McKiernan, Valerie McLin (+5 others)
2018 Journal of Pediatric Gastroenterology and Nutrition - JPGN  
However, there is no generally accepted optimal pathway of care for the transition from paediatric care to the adult health system.  ...  Conclusions: Transfer of medical care of individuals with paediatric onset hepatobiliary chronic diseases to adult facilities is a complex task requiring multiple involvements of patients and both paediatric  ...  What Is New The first agreed intersocietal transition pathway for patients with paediatric-onset liver diseases.  ... 
doi:10.1097/mpg.0000000000001965 pmid:29570559 fatcat:ldnvuwfmgvftfcafco2jg7f3ny

Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014)

Michael Ewer, Luca Gianni, Fabrizio Pane, Maria Teresa Sandri, Rudolf K Steiner, Leszek Wojnowski, Edward T Yeh, Joseph R Carver, Steven E Lipshultz, Giorgio Minotti, Gregory T Armstrong, Daniela Cardinale (+10 others)
2014 ecancermedicalscience  
Cardio-oncology is a relatively new discipline that focuses on the cardiovascular sequelae of anti-tumour drugs.  ...  The programme was split into five sessions of broad investigational and clinical relevance (what is cardiotoxicity?  ...  Only then can data-driven practice guidelines be incorporated into clinical pathways.  ... 
doi:10.3332/ecancer.2014.433 pmid:24932213 pmcid:PMC4039411 fatcat:syoeghvypnb2berbd5gonx6nmy

European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on risk assessment in cardiac arrhythmias: use the right tool for the right outcome, in the right population

Jens Cosedis Nielsen, Yenn-Jiang Lin, Marcio Jansen de Oliveira Figueiredo, Alireza Sepehri Shamloo, Alberto Alfie, Serge Boveda, Nikolaos Dagres, Dario Di Toro, Lee L. Eckhardt, Kenneth Ellenbogen, Carina Hardy, Takanori Ikeda (+39 others)
2020 Heart Rhythm  
Mortality and morbidity The impact of the ablation on hard clinical endpoints is much less evident.  ...  cardiomyopathies as an underlying cause, given that these conditions may benefit from specific aetiology-driven treatments.  ... 
doi:10.1016/j.hrthm.2020.05.004 pmid:32553607 fatcat:3jda2cmyffaxtez6mhbfgb7bsy

Cardiovascular magnetic resonance imaging: what the general cardiologist should know

D P Ripley, T A Musa, L E Dobson, S Plein, J P Greenwood
2016 Heart  
This trial is designed to assess the impact of each strategy in reducing the rates of unnecessary invasive angiography, which is important from a clinical, economic and patient preference perspective  ...  The test for any new imaging modality is how it can translate into the clinical pathway by changing patient management and affecting clinical outcomes and ongoing studies will address this.  ... 
doi:10.1136/heartjnl-2015-307896 pmid:27559093 fatcat:6pqpjki775bitllarleevwgb7i

Zebrafish as a tractable model of human cardiovascular disease

George Bowley, Elizabeth Kugler, Rob Wilkinson, Allan Lawrie, Freek van Eeden, Tim J A Chico, Paul C Evans, Emily S Noël, Jovana Serbanovic-Canic
2021 British Journal of Pharmacology  
We also review the use of zebrafish for studying pharmacological responses to cardiovascular drugs, and describe several features of zebrafish that make them a compelling model for in vivo screening of  ...  , cardiomyopathy, conduction disorders, regeneration) and vascular (endothelial dysfunction and atherosclerosis, lipid metabolism, vascular ageing, neurovascular physiology and stroke) pathologies.  ...  Using a zebrafish model of doxorubicin-induced cardiomyopathy for small-molecule screening, cytochrome P450 family 1 (CYP1) has been recently identified as a candidate therapeutic target for clinical cardioprotection  ... 
doi:10.1111/bph.15473 pmid:33788282 fatcat:4bmxzub6mzahpjv2azyeuuddji

The Endocannabinoid System and Cannabidiol: Past, Present, and Prospective for Cardiovascular Diseases

Martina Rabino, Sara Mallia, Elisa Castiglioni, Davide Rovina, Giulio Pompilio, Aoife Gowran
2021 Pharmaceuticals  
Such high degree of pathophysiological involvement suggests the endocannabinoid system is a promising therapeutic target and prompted the translation of resurgent scientific findings into clinical therapies  ...  The endocannabinoid system is a complex and heterogeneous pro-homeostatic network comprising different receptors with several endogenous ligands, numerous metabolic enzymes and regulatory proteins.  ...  Studies in rodent models of cardiomyopathy have demonstrated that CB1-activated pathways promote oxidative damage, while CB2 stimulation limits oxidant-evoked myocardial injury.  ... 
doi:10.3390/ph14090936 pmid:34577636 pmcid:PMC8472406 fatcat:kfrnfqez3bcglkq5u6ho3rvrc4

The Landscape of Pediatric Precision Oncology: Program Design, Actionable Alterations, and Clinical Trial Development

Karin P S Langenberg, Eleonora J Looze, Jan J Molenaar
2021 Cancers  
The first biomarker-driven trials for childhood cancer have been initiated, but until now the effect of precision medicine on clinical outcome has only been reported for a small number of patients, demonstrating  ...  clinical benefit in some.  ...  These studies investigat the potential of molecular-driven precision medicine and began to assess the clinical be efit of targeted therapies.  ... 
doi:10.3390/cancers13174324 pmid:34503139 fatcat:hwouq7saprdmxhqz3bmj7hxl2q

Clinical research directions in pediatric cardiology

Steven E Lipshultz, James D Wilkinson, Sarah E Messiah, Tracie L Miller
2009 Current opinion in pediatrics  
Renewed interest in federally funded clinical research makes it timely to propose a comprehensive research agenda that, with its associated rationale, will attract public funds for research into child  ...  Recent findings-We propose here a comprehensive pediatric cardiology research agenda consisting of 22 topics and associated research questions.  ...  [PubMed: 18496603] ••A review of the approach behind a comprehensive assessment of exercise capacity in children with cardiomyopathy.  ... 
doi:10.1097/mop.0b013e32832e48df pmid:19584723 pmcid:PMC2892901 fatcat:opsfgsiyezhfzmyvhelhzqmpiu
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