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Model predictive control and moving horizon estimation for adaptive optimal bolus feeding in high-throughput cultivation of E. coli [article]

Jong Woo Kim, Niels Krausch, Judit Aizpuru, Tilman Barz, Sergio Lucia, Peter Neubauer, Mariano Nicolas Cruz Bournazou
2022 arXiv   pre-print
We discuss the application of a nonlinear model predictive control (MPC) and a moving horizon estimation (MHE) to achieve an optimal operation of E. coli fed-batch cultivations with intermittent bolus  ...  feeding. 24 parallel experiments were considered in a high-throughput microbioreactor platform at 10 mL scale.  ...  Acknowledgment This work was supported by the German Federal Ministry of Education and Research through the Program International Future Labs for Artificial Intelligence (Grant number 01DD20002A).  ... 
arXiv:2203.07211v1 fatcat:6anbk46knrdlff3kjcmxh7z6lu

Abstracts from the 25th European Society for Animal Cell Technology Meeting: Cell Technologies for Innovative Therapies

2018 BMC Proceedings  
Acknowledgements The authors acknowledge São Paulo Research Foundation -FAPESP (2015/ 19017-6), Centro de Pesquisa, Inovação e Difusão (CEPID), and National Institute of Science and Technology in Stem  ...  Acknowledgements Allison Kurz, Gian Andrea Signorell, Genedata AG P-132 High glucose concentration and low specific cell growth rate improve specific r-tPA productivity in chemostat culture of CHO Acknowledgements  ...  cycle includes getting data from the running cultivation, automated adaption of model parameters, prediction of future process course, computation of optimal feed profiles and realization.  ... 
doi:10.1186/s12919-018-0097-x fatcat:ty22x2oz5zfzlmbnh4p3twdx74

Proceedings of the British Society of Animal Science

2019 Advances in Animal Biosciences  
best practices for feeding pigs.  ...  References Acknowledgements The work was supported by BBSRC grants BBS/E/C/00010320 and BBS/E/C/000J0100 References Acknowledgements The Author is grateful for the award of a PhD scholarship with  ...  Supplementation of calf diets with a high dose of EO for a short period did not lead to an increased AMR in E. coli.  ... 
doi:10.1017/s2040470019000013 fatcat:n6z4zd7kijh3tavwtsqp6prske

Accelerating biological screenings through the combination of high-throughput and modeling [article]

Sebastian Hans, Technische Universität Berlin, Mariano Nicolas Cruz-Bournazou
The added value of the high-throughput turbidostat cultivations is demonstrated with a variety of Escherichia coli strains using a simple growth model in multi-well plates.  ...  This allows for: i) a better control of the pre-culture and a highly flexible inoculation strategy, ii) screening for fast growing mutants under controlled conditions, and iii) high throughput evolution  ...  We thank Maximillian Schulz from UniteLabs for his patient introduction and support for the SiLA2 implementation in Java and we thank Agnieszka Gawin for the good cooperation in the LEANPROT project.  ... 
doi:10.14279/depositonce-12144 fatcat:53bdpenssngbjlrnpknubd66re


2014 Advances in Animal Biosciences  
We develop a mathematical model of the ecology of the free-living stages of Fasciola hepatica, aiming to predict periods of risk under current and future climate scenarios and to explore control strategy  ...  It is transmitted by certain species of biting midge (Culicoides spp.) and can cause high levels of morbidity and mortality particularly in naive populations of sheep and certain species of deer.  ...  We are very grateful to E. Jones and Dr S. E. Girdwood for their technical assistance.  ... 
doi:10.1017/s2040470014000028 fatcat:2x2igc5erngbtejpnvvlwcukoy

Theatre presentations

2011 Advances in Animal Biosciences  
In: Bioengineering of the skin: water and the stratum corneum. Eds: P. Elsner, E. Berardesca, H.I. Maibach. C.R.C Press, Florida, 13-22.  ...  Acknowledgements I wish to thank the BBSRC for funding and the Donkey Sanctuary team in the UK and Ethiopia and Professor Stuart Reid for their help and support.  ...  The output from the model was used to estimate the sensitivity of the IMS method for a single E. coli O157 colony forming unit (CFU) which was defined as the probability of detection of single CFU (at  ... 
doi:10.1017/s2040470011000045 fatcat:bvlod4wzyzfrnnq4nfctvrocvu

Submitted summaries

2012 Advances in Animal Biosciences  
To achieve dietary inputs required to sustain high levels of milk production and allow tighter control over management inputs more cows in future may be managed in continuous housing systems (CHS).  ...  The frequency of lying and standing bouts (P<0.001) was lower in parasitized than in control bulls.  ...  In vitro evaluation, in vivo quantification, and microbial diversity studies of nutritional strategies for reducing enteric methane production.  ... 
doi:10.1017/s2040470012000039 fatcat:x2tbmnsxqndh3j7puwxgyq2sqe

Abstracts of Papers Presented at the 2007 Pittsburgh Conference

Peter B. Stockwell
2007 Journal of automated methods & management in chemistry (Print)  
Temperature is not possible to be controlled in the field but we can control the agitation of the fiber in the water sample.  ...  But for soldiers, who have many other tasks in which they must also continuously maintain skills, the design of both the detector and the training task must be as simple as can be safe and effective.  ...  ACKNOWLEDGMENTS Funding of this research by MPB Technologies Inc. and the Natural Sciences and Engineering Research Council of Canada is gratefully acknowledged.  ... 
doi:10.1155/2007/71943 pmid:18528514 pmcid:PMC2391256 fatcat:x3ojznxiufafpcjumeymzd5ise

Proceedings of the XIIIth International Symposium on Ruminant Physiology (ISRP 2019)

2019 Advances in Animal Biosciences  
Effect of Proteolytic Enzymes on Cytokine Concentrations, Uterine Inflammation and Fertility in Postpartum Water Buffalo with Cytological Endometritis Harpreet Singh 1,2 , Parkash Singh Brar 2 , Mrigank  ...  high-throughput phenotyping.  ...  Results demonstrate high precision of the EDOM method and its additive property, being an advantage for the estimation of OMD in compound feeds.  ... 
doi:10.1017/s2040470019000037 fatcat:hpfsjzye5nhznghzjci37jvwie

AMPERE 2021 Proceedings [article]

Per Olof Hedekvist, Birgitta Raaholt
2021 Zenodo  
The authors of the book are the chairs of the conference, and have been the editors of the book.  ...  All presenters are also encouraged to upload their full paper indivdually to the Zenodo community, for easier search and access.  ...  Acknowledgement The authors wish to thank BSH HAUSGERÄTE GMBH, Germany, for providing photos and IR pictures taken in Traunreut Plant together with Inventor Part Files with models for QuickWave software  ... 
doi:10.5281/zenodo.5644775 fatcat:bgrvslzxyrd6jnla4i327b5duq

Xxxii Scar Open Science Conference 'Antarctic Science And Policy Advice In A Changing World - Conference Abstracts [article]

Eoghan Griffin, Renuka Badhe
2016 Zenodo  
Abstracts from the 2012 Open Science Conference of the Scientific Committee on Antarctic Research (SCAR), Antarctic Science and Policy Advice in a Changing World, held in Portland, Oregon, USA  ...  In particular, improved modeling of geodynamic evolution of the Antarctic lithosphere that was a key  ...  These new magnetic data together with survey data that were not previously in the public domain can significantly upgrade the ADMAP compilation for crustal studies of the Antarctic.  ... 
doi:10.5281/zenodo.53122 fatcat:o56w4vr3n5bsvkyj6vnetfem3e

Abstracts Of The 16 Th International Conference On Electrical Bio-Impedance And 17 Th International Conference On Electrical Impedance Tomography [article]

Stig Ollmar, Farhad Abtahi, Björn-Erik Erlandsson, Birgitta Janerot-Sjöberg, Kaj Lindecrantz, Mannan Mridha, Ingrid Nicander, Fernand Seoane, Heikki Teriö
2016 Zenodo  
16 th International Conference on Electrical Bio-Impedance (ICEBI) 17 th International Conference on Electrical Impedance Tomography (EIT) Stockholm 19–23 June 2016 Book of Abstracts  ...  This enables a low-cost high-throughput microfluidic device for applications in biotechnology. MethoDs Escherichia Coli (E.  ...  Coli) K12 was chosen for these experiments because of its rapid doubling time. During preliminary culture the E. Coli was grown overnight to its maximum growth.  ... 
doi:10.5281/zenodo.55753 fatcat:fh3blon7kfhonbepjfllnwqjbq

8th international congress "sepsis and multiorgan dysfunction"

2017 Infection - Journal for the clinical study and treatment of infections  
They also thank Irene Serrano for helping with the statistical analysis and Dr Miguel Sánchez Garcia, head of the ICU for his advice interpreting the results.  ...  Also it is known that survivors often need help in coping with their everyday lives and are dependent on the support of family members.  ...  Results: We started feeding the model with gene expression data of each of the 8 carbon sources at a time and predicted the fluxes.  ... 
doi:10.1007/s15010-017-1046-8 pmid:28799000 fatcat:ozedtm56l5g6jle2nbnqstyy3e


2017 Biomedical Engineering  
For thin hepatic models (300 µm) no significant differences in albumin and urea secretion was observed between the printed and non-printed control group.  ...  Background Bioprinting offers huge potential for the generation of 3D in-vitro models for drug and toxicity testing.  ...  References Acknowledgements This work was supported by the InfectControl2020 HYFLY project "Effective strategies for the controlling and dealing with transmission pathways of pathogens in air traffic  ... 
doi:10.1515/bmt-2017-6016 fatcat:oooydssphfaptpn6ugxdpzfh2u

Abstracts from the 2016 OAS Annual Meeting

The Ohio Academy of Science
2016 The Ohio journal of science  
Abstracts from the 2016 Ohio Academy of Science Annual Meeting  ...  Systems with an optimized band gap can be used in diode lasers and high-speed transistor devices.  ...  Lacc2-pGEMt was cloned into DH10B E. coli competent cells and plated on LB (Ampicillin) media.  ... 
doi:10.18061/ojs.v116i1.5373 fatcat:y2fm2f7lcfdefpgylnuiuh3cji
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