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Model-based recommendations for optimal surgical placement of epiretinal implants [article]

Michael Beyeler, Geoffrey M. Boynton, Ione Fine, Ariel Rokem
2019 bioRxiv   pre-print
Here we systematically explored the space of possible implant configurations to make recommendations for optimal intraocular positioning of the electrode array.  ...  However, this knowledge has yet to be incorporated into the surgical placement of retinal implants.  ...  First, we present a strategy to optimize the intraocular placement of epiretinal implants, based on a psychophysically validated computational model of the vision provided by Argus II.  ... 
doi:10.1101/743484 fatcat:opo6ub4p4jgj5lncoam4vamcwa

COMPARISON OF VISUAL AND ANATOMICAL OUTCOMES OF EYES UNDERGOING TYPE I BOSTON KERATOPROSTHESIS WITH COMBINATION PARS PLANA VITRECTOMY WITH EYES WITHOUT COMBINATION VITRECTOMY

Jennifer I. Lim, Lindsay Machen, Andrea Arteaga, Faris I. Karas, Robert Hyde, Dingcai Cao, Marcia Niec, Thasarat S. Vajaranant, M. Soledad Cortina
2018 Retina  
Visual acuities improved postoperatively by one month after keratoprosthesis implantation for both groups and improved three or more lines of Snellen acuity in the majority of eyes for both groups (≥72%  ...  undergoing keratoprosthesis placement alone.  ...  Acknowledgments The authors wish to acknowledge the following UIC physicians who participated in the care of some of these patients: Ahmad Aref MD, Michael Blair MD, Felix Y.  ... 
doi:10.1097/iae.0000000000002036 pmid:29370031 pmcid:PMC6056324 fatcat:dxz7giu7krcjjnsmahqky4mon4

Chapter 1 - Restoring Vision to the Blind: The New Age of Implanted Visual Prostheses

2014 Translational Vision Science & Technology  
Recent Advances in Retinal Stimulation: Clinical Applications Of the many devices investigated, retina-based devices have shown the greatest success.  ...  At present, there are seven major ongoing retinal prosthesis projects that have either implanted test subjects or have concrete plans to do so in the near future.  ...  Epiretinal implants employ a simpler surgical procedure than subretinal implants to target the ganglion cells for more direct control of the output signals of the retina.  ... 
doi:10.1167/tvst.3.7.3 pmid:25653887 pmcid:PMC4314997 fatcat:lbzjkdkhyrd7zmfujg3dkhoznq

Argus II retinal prosthesis system: a review of patient selection criteria, surgical considerations, and post-operative outcomes

Avni Finn, Dilraj Grewal, Lejla Vajzovic
2018 Clinical Ophthalmology  
Careful pre-operative screening, counseling, and management of patient expectations are critical for the successful implantation and visual rehabilitation of patients with the Argus II device.  ...  The Argus II retinal prosthesis system is one such artificial vision device approved for patients with RP. This review focuses on the factors important for patient selection.  ...  The manufacturer recommended axial length parameters are between 20.5 and 26 mm as the available cable lengths will not allow for optimal array placement in shorter or longer eyes.  ... 
doi:10.2147/opth.s137525 pmid:29942114 pmcid:PMC6005308 fatcat:3to6nhhrobh6fkt3vmmf5ohyqi

Retinal implants

Gislin Dagnelie
2012 Current Opinion in Neurology  
Summary At present, clinical applications of retinal implant technology are dominated by one or two groups/ companies, but the field is wide open for others to take the lead through novel approaches in  ...  OPINION Retinal implants: emergence of a multidisciplinary field Gislin Dagnelie Purpose of review This review summarizes the current status of retinal prostheses, recent accomplishments, and major remaining  ...  Conflicts of interest The author is a center principal investigator for the Argus II Retinal Implant Feasibility Study sponsored by Second Sight Medical Products Inc.  ... 
doi:10.1097/wco.0b013e32834f02c3 pmid:22185902 pmcid:PMC3291121 fatcat:hzmcjmtr7fasvc4ddl6rexkxba

New epiretinal implant with integrated sensor chips for optical capturing shows a good biocompatibility profile in vitro and in vivo

Kim Schaffrath, Tibor Lohmann, Jan Seifert, Claudia Ingensiep, Pascal Raffelberg, Florian Waschkowski, Reinhard Viga, Rainer Kokozinski, Wilfried Mokwa, Sandra Johnen, Peter Walter
2021 BioMedical Engineering OnLine  
In this study, the biocompatibility and surgical feasibility of a newly developed epiretinal stimulator (OPTO-EPIRET) was investigated.  ...  The previously developed implant was extended by an integrated circuit-based optical capturing, which will enable the immediate conversion of the visual field into stimulation patterns to stimulate retinal  ...  Acknowledgements The authors thank Anne Freialdenhoven and Claudia Werner (Department of Ophthalmology, RWTH Aachen University Hospital, Aachen, Germany) for excellent technical support and the Institute  ... 
doi:10.1186/s12938-021-00938-9 pmid:34641889 pmcid:PMC8507367 fatcat:lej6tfx5pngrtggy2v7tkhpwrm

Electronic approaches to restoration of sight

G A Goetz, D V Palanker
2016 Reports on progress in physics (Print)  
We summarize results of pre-clinical evaluation of prosthetic visual functions in-and ex vivo, as well as the outcomes of current clinical trials of various retinal implants.  ...  Retinal prostheses are a promising means for restoring sight to patients blinded by the gradual atrophy of photoreceptors due to retinal degeneration.  ...  Acknowledgments We would like to thank Dr L Grosberg for proof-reading the manuscript.  ... 
doi:10.1088/0034-4885/79/9/096701 pmid:27502748 pmcid:PMC5031080 fatcat:o7zayslbhzegnnxn2fz5jjkozy

Prevention and Management of Cataracts in Children with Juvenile Idiopathic Arthritis–Associated Uveitis

Sheila Angeles-Han, Steven Yeh
2011 Current Rheumatology Reports  
Various factors should be taken into consideration when deciding on cataract management, including timing of surgery and placement of an intraocular lens.  ...  Risk factors for cataracts include posterior synechiae and longstanding ocular inflammation. Prevention of cataract development is crucial through appropriate control of uveitis.  ...  K23EY021760 grant from the National Eye Institute (content is solely the responsibility of the authors and does not necessarily represent the official views of the National Eye Institute or the National  ... 
doi:10.1007/s11926-011-0229-z pmid:22201032 pmcid:PMC3751191 fatcat:uj5bdp5jbvbpnhwbzqr62fxuwq

Factors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis

Mohit N. Shivdasani, Nicholas C. Sinclair, Peter N. Dimitrov, Mary Varsamidis, Lauren N. Ayton, Chi D. Luu, Thushara Perera, Hugh J. McDermott, Peter J. Blamey
2014 Investigative Ophthalmology and Visual Science  
IOVS 2012;53:ARVO E-Abstract 6953), and a sustained increase in the number of microaneurysms in patients with subretinal devices. 9 Moreover, the surgical  ...  in patients with epiretinal devices (Humayun MS, et al.  ...  for number of days post implantation.  ... 
doi:10.1167/iovs.14-14396 pmid:25205858 fatcat:wzmkwje7mnhy7m2ug4alnwxz3m

The Appropriate Use of Neurostimulation of the Spinal Cord and Peripheral Nervous System for the Treatment of Chronic Pain and Ischemic Diseases: The Neuromodulation Appropriateness Consensus Committee

Timothy R. Deer, Nagy Mekhail, David Provenzano, Jason Pope, Elliot Krames, Michael Leong, Robert M. Levy, David Abejon, Eric Buchser, Allen Burton, Asokumar Buvanendran, Kenneth Candido (+32 others)
2014 Neuromodulation (Malden, Mass.)  
The remaining authors contributed sections of the manuscript or provided critical reviews. Opinions expressed herein are not necessarily shared by all authors.  ...  and comorbidities, and awareness of contemporary lead configurations and their optimal applications and proper placement and programming.  ...  higher with surgically implanted paddle leads (182) .  ... 
doi:10.1111/ner.12208 pmid:25112889 fatcat:fg7chhti3zgifh5zymk6576zee

Multifocal intraocular lenses: Relative indications and contraindications for implantation

Rosa Braga-Mele, David Chang, Steven Dewey, Gary Foster, Bonnie An Henderson, Warren Hill, Richard Hoffman, Brian Little, Nick Mamalis, Thomas Oetting, Donald Serafano, Audrey Talley-Rostov (+2 others)
2014 Journal of cataract and refractive surgery  
In-the-bag IOL placement should be the goal for placement of multifocal IOLs because of the stability this offers.  ...  DISCUSSION This review of best practices for multifocal IOLs outlines general recommendations for the currently available multifocal IOLs in the U.S.  ... 
doi:10.1016/j.jcrs.2013.12.011 pmid:24461503 fatcat:fdiu4p5555dmbeeotanhizicma

Glaucoma drainage devices: a systematic literature review and current controversies

Chian-Huey Hong, Analisa Arosemena, David Zurakowski, Ramesh S. Ayyala
2005 Survey of ophthalmology  
This review provides a systematic review of the literature and outlines the current controversies involving different glaucoma drainage devices and their design, overall surgical success, and complications  ...  Glaucoma drainage devices are being used more frequently in the treatment of glaucoma that does not respond to medications or trabeculectomy operations.  ...  use of current or newer antifibrotic agents with innovative drug delivery systems, we may be able to achieve the ideal glaucoma drainage device.  ... 
doi:10.1016/j.survophthal.2004.10.006 pmid:15621077 fatcat:phjxevsfkncutfmkbr4v54qmou

Surgical Transplantation of Human RPE Stem Cell-Derived RPE Monolayers into Non-Human Primates with Immunosuppression

Zengping Liu, Bhav Harshad Parikh, Queenie Shu Woon Tan, Daniel Soo Lin Wong, Kok Haur Ong, Weimiao Yu, Ivan Seah, Graham E. Holder, Walter Hunziker, Gavin S.W. Tan, Veluchamy Amutha Barathi, Gopal Lingam (+3 others)
2021 Stem Cell Reports  
Human RPE stem cell-derived RPE (hRPESC-RPE) transplantation can rescue vision in a rat model of retinal dystrophy and survive in the rabbit retina for at least 1 month.  ...  The present study placed hRPESC-RPE monolayers under the macula of a non-human primate model for 3 months. The transplant was able to recover in vivo and maintained healthy photoreceptors.  ...  At 3 months post-implantation, all the implants remained at the site of original placement within the macula (Figures 2 and S2 and Table S1 ), except for case 5, wherein a large bleb was created during  ... 
doi:10.1016/j.stemcr.2020.12.007 pmid:33450191 pmcid:PMC7878718 fatcat:k2qyjojvo5e4xita3sogafbxye

What Is the Impact of Intraoperative Microscope-Integrated OCT in Ophthalmic Surgery? Relevant Applications and Outcomes. A Systematic Review

Chiara Posarelli, Francesco Sartini, Giamberto Casini, Andrea Passani, Mario Damiano Toro, Giovanna Vella, Michele Figus
2020 Journal of Clinical Medicine  
Method: A total of 314 studies were identified, following a literature search adhering to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines.  ...  MI-OCT can help anterior and posterior segment surgeons in the decision-making process, providing direct visualization of anatomic planes before and after surgical manoeuvres, assisting in complex cases  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/jcm9061682 pmid:32498222 fatcat:kmm7fqgzofhslesesaujk5x3gi

Cataract Surgery in Post-Vitrectomized Eyes [chapter]

Olivia Esteban, Javier Mateo, Paula Casas, Javier Lara, Javier Ascaso
2021 Current Cataract Surgical Techniques  
Because of the application of vitreoretinal surgical techniques to a broader range of posterior segment diseases and because cataract develops frequently in postvitrectomy eyes, cataract surgeons should  ...  Cataract surgery after pars plana vitrectomy significantly improves visual acuity in 85% of cases, limited by retinal comorbidity and surgical complications.  ...  However, lens constant optimization enabled optimal and comparable results for all formulas. As general recommendations to calculate IOL in vitrectomized eyes we suggest.  ... 
doi:10.5772/intechopen.95467 fatcat:pkqyr6h2pfejvl3wty6roixt5y
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